Zu-Lan Su

Sun Yat-sen University

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Chun‐Kui Shao

Third Affiliated Hospital of Sun Yat-sen University

Zhiying Feng

Zhejiang University

Li Ling

Sun Yat-sen University

Lu-Ying Tang

Third Affiliated Hospital of Sun Yat-sen University

Jun Pang

The Seventh Affiliated Hospital of Sun Yat-sen University

Weipeng Liu

Nanchang University

Qipeng Sun

Guangdong Academy of Medical Sciences

Xin Gao

Zhongshan Hospital

Dan He

Syneos Health (United States)

Jianguang Qiu

Fujian Academy of Agricultural Sciences

Cooperative Institutions

Sun Yat-sen University

Third Affiliated Hospital of Sun Yat-sen University

Guangzhou Medical University

Southern Medical University

Sichuan University

Guangdong Provincial People's Hospital

Fudan University

Guangdong Academy of Medical Sciences

Sun Yat-sen University Cancer Center

Chinese Academy of Medical Sciences & Peking Union Medical College

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[Significance of ALK gene expression in neoplasms and normal tissues].

PubMed (2002)

Chun‐Kui Shao Zu-Lan Su Zhiying Feng Hui‐Lan Rao Lu-Ying Tang

This study was designed to investigate the clinicopathologic significance of the ALK gene expression in neoplasms and normal tissues.Using the immunohistochemical method, the expressions of ALK gene were examined on 14 anaplastic large cell lymphoma (ALCL). 10 Hodgkin's lymphoma, 46 B lymphoma, 13 T lymphoma, 21 malignant astrocytoma, 5 medulloblastoma, 5 ependymoma, 69 carcinomas, 19 sarcomas, and many normal tissues.(1) The expression rate of ALK was 64.3% in ALCL, it is significantly higher than that in Hodgkin's lymphoma, B lymphoma, and other T lymphoma(P < 0.01). (2) There was strongly expression of ALK in hepatocellular carcinoma, malignant astrocytoma, and medulloblastoma. (3) There was weakly expression of ALK in placenta tissue and astrocyte.(1) The ALK protein is a very important molecular marker in ALCL, it is very helpful for diagnosing and distinquishing ALCL. (2) ALK gene may take part in the origin and development of hepatocellular carcinoma, malignant astrocytoma, and medulloblastoma and may be an important gene associated with neoplasms.

Ependymoma

Anaplastic large-cell lymphoma

Anaplastic astrocytoma

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An animal model of chronic rheumatic valvulitis induced by formalin-killed streptococci

Rheumatology International (2009)

Xujing Xie Han-jian Zhou Jianlin Huang Huanlei Huang Zhiying Feng

Animal model

10.1007/s00296-009-1246-3

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Role of co-expression of c-Myc, EZH2 and p27 in prognosis of prostate cancer patients after surgery

Chinese Medical Journal (2013)

Ke Li Ming-Kun Chen Jie Situ Wentao Huang Zu-Lan Su

Background c-Myc , EZH2 and p27 were defined to modulate the behavior of prostate cancer with pro-tumoral or anti-tumoral effects and had ability in predicting prostate cancer progression, but the research of their co-expression value of prognosis is rarely. This study aimed to investigate the prognostic value of combining tri-marker together in patients with intermediate-risk prostate cancer after surgery. Methods Expression levels of c-Myc , EZH2 and p27 in 129 patients with intermediate-risk prostate cancer were assessed using immunohistochemistry in a semi-quantitative manner. The expression profiles of these three markers were analyzed and investigated for association with biochemical recurrence. Results In all, fifty of 129 cases experienced biochemical recurrence during a median follow-up time of 31 months (range, 6-60 months). Of these relapse patients, one case without and 10 cases with any single positive marker were observed; 39 cases were detected with any two or all three positive markers (22 cases with any two and 17 cases with all three positive markers). Survival analysis showed that patients with over-expression of c-Myc or EZH2 , and lower expression of p27 manifested significantly higher biochemical recurrence rates. Subsequent multivariate analysis revealed that c-Myc , EZH2 and p27 expression statuses showed potential in predicting relapse, respectively. Notably, combining three markers together as a “composite index” (0 or 1, vs. 2 or 3 positive markers) provided powerful prognostic value ( HR 6.57, 95% CI 3.02-14.31, P <0.001). There was a significant difference between the patient subgroups with 0 or 1 and those with 2 or 3 positive markers expression statuses, and tri-marker composite index was an independent risk factor for predicting relapse in patients with intermediate-risk prostate cancer after surgery. Conclusion Composite index of c-Myc , EZH2 , and p27 can be valued as powerful prognosis parameter for intermediate-risk prostate cancer patients after the surgery, and postoperative adjuvant therapy can be adopted accordingly.

Biochemical recurrence

10.3760/cma.j.issn.0366-6999.20122477

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Citations (22)

Profiling Protein Markers Associated with Lymph Node Metastasis in Prostate Cancer by DIGE-based Proteomics Analysis

Journal of Proteome Research (2009)

Jun Pang Weipeng Liu Xiaopeng Liu Li Ling Youqiang Fang

Current predictive tools and imaging modalities are not accurate enough for preoperative diagnosis of lymph node metastatic prostate cancer (LNM PCa). Proteomic analysis is introduced to screen potential biomarkers for early detection of LNM PCa. In our initial study, protein samples from localized and LNM PCa as well as benign prostatic hyperplasia tissues were analyzed using two-dimensional fluorescence difference in gel electrophoresis (2-D DIGE) coupled with MALDI-TOF/TOF MS. We identified 58 proteins that were differentially expressed in the LNM PCa group relative to the localized PCa group. Six of these proteins, e-FABP5, MCCC2, PPA2, Ezrin, SLP2, and SM22, are functionally relevant to cancer metastasis. Expression of these proteins was therefore further validated in tissue samples from the original cohort and also from a larger, independent cohort of patients using real time PCR, Western blotting, and immunohistochemistry staining. In addition, the serum levels of e-FABP5 were also examined by ELISA. Relative to localized PCa tissues, LNM PCa tissues had increased expression of e-FABP5, MCCC2, PPA2, Ezrin, and SLP2 and decreased expression of SM22. Patients with LNM PCa had significantly higher levels of serum e-FABP5. This study presents evidence that increased expression of e-FABP5, MCCC2, PPA2, Ezrin, and SLP2 and decreased expression of SM22 are useful diagnostic markers for the existence of LNM PCa.

