Hui Geng

First Affiliated Hospital of Xi'an Jiaotong University

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Siu Ki Yu

Hong Kong Sanatorium and Hospital

K.Y. Cheung

Fujifilm (United States)

W.W. Lam

Hong Kong Sanatorium and Hospital

Bin Yang

Hong Kong Sanatorium and Hospital

Linhua Ji

Shanghai Jiao Tong University

Ka Keung Tang

Hong Kong Sanatorium and Hospital

Yeung Sum Wong

Hong Kong Sanatorium and Hospital

Wing Ki Claudia Chan

Hong Kong Sanatorium and Hospital

Ka Ki Lau

Hong Kong Sanatorium and Hospital

Zhanquan Li

Qinghai University Affiliated Hospital

Cooperative Institutions

Peking University

Hong Kong Sanatorium and Hospital

Xi'an Jiaotong University

Chinese Academy of Medical Sciences & Peking Union Medical College

First Affiliated Hospital of Xi'an Jiaotong University

Qinghai University

Qinghai University Affiliated Hospital

Chinese Academy of Sciences

Sun Yat-sen University

Huazhong University of Science and Technology

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Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis

Arthritis Research & Therapy (2008)

Hui Geng Stefan Carlsén Kutty Selva Nandakumar Rikard Holmdahl Anders Aspberg

Abstract Introduction Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. Methods COMP-deficient mice in the 129/Sv background were backcrossed for 10 generations against B10.Q mice, which are susceptible to chronic CIA. COMP-deficient and wild-type mice were tested for onset, incidence, and severity of arthritis in both the collagen and collagen antibody-induced arthritis models. Serum anti-collagen II and anti-COMP antibodies as well as serum COMP levels in arthritic and wild-type mice were measured by enzyme-linked immunosorbent assay. Results COMP-deficient mice showed a significant early onset and increase in the severity of CIA in the chronic phase, whereas collagen II-antibody titers were similar in COMP-deficient and wild-type controls. COMP antibodies were not found in wild-type mice. Finally, COMP-deficient and wild-type mice responded similarly to collagen antibody-induced arthritis, indicating no difference in how collagen II antibodies interact with COMP-deficient cartilage during the initial stages of arthritis. Conclusions COMP deficiency enhances the early onset and development of chronic arthritis but does not affect collagen II autoimmunity. These findings accentuate the importance of COMP in cartilage stability.

Type II collagen

10.1186/ar2551

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Chronic Hypoxia-Induced Microvessel Proliferation and Basal Membrane Degradation in the Bone Marrow of Rats Regulated through the IL-6/JAK2/STAT3/MMP-9 Pathway

BioMed Research International (2020)

Mingming Zhu Min Yang Quanyu Yang Wen‐ling Liu Hui Geng

Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Therefore, this study investigated the role of the IL-6/JAK2/STAT3/MMP-9 pathway in hypoxia-mediated microvessel proliferation and BM degradation in the rat bone marrow. Eighty pathogen-free Sprague Dawley male rats were randomly divided into four groups (20 per group)-control group, CH group (exposed to hypoxia in a hypobaric chamber at a simulated altitude of 5000 m for 28 d), CH + STAT3 inhibitor group (7.5 mg/kg/d), and CH + DMSO group. Microvessel density (MVD) and BM degradation in the bone marrow were determined by immunofluorescence staining and transmission electron microscopy. Serum IL-6 levels were assessed by enzyme-linked immunosorbent assay (ELISA), and the levels of P-JAK2, P-STAT3, and MMP-9 were assessed by western blot analysis and real-time reverse transcription PCR (RT-PCR). Hypoxia increased serum IL-6 levels, which in turn increased JAK2 and STAT3 phosphorylation, which subsequently upregulated MMP-9. Overexpression of MMP-9 significantly promoted the elevation of MVD and BM degradation. Inhibition of STAT3 using an inhibitor, SH-4-54, significantly downregulated MMP-9 expression and decreased MVD and BM degradation. Surprisingly, STAT3 inhibition also decreased serum IL-6 levels and JAK2 phosphorylation. Our results suggest that the IL-6/JAK2/STAT3/MMP-9 pathway might be related to CH-induced microvessel proliferation and BM degradation in the bone marrow.

Hypoxia

Microvessel

10.1155/2020/9204708

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Citations (17)

Influence of X-ray energy spectrum in the post-reconstruction method for beam hardening correction in polyenergetic CT reconstruction

Bin Yang Hui Geng W.W. Lam Wing Kei Rebecca Wong K.Y. Cheung

Poster: ECR 2016 / C-2103 / Influence of X-ray energy spectrum in the post-reconstruction method for beam hardening correction in polyenergetic CT reconstruction by: B. Yang, H. Geng, W. W. Lam, W. K. R. Wong, K. Y. Cheung, S. K. Yu; Hong Kong/HK

Energy spectrum

Hardening (computing)

Beam energy

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苹果属观赏海棠 McCHI 基因的克隆及不同叶色品种间表达差异分析

耿慧 Hui Geng 沈红香 Shen Hong-xiang 姚允聪

以苹果属观赏海棠品种‘王族’叶片提取的总RNA为模板, 通过RT-PCR与RACE扩增, 获得1条660 bp的查尔酮异构酶(CHI)基因的全长cDNA序列, 编码219个氨基酸, 命名为McCHI。该基因DNA序列全长1 180 bp, 由3个内含子和4个外显子组成, 具有CHI基因的典型结构。采用实时荧光定量PCR和紫外可见光分光光度计法, 对3类不同叶色类型的观赏海棠品种‘火焰’(绿色类叶片)、‘绚丽’(新叶有色类红色叶片)、‘高原之火’ (新叶有色类红色叶片)和‘王族’(常色叶类紫色叶片)幼叶和功能叶中的McCHI表达及其花色苷含量进行测定分析, 结果表明: McCHI在4个品种的幼叶和功能叶中均有表达, 其表达量与花色苷积累随品种不同和叶龄不同表现出明显差异。

