Yuzhang Zhu

First Hospital of China Medical University

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Xueyi Wang

Hebei Medical University

Hong Deng

Ghent University

Lanfen Liu

Hebei Provincial Center for Disease Control and Prevention

Jonathan Flint

University of California, Los Angeles

Shenxun Shi

Huashan Hospital

Jing Sun

Griffith University

Wei Liang

Shenzhen University

Kenneth S. Kendler

Virginia Commonwealth University

Yunchun Chen

First Affiliated Hospital of Xi'an Jiaotong University

Yihan Li

Guangxi University

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Central South University

Zhejiang University

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Capital Medical University

Shandong University

Huazhong University of Science and Technology

Xi'an Jiaotong University

Sun Yat-sen University

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Suicidal Risk Factors of Recurrent Major Depression in Han Chinese Women

PLoS ONE (2013)

Yuzhang Zhu Hongni Zhang Shenxun Shi Jingfang Gao Youhui Li

The relationship between suicidality and major depression is complex. Socio- demography, clinical features, comorbidity, clinical symptoms, and stressful life events are important factors influencing suicide in major depression, but these are not well defined. Thus, the aim of the present study was to assess the associations between the above-mentioned factors and suicide ideation, suicide plan, and suicide attempt in 6008 Han Chinese women with recurrent major depression (MD). Patients with any suicidality had significantly more MD symptoms, a significantly greater number of stressful life events, a positive family history of MD, a greater number of episodes, a significant experience of melancholia, and earlier age of onset. Comorbidity with dysthymia, generalized anxiety disorder (GAD), social phobia, and animal phobia was seen in suicidal patients. The present findings indicate that specific factors act to increase the likelihood of suicide in MD. Our results may help improve the clinical assessment of suicide risk in depressed patients, especially for women.

Depression

10.1371/journal.pone.0080030

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CLINICAL PREDICTORS OF FAMILIAL DEPRESSION IN HAN CHINESE WOMEN

Depression and Anxiety (2011)

Lina Wang Dongdong Qiao Yihan Li Liwei Wang Jianer Ren

Background A number of clinical features potentially reflect an individual's familial vulnerability to major depression (MD), including early age at onset, recurrence, impairment, episode duration, and the number and pattern of depressive symptoms. However, these results are drawn from studies that have exclusively examined individuals from a European ethnic background. We investigated which clinical features of depressive illness index familial vulnerability in Han Chinese females with MD. Methods We used lifetime MD and associated clinical features assessed at personal interview in 1,970 Han Chinese women with DSM-IV MD between 30–60 years of age. Odds Ratios were calculated by logistic regression. Results Individuals with a high familial risk for MD are characterized by severe episodes of MD without known precipitants (such as stress life events) and are less likely to feel irritable/angry or anxious/nervous. Conclusions The association between family history of MD and the lack of a precipitating stressor, traditionally a characteristic of endogenous or biological depression, may reflect the association seen in other samples between recurrent MD and a positive family history. The symptomatic associations we have seen may reflect a familial predisposition to other dimensions of psychopathology, such as externalizing disorders or anxiety states. Depression and Anxiety 0:1–6, 2011. © 2011 Wiley-Liss, Inc.

Depression

Family aggregation

Stressor

10.1002/da.20878

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