Yu‐Cheng Chen

Southwest University

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Chih‐Da Wu

National Cheng Kung University

Lei Huang

Chongqing Academy of Agricultural Sciences

Zhimin Yang

Southwest University

Perng‐Jy Tsai

National Cheng Kung University

Chin-Yu Hsu

Ming Chi University of Technology

Shih‐Chun Candice Lung

Research Center for Environmental Changes, Academia Sinica

Pinpin Lin

National Health Research Institutes

Pau‐Chung Chen

National Taiwan University

Guor‐Cheng Fang

Chongqing University of Technology

Yue Leon Guo

National Taiwan University

Cooperative Institutions

National Cheng Kung University

165

National Taiwan University

138

National Yang Ming Chiao Tung University

107

National Health Research Institutes

Southwest University

Chinese Academy of Sciences

Kaohsiung Medical University

Chang Gung University

National Tsing Hua University

China Medical University

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Microbial Risks in Household UF Purifiers and Disinfection Strategy with Electrolysis

E3S Web of Conferences (2020)

Yu‐Cheng Chen Jian-nan Fu Yi Wang Jian Ding Xiaoying Lian

The research studied microbial deterioration in household ultrafiltration membrane (UF) purifiers with residence time and anti-bacterial strategy with electrolysis. The pilot test was conducted on a household drinking water purifier. A 72-h stagnation test and a 60-min anti-bacterial test with electrolysis were subsequently done. There were some findings in this study: (1) The level of HPC exceeded the hygienic standard when the stagnation time was more than 3 h. (2) The lag phase of bacterial growth was no more than 12 h in filters. (3) With the method of electrolysis, microbial contamination induced by water stagnation can be controlled in the acceptable range, which was more efficient than the method of flushing with tap water.

Ultrafiltration (renal)

Tap water

Laundry

10.1051/e3sconf/202014302028

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Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression

Marine Drugs (2018)

Yu‐Cheng Chen Mei‐Chin Lu Mohamed El‐Shazly Kuei-Hung Lai Tung-Ying Wu

Heteronemin, the most abundant secondary metabolite in the sponge Hippospongia sp., exhibited potent cytotoxic activity against several cancer cell lines. It increased the percentage of apoptotic cells and reactive oxygen species (ROS) in Molt4 cells. The use of ROS scavenger, N-acetyl cysteine (NAC), suppressed both the production of ROS from mitochondria and cell apoptosis that were induced by heteronemin treatment. Heteronemin upregulated talin and phosphorylated talin expression in Molt4 cells but it only upregulated the expression of phosphorylated talin in HEK293 cells. However, pretreatment with NAC reversed these effects. Talin siRNA reversed the activation of pro-apoptotic cleaved caspases 3 and 9. On the other hand, the downstream proteins including FAK and NF-κB (p65) were not affected. In addition, we confirmed that heteronemin directly modulated phosphorylated talin expression through ROS generation resulting in cell apoptosis, but it did not affect talin/FAK complex. Furthermore, heteronemin interfered with actin microfilament and caused morphology changes. Taken together, these findings suggest that the cytotoxic effect of heteronemin is associated with oxidative stress and induction of phosphorylated talin expression. Our results suggest that heteronemin represents an interesting candidate which can be further developed as a drug lead against leukemia.

Derivative (finance)

Over expression

10.3390/md16060212

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Citations (25)

Human health risk visualization of potentially toxic elements in farmland soil: A combined method of source and probability

Ecotoxicology and Environmental Safety (2021)

Kong Fanjing Yu‐Cheng Chen Lei Huang Zhimin Yang Kangwen Zhu

Human health is adversely affected by potentially toxic elements (PTEs) in the topsoil, entering the bodies via inhalation, ingestion, and dermal contact. To visualize human health risks, we investigated five PTEs (Cd, As, Pb, Hg, and Cr) in 72 farmland topsoil samples from a town in Chongqing City, southwest China. Based on the human health risk assessment model, sequential indicator simulation (SIS) and the positive matrix factorization model (PMF) were used to construct the spatial health risks and to analyze the sources of PTEs; finally, health risks were combined with the source by ArcGIS. Based on our results, the use of SIS is feasible for the prediction of the spatial distribution of PTEs. Among the risks, the non-cancer risk of As for children most likely exceeded the accepted level in some areas, making As a priority pollutant. Although the health risks of soil Cd were acceptable in the region, the spatial probability distribution of Cd> 0.3 mg/kg represents a threat as Cd enters the human food chain. Even if the industrial discharge was the lowest individual contributor (29.33%), due to the impact of industrial discharge, the total non-cancer risk with a high probability (>0.85) for children still exceeded the accepted level in the northwestern area, which should be regarded as the priority pollution source. The combined method was useful to reduce efforts in environmental management, thus providing a basis for soil remediation and pollution source control.

