Fen Wang

Central South University

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Cong Wang

Guangdong Provincial Hospital of Traditional Chinese Medicine

Ziying Liu

Jiujiang University

Yuepeng Ke

Texas A&M University

Jianping Jia

Capital Medical University

Junchen Liu

Shenzhen Institutes of Advanced Technology

Tyler M. Berzin

Beth Israel Deaconess Medical Center

Yi Gao

Peking Union Medical College Hospital

Douglas K. Pleskow

Beth Israel Deaconess Medical Center

Mandeep S. Sawhney

Beth Israel Deaconess Medical Center

Aihong Zhou

Hebei GEO University

Cooperative Institutions

Capital Medical University

Huazhong University of Science and Technology

Sun Yat-sen University

National Clinical Research Center for Digestive Diseases

Shanghai Jiao Tong University

Texas A&M University

Central South University

Harvard University

Ministry of Education of the People's Republic of China

Peking University

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Progress in Innate Immunity

Int J Genet (2009)

Tianjiao Zhang Fen Wang

Recently,there are tremendous progresses in the stuay of innate immunity,particularly in the identification and characterization of the pattem recognition receptors (PRRs) which recognize the pathogen associated molecular patterns (PAMPs).It has been well accepted that innate immunity not only provides the first line to protect host avoiding infection but also plsys an essential role to activate adaptive immunity.Without innate immunity,the adaptive immunity is feeble.Toll-like receptors are the key molecular sensor of innate immunity and the well-churacterized PRRs.The activated TLR signaling rapidly induces the expression of a variety of genes involved in the inflammatory and immune responses.All these new insights into TLRs and TLR signaling have been changing our understanding and treatment of infectious and inflammatory diseases. Key words: Toll-like receptor; Innate immunity; TLR signaling; Infection

Intrinsic immunity

10.3760/cma.j.issn.1673-4386.2009.05.002

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[Propofol combined with midazolam intravenous sedation anesthesia in pediatric upper gastrointestinal endoscopy].

PubMed (2009)

Dinghua Xiao Fen Wang Xiaoyan Wang Wuliang Tang Wen Ouyang

To explore the application of propofol combined with midazolam intravenous anesthesia in pediatric upper gastrointestinal endoscopy.A total of 497 ASA I~II patients who received sedative upper gastrointestinal endoscopy were assigned to a children group (2-14 years) and an adults group (18-65 years).The 2 groups were treated with midazolam (0.02-0.03 mg/kg, iv) and propofol(0.6-0.7 mg/s,iv) with an interval of 3-5 minutes. Enterscopy was inserted at light sleep, relaxing muscles, and disappearance of eyelash relaxation. Combining of pro-endoscopy, reaction to intravenous administration, dose of propofol, reaction to endoscopy, time of returning to consciousness, changes of SpO2, R, HR, and BP, and sedative quality were evaluated.Good sedation of the 2 groups after intravenous administration was observed. Rate of combining of pro-endoscopy in children was lower (42%) than that in adults(100%). The incidence of restlessness, hyperphasia, temporary decreasing of SpO2, dose of propofol of per kilogram weight, time of returning to consciousness in the children were 82.7%, 17%, 2.4 mg/kg, and (17.5+/-3.2) min, respectively, which were all higher in the adults [9%, 4%, 1.4 mg/kg, and (9.5+/-1.3) min, P<0.01]. HR and BP decreased in the 2 groups, and recovered rapidly after the endoscopy. There was no significant difference between the 2 groups(P>0.05).It is safe and effective to use propofol combined with midazolam intravenous sedation anesthesia in pediatric upper gastrointestinal endoscopy.

Midazolam

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Juxtaglomerular cell tumor: Clinical and immunohistochemical features

Journal of Clinical Hypertension (2017)

Fen Wang Chuan Shi Yunying Cui Chunyan Li Anli Tong

Juxtaglomerular cell tumor (JGCT) is a rare tumor, with approximately 100 cases reported in the literature. The authors respectively studied the clinical data of 11 patients diagnosed with JGCT in Peking Union Medical College Hospital from 2004 to 2014, and investigated the immunohistochemical profiles in 10 tumors. Nine of the 11 patients were diagnosed before the age of 40 years. Hypertension was present in all patients, while hypokalemia occurred in seven of 11 patients. Computed tomography detected JGCTs with a sensitivity of 100%. Immunoreactivities for CD34 and vascular endothelial growth factor were observed in most tumor specimens, suggesting that JGCTs express a variety of vessel-related immunohistochemical markers, although JGCTs are considered a tumor without abundant blood supply. Nuclear accumulation of cyclin D1 was common in JGCTs. Results from immunohistochemistry were negative for BRAF, HER2, and TFE3, suggesting that BRAF, HER2, and TFE3 genes might not play a part in tumorigenesis in JGCTs.

