Xu Wang

Université Paris-Est Créteil

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Mireille Cosquer

Centre de recherche en Epidémiologie et Santé des Populations

Bruno Falissard

Université Paris-Saclay

Catherine Jousselme

Inserm

Emmanuelle Corruble

Inserm

Florence Gressier

Centre de recherche en Epidémiologie et Santé des Populations

Quan Gan

Kunming Children's Hospital

Aminata Ali

Centre de recherche en Epidémiologie et Santé des Populations

Liang Zheng

Jilin Agricultural Science and Technology University

Kewei Ma

First Hospital of Jilin University

Min Zhuang

UCLouvain Saint-Louis Brussels

Cooperative Institutions

National University of Singapore

National University Health System

Jilin University

Inserm

Capital Medical University

Nanjing Medical University

Assistance Publique – Hôpitaux de Paris

Université Paris Cité

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

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Genome-Wide Linkage Scan of a Pedigree with Familial Hypercholesterolemia Suggests Susceptibility Loci on Chromosomes 3q25-26 and 21q22

PLoS ONE (2011)

Xu Wang Xin Li Yong‐Biao Zhang Feng Zhang Liyuan Sun

Background Familial hypercholesterolemia (FH) is a heritable disorder that can increase the risk of premature coronary heart disease. Studies suggest there are substantial genetic heterogeneities for different populations. Here we tried to identify novel susceptibility loci for FH in a Chinese pedigree. Methodology/Principal Findings We performed a SNP-based genome-wide linkage scan with the Chinese FH pedigree. Two suggestive linkage loci not previously reported were identified on chromosomes 3q25.1-26.1 (NPL = 9.01, nominal P<0.00001, and simulated occurrence per genome scan = 1.08) and 21q22.3 (NPL = 8.95, nominal P<0.00001, and simulated occurrence per genome scan = 1.26). In the interaction analysis with a trimmed version of the pedigree, we obtained a significantly increased joint LOD score (2.70) compared with that obtained when assuming the two loci uncorrelated, suggesting that more than one locus was involved in this pedigree. Exon screening of two candidate genes ABCG1 and LSS from one of the suggestive region 21q22 didn't report any causative mutations. Conclusions/Significances These results confirm complex etiologies and suggest new genetic casual factors for the FH disorder. Further study of the two candidate regions is advocated.

Genome Scan

Genetic linkage

SNP

Candidate gene

10.1371/journal.pone.0024838

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Malaria outbreaks in China (1990–2013): a systematic review

Malaria Journal (2014)

Guangyu Lu Shuisen Zhou Olaf Horstick Xu Wang Yali Liu

China has already achieved remarkable accomplishments in shrinking the malaria burden since the mid-20th Century. The country now plans to eliminate malaria by the year 2020. Looking at the dynamics of malaria outbreaks during the last decades might provide important information regarding the potential challenges of such an elimination strategy and might help to avoid mistakes of the past.

10.1186/1475-2875-13-269

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Citations (44)

The associated factors of suicide attempt in French sexual minority adolescents

Minerva Psychiatry (2023)

Xu Wang Zidong Zhang Mireille Cosquer Quan Gan Catherine JOUSSELME

BACKGROUND: Sexual minority adolescents have greater risk for suicide attempt (SA) than heterosexual youth. However, research on risk and protective factors is lacking in sexual minority youth. In this study, we aimed to identify novel risk and protective factors for suicide attempt using machine learning decision tree method.METHODS: The French cross-sectional study Portraits d’adolescents included 14,265 aged 13-20 years old adolescents. Decision tree algorithm was used to predict SA and to compare the different risk and protective factors between sexual minority youth and heterosexual peers.RESULTS: Twenty predictive factors were identified among the 70 survey fields output from the predictive modeling for SA. Substance consumptions were among the top risk factors for SA. Parental support was an important protective factor among all adolescents regardless of sexual orientation. Interestingly, through the decision tree, real-life friend support was found protective in heterosexual youth, online friend support was a protective factor in homosexual adolescents.CONCLUSIONS: Using the decision tree-based algorithm, we not only verified those important protective factors that were demonstrated in existing studies, but also discovered novel protective and attributive factors, such as real-life and online friend support. We urge that social networks should be optimized to provide safety and support for the sexual minority adolescents.

