Bide Wu

Zhangzhou Municipal Hospital of Fujian Province

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Shanying Chen

Zhangzhou Municipal Hospital of Fujian Province

Xiaofei Shao

Third Affiliated Hospital of Southern Medical University

Youming Chen

Shanghai Public Health Clinical Center

Mi Li

Huazhong University of Science and Technology

Hequn Zou

Third Affiliated Hospital of Southern Medical University

Yan Liang

Huazhong University of Science and Technology

Harry Holthöfer

University of Helsinki

Xuejian Lian

Zhangzhou Municipal Hospital of Fujian Province

Xinyu Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Yongqiang Li

First People's Hospital of Nanning

Cooperative Institutions

Zhangzhou Municipal Hospital of Fujian Province

Fujian Medical University

Third Affiliated Hospital of Southern Medical University

Southern Medical University

Shenzhen University

The Synergetic Innovation Center for Advanced Materials

Nanjing University of Posts and Telecommunications

Wenzhou Medical University

First Affiliated Hospital of Wenzhou Medical University

Chongqing Medical University

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Insulin resistance and metabolic syndrome in normal-weight individuals

Endocrine (2013)

Shanying Chen Youming Chen Xinyu Liu Mi Li Bide Wu

10.1007/s12020-013-0079-8

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Citations (50)

Association of Insulin Resistance with Chronic Kidney Disease in Non-Diabetic Subjects with Normal Weight

PLoS ONE (2013)

Shanying Chen Youming Chen Xinyu Liu Mi Li Bide Wu

ObjectiveTo the best of our knowledge, the association of insulin resistance (IR) with chronic kidney disease (CKD) has not been well studied in normal-weight individuals. The aim of this study is to examine whether IR is associated with CKD in non-diabetic subjects with normal weight. We also examine whether the presence of obesity modifies the association of IR with CKD. MethodsData were drawn from a cross-sectional survey in China. Both estimated glomerular filtration rate and urinary albumin to creatinine ratio were used as markers of CKD. Logistic regression models and the quartiles of homeostatic model assessment of insulin resistance were used to explore the associations of IR with CKD in entire cohort, normal-weight and overweight/obese subpopulations. ResultsIn normal-weight subpopulation, the prevalence of IR and metabolic syndrome were 11.11% and 8.99%, respectively. In the entire cohort, the highest quartile HOMA-insulin resistance had a 70% increased risk for CKD (RR 1.70, 95% CI 1.07, 2.71, P=0.03, comparing the highest to the lowest quartile). However, when adding obesity to the model, the association was abolished. IR was associated with CKD in overweight/obese subpopulation but not in normal-weight subpopulation. ConclusionIR and MetS in normal-weight individuals is common in the Chinese population. IR is associated with CKD in overweight/obese subpopulation but not in normal-weight subpopulation and the presence of obesity modifies the association of IR with CKD.

Quartile

Homeostatic model assessment

10.1371/journal.pone.0074058

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Citations (38)

Association of Anthropometric indexes with chronic kidney disease in a Chinese population

Clinical Nephrology (2013)

Shanying Chen Bide Wu Xinyu Liu Youming Chen Yongqiang Li

Obesity is associated with an increased risk of chronic kidney disease (CKD), but the best anthropometric obesity measure remains controversial. This study aimed to examine the associations of anthropometric indexes with CKD risk and which anthropometric index is a better predictor of CKD.Data was drawn from a cross-sectional study in China. We used four anthropometric indexes: body mass index (BMI), waist circumference (WC), waist-to hip ratio (WHR), and waist-to-height ratio (WHtR). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/ min/1.73 m2 or urinary albumin to creatinine ratio (ACR) ≥ 30 mg/g. Logistic regressions were used for the analyses.1,834 participants were included in the analyses. After adjusting for potential confounders, BMI, WC and WHtR were significantly associated with CKD in men and women. The respective odd ratios for BMI (every SD increment), WC (every SD increment), and WHtR (every SD increment) were 1.46, 1.40, and 1.45 in men as well as 1.21, 1.31, and 1.38 in women. After adjusting for potential confounders, WHR was associated with CKD in women but not men. In women, the associations of WC, WHR and WHtR with CKD was independent of other MetS components. No difference in WHtR was observed between men and women.Anthropometric indexes are associated with CKD. The associations of anthropometric indexes with CKD are independent of other MetS components in women but not men. In women, central obesity indexes are better than BMI for predicting of CKD.

Waist-to-height ratio

Waist–hip ratio

10.5414/cn108002

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Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre

International Journal of Environmental Research and Public Health (2015)

Shanying Chen Xuejuan Sun Bide Wu Xuejian Lian

Objective: To evaluate the outcome of 80 pregnant women with systemic lupus erythematosus (SLE) and explore the risk factors for lupus flare, obstetric complications and fetal loss. Methods: 83 pregnancies in 80 women were divided into three groups. Group A: patients in remission for > 6 months before pregnancy, proteinuria < 0.5 g per day, without renal failure and discontinuation of cytotoxic drugs for > one year; Group B: patients with SLE disease activity in the six months before pregnancy; Group C: patients with new onset SLE during pregnancy. Results: In group A, 76.47% pregnancies achieved full-term deliveries and 80.39% achieved live born infants. In group B and C, the outcome was poor. Among 62 patients (64 pregnancies) diagnosed as SLE before pregnancy, SLE flares occurred in 27 (42.19%) pregnancies. SLE disease activity in the six months before pregnancy was significantly associated with lupus flare (OR 5.00, 95% CI 1.14–21.87, p = 0.03) and fetal loss. New onset lupus during pregnancy was independently associated with obstetric complications (OR 7.22, 95% CI 2.14–24.38, p = 0.001). Conclusions: The current study confirmed the previous report that SLE should be considered a high risk of pregnancy. If pregnancy is planned after remission for > 6 months, the favorable outcome can be achieved.

Discontinuation

10.3390/ijerph120809876

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The Transcriptome Study of Subtype M2 Acute Myeloblastic Leukemia

Cell Biochemistry and Biophysics (2015)

A-Yang Wu Hui-Cong Yang Congmeng Lin Bide Wu Qi-shui Qu

Acute myeloblastic leukemia

10.1007/s12013-014-0432-4

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Cardiac Troponin I in Non- Acute Coronary Syndrome Patients with Chronic Kidney Disease

PLoS ONE (2013)

Shanying Chen Chunhong Huang Bide Wu Xuejian Lian Xuqiao Mei

ObjectiveThe aim of this study was to assess the results of troponin I (cTnI) in non- acute Coronary Syndrome (ACS) patients with chronic kidney disease (CKD). We also examined the risk factors for elevated cTnI in non-ACS patients with CKD and whether stage 5 CKD modifies the associations of elevated cTnI and the risk factors in non-ACS patients with CKD. MethodsA retrospective study was performed. Logistic regression models were used. Results293 non-ACS patients with CKD were included in the current study. 43.34% non-ACS patients with CKD have an elevated cTnI level and 5.12% have an elevated cTnT level in MI range. In CKD patients without ACS and heart failure, only 26.03% (38/146) patients have an elevated cTnT level. In adjusted analyses, age, diastolic blood pressure and congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD. Congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD (OR 2.30, 95% CI 1.08,4.88, P=0.03). Stage 5 CKD does not modify the association of congestive heart failure and an elevated cTnI level. Conclusion43.34% non-ACS patients with CKD and 26.03% CKD patients without ACS and congestive heart failure have an elevated cTnI level. Congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD. Stage 5 CKD does not modify the association of congestive heart failure and an elevated cTnI level.

10.1371/journal.pone.0082752

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Citations (19)