Yan Cui

Northeastern University

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Zhiyu Zhang

Fourth Affiliated Hospital of China Medical University

Duoyi Zhao

Fourth Affiliated Hospital of China Medical University

Wei Zhao

Anqing City Hospital

Chengbin Ma

Fourth Affiliated Hospital of China Medical University

Jiajun Zhu

Soochow University

Min Huang

Northeastern University

Weilin Zhang

Guangdong Medical College

Kai Cui

Guizhou University

Zhi‐yu Zhang

Peking University

Xuesi Chen

Changchun Institute of Applied Chemistry

Cooperative Institutions

China Medical University

Fourth Affiliated Hospital of China Medical University

Chinese Academy of Sciences

Jilin University

Northeastern University

University of Chinese Academy of Sciences

Changchun Institute of Applied Chemistry

State Key Laboratory of Synthetical Automation for Process Industries

Chinese Academy of Medical Sciences & Peking Union Medical College

Sichuan University

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Interleukin 10 gene −1082A/G polymorphism is associated with osteosarcoma risk and poor outcomes in the Chinese population

Tumor Biology (2015)

Yan Cui Jiajun Zhu Chengbin Ma Kai Cui Feng Wang

Interleukin-10 (IL-10) is a multifunctional cytokine that participates in the development and progression of various malignant tumors. However, data regarding the role of IL-10 polymorphisms in osteosarcoma development are not available. A case-control study was conducted in 260 patients with osteosarcoma and 260 healthy controls to investigate the possible association between IL-10 polymorphisms and the risk of osteosarcoma. Our results indicate the IL-10 -1082A/G (rs1800896) polymorphism is significantly associated with an increased risk of osteosarcoma in all genetic models (AG vs. AA, odds ratio (OR) = 1.56; 95 % confidence interval (CI) = 1.28-2.32, P = 0.017; GG vs. AA, OR = 1.62, 95 % CI 1.24-2.61, P = 0.013; AG + GG vs. CC, OR = 1.76, 95 % CI = 1.31-3.01, P = 0.019). However, the genotype and allele frequencies of IL-10 -819C/T (rs1800871) and -592A/C (rs1800872) polymorphisms in osteosarcoma patients did not significantly differ from controls. Further analyses revealed that the IL-10 -1082A/G (rs1800896) genotypes were associated with advanced tumor stages and metastasis in osteosarcoma patients. Additionally, a statistically significant association between the IL-10 -1082A/G (rs1800896) genotype and poor survival in osteosarcoma patients was observed. Our results demonstrate that the IL-10 -1082A/G (rs1800896) genotype is associated with an increased susceptibility and worse outcome for osteosarcoma patients in the Chinese Han population.

10.1007/s13277-015-4238-9

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Citations (10)

Effect of lentivirus-mediated miR-182 targeting FGF9 on hallux valgus

International Journal of Medical Sciences (2021)

Weilin Zhang Duoyi Zhao Wei Zhao Yan Cui Qin Li

The pathogenesis of hallux valgus is not clearly understood.However, genetics research about hallux valgus is rare.Therefore, the present study aimed to explore the pathogeny of hallux valgus from the perspective of genetics.Human samples were collected from normal bone tissue and hallux valgus region bone tissue.The bone samples were studied using real time-PCR, western blot and immunohistochemical.Lentivirus-mediated miR-182 transfected osteoblasts and tested the expression of FGF9 mRNA with real time-PCR.To test alkaline phosphatase activity, number of calcium nodules and proliferation of osteoblast with enzymatic activity analysis, calcium nodules stained and MTT assay.We found that (1) FGF9 expressed in hallux valgus region bone tissue was significantly higher than normal bone tissue.(2) miR-182 expression levels in hallux valgus region bone tissue were notably lower than those of normal bone tissue.(3) miR-182 could negatively regulate the expression of FGF9 in osteoblasts.(4) FGF9 may enhance osteoblasts proliferation.We have demonstrated that miR-182 promotes the formation of bone by targeting FGF9, implicating an essential role of miR-182 in the etiology of hallux valgus.Moreover, miR-182 might potentially be a therapeutic target for hallux valgus treatment.

FGF9

10.7150/ijms.50984

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Tartary buckwheat flavonoid activates caspase 3 and induces HL-60 cell apoptosis

Methods and Findings in Experimental and Clinical Pharmacology (2001)

W. Ren Qiao Zhang H. Wang Lei Zhu L. Zhang

It has been proposed that flavonoids may have potential as anticancer agents. In this study, we showed that tartary buckwheat flavonoid (TBF) obviously inhibits the growth of human acute myelogenous leukemia (AML) HL-60 cells by MTT assay. The inhibitory effect of TBF on the proliferation of HL-60 cells is related to the induction of apoptosis, which is confirmed by DNA ladder formation on gel electrophoresis and apoptosis morphological changes under light microscope. Furthermore, HL-60 cells undergo rapid apoptosis upon treatment with TBF, as indicated by increased annexin V binding capacity and caspase 3 activation with flow cytometric analysis. Thus, our data provide a potential mechanism for the chemopreventive activity of tartary buckwheat flavonoid and suggest that it may have a potentially therapeutic role for human leukemia.

