Guillermo Reyes

Hospital Universitario de La Princesa

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Sara Badía

Hospital Universitari Germans Trias i Pujol

Juan Bustamante

Hospital Universitario La Paz

Juan Duarte

Universidad de Granada

Anas Sarraj

Universidad Autónoma de Madrid

Fernándo Alfonso

Hospital Universitario de La Princesa

J.M. Nuche

Madrid Health Service

A. Sarraj

University Hospitals of Cleveland

PÁ

P. Álvarez

Hospital Universitario de La Princesa

Emilio Monguió

Hospital Universitario de La Princesa

Río Aguilar

Centro de Investigación Biomédica en Red de Salud Mental

Cooperative Institutions

Hospital Universitario de La Princesa

140

Centro de Investigación en Red en Enfermedades Cardiovasculares

Centro de Investigación Biomédica en Red

Universidad Autónoma de Madrid

Instituto de Salud Carlos III

Society of Thoracic Surgeons

Spanish National Centre for Cardiovascular Research

Hospital General Universitario Gregorio Marañón

Universidad Complutense de Madrid

Universidad de Valladolid

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How Could These Mini Saccular Aneurysms of Ascending Aorta Be Classified?

The Annals of Thoracic Surgery (2017)

Anas Sarraj Daniel-Edgardo Muñoz Corazón-Mabel Calle Valda Emilio Monguió Guillermo Reyes

Saccular aneurysm

10.1016/j.athoracsur.2016.09.072

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Citations (3)

Restoration of atrial contractility after surgical cryoablation: clinical, electrical and mechanical results

Interactive Cardiovascular and Thoracic Surgery (2009)

Guillermo Reyes Amparo Benedicto Juan Bustamante Anas Sarraj J.M. Nuche

To assess the electrical sinus rhythm (SR) recovery and the mechanical effectiveness of the atrial contraction by echocardiography is essential in patients undergoing atrial fibrillation (AF) surgery. Between September 2006 and May 2008, patients with chronic AF (n=33; permanent=23 or paroxysmal=10) underwent mitral surgery and surgical cryoablation for AF. Exclusion criteria were: AF that has persisted for 10 years and left atrium (LA) >65 mm. Echocardiography study was performed at six months after surgery. Mean age was 62 years (22 female, 11 male). Mean AF duration was three years (range 0.5-7.4). Mean atria size was 52.4+/-5.6 mm. Mitral valve surgery involved 32 prosthetic replacements and one mitral valve repair. There was no surgical mortality. Success rate for SR at three and six months was 90% and 82%, respectively. The only predictor of conversion to SR at six months was being at SR when discharge from the hospital. In patients in SR, echocardiographic study provided mechanical effectiveness of the atria in 100% of right atrium and 70% of the LA. Cryoablation for AF is an effective technique to recover electrocardiographic SR while being able to recover atrial contraction effectiveness.

Cryoablation

Contractility

Atrium (architecture)

10.1510/icvts.2009.208173

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Citations (10)

Redundant Anterior Aortic Valve

The Annals of Thoracic Surgery (2010)

Anas Sarraj José-Manuel Nuche Lourdes Domínguez Juan Bustamante Guillermo Reyes

10.1016/j.athoracsur.2009.10.019

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Citations (1)

Tratamiento quirúrgico del embolismo pulmonar masivo tras doble parada cardiaca

Revista Española de Cardiología (2007)

Guillermo Reyes Akiko Tamura José Luis González-Guerrero Luis M. Hernando

10.1157/13109007

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Citations (1)

What's on your mind? A Mental and Perceptual Load Estimation Framework towards Adaptive In-vehicle Interaction while Driving

arXiv (Cornell University) (2022)

Amr Gomaa Alexandra Alles Elena Meiser Lydia Helene Rupp Marco Molz

Several researchers have focused on studying driver cognitive behavior and mental load for in-vehicle interaction while driving. Adaptive interfaces that vary with mental and perceptual load levels could help in reducing accidents and enhancing the driver experience. In this paper, we analyze the effects of mental workload and perceptual load on psychophysiological dimensions and provide a machine learning-based framework for mental and perceptual load estimation in a dual task scenario for in-vehicle interaction (https://github.com/amrgomaaelhady/MWL-PL-estimator). We use off-the-shelf non-intrusive sensors that can be easily integrated into the vehicle's system. Our statistical analysis shows that while mental workload influences some psychophysiological dimensions, perceptual load shows little effect. Furthermore, we classify the mental and perceptual load levels through the fusion of these measurements, moving towards a real-time adaptive in-vehicle interface that is personalized to user behavior and driving conditions. We report up to 89% mental workload classification accuracy and provide a real-time minimally-intrusive solution.

