Review question / Objective: (1)Patients: Subjects were depressed patients with a disease diagnosis that met the Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria for depressive episodes (including major depression diagnostic criteria and bipolar disorder diagnostic criteria) or the patient has moderate or higher depression; (2) Intervention measures: magnetic seizure treatment ; (3) Control group: electroconvulsive therapy; (4) Outcomes: the main outcome indicator is the total score of the depression s c a l e a n d t h e s c o r e o f e a c h d i m e n s i o n o f t h e neuropsychological test; Secondary indicators are reorientation time and recovery time; (5) Study design: Control study.
Objective: To study the changes in urine metabolism in female water polo players before and after high-intensity training by using ultra-high performance liquid chromatography-mass spectrometry, and to explore the biometabolic characteristics of urine after training and competition. Methods: Twelve young female water polo players (except goalkeepers) from Shanxi Province were selected. A 4-week formal training was started after one week of acclimatization according to experimental requirements. Urine samples (5 ml) were collected before formal training, early morning after 4 weeks of training, and immediately after 4 weeks of training matches, and labeled as T1, T2, and T3, respectively. The samples were tested by LC-MS after pre-treatment. XCMS, SIMCA-P 14.1, and SPSS16.0 were used to process the data and identify differential metabolites. Results: On comparing the immediate post-competition period with the pre-training period (T3 vs T1), 24 differential metabolites involved in 16 metabolic pathways were identified, among which niacin and niacinamide metabolism and purine metabolism were potential post-competition urinary metabolic pathways in the untrained state of the athletes. On comparing the immediate post-competition period with the post-training period (T3 vs T2), 10 metabolites involved in 3 metabolic pathways were identified, among which niacin and niacinamide metabolism was a potential target urinary metabolic pathway for the athletes after training. Niacinamide, 1-methylnicotinamide, 2-pyridone, L-Gln, AMP, and Hx were involved in two metabolic pathways before and after the training. Conclusion: Differential changes in urine after water polo games are due changes in the metabolic pathways of niacin and niacinamide.
With the applicable functions of suggestion,instruction,limitation and coerciveness,the public language show impact extensively on the aspects of daily life.Serious problems existed in the language translation with incorrect instruction and assistance and caused malignant influence on foreign friends.The essay listed wrong and severe consequence in English public language show,analyzed applicable functions and features of public language show from distinguished categories,simultaneously,introduced translating strategies via instances to promote improvement of public show language's translating quality.
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-β (IFN-β) response by increasing expression of interferon-stimulated genes in the lung. These effects were associated with reduction of viral load and pulmonary inflammation in RSV-infected mice. Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential for acetate antiviral activity in pulmonary epithelial cell lines and for the acetate protective effect in RSV-infected mice. Activation of Gpr43 in pulmonary epithelial cells reduced virus-induced cytotoxicity and promoted antiviral effects through IFN-β response. The effect of acetate on RSV infection was abolished in Gpr43-/- mice. Our findings reveal antiviral effects of acetate involving IFN-β in lung epithelial cells and engagement of GPR43 and IFNAR.
Given the availability of daily data over 1926-1962, it is surprising that there is no research examining the idiosyncratic volatility (IV) puzzle over this early period. This paper conducts an out-of-sample test on the IV phenomenon. We find that the negative relation between IV and expected returns only exists during the period 07/1963-12/1989, implying that the puzzle may be a result of data snooping bias. The result on time-special anomaly is robust for different sorting breakpoints and alternative measure of idiosyncratic volatility. Infrequent trading cannot account for the low average returns of stocks with high idiosyncratic volatility. With a striking contrast, the involving of short-term return reversals eliminates this dilemma.
To evaluate whether applying image filters (smooth 3D+ and edge-2) improves image quality in coronary CT angiography (CCTA).Ninety patients (routine group) with suspected coronary artery diseases based on 16-cm wide coverage detector CT findings were retrospectively enrolled at a chest pain center from December 2019 to September 2021. Two image filters, smooth 3D+ and edge-2 available on the Advantage Workstation (AW) were subsequently applied to the images to generate the research group (SE group). Quantitative parameters, including CT value, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), image sharpness and image quality score, and diagnostic accuracy were compared between the two groups.A total of 900 segments from 270 coronary arteries in 90 patients were analyzed. SNR, CNR, and image sharpness for vessels and image quality scores in the SE group were significantly better than those in the routine group (all p < 0.001). The SE group showed a slightly higher negative predictive value (NPV) on the left anterior descending artery and right coronary artery (RCA) stenosis evaluations, as well as total NPV. The SE group also showed slightly higher sensitivity and accuracy than the routine group on RCA stenosis evaluation.The use of an image filter combining smooth 3D+ and edge-2 on an AW could improve the image quality of CCTA and increase radiologists' diagnostic confidence.
Objective
To investigate the risk factors of left ventricular hypertrophy (LVH) in non-dialysis dependent end-stage renal disease (ESRD) patients.
Methods
ESRD patients in the First Affiliated Hospital of Sun Yat-sen University from Jan to July 2019 were enrolled. Demographic data of patients were collected and biochemical parameters were measured. Hydration status index (extracellular water/total body water, ECW/TBW) was measured by bioelectrical impedance analysis (BIA), and LVH was diagnosed by echocardiography. Patients were divided into LVH group and non-LVH group according to LVH diagnostic criteria, and the incidence of LVH in ESRD non-dialysis patients was calculated. Logistic regression was used to analyze the risk factors of LVH.
Results
A total of 105 non-dialysis dependent ESRD patients aged (47.03±12.56) years (21-78 years) were enrolled in present study, among whom 74 patients (70.5%) had LVH. Compared to non-LVH group, patients in LVH group had higher proportion of diabetes and calcium antagonist used, higher value of ECW/TBW and ECW/Height, higher level of night systolic pressure, and were older (all P<0.05). Spearman correlation analysis showed LVH was positively correlated to diabetes (r=0.345, P<0.001), night systolic pressure (r=0.286, P<0.001), night diastolic pressure (r=0.251, P=0.012), calcium antagonist used (r=0.381, P=0.013), ECW/TBW (r=0.383, P=0.005), ECW/Height (r=0.298, P=0.003), 24 h sodium urinary excretion (r=0.257, P=0.025), brain natriuretic peptide (r=0.315, P=0.005) and hemoglobin (r=0.307, P=0.018), and negatively correlated to 24 h potassium urinary excretion (r=-0.248, P=0.023). Logistic regression showed that increased night diastolic pressure (OR=2.036, 95%CI 1.144-3.623, P=0.016) and ECW/TBW (OR=1.232, 95%CI 1.025-1.523, P=0.014) were the independent risk factors of LVH after adjusting for gender, age, diabetes, nocturnal blood pressure, antihypertensive drugs used, ECW/TBW, urinary sodium excretion and hemoglobin.
Conclusions
LVH is common in non-dialysis dependent ESRD patients. Over hydration and high night diastolic blood pressure are the independent risk factors of LVH in non-dialysis dependent ESRD patients.
Key words:
Hypertrophy, left ventricular; Risk factors; Electric impedance; End-stage renal disease
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