Topsoil

Health Risk Assessment

10.1016/j.ecoenv.2021.111922

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Citations (35)

3-D AIR POLLUTION ESTIMATION USING A HYBRID SPATIAL MODEL: A CASE STUDY OF ZHUNAN-MIAOLI AREA, TAIWAN

The international archives of the photogrammetry, remote sensing and spatial information sciences/International archives of the photogrammetry, remote sensing and spatial information sciences (2024)

C. W. Hsu Yinq-Rong Chern J. J. Su Chandra Wijaya Yu‐Cheng Chen

Abstract. The rapid global urbanization has transformed cityscapes, giving rise to iconic skyscrapers that define modern cities. However, alongside this urban evolution, a pressing concern arises –the air quality within these towering urban environments. Fine particulate matter, known as PM2.5, poses a grave threat to human health and the environment. These tiny particles, measuring 2.5 micrometers or less, can penetrate deep into the human respiratory system, posing severe health risks. Due to the limitations of traditional land-use regression models in estimating the variation of air pollution with altitude, this study employs a novel hybrid spatial model to assess the three-dimensional distribution of PM2.5 in the atmosphere.We employ a comprehensive methodology, integrating diverse datasets and advanced modelling techniques, to uncover significant findings. Our analysis reveals the non-uniform nature of PM2.5 distribution, both horizontally and vertically. Variable selection identifies key factors influencing PM2.5 levels, including Broadleaf Forest, Carbon Monoxide (CO), and Height. Our ensemble model demonstrates robust performance, with Gradient Boosting Regression (GBR) and Random Forest Regression (RFR) exhibiting superior predictive capabilities. This study provides valuable insights into the complex interplay of environmental factors affecting PM2.5 concentrations in high-rise urban environments, emphasizing the need for targeted air quality management strategies considering both horizontal and vertical variations.

10.5194/isprs-archives-xlviii-4-w8-2023-301-2024

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Using a Mobile Measurement to Characterize Number, Surface Area, and Mass Concentrations of Ambient Fine Particles with Spatial Variability during and after a PM Episode

Aerosol and Air Quality Research (2016)

Chin-Yu Hsu Ming-Yeng Lin Hung-Che Chian Mu-Jean Chen Tzu-Yu Lin

Fine particles play a key role in regional air quality deterioration. Commonly used central-site monitoring data, which offer rough determinations of spatial particulate matter (PM) distributions, is insufficient to estimate potential local emissions or population exposure levels. This study characterizes the spatial variability of fine particles in suburban and rural regions during and after a winter episode of elevated PM (PM episode). Commercial instruments of high time resolution in a mobile laboratory platform were deployed to measure the distribution, number, surface area, and mass concentrations of fine particles. Spatial variations of those particle properties were mainly affected by regional feature, PM episode, local primary source and wind speed. Particle concentrations and size distributions were found to differ considerably during and after PM episode. The PM episode was found to exhibit a lower degree of spatial concentration contrast with respect to particle number, surface area and mass, where similar particle size patterns were distributed across all study regions with decreased particle number under nucleation and Aitken modes and increased number under the accumulation mode. The mobile measurement may supplement information on spatial particle distributions for estimating levels of population exposure and for characterizing detailed physical properties of short-term, high-exposed scenarios.

10.4209/aaqr.2014.12.0311

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Citations (8)

Identification the Content of the Windbox Dust Related to the Formation of PCDD/Fs during the Iron Ore Sintering Process

Aerosol and Air Quality Research (2011)

Yu-Chieh Kuo Yu‐Cheng Chen Chih‐Wei Yang Jin-Luh Mou Tung-Sheng Shih

This study measured the contents of the ionic and elemental constituents, and the chemical compounds containing in windbox (WB) dusts collected from a commercial iron ore sintering plant, then the results were used to identify possible PCDD/Fs formation pathways in the WB. We found that the abundance in both KCl and NaCl may provide a suitable condition for de novo synthesis of PCDD/Fs in the WB. Al, Fe, K, Ca, and Pb were the top five contents in WB16 dusts, but the co-existence of the above five metal contents warrants the need for further investigation on their roles in PCDD/F formation processes in the future. Although a low concentration of Cu was detected, it might be of importance to PCDD/Fs formation inside the WB. A total of 29 chemical compounds were identified. Among them, several oxygenated organic compound might be associated with PCDD/F formations at the beginning stage, but the roles of aromatic oxygenates on the formation of PCDD/Fs required further investigation. Finally, possible de novo synthesis pathways of PCDD/Fs were proposed based on the above findings. However, the above pathways are required further laboratory studies for validation before possible formation suppression approaches can be determined.

Oxygenate

De novo synthesis

10.4209/aaqr.2011.03.0024

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Citations (15)

Source and health risk apportionment for PM2.5 collected in Sha-Lu area, Taiwan

Atmospheric Pollution Research (2020)

Perng‐Jy Tsai Li‐Hao Young Bing‐Fang Hwang Ming-Yeng Lin Yu‐Cheng Chen

Health Risk Assessment

Apportionment

10.1016/j.apr.2020.01.013

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