Protective factor

10.23736/s2724-6612.22.02347-8

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Citations (1)

Optimising routine surveillance systems for informing tuberculosis control policies in China

Health Policy and Planning (2017)

Mishal Khan Shishi Wu Xu Wang Richard Coker

Tuberculosis control

10.1093/heapol/czx051

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p21 rs3176352 G>C and p73 rs1801173 C>T Polymorphisms Are Associated with an Increased Risk of Esophageal Cancer in a Chinese Population

PLoS ONE (2014)

Liang Zheng Weifeng Tang Yijun Shi Suocheng Chen Xu Wang

Objective Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009. Genetic factors might play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis. Designs and Methods To evaluate the effect p21, p53, TP53BP1 and p73 single nucleotide polymorphisms (SNPs) on the risk of ESCC, we conducted a hospital based case–control study. A total of 629 ESCC cases and 686 controls were recruited. Their genotypes were determined using ligation detection reaction (LDR) method. Results When the p21 rs3176352 GG homozygote genotype was used as the reference group, the CC genotype was associated with a significantly increased risk of ESCC. When the p73 rs1801173 CC homozygote genotype was used as the reference group, the CT genotype was associated with a significantly increased risk of ESCC. After Bonferroni correction, for p21 rs3176352 G>C, the pcorrect was still significant. For the other six SNPs, in all comparison models, no association between the polymorphisms and ESCC risk was observed. Conclusions p21 rs3176352 G>C and p73 rs1801173 C>T SNPs are associated with increased risk of ESCC. To confirm the current findings, additional, larger studies and tissue-specific biological characterization are required.

Bonferroni correction

10.1371/journal.pone.0096958

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Immunogenicity of 4-dose Essen intramuscular regimen for rabies post-exposure prophylaxis: A multi-center cross-sectional study in China

Travel Medicine and Infectious Disease (2024)

Qisheng Hou Si Liu Cheng Liu Xu Wang Jirong Shi

The 4-dose Essen intramuscular (IM) regimen for rabies post-exposure prophylaxis (PEP) has been recommended by Advisory Committee on Immunization Practices (ACIP) and World Health Organization (WHO), but the large-sample clinical evidence is still limited. Rabies virus neutralizing antibodies of 11,752 patients were detected from 409 rabies prevention clinics in 27 provinces in China. Patients with serum collected before or no later than 1 h after injection on the day of the fifth dose (day 28) of 5-dose Essen regimen were included in Group A to observe the immune efficacy of 4-dose Essen IM regimen, and patients with serum collected 14–28 days after injection of the fifth dose were included in Group B to observe the immune efficacy of 5-dose Essen IM regimen. Finally, 2351 cases met the inclusion and exclusion criteria, including 2244 cases in Group A and 107 cases in Group B. The antibody titer of Group A was higher than that of Group B [12.21 (4.15, 32.10) IU/ml vs. 9.41 (3.87, 27.38) IU/ml] (P = 0.002). In Group A, the median antibody titers were 4.01IU/ml, 11.63IU/ml and 29.46IU/ml in patients vaccinated with purified hamster kidney cell vaccine (PHKCV), purified Vero cell vaccine (PVRV), and human diploid cell rabies vaccine (HDCV), respectively, with statistical significance (P < 0.001). The 4-dose Essen IM regimen could provide satisfactory immune effect, and HDCV induced higher antibody titer than PHKCV or PVRV.

Regimen

Rabies vaccine

Post-exposure prophylaxis

Antibody titer

10.1016/j.tmaid.2024.102735

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Citations (1)

148 Dégradation des propriétés biomécaniques du supraspinatus dans la rupture de la coiffe des rotateurs

Revue de Chirurgie Orthopédique et Réparatrice de l Appareil Moteur (2004)

Sai͏̈d Slimani Xu Wang Blaise Michel Jean‐François Stoltz Pierre Lascombes

Gradation

10.1016/s0035-1040(04)70603-0

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A systematic review of the factors associated with suicide attempts among sexual-minority adolescents

medRxiv (Cold Spring Harbor Laboratory) (2022)