Cognitive Load

Interface (matter)

10.48550/arxiv.2208.05564

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Mid-Term Results of Surgical Treatment of Atrial Fibrillation in Valvular Heart Disease Assesed by Speckle Tracking Echocardiography

Figshare (2018)

Natalia Lorenzo Irene Méndez Mikel Taibo Urquía Gianfranco Martinis Sara Badía

Abstract Background: Atrial fibrillation frequently affects patients with valvular heart disease. Ablation of atrial fibrillation during valvular surgery is an alternative for restoring sinus rhythm. Objectives: This study aimed to evaluate mid-term results of successful atrial fibrillation surgical ablation during valvular heart disease surgery, to explore left atrium post-ablation mechanics and to identify predictors of recurrence. Methods: Fifty-three consecutive candidates were included. Eligibility criteria for ablation included persistent atrial fibrillation <10 years and left atrium diameter < 6.0 cm. Three months after surgery, echocardiogram, 24-hour Holter monitoring and electrocardiograms were performed in all candidates who maintained sinus rhythm (44 patients). Echo-study included left atrial deformation parameters (strain and strain rate), using 2-dimensional speckle-tracking echocardiography. Simultaneously, 30 healthy individuals (controls) were analyzed with the same protocol for left atrial performance. Significance was considered with a P value of < 0.05. Results: After a mean follow up of 17 ± 2 months, 13 new post-operative cases of recurrent atrial fibrillation were identified. A total of 1,245 left atrial segments were analysed. Left atrium was severely dilated in the post-surgery group and, mechanical properties of left atrium did not recover after surgery when compared with normal values. Left atrial volume (≥ 64 mL/m2) was the only independent predictor of atrial fibrillation recurrence (p = 0.03). Conclusions: Left atrial volume was larger in patients with atrial fibrillation recurrence and emerges as the main predictor of recurrences, thereby improving the selection of candidates for this therapy; however, no differences were found regarding myocardial deformation parameters. Despite electrical maintenance of sinus rhythm, left atrium mechanics did not recover after atrial fibrillation ablation performed during valvular heart disease surgery.

valvular heart disease

Speckle tracking echocardiography

10.6084/m9.figshare.6317924

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Citations (0)

Mid-Term Results of Surgical Treatment of Atrial Fibrillation in Valvular Heart Disease Assesed by Speckle Tracking Echocardiography

Arquivos Brasileiros de Cardiologia (2018)

Natalia Lorenzo Irene Méndez Mikel Taibo Urquía Gianfranco Martinis Sara Badía

Background: Atrial fibrillation frequently affects patients with valvular heart disease. Ablation of atrial fibrillation during valvular surgery is an alternative for restoring sinus rhythm. Objectives: This study aimed to evaluate mid-term results of successful atrial fibrillation surgical ablation during valvular heart disease surgery, to explore left atrium post-ablation mechanics and to identify predictors of recurrence. Methods: Fifty-three consecutive candidates were included. Eligibility criteria for ablation included persistent atrial fibrillation <10 years and left atrium diameter < 6.0 cm. Three months after surgery, echocardiogram, 24-hour Holter monitoring and electrocardiograms were performed in all candidates who maintained sinus rhythm (44 patients). Echo-study included left atrial deformation parameters (strain and strain rate), using 2-dimensional speckle-tracking echocardiography. Simultaneously, 30 healthy individuals (controls) were analyzed with the same protocol for left atrial performance. Significance was considered with a P value of < 0.05. Results: After a mean follow up of 17 ± 2 months, 13 new post-operative cases of recurrent atrial fibrillation were identified. A total of 1,245 left atrial segments were analysed. Left atrium was severely dilated in the post-surgery group and, mechanical properties of left atrium did not recover after surgery when compared with normal values. Left atrial volume (≥ 64 mL/m2) was the only independent predictor of atrial fibrillation recurrence (p = 0.03). Conclusions: Left atrial volume was larger in patients with atrial fibrillation recurrence and emerges as the main predictor of recurrences, thereby improving the selection of candidates for this therapy; however, no differences were found regarding myocardial deformation parameters. Despite electrical maintenance of sinus rhythm, left atrium mechanics did not recover after atrial fibrillation ablation performed during valvular heart disease surgery.

