Li Hao

Shandong University

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Fei Xie

Chinese PLA General Hospital

Zhenzhong Li

Second Hospital of Hebei Medical University

Huaxiang Liu

Qilu Hospital of Shandong University

Mingjie Lin

Peking University First Hospital

Bing Rong

Chinese Academy of Medical Sciences & Peking Union Medical College

Jingquan Zhong

Chinese Academy of Medical Sciences & Peking Union Medical College

Jingquan Zhong

Shandong University

Zhen Liu

Shandong University

Liyuan Gao

Tianjin Medical University General Hospital

Kaiguo Wang

Shandong First Medical University

Cooperative Institutions

Shandong University

Shandong First Medical University

Qilu Hospital of Shandong University

Shandong Provincial Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Shandong Tumor Hospital

Chinese Academy of Sciences

University of Turku

Shanghai Jiao Tong University

University of Science and Technology of China

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GW29-e1209 The neutrophil-to-lymphocyte ratio is an indicator of clinically relevant non-major bleeding after catheter ablation in atrial fibrillation patients

Journal of the American College of Cardiology (2018)

Li Hao Jingquan Zhong

10.1016/j.jacc.2018.08.675

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Analysis of risk factors related to patients with Sagliker syndrome

Chin J Nephrol (2015)

Haiyan Wang Guiling Liu Wang Ju Guixia Zhang Yufang Xue

Objective To explore the clinical characteristics and related risk factors in patients with severe uremic secondary hyperparathyroidism (SHPT) complicated with Sagliker syndrome (SS). Methods A total of 229 patients with severe uremic SHPT admitted in our hospital from February 2011 to April 2015 were enrolled, among which 33 cases were taken as positive group (SS group), and 196 cases as control group. The differences between two groups in demographic data (such as gender and age), complications, and biochemical indexes were compared, with potential risk factors of SS being analyzed. Results There were significant differences between median duration of dialysis in positive group (11 years) and that in control group (8 years, P 10 years, OR=6.182, P=0.002), higher serum levels of ALP (>347 U/L, OR=5.786, P=0.002) and iPTH (>1764 ng/L, OR=4.960, P=0.001), and calcification in heart valves and abdominal aortic (OR=8.635, P 10 years, OR=5.121, P=0.036), higher serum level of iPTH (>1764 ng/L, OR=4.130, P=0.017), calcification in heart valves (OR=11.714, P <0.001) were independent risk factors of SS. Conclusions Severe uremic SHPT patients with longer duration of dialysis and higher serum level of iPTH are more likely to develop SS. Key words: Kidney failure, chronic; Hyperparathyroidism, secondary; Risk factors; Sagliker syndrome

10.3760/cma.j.issn.1001-7097.2015.10.005

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Development of steering wheel angle sensor used for torque coordinating control of in-wheel motor driven electric vehicle

International Conference on Electrical Machines and Systems (2011)

Li Hao Yanliang Xu Yun Zhang Yuandong Li

In-wheel motor driven electric vehicle (EV) is one of the main aspects in EV development where the electronic differential should be solved first of all. How to obtain ±720° steering wheel angle is fatal to realize the electronic differential and then coordinating control of in-wheel motor driven EV. The integrated Giant Magneto Resistance (iGMR) based steering wheel angular sensor is developed in this paper and its mechanical design, hardware and software design and error analysis are concerned. The prototyped angular sensor verified the design and can be applied feasibly in in-wheel motor driven EV.

Electronic differential

10.1109/icems.2011.6073541

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Citations (12)

Neuroprotective effect of insulin-like growth factor-1: Effects on tyrosine kinase receptor (Trk) expression in dorsal root ganglion neurons with glutamate-induced excitotoxicity in vitro

Brain Research Bulletin (2013)

Li Hao Haixia Dong Jianmin Li Huaxiang Liu Zhen Liu

Excitotoxicity

Trk receptor

Dorsal root ganglion

10.1016/j.brainresbull.2013.05.014

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Citations (14)

1.6 Male Cinderella on the Small Screen in mainland China

Amsterdam University Press eBooks (2019)

Li Hao

China mainland

Mainland

10.1515/9789048535538-009

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The exposure-response association between humidex and bacillary dysentery: A two-stage time series analysis of 316 cities in mainland China

The Science of The Total Environment (2021)

Ran Zhao Qi Gao Qiang Hao Shuzi Wang Yiwen Zhang

Bacillary dysentery

Mainland

10.1016/j.scitotenv.2021.148840

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In vitro neuroprotective effects of ciliary neurotrophic factor on dorsal root ganglion neurons with glutamate-induced neurotoxicity

Neural Regeneration Research (2017)

Yi Xing Shu-yun Wen Aimin Li Kuan-qing Mi Rui-zheng Wang

Ciliary neurotrophic factor has neuroprotective effects mediated through signal transducer and Janus kinase (JAK) 2/activator of transcription 3 (STAT3) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways. Whether ciliary neurotrophic factor is neuroprotective for glutamate-induced excitotoxicity of dorsal root ganglion neurons is poorly understood. In the present study, the in vitro neuroprotective effects of ciliary neurotrophic factor against glutamate-induced excitotoxicity were determined in a primary culture of dorsal root ganglion neurons from Wistar rat embryos at embryonic day 15. Whether the JAK2/STAT3 and PI3K/Akt signaling pathways were related to the protective effects of ciliary neurotrophic factor was also determined. Glutamate exposure inhibited neurite outgrowth, cell viability, and growth-associated protein 43 expression and promoted apoptotic neuronal cell death, all of which were reversed by the administration of exogenous ciliary neurotrophic factor. Additionally, preincubation with either JAK2 inhibitor AG490 or PI3K inhibitor LY294002 blocked the neuroprotective effect of ciliary neurotrophic factor. These data indicate that the two pathways JAK2/STAT3 and PI3K/Akt play major roles in mediating the in vitro neuroprotective effects of ciliary neurotrophic factor on dorsal root ganglion neurons with glutamate-induced neurotoxicity.

