Wenwen Wang

Fudan University

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Chenglong Xie

Wenzhou Medical University

Shixuan Wang

Tongji Hospital

Xinshi Wang

First Affiliated Hospital of Wenzhou Medical University

Bu-Hui Liu

Nanjing University of Chinese Medicine

Yi‐Gang Wan

Nanjing Drum Tower Hospital

Qi‐Jun Fang

Nanjing University of Chinese Medicine

Shixuan Wang

Huazhong University of Science and Technology

Yinglu Liu

Nanjing Drum Tower Hospital

Zengrui Zhang

Zhejiang Chinese Medical University

Xin Zhu

University of Aizu

Cooperative Institutions

Huazhong University of Science and Technology

125

Chinese Academy of Sciences

Shanghai Jiao Tong University

Tongji Hospital

Fudan University

Sun Yat-sen University

Wenzhou Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shandong University

Union Hospital

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Jidong ovarian aging cohort study: Objective, design, and baseline characteristics

Maturitas (2024)

Wu Ren Fangfang Fu Wenwen Wang Man Wang Wenqing Ma

Baseline (sea)

10.1016/j.maturitas.2024.107933

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シタビラメ36遺伝子のCDNAクローンと発現解析を行った。【JST・京大機械翻訳】

Nongye Shengwu Jishu Xuebao (2016)

Wenwen Wang Zhu Ying Zhanfei Wei Zheng Weiwei Dong Zhongdian

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Research on the Application of Diversified Teaching in Gynecological Clinical Teaching

Food and Health (2021)

WenMing Chao Wenwen Wang GuoQing Qi KuiMei Zhang Xiurong Wang

10.53388/fthc20210202

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A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke

Scientific Reports (2015)

Chenglong Xie Wenwen Wang Xiaodong Xue Sufang Zhang Jing Gan

The neuroprotective actions of Ginsenoside-Rg1 (G-Rg1) have been documented for experimental stroke therapy. We used a systematic review and meta-analysis to assess the efficacy of G-Rg1 in experimental ischemic stroke. We identified studies describing the efficacy of G-Rg1 in animal models of focal cerebral ischemia. Primary outcomes were infarct volume and neurological function score (NFS). In all, eleven studies reported significant effects of G-Rg1 for improving the NFS when compared with the control group (P<0.00001) and four studies reported significant effects of G-Rg1 for reducing infarct volume compared with middle cerebral artery occlusion group (P<0.00001). Meanwhile, studies reported G-Rg1 was more efficacious than positive control drug nimodipine (0.7 or 1 mg/kg, intraperitoneal) according to NFS (P = 0.009) and infarct volume (p = 0.0002). The results demonstrate a marked efficacy of G-Rg1 in experimental acute ischemic stroke, but raise concerns that our value of effect size might be overestimate due to factors such as study quality and possible publication bias. Even so, the findings suggest G-Rg1 as a candidate neuroprotective drug for human ischemic stroke.

Ginsenoside Rg1

Stroke

Nimodipine

10.1038/srep07790

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Automatic endometrial segmentation in ultrasound images using deep learning

Yiyang Liu Boyuan Peng Xin Zhu Wenwen Wang Qin Zhou

Endometrial segmentation plays a vital role in the computerized evaluation of uterine ultrasonic images. Accurate segmentation of endometrial regions may improve the accuracy and efficiency of diagnosis. Recent studies have been focused on the employment of deep learning in medical image segmentation. In this study, we compared six models, including five convolutional neural networks with different network architectures (UNet, Segnet) and backbones (Resnet50, Vanilla CNN, VGG16) for the segmentation of endometrium, and one model called deep dual-resolution networks (DDRNets). The training and test datasets were composed of 840 and 210 images from 302 and 68 cases, respectively. Through validation, DRRNets demonstrated the best performance for endometrial segmentation with an average Dice coefficient (DSC) of 0.895.

