Juntao Chen

First Affiliated Hospital of Henan University

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Lijing Fang

Shenzhen Institutes of Advanced Technology

Huashun Li

Anhui University of Science and Technology

Hongchang Li

Shenzhen Institutes of Advanced Technology

Lijiao Ao

Jinan University

Ximing Shao

Shenzhen Institutes of Advanced Technology

Wu Su

Panyu Hospital of Chinese Medicine

Zhengyin Pan

Sun Yat-sen University

Zhihao Ding

Sir Run Run Shaw Hospital

Yuanyan Tan

City University of Hong Kong

Haiyan Sun

Genesis Medical Center

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Sun Yat-sen University

Fudan University

Zhongshan Hospital

The First Affiliated Hospital, Sun Yat-sen University

Chinese Academy of Sciences

Shanghai Institute of Organic Chemistry

Zhejiang University

Chaohu Hospital of Anhui Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

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Figure S4 Cellular uptake and nuclear localization of PIPs. from Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu Lijing Fang Haiyan Sun Zhengyin Pan Jianchao Zhang

Hela cells or A549 cells stably expressing histone H2B-RFP were incubated with 10 μM of different PIPs for 24 h. Cells were then subjected to live-imaging using confocal microscopy. Scale bar, 10 μm.

HeLa

Conjugate

10.1158/1535-7163.22504989

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Supplementary Materials from Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu Lijing Fang Haiyan Sun Zhengyin Pan Jianchao Zhang

Supplementary Materials

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Imidazole

Pyrrole

10.1158/1535-7163.22504944.v1

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Mapping the Knowledge Landscape: A Bibliometric Analysis of Exosome Research in Osteoarthritis (2004–2023)

Heliyon (2024)

Hui Xu Zhen Wang Zheng Wang Juntao Chen Chi Zhao

Exosomes have emerged as a crucial focus in advancing the diagnosis and treatment of osteoarthritis (OA). However, there are limited bibliometric studies on this topic. This study aimed to delineate the literature landscape on exosomes in OA, identifying global research trends and key areas. We utilised the Web of Science Core Collection to retrieve articles published from 2004 to 2023. Our analysis included 456 publications across 671 institutions from 40 countries/regions. Publication volume, citations, and emerging research foci and trends were examined. Our results reveal a consistently increased interest in exosomes related to OA over the past two decades. Prominent institutions contributing to this research include Shanghai Jiao Tong University and Shenzhen University. The leading journal for these publications is the

Exosome

10.1016/j.heliyon.2024.e40079

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Figure S6 Correlation between Plk1 expression level and PIP3 sensitivity. from Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu Lijing Fang Haiyan Sun Zhengyin Pan Jianchao Zhang

(a and b) Plk1 mRNA levels (a) and Plk1 protein levels (b) in various cell lines. (c-e) Pearson correlation co-efficiency was calculated between Plk1 mRNA level, Plk1 protein expression level, and PIP3 sensitivity (represented by IC50 value).

PLK1

Polo-like kinase

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Positive correlation

Imidazole

Pyrrole

IC50

10.1158/1535-7163.22504983.v1

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Figure S3 Time-dependent cellular uptake of PIP3. from Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu Lijing Fang Haiyan Sun Zhengyin Pan Jianchao Zhang

(a) Hela cells or (b) A549 cells stably expressing histone H2B-RFP were incubated with 10 μM of PIP3. At different time points, cells were harvested, stained, and imaged. Scale bar, 50 μm. (c) Nuclear localization of PIP3 in A549 cells. Scale bar, 10 μm.

HeLa

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10.1158/1535-7163.22504992

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The influence of childhood emotional neglect on emotional face processing in young adults

Acta Psychologica (2022)

Xiaokang Jin Bin Xu Huiyan Lin Juntao Chen Ruitong Xu

Childhood emotional neglect (CEN) refers to a failure to meet the basic emotional needs of a child, which can seriously impact interpersonal communication and psychological health in young adults. Emotional face processing is critical in interpersonal communication; however, whether CEN affects this processing in young adults has not been investigated. Therefore, the current study aimed to explore the effects of CEN on emotional face processing in young adults. Using the Child Trauma Questionnaire, an online survey was conducted with 5010 students from four universities in Tianjin, China. After online interviews and diagnosis by professional doctors, we obtained 20 participants with CEN (CEN group) and 20 without CEN (control group). None of the participants had any mental diseases. A 2 × 4 mixed design was used to investigate the differences in accuracy and response time when identifying the valence of the emotional faces. Compared to the control group, the CEN group identified the valence of all emotional faces more slowly, but there was no significant difference between the two groups in terms of accuracy. CEN caused delayed emotional face processing in young adults, which may be related to unresponsive, unavailable, and limited emotional interaction patterns between parents and their children.

Emotional expression

10.1016/j.actpsy.2022.103814

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Supplementary Materials from Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu Lijing Fang Haiyan Sun Zhengyin Pan Jianchao Zhang

Supplementary Materials

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Imidazole

Pyrrole

10.1158/1535-7163.22504944

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Figure S5 Flow cytometry analysis of apoptosis upon PIP3 treatment. from Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu Lijing Fang Haiyan Sun Zhengyin Pan Jianchao Zhang

Hela cells were treated with or without 10 μM PIP3 for 72 hours and then labeled by Propidium iodide and Annexin V-FITC for detecting early and late apoptotic signal.

Propidium iodide

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HeLa

10.1158/1535-7163.22504986

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Movie S1 from Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu Lijing Fang Haiyan Sun Zhengyin Pan Jianchao Zhang

Live imaging of mitotic progression in control Hela cells.

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Pyrrole

Imidazole

10.1158/1535-7163.22504974

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Figure S2 PIP3 but not Hoechst 33258 shows Plk1 suppression ability. from Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu Lijing Fang Haiyan Sun Zhengyin Pan Jianchao Zhang

(a) Comparison of the cellular uptake of PIP3 and Hoechst 33258. Hela cells were incubated with different concentrations of PIP3 or Hoechst 33258 for 24 hours. Fluorescent microscopy images were acquired and as shown. (b) PIP3 but not Hoechst 33258 shows Plk1 suppression ability. Hela cells were treated with different concentrations of PIP3 or Hoechst 33258 for 72 hours and then collected for western blotting analysis to examine the Plk1 expression. (c) Evaluation of PIP3 stability in vitro. Hela cells were treated with 10 μM PIP3 for 72 hours, then cells were collected and lysed. Released PIP3 was monitored by RP-HPLC analysis. PIP3 dissolved in water was served as control.

HeLa

Conjugate

PLK1

10.1158/1535-7163.22504995

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