Difference gel electrophoresis

Proteome

10.1021/pr900953s

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Citations (107)

Significance of typing in the survival malignant lymphoma

Chinese Journal of Cancer Research (1993)

Zu-Lan Su Bin Chen Zikang Zhang Shangfu Zhang Qincai Cheng

The significance of typing and subtyping in the survival rate of 116 patients suffering from pathologically proved malignant lymphoma is presented. Our data show that Hodgkin's disease was least malignant, having the highest survival curve (P less than 0.005). Lymphoblastic lymphoma had the highest degree of malignancy, having the lowest survival curve. Yet, the middle portion of its curve resembled that of the peripheral T cell lymphoma. Although the degree of malignancy and the curve of peripheral T cell lymphoma and B cell lymphoma were similar (0.05 greater than P greater than 0.05), their middle portion were separated, a fact worthy of further study. Typing of malignant lymphomas is of practical importance.

Subtyping

Malignant lymphoma

10.1007/bf02997606

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Expression of UBE1 and Bcl-2 in diffuse large B cell lymphoma and its clinical significance

Academic Journal of Second Military Medical University (2013)

Bing Chen Zu-Lan Su

Clinical Significance

Expression (computer science)

10.3724/sp.j.1008.2013.00295

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Detection of TMPRSS2-ETS Fusions by a Multiprobe Fluorescence in Situ Hybridization Assay for the Early Diagnosis of Prostate Cancer

Journal of Molecular Diagnostics (2010)

Qipeng Sun Li Ling Zhong Chen Jun Pang Wei-Jiao Yang

TMPRSS2

Prostate biopsy

10.2353/jmoldx.2010.100002

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Citations (27)

[Expressions of matrix metalloproteinase 9 in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus infection].

Zhiying Feng Xiang-Lan Mo Chun‐Kui Shao Zu-Lan Su

To investigate the expression of matrix metalloproteinase 9 (MMP9) in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus (EBV) infection.The expression of MMP9 and EBV-encoded RNA (EBER) were detected by immunohistochemistry and in situ hybridization in 59 cases of mucosal natural killer/T cell and mature T cell lymphomas.The positivity rates of MMP9 and EBERs were 83.05% and 72.88% respectively. The positivity rate of EBERs was correlated with histopathological subtype (P<0.05), but not with clinical stage, vascular invasion or the patients' survival time (P>0.05). The expression level of MMP9 was not correlated with the clinical stage, vascular invasion or survival time (P>0.05). No significant correlation was found between MMP9 expression and EBV infection.EBV may play an important role in the development of mucosal natural killer/T cell and mature T cell lymphomas and promote disease progression by up-regulating MMP9 expression indirectly. Elimination of EBV infection may be helpful to prevent the development of lymphoma.

MMP9

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Prospective validation of DACH2 as a novel biomarker for prediction of metastasis and prognosis in muscle-invasive urothelial carcinoma of the bladder

Biochemical and Biophysical Research Communications (2015)

Yadi He Zihuan Luo Ming Yang Xing-Xing Ruan Shaoyuan Liu

10.1016/j.bbrc.2015.02.119

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[Protein expressions of Fas and FasL in B-cell lymphoma and their significances].

PubMed (2005)

Yi Jin Ying-Chun Li Zu-Lan Su Lu-Ying Tang Zhiying Feng

Fas and FasL have been proved to be the inductional genes of cell apoptosis. Genesis of many tumors relates with functional disorder and abnormal expressions of Fas and FasL. This study was designed to detect protein expressions of Fas and FasL in B-cell non-Hodgkin's lymphoma (B-NHL) and benign lymphoid tissue, and to provide new markers for diagnosis of lymphoma.Immunohistochemistry was used to detect protein expressions of Fas and FasL in 92 specimens of B-NHL, and 20 specimens of benign lymphoid tissue.Fas mostly expressed on membrane. FasL mostly expressed in cytoplasm, and partially expressed in nuclei. Positive rate of Fas in B-NHL was 66.3% (61/92), and that of FasL in B-NHL was 67.4% (62/92). Positive rates of both Fas and FasL in benign lymphoid tissue were 60.0% (12/20). There was no significant difference in expressions of Fas and FasL between B-NHL group and benign group (P>0.05), but positive locations of Fas and FasL in these 2 groups are different. Positive rates of Fas and FasL were higher in diffuse large B-cell lymphoma (DLBL) than in follicular lymphoma (FL), and small cell lymphoma (SLL) (87.2% vs. 64.5%, and 31.8%, P<0.05u 89.7% vs. 67.7%, and 27.3%, P<0.05). Positive rates of Fas and FasL in FL were higher than those in SLL. No correlation was found between Fas/FasL expression and patients' gender, age, and tumor location.The expressions of Fas and FasL are not useful for distinguishing benign lymphoid tissue from lymphoma tissue, while their locational characteristics are valuable for differential diagnosis. The expressions of Fas and FasL are considered valuable in evaluating the malignant grade of B-NHL.

Fas ligand

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