Colon targeted drug delivery system (CTDDS) delivered as both local and systemic delivery of drugs. Local delivery could, for example, allow topical treatment of inflammatory bowel disease (IBD). Treatment could be enhanced when drug delivered to the target site on the colon. Systemic side effects could also be reduced. Colon specific systems is most important delivery of those drug which are normally inactivated in the upper parts of the gastrointestinal tract (GIT). Primary approaches for CTDDS (Colon targeted Drug Delivery System), which includes prodrugs, pH and time dependent systems, Bacterial enzyme dependent colonic DDS and pH and bacterial enzyme dependent colonic DDS. The novel approach of CTDDS, which includes pressure controlled colonic delivery capsules (PCDCS), CODES and osmotic controlled drug delivery are specific technique.
This paper is an attempt to study Vṛṣṇi cult in a holistic manner. The author has already worked on the cult in his previously published article “Vṛṣṇis in Ancient Art and Literature”. This article adds to the already published work with three new important findings. The most important finding is the rock painting from Naldah, District Bundi which the author has identified as Pañca-Vṛṣṇi Vīras, the other is important finding of this cult from Pasopa, District Bharatpur and the last is the newly found Vṛṣṇi triad from Berenike, Egypt which has been recently published online by Shailen Bhandare. This article also combines the information on Vṛṣṇi cult in south India which the author had published in a joint paper with Late Mrs. (Dr.) Haripriya Rangarajan
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