Sørensen–Dice coefficient

Dice

10.1109/mcsoc57363.2022.00020

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Notch1 activation protects against triptolide-induced oxidative damage and apoptosis in hepatocytes

Acta Scientiarum Naturalium Universitatis Sunyatseni (2017)

Zhewen Xiong Wang Li Jiamin Kong Wenwen Wang Yisen Cheng

Triptolide

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Determination of multiple pesticide residues in teas by gas chromatography with accurate time‐of‐flight mass spectrometry

Journal of Separation Science (2019)

Jianxun Li Xiaoyu Teng Wenwen Wang Zijuan Zhang Chun‐Lin Fan

Abstract In this work, gas chromatography tandem with electron ionization and full‐scan high‐resolution mass spectrometry with a time‐of‐flight mass analyzer was evaluated for analyzing pesticide residues in teas. The relevant aspects for mass spectrometry analysis, including the resolution and mass accuracy, acquisition rate, temperature of ion source, were investigated. Under acquisition condition in 2‐GHz extended dynamic range mode, accurate mass spectral library including 184 gas chromatography detectable pesticides was established and retrieval parameters were optimized. The mass spectra were consistent over a wide concentration range (three orders) with good match values to those of NIST (EI‐quadrupole). The methodology was verified by the validation of 184 pesticides in four tea matrices. A wide linear range (1–1000 μg/kg) was obtained for most compounds in four matrices. Limit of detection, limit of quantification, and limit of identification values acquired in this study could satisfy the requirements for maximum residue levels prescribed by the European Community. Recovery studies were performed at three concentrations (10, 50, and 100 μg/kg). Most of the analytes were recovered at an acceptable range of 70–120% with relative standard deviations ≤ 20% in four matrices. The potential extension of qualitative screening scope makes gas chromatography tandem with electron ionization and mass spectrometry with a time‐of‐flight mass analyzer a more powerful tool compared with gas chromatography with tandem mass spectrometry.

Mass

10.1002/jssc.201800975

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Citations (20)

Characterization of CrufCSP1 and Its Potential Involvement in Host Location by Cotesia ruficrus (Hymenoptera: Braconidae), an Indigenous Parasitoid of Spodoptera frugiperda (Lepidoptera: Noctuidae) in China

Insects (2023)

Kai-Ru Han Wenwen Wang Wenqin Yang Xian Li Tong‐Xian Liu

Chemosensory proteins (CSPs) are a class of soluble proteins that facilitate the recognition of chemical signals in insects. While CSP genes have been identified in many insect species, studies investigating their function remain limited. Cotesia ruficrus (Hymenoptera: Braconidae) holds promise as an indigenous biological control agent for managing the invasive pest Spodoptera frugiperda (Lepidoptera: Noctuidae) in China. This study aimed to shed light on the gene expression, ligand binding, and molecular docking of CrufCSP1 in C. ruficrus. A RT-qPCR analysis revealed that the expression of CrufCSP1 was higher in the wings, with male adults exhibiting significantly higher relative expression levels than other developmental stages. A fluorescence competitive binding analysis further demonstrated that CrufCSP1 has a high binding ability with several host-related volatiles, with trans-2-hexenal, octanal, and benzaldehyde showing the strongest affinity to CrufCSP1. A molecular docking analysis indicated that specific amino acid residues (Phe24, Asp25, Thr53, and Lys81) of CrufCSP1 can bind to these specific ligands. Together, these findings suggest that CrufCSP1 may play a crucial role in the process of C. ruficrus locating hosts. This knowledge can contribute to the development of more efficient and eco-friendly strategies for protecting crops and managing pests.

10.3390/insects14120920

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The function of aquaporin4 in ischemic brain edema

Clinical Neurology and Neurosurgery (2014)

Wenwen Wang Chenglong Xie Lili Zhou Guosheng Wang

Cerebral edema

Brain Edema

Brain herniation

10.1016/j.clineuro.2014.09.012

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Citations (33)