Background: Patients with acute coronary syndrome (ACS) treated with primary percutaneous coronary intervention (PCI) are at increased risk of contrast-induced acute kidney injury (AKI), which is a...

Source

Cite

Citations (0)

Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction

Clinical Chemistry (1997)

Junnichi Ishii Jianhua Wang Hiroyuki Naruse Shinn Taga Masatomo Kinoshita

We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95% confidence interval (CI) = 0.913-0.979] and myoglobin (0.895, 95% CI = 0.846-0.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.765-0.881). In 165 patients, the sensitivity (81.8%, 95% CI = 74.2-89.4%), specificity (86.4%, 95% CI = 78.1-94.6%), and predictive accuracy (83.6%, 95% CI = 78.0-89.3%) of H-FABPc > 12 micrograms/L in diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABPc > 12 micrograms/L and the ratio < or = 14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.

10.1093/clinchem/43.8.1372

Cite

Citations (128)

Advantages and Disadvantages of Dobutamine Stress Echocardiography Compared With Treadmill Exercise Electrocardiography in Detecting Ischemia

Japanese Circulation Journal (1996)

Masatsugu Iwase Masako Fukui Hiromi Tamagaki Miyuki Kimura Kazuo Hasegawa

We compared the effectiveness and practicability of dobutamine stress echocardiography (DSE) and treadmill exercise electrocardiographic testing (TMT) for detecting coronary artery disease. Ninety-six patients (mean age 58.8±9.0 years) who presented for coronary angiography underwent both DSE and symptom-limited TMT. Two-dimensional echocardiography was performed to detect ischemia-induced wall motion abnormalities during incremental dobutamine infusion (5-40 μg/kg per min administered in 5 min steps). The sensitivity of detecting ischemia was 63% for TMT and 79% for DSE (p<0.05); the specificity was 61% for TMT and 88% for DSE (p<0.05). The accuracy of TMT was 63% and of DSE 82% (p<0.01). In patients in whom both tests gave true-positive results, the maximum ST depression was evaluated during DSE and TMT (n=31). The ST segment depressions detected by DSE were significantly smaller than those detected by TMT (0.04±0.04 mV vs 0.17±0.07 mV, p<0.01), and 10 patients had no evidence of ST segment depression despite the presence of new wall motion abnormalities. DSE took significantly longer to perform than TMT (26.0±5.0 min vs 5.5±2.0 min, p<0.01). Thus, DSE is more sensitive, specific and accurate than TMT in detecting coronary artery disease and can detect ischemia at an earlier stage. However, it takes longer to perform than TMT and thus may be less suitable for routine clinical use. (Jpn Circ J 1996; 60: 954 - 960)

ST depression

Dobutamine

Treadmill

Depression

Stress Echocardiography

10.1253/jcj.60.954

Cite

Citations (11)

Early detection of successful coronary reperfusion based on serum concentration of human heart-type cytoplasmic fatty acid-binding protein

Clinica Chimica Acta (1997)

Junnichi Ishii Y. Nagamura Masanori Nomura Jian-hua Wang Shinn Taga

Reperfusion Therapy

TIMI

Myocardial reperfusion

10.1016/s0009-8981(97)06547-9

Cite

Citations (30)

PTH measurement validation in uremic patients on hemodialysis.

Nihon Toseki Igakkai Zasshi (1997)

Masanori Nomura Osamu Takase Yusuke Tsukamoto T Ando

血液透析を受けている慢性腎不全患者において3種類のPTH測定キット (C-PTH, HS-PTH, AI-PTH) の精度評価を行い下記の結果を得た.(1) 標準血清を用いて求めた検出曲線は3種のPTHとも良好な反応曲線が得られた. 検出感度は, C-PTHは0.3-0.4ng/ml, HS-PTHは120pg/ml付近, AI-PTHは2pg/mlであった. (2) 血液透析患者における同時再現性 (intra-assay) と測定間再現性 (inter-assay) は変動係数でそれぞれ, C-PTHが4.4%, 3.9%, HS-PTHが4.5%, 7.0%, AI-PTHで3.4%, 8.5%であり, いずれも良好な測定精度が得られた. (3) 採血後全血状態での放置時間が安定性に及ぼす影響を検討したところ, C-PTHは15分から24時間まで安定, HS-PTHは15分から8時間まで安定で24時間では有意に低下, AI-PTHは30分から2時間までバラツキの少ない安定した測定値が得られたが, 15分でやや高値, 4時間以降有意な低値を示した. 従って, 血液透析患者で安定したPTHの測定値を得るにはC-PTHは採血後15分から24時間, HS-PTHは15分から8時間, AI-PTHは30分から2時間放置して血清分離することがすすめられる. (4) 同一条件下に管理された患者での週差変動は変動係数で, C-PTHが8.1%, HS-PTHが9.7%, AI-PTHが20.7%であった.

10.4009/jsdt.30.191

Cite

Citations (1)