Speckle tracking echocardiography

valvular heart disease

Atrium (architecture)

10.5935/abc.20180040

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Citations (3)

Trifecta Bioprosthesis Sudden-Onset Three-Leaflet Detachment

The Annals of Thoracic Surgery (2020)

Guillermo Reyes Emilio Monguió MiguelAngel Gomez-Marino V. Gómez-Tello JoseMaria Cortina

Cuff

Leaflet (botany)

10.1016/j.athoracsur.2020.05.065

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Citations (5)

Cell saving systems do not reduce the need of transfusion in low-risk patients undergoing cardiac surgery

Interactive Cardiovascular and Thoracic Surgery (2010)

Guillermo Reyes M. Auxiliadora Prieto P. Álvarez M.J. Orts Juan Bustamante

Objective: Cell saving systems have been widely used to reduce blood loss and need of transfusions. These device are mainly indicated in complex cardiac surgery procedures and in those patients with a high risk of bleeding. However, it is not clear if there is a benefit of a cell saver (CS) system in low-risk patients undergoing cardiac surgery. Our aim was to analyze if the use of CS systems reduce the need of blood products in low-risk patients undergoing cardiac surgery. Methods: Between February and June 2009 all low-risk patients (EuroSCORE <10%) undergoing coronary or valve procedure were selected (n=63). Exclusion criteria were: combined procedure, aorta procedure, redo surgery, emergency procedures, creatinine levels >2 mg/ml, anemic patients and patients with a body surface area (BSA) <1.6 m2. Patients were randomized to undergo cardiac surgery with a cell saving system (group CS) (n=34) or without (control group, CO) (n=29). All patients received tranexamic acid during the procedure. Need of blood products and clinical outcomes were analyzed in both groups. Results: Mean age was 64.7±12.3 years old with 33% of female patients. Baseline clinical characteristics and preoperative blood count cell were similar in both groups. Mean CS blood reinfused was 461±174 ml (maximum: 985 minimum: 259). A total of 59 red blood packages were transfused in 25 patients (mean 1.02±1.3; range: 0–5). The proportion of patients being transfused was similar in both groups (CS: 40% vs. CO: 46.4%; P=0.79). Eleven plasma packages were transfused (CS: 8 vs. CO: 3; P=0.77) and three platelet pools were used in group CS and none in group CO (P=0.08). Multivariate analysis showed that preoperative hemoglobin levels >13.3 g/dl [relative risk (RR): 0.29; confidence interval (CI): 0.09–0.99] and BSA >1.74 (RR: 0.19; CI: 0.54–0.68) were protective against blood transfusion. Conclusions: In low-risk patients CS system did not reduce the need of blood transfusion. Clinical outcomes were similar regardless of the use of a cell saver system. A low preoperative hemoglobin level and a low BSA were related with the use of blood products.

EuroSCORE

Blood product

10.1510/icvts.2010.251538

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Citations (22)

Bone marrow laser revascularisation for treating refractory angina due to diffuse coronary heart disease☆

European Journal of Cardio-Thoracic Surgery (2009)

Guillermo Reyes Keith B. Allen Beatriz Aguado Juan Duarte

To increase the angiogenic response and clinical efficacy of TMR, the potential synergy and safety of combining TMR with concentrated autologous bone marrow derived stem cells was evaluated. Fourteen patients with diffuse coronary artery disease and medically refractory class III/IV angina who were not candidates for conventional therapies were treated using TMR in combination with intramyocardial injection of concentrated stem cells. At the time of surgery, autologous bone marrow (120 cc) was aspirated from the iliac crest and processed over 15 min into 20 cc of concentrated mononuclear cells using a centrifugal system (HARVEST, Boston, MA). A single device performed holmium: YAG:TMR (CardioGenesis, Irvine, CA) with injection of 1 cc of concentrated stem cells through three multi-holed needles into the border zone around each laser channel. There were no perioperative adverse events including no arrhythmias. Mean number of injected cells per milliliter were: total mononuclear cells (81.3 × 106), CD34+ cells (0.6 × 106), and CD133+ cells (0.37 × 106). At 7 months mean follow-up average angina class was significantly improved (3.5 ± 0.5 vs 1.4 ± 0.5; p = 0.004). There was no death during the follow-up. Efficient delivery of stem cells combined with TMR in a single device seems to be safe and effective for treating unmanageable angina.

Refractory (planetary science)

10.1016/j.ejcts.2009.03.022

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Citations (9)