Ciliary neurotrophic factor

Excitotoxicity

Dorsal root ganglion

Ciliary ganglion

LY294002

10.4103/1673-5374.217352

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Citations (16)

Role of group I metabotropic glutamate receptors, mGluR1/mGluR5, in connexin43 phosphorylation and inhibition of gap junctional intercellular communication in H9c2 cardiomyoblast cells

Molecular and Cellular Biochemistry (2014)

Fei Xie Shao-lei Yi Li Hao Yun Zhang Jingquan Zhong

10.1007/s11010-014-2278-x

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Nitric oxide, PKC-ε, and connexin43 are crucial for ischemic preconditioning-induced chemical gap junction uncoupling

Oncotarget (2016)

Bing Rong Fei Xie Tao Sun Li Hao Mingjie Lin

Ischemic preconditioning (IPC) maintains connexin43 (Cx43) phosphorylation and reduces chemical gap junction (GJ) coupling in cardiomyocytes to protect against ischemic damage. However, the signal transduction pathways underlying these effects are not fully understood. Here, we investigated whether nitric oxide (NO) and protein kinase C-ε (PKC-ε) contribute to IPC-induced cardioprotection by maintaining Cx43 phosphorylation and inhibiting chemical GJ coupling. IPC reduced ischemia-induced myocardial infarction and increased cardiomyocyte survival; phosphorylated Cx43, eNOS, and PKC-ε levels; and chemical GJ uncoupling. Administration of the NO donor SNAP mimicked the effects of IPC both in vivo and in vitro, maintaining Cx43 phosphorylation, promoting chemical GJ uncoupling, and reducing myocardial infarction. Preincubation with the NO synthase inhibitor L-NAME or PKC-ε translocation inhibitory peptide (PKC-ε-TIP) abolished these effects of IPC. Additionally, by inducing NO production, IPC induced translocation of PKC-ε, but not PKC-δ, from the cytosolic to the membrane fraction in primary cardiac myocytes. IPC-induced cardioprotection thus involves increased NO production, PKC-ε translocation, Cx43 phosphorylation, and chemical GJ uncoupling.

Cardioprotection

Ischemic Preconditioning

10.18632/oncotarget.12087

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Citations (17)

Melatonin Inhibits the Ferroptotic Pathway in Rat Bone Marrow Mesenchymal Stem Cells by Activating the PI3K-AKT-mTOR Signaling Axis to Attenuate Steroid-induced Osteoporosis

Research Square (Research Square) (2021)

Meng Li Ning Yang Li Hao Wei Zhou Lei Li

Abstract ObjectivesSteroid-induced osteoporosis (SIOP) is a secondary osteoporosis, which is a systemic bone disease characterized by low bone mass, bone microstructure damage, increased bone fragility, and easy fracture. However, the specific mechanism remains unclear. Glucocorticoid-induced death of osteoblasts and bone marrow mesenchymal stem cells (BMSCs) is an important factor in SIOP. Ferroptosis is an iron-dependent programmed cell death that differs from apoptosis, cell necrosis, and autophagy, which can be induced by many factors. Herein, we aimed to explore whether glucocorticoids (GCs) cause ferroptosis in BMSCs and determine possible treatment pathways and mechanisms of action. Melatonin (MT), a hormone secreted by the pineal gland, displays strong antioxidant abilities to scavenge free radicals and alleviates ferroptosis in many tissues and organs. MethodsIn this study, we used high-dose dexamethasone (DEX) to observe whether glucocorticoids induced ferroptosis in BMSCs. We then assessed whether MT can inhibit the ferroptotic pathway, thereby providing early protection against GC-induced SIOP, and investigated the signaling pathways involved.Results In vitro experiments showed that MT intervention significantly improved GC-induced ferroptosis in BMSCs and significantly improved SIOP in vivo . Pathway analysis showed that MT improves ferroptosis by activating the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) axis. MT upregulates expression of PI3K, which is an important regulator of ferroptosis resistance. PI3K activators mimic the anti-ferroptosis effect of MT, but after blocking the PI3K pathway, the effect of MT is weakened. Obviously, MT can protect against SIOP induced by GC. Notably, even after GC-induced ferroptosis begins, MT can confer protection against SIOP. ConclusionOur research confirms that GC-induced ferroptosis is closely related to SIOP. Melatonin can inhibit ferroptosis by activating the PI3K-AKT-mTOR signaling pathway, thereby reducing the occurrence of steroid-induced osteoporosis. Therefore, MT may provide a novel strategy for preventing and treating SIOP.

10.21203/rs.3.rs-850531/v1

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Citations (2)