TFE3

10.1111/jch.12997

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Study on Ultra-weak Luminescence of Maize Seeds

He'nan nongye kexue (2014)

Fen Wang

In order to understand the relationships between the structure characteristics and metabolic activity of maize seeds,the ultra-weak luminescence(UWL)properties of maize seeds were studied.Before UWL measurement,the maize seeds were moistened in distilled water for various times(2h,4h,6hand 8h).And then the seeds were dried to the mass before they were moistened.Single factor analysis of variance method was used to analyze the spontaneous UWL characteristics.The result showed that the soaking time was a significant factor affecting seed UWL characteristics.The distilled water was injected into the tested samples first,and then the stressed UWL data were measured.A kind of double exponential function was proved to fit the tested data well,the determination coefficient of fitting being above 0.97.It was observed that the soaking treatment had a significant impact on the stressed UWL characteristics of maize seeds.The dry seeds after soaked contain a large number of hydrophilic pores,so water can quickly permeate into maize seeds and force the seeds to produce stress UWL after the water injection.Generally,the stressed UWL level became lower when the soaking time was longer.The intensity of the stressed UWL depended on the structure of seeds and the time of moistening.

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Ultrasound shear wave elastography of breast lesions: correlation of anisotropy with clinical and histopathological findings

Cancer Imaging (2018)

Ya-Ling Chen Yi Gao Cai Chang Fen Wang Wei Zeng

Ultrasound shear-wave elastography (SWE) may increase specificity of breast lesion assessment with ultrasound, but elasticity measurements may change with transducer orientation, defined as anisotropy. In this study, we aimed to observe the anisotropy of SWE of breast lesions, and its correlation with clinical and histopathological findings.This retrospective study was approved by institutional review board. From June 2014 to June 2015, a total of 276 women (mean age, 48.75 ± 12.12 years) with 276 breast lesions (174 malignant, 102 benign) were enrolled for conventional ultrasound and SWE before surgical excision. Elasticity modulus in the longest diameter and orthogonal diameter were recorded, including maximum elasticity (Emax), mean elasticity (Emean), standard deviation (Esd) and ratio between mean elasticity of lesion and normal fatty tissue (Eratio). Anisotropy coefficients including anisotropic difference (AD) and anisotropy factors (AF) were calculated, and correlations with malignancy, tumor size, palpability, movability, lesion location and histopathology were analyzed.The average Emax, Emean, Esd and Eratio of the longest diameter were significantly higher than orthogonal diameter (P < 0.05). AUCs of ADs and AFs were inferior to quantitative parameters (P < 0.001), with AUCs of AFs superior to ADs (P < 0.001). ADs showed no significant correlation with malignancy, palpability, movability, distance from nipple and skin, and histopathological patterns. ADmean was significantly higher in inner half than outer half of the breast (P = 0.034). Higher AFs were significantly correlated with larger lesion size (P = 0.042), palpability (P < 0.05), shorter distance from nipple and skin (P < 0.05) and higher suspicion for malignancy (P < 0.001). AFs were significantly higher in IDC than DCIS (P < 0.05), higher in Grade II/III than Grade I IDC (P < 0.001), and correlated with ER/PR(+) (P < 0.05).AF of SWE was an indicator for malignancy and more aggressive breast cancer.