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A comparative study of two different hand-drying methods

Zhonghua xiandai huli zazhi (2009)

Li Li Li-hong Zuo Xiaofeng Kang Hui Geng

Objective To provide clinical practice the simple,convenient and suitable hand-drying methods.Methods 64 clinical nurses were randomly divided into 2 groups.AIl of the subjects washed hands.One group members used disposable paper towels for drying hands after washing,and another group used sterile towels.Bacteria ntlmbers and the cost were compared between two groups.Results There were no significant differences between use of disposable paper towels and sterile towels in bacteria numbers and the cost of handaryins.Conclusions Disposable paper towels and sterile towels are both effective hand drying methods,but the former is more convenient and available. Key words: Clinical; Hand-drying; Methods; Effectiveness; Cost

10.3760/cma.j.issn.1674-2907.2009.31.003

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Development and validation of a new risk assessment model for immunomodulatory drug-associated venous thrombosis among Chinese patients with multiple myeloma

Thrombosis Journal (2023)

Xiaozhe Li Xiuli Sun Baijun Fang Yun Leng Fangfang Sun

Abstract Background Individuals with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs) are at risk of developing venous thromboembolism (VTE), a serious complication. There is no established clinical model for predicting VTE in the Chinese population. We develop a new risk assessment model (RAM) for IMiD-associated VTE in Chinese MM patients. Methods We retrospectively selected 1334 consecutive MM patients receiving IMiDs from 16 medical centers in China and classified them randomly into the derivation and validation cohorts. A multivariate Cox regression model was used for analysis. Results The overall incidence of IMiD-related VTE in Chinese MM patients was 6.1%. Independent predictive factors of VTE (diabetes, ECOG performance status, erythropoietin-stimulating agent use, dexamethasone use, and VTE history or family history of thrombosis) were identified and merged to develop the RAM. The model identified approximately 30% of the patients in each cohort at high risk for VTE. The hazard ratios (HRs) were 6.08 (P < 0.001) and 6.23 (P < 0.001) for the high-risk subcohort and the low-risk subcohort, respectively, within both the derivation and validation cohorts. The RAM achieved satisfactory discrimination with a C statistic of 0.64. The stratification approach of the IMWG guidelines yielded respective HRs of 1.77 (P = 0.053) and 1.81 (P = 0.063). The stratification approach of the SAVED score resulted in HRs of 3.23 (P = 0.248) and 1.65 (P = 0.622), respectively. The IMWG guideline and the SAVED score-based method yielded C statistics of 0.58 and 0.51, respectively. Conclusions The new RAM outperformed the IMWG guidelines and the SAVED score and could potentially guide the VTE prophylaxis strategy for Chinese MM patients.

Guideline

10.1186/s12959-023-00534-y

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Clinical implementation of kVCT-guided tomotherapy with ClearRT

Physical and Engineering Sciences in Medicine (2022)

Bin Yang Hui Geng Tien Yee Amy Chang Mei Yan Tse W.W. Lam

Tomotherapy

10.1007/s13246-022-01162-y

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Citations (2)

[Clinical Therapeutic Efficacy of Rituximab Combined with Methotrexate on Primary Central Nervous System Lymphoma].

PubMed (2016)

Wei Luo Linhua Ji Hui Geng Xiaojing Ma Hua Xiong

To investigate the therapeutic efficacy of rituximab combined with methotrexate on patients with primary central nervous system lymphoma.Fifty eight patients with central nervous system lymphoma treated in our hospital from February 2008 to September 2011 years were randomly divided into the observation group and the control group. The control group was treated with methotrexate combined with whole brain radiotherapy; the observation group was treated by rituximab combined with methotrexate. The curative efficacy, adverse effects, life quality, and the 1 and 3 year survival rate after 2 cycles of treatment were compared between 2 groups.The total effective rate of observation group was 82.76%, which significantly higher than 58.62% of the control group (P < 0.05). In observation group, the incidences of anemia, liver damage, gastrointestinal side effect and oral ulcer were significantly lower than that in control group, respectively (P < 0.05). The physiological function, physical function, health status, social and emotional function in the observation group were significantly higher than those in the control group (P < 0.05), 1 and 3 years survival rates in the observation group were 86.21% and 62.07%, significantly higher than 58.62% and 31.03% in the control group (P < 0.05).Targeted therapy combined with chemotherapy for the primary central nervous system lymphoma can improve the patients' outcomes, reduce adverse effects, and improve the quality of life and survival rate.

10.7534/j.issn.1009-2137.2016.02.025

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Citations (4)

[ACE2-Ang-(1-7)-Mas axis level of local bone marrow in chronic mountain sickness patients].

PubMed (2014)

Hongli Zhang Linhua Ji Zhanquan Li Sen Cui Juan Su

10.3760/cma.j.issn.0253-2727.2014.07.021

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The Application of Wavesurfer in Birdsong Analysis

Journal of Liaoning Normal University (2005)

Hui Geng

Wavesurfer is a kind of software designed by KTH in 2000.It can analyze different sounds.It can be used in birdsong analysis and get specific acoustic character of birdsong.It offer technical support for research of vocal behavior of birds.

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