Xu Wang Quan Gan Junwen Zhou Mireille Cosquer Bruno Falissard

Abstract Introduction Suicide attempt is a worldwide major public health problem, that accounts for 1.4% of all deaths worldwide Recent literature reported higher risk of suicide attempt among adolescents associated with sexual minority status but few systematic reviews focused on the risk and protective factors. For that reason, it seems necessary to examine risk and protective factors of attempted suicide in sexual minority adolescents. Methods We conducted a systematic review of published studies on factors associated with suicide attempts in LGBT adolescents. 4 databases up to December 2020 were searched to find relevant studies. Results In addition to the factors usually found in general population (gender, ethnic minorities, childhood trauma, psychiatric symptoms, addictive behaviors), some factors have been independently associated with suicide attempt in LGBT population: early coming out, not acceptable by families, not satisfied with LGBT friendship, too few number of friends, physical abuse, sexual abuse and bullying. The protective factors of suicide attempt reported in LGBT population were feeling safety at school, teacher support, anti-bullying policy, and other adult’s support. Conclusion Effective preventive measures for suicide attempt among LGBT youth need to be developed and implemented. The impact of interventions targeting teacher responses to LGBT stigma, discussion of LGBT issues in class and reactions of family and friends to the coming out of LGBT youth should be further investigated.

10.1101/2022.01.19.22269164

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Forecasting the burden of type 2 diabetes in Singapore using a demographic epidemiological model of Singapore

BMJ Open Diabetes Research & Care (2014)

Thao Phuong Phan Leontine Alkema E Shyong Tai Kok Hian Tan Qian Yang

Singapore is a microcosm of Asia as a whole, and its rapidly ageing, increasingly sedentary population heralds the chronic health problems other Asian countries are starting to face and will likely face in the decades ahead. Forecasting the changing burden of chronic diseases such as type 2 diabetes in Singapore is vital to plan the resources needed and motivate preventive efforts.This paper describes an individual-level simulation model that uses evidence synthesis from multiple data streams-national statistics, national health surveys, and four cohort studies, and known risk factors-aging, obesity, ethnicity, and genetics-to forecast the prevalence of type 2 diabetes in Singapore. This comprises submodels for mortality, fertility, migration, body mass index trajectories, genetics, and workforce participation, parameterized using Markov chain Monte Carlo methods, and permits forecasts by ethnicity and employment status.We forecast that the obesity prevalence will quadruple from 4.3% in 1990 to 15.9% in 2050, while the prevalence of type 2 diabetes (diagnosed and undiagnosed) among Singapore adults aged 18-69 will double from 7.3% in 1990 to 15% in 2050, that ethnic Indians and Malays will bear a disproportionate burden compared with the Chinese majority, and that the number of patients with diabetes in the workforce will grow markedly.If the recent rise in obesity prevalence continues, the lifetime risk of type 2 diabetes in Singapore will be one in two by 2050 with concomitant implications for greater healthcare expenditure, productivity losses, and the targeting of health promotion programmes.

10.1136/bmjdrc-2013-000012

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Citations (179)

The role of parental and friends’ support preventing suicide attempts among French sexual minority adolescents

Xu Wang Mireille Cosquer Min Zhuang Aminata Ali Bruno Falissard

This present study aimed to search for parental and friend support roles to prevent suicide attempts among adolescents who identify as lesbian, gay, and bisexual (LGB) in France. Data were drawn from a French cross-sectional study entitled “Portrait d’Adolescents”. An anonymous self-questionnaire was fulfilled by 14,265 French adolescents (ages from 13 to 20) in 2013, and 637 (4.47%) were identified as LGB. Chi-square analysis was used to estimate statistical differences between self-reported suicide and non-suicide attempters in the whole sample and then in LGB and heterosexual subgroups separately. Multiple logistic regression analyses were then performed to examine the associations of self-reported suicide attempts (dependent variable) with the effects of parental and friend support and other factors based on the whole data and further on the data subsets among the LGB and the heterosexual subjects. Suicide attempt was independently associated with sexual orientation (30.7% vs 10.6%; OR=2.04 [1.62-2.56]; p<0.0001). Both parental and friend support appeared protective factors in the heterosexuals (OR=0.52 [0.45-0.60] and OR=0.75 [0.61-0.93]), whereas only parental support was significant in the LGB group (OR=0.51 [0.31-0.82]), independently of other variables. French adolescents who identify as LGB have a higher risk for suicidality than their heterosexual peers. Special attention needs to be given to this vulnerable population when developing suicide prevention programs. Parental support identified as an effective protective factor should be systematically searched to prevent suicidality among LGB.

10.31234/osf.io/k6txg

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