Z-S Zeng

Memorial Sloan Kettering Cancer Center

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L-R Zhang

Center for Translational Molecular Medicine

J G Guillem

Memorial Sloan Kettering Cancer Center

Yaping Li

Shanghai Institute of Materia Medica

G-W Feng

W W Shang

First Affiliated Hospital of Zhengzhou University

Zuo‐Feng Zhang

University of California, Los Angeles

JR Marshall

Duke University

W-H Yang

National Yang Ming University Hospital

Carlos Cordon‐Cardo

Icahn School of Medicine at Mount Sinai

X-W Ren

Viva Biotech (China)

Cooperative Institutions

Memorial Sloan Kettering Cancer Center

Columbia University

Icahn School of Medicine at Mount Sinai

Columbia University Irving Medical Center

Cornell University

Center for Translational Molecular Medicine

Shanghai Institute of Materia Medica

Chinese Academy of Sciences

Jiangsu University of Science and Technology

Second Affiliated Hospital of Xi'an Jiaotong University

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Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancer

British Journal of Cancer (1995)

Zuo‐Feng Zhang Z-S Zeng AS Sarkis Ds Klimstra Elizabeth Charytonowicz

Quartile

Etiology

10.1038/bjc.1995.171

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Citations (17)

Simvastatin-induced myopathy with concomitant use of cyclosporine: case report

International Journal of Clinical Pharmacology and Therapeutics (2011)

W-H Yang Z-S Zeng X-W Ren Yaping Li W W Shang

Simvastatin has been shown to play an important role in reducing the risk of cardiovascular events caused by atherosclerosis. To promote the understanding of the potential toxicity of simvastatin and individualized treatment in genetic factors, we report a case of a renal transplant in a female patient who had developed acute myopathy after taking simvastatin.By PCR restriction fragment length polymorphism (PCR-RFLP) and allele-specificity polymerase chain reaction (AS-PCR) and direct sequencing. The genotypes of CYP3AP1, CYP3A5, CYP3A4 and SLCO1B1 were analyzed.The patient was identified to have mutant genotypes of CYP3AP1*3/*3 (-44G > A), CYP3A5*3/*3 (6986A > G) and wild genotype of CYP3A4*1/*1 and SLCO1B1*1/*1, which finally led to the elevation of her cyclosporine level except the SLCO1B1*1/*1 genotype and the acceleration of simvastatin-induced acute myopathy.Genetic factors have partly contributed to the development of simvastatin-induced myopathy with concomitant use of cyclosporine, and provided information on the adverse reactions of statins. What is different from other studies is that the SNP of SLCO1B1*5 does not take part in this adverse reaction.

SLCO1B1

Concomitant

SNP

10.5414/cp201623

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Citations (11)