MTT assay

10.1358/mf.2001.23.8.662129

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Genetic polymorphisms in MMP 2, 3 and 9 genes and the susceptibility of osteosarcoma in a Chinese Han population

Biomarkers (2016)

Yan Cui Jiajun Zhu Chengbin Ma Kai Cui Feng Wang

Background: There are no data about the role of MMPs polymorphism in development of osteosarcoma.Patients and methods: Two-hundred fifty-one patients with osteosarcoma and 251 healthy controls were included to investigate the association between the MMP2, 3, 9 polymorphisms and the risk of osteosarcoma.Results: Compared with the MMP2 SNP rs243865 homozygote CC, The heterozygous CT genotype was associated with significantly increased risk for osteosarcoma (OR = 1.86, 95% CI = 1.18–4.22, p = 0.014); the TT genotype was associated with increased risk for osteosarcoma (OR = 1.92, 95% CI = 1.21–3.52, p = 0.028). However, the genotype and allele frequencies of MMP3 rs3025058 and MMP9 rs3918242 polymorphisms were not significantly different.Conclusion: MMP2 rs243865 genotype was associated with increased risk for development of osteosarcoma in Chinese Han population.

SNP

MMP2

10.3109/1354750x.2015.1118550

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Calcium-mineralized polypeptide nanoparticle for intracellular drug delivery in osteosarcoma chemotherapy

Bioactive Materials (2020)

Ke Li Di Li Zhao Li Yonghe Chang Yi Zhang

The acidic microenvironments of tumor tissue and cells provide an opportunity for the development of pH-responsive drug delivery systems in cancer therapy. In this work, we designed a calcium carbonate (CaCO3)-core-crosslinked nanoparticle of methoxy poly(ethylene glycol)-block-poly(l-glutamic acid) through mineralization for intracellular delivery of doxorubicin (DOX), referred to as CaNP/DOX. CaNP/DOX exhibited high drug loading capability, uniform nanoparticle size, and pH-dependent DOX release. In the meantime, the enhanced cell uptake, superior cytotoxicity toward mouse osteosarcoma K7 cells, extended circulation half-life, and improved accumulation of DOX in K7 allograft tumor from CaNP/DOX were also demonstrated. More interestingly, CaNP/DOX displayed improved antitumor effect and reduced side effects against the K7 osteosarcoma-allografted mouse model and the 143B orthotopic osteosarcoma mouse model. Given the superior properties of Ca-mineralized polypeptide nanoparticle for intracellular drug delivery, the smart drug delivery system showed strong competitiveness in clinical chemotherapy of cancers.

Calcium in biology

Targeted drug delivery

10.1016/j.bioactmat.2020.04.010

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Citations (62)

Body Scanning Avatar and Draping Simulation

Shu‐Hwa Lin Ju‐Young M. Kang Yan Cui Didier Stricker

Speedy developing CAD technology has changed the product development process in the apparel industry (Cho, Park, Boeing, & Hingston, 2010). For more than a decade, body scanning has provided accurate body measurements, garment-fitting simulations, and an improved sizing system. In less than four years, Kinect technology has been adopted in several laboratories to scan human bodies (Aitpayev & Gaber, 2012; Weiss, Hirshberg & Black, 2011).

3D Scanning

Avatar

10.31274/itaa_proceedings-180814-464

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Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy

Frontiers in Bioengineering and Biotechnology (2022)

Zhihong Cheng Yongshuang Li Duoyi Zhao Wei Zhao Meng Wu

In the past few decades, the combination of proteins and small-molecule drugs has made tremendous progress in cancer treatment, but it is still not satisfactory. Because there are great differences in molecular weight, water solubility, stability, pharmacokinetics, biodistribution, and the ways of release and action between macromolecular proteins and small-molecule drugs. To improve the efficacy and safety of tumor treatment, people are committed to developing protein and drug co-delivery systems. Currently, intracellular co-delivery systems have been developed that integrate proteins and small-molecule drugs into one nanocarrier via various loading strategies. These systems significantly improve the blood stability, half-life, and biodistribution of proteins and small-molecule drugs, thus increasing their concentration in tumors. Furthermore, proteins and small-molecule drugs within these systems can be specifically targeted to tumor cells, and are released to perform functions after entering tumor cells simultaneously, resulting in improved effectiveness and safety of tumor treatment. This review summarizes the latest progress in protein and small-molecule drug intracellular co-delivery systems, with emphasis on the composition of nanocarriers, as well as on the loading methods of proteins and small-molecule drugs that play a role in cells into the systems, which have not been summarized by others so far.

Nanocarriers

Biodistribution

Cancer Therapy

10.3389/fbioe.2022.994655

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Citations (20)

MicroRNA-603 functions as an oncogene by suppressing BRCC2 protein translation in osteosarcoma

Oncology Reports (2016)

Chengbin Ma Chuan Zhan Hongmou Yuan Yan Cui Zhiyu Zhang

10.3892/or.2016.4718

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Citations (25)

Distinct roles of parafibromin in the extracellular environment, cytoplasm and nucleus of osteosarcoma cells.

PubMed (2016)

Jiajun Zhu Yan Cui Kai Cui Xi Li Zhi‐yu Zhang

Osteosarcoma (OS) is the most common primary malignant bone tumor. Parafibromin-inactivating mutations have been reported in various malignancies. In this study, the effects and relevant mechanisms of ectopic parafibromin expression were identified in the extracellular environment, cytoplasm and nucleus of OS cells. Our results indicate that parafibromin located in the nucleus can induce apoptosis and G1 phase arrest in OS cells. Parafibromin was found to suppress the MEK/ERK and PI3K/AKT signaling pathways, leading to activation of caspase 3 and caspase 9. Overall, these studies demonstrate the anti-tumor activity of parafibromin in the OS cell line, and provide insight into relevant mechanisms that may lead to novel treatments for OS.

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Citations (8)

Ezrin-targeted calcium (II)-crosslinked nanoparticle intracellularly co-delivers doxorubicin and chlorambucil for synergistic chemotherapy of osteosarcoma

Journal of Controlled Release (2017)

Yonghe Chang Yan Cui Jiajun Zhu Jianxun Ding Zhiyu Zhang

CD80

CD86

10.1016/j.jconrel.2017.03.349

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Citations (1)