Histopathology

10.1186/s40644-018-0144-x

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The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma

BMC Cancer (2015)

Thai H. Ho Xian-De Liu Yanqing Huang Carla L. Warneke Marcella M. Johnson

Angiogenesis plays a role in tumor growth and is partly mediated by factors in both the fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) pathways. Durable clinical responses with VEGF tyrosine kinase inhibitors (TKIs) may be limited by intrinsic tumor resistance. We hypothesized that FGF signaling may impact clinical responses to sorafenib.Nephrectomy material was available from 40 patients with metastatic renal cell carcinoma (RCC) enrolled in a phase II clinical trial of sorafenib ± interferon (ClinicalTrials.gov Identifier NCT00126594). Fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor receptor substrate 2 alpha (FRS2α) expression was assessed by in situ hybridization and immunofluorescence, respectively. The relationship between fibroblast growth factor pathway marker levels and progression-free survival (PFS) was analyzed using Kaplan-Meier and Cox proportional hazards regression methods.Univariate analysis indicated that more intense FGFR1 staining was associated with shorter PFS (log-rank P = 0.0452), but FRS2α staining was not significantly associated with PFS (log-rank P = 0.2610). Multivariate Cox proportional hazards regression models were constructed for FGFR1 and FRS2α individually, adjusting for baseline Eastern Cooperative Oncology Group performance status, treatment arm and anemia status. When adjusted for each of these variables, the highest intensity level of FGFR1 (level 3 or 4) had increased progression risk relative to the lowest intensity level of FGFR1 (level 1) (P = 0.0115). The highest intensity level of FRS2α (level 3 or 4) had increased progression risk relative to the lowest intensity level of FRS2α (level 1) (P = 0.0126).Increased expression of FGFR1 and FRS2α was associated with decreased PFS among patients with metastatic RCC treated with sorafenib. The results suggest that FGF pathway activation may impact intrinsic resistance to VEGF receptor inhibition.

10.1186/s12885-015-1302-1

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Treatment of Conbercept for macular edema secondary to branch retinal vein occlusion in minority areas of Southeast Guizhou

Research Square (Research Square) (2022)

Tongle Zhu Fen Wang Chunman Yang Xiaoying Xu Zhu-min Yang

Abstract Objective : To evaluate the clinical efficacy of Conbercept on macular edema secondary to branch retinal vein occlusion and to explore the relevant influencing factors. Method : The clinical data of 94 patients (94 eyes) with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) in the Second Affiliated Hospital of Guizhou Medical University from January 2015 to September 2019 were collected. All patients received intravitreal injection of Conbercept. The best corrected visual acuity (BCVA), central macular thickness (CMT), ellipsoid zone and external membrane integrity were observed before treatment and 1, 3, 6 and 12 months after treatment. Result: The constituent characteristics of different nationalities in this study are 38.30% (36 / 94) of Han nationality, 34.04% (32 / 94) of Miao nationality and 27.66% (26 / 94) of Dong nationality. The clinical baseline data (age, gender, preoperative BCVA, and CMT) of ME secondary to BRVO in different nationalities were not statistically significant. There was no significant difference in BCVA and CMT between Han, Miao and Dong nationalities at 1, 3, 6 and 12 months after operation. BCVA in patients of different nationalities at 1, 3, 6 and 12 months after operation was significantly higher than that before treatment ( P < 0.05). CMT in patients of different nationalities decreased significantly after 1, 3, 6 and 12 months ( P < 0.05). In the multiple regression analysis of this study, baseline CMT was not related to baseline BCVA ( P > 0.05). Age, course of disease and ellipsoid band integrity were related to baseline BCVA ( P < 0.05). Baseline BCVA and baseline external membrane integrity were related to BCVA ( P < 0.05). Conclusion : In the treatment of ME secondary to BRVO, Conbercept shows time stability and broad-spectrum demographic characteristics, and it can be widely used in ethnic minority areas in Southeast Guizhou.

Han nationality

10.21203/rs.3.rs-2288330/v1

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General anesthesia for emergency cesarean section clinical experience

Fen Wang

Objective: surgery and anesthesia during pregnancy, there is the particularity requirement is to ensure mother and anesthesia safety. Methods: 32 patients were pregnant women, cesarean section under general anesthesia, the Result: The vital signs were stable, without anesthesia accidents, a total of 12 cases of neonatal resuscitation be OK, including premature birth, low body mass accounted for most of the 2 cases recovery 5 min. Conclusion: General anesthesia for critically ill pregnant women, cesarean section, is a high risk, should carefully consider the way medication, dosage, administration time, and the fetus and the mother's general condition. [Key words] general anesthesia; cesarean section; application

Section (typography)

Vital signs

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Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment

Journal of Biological Chemistry (2015)

Yanqing Huang Tomoaki Hamana Junchen Liu Cong Wang Lei An

Prostate stem cells (P-SCs) are capable of giving rise to all three lineages of prostate epithelial cells, including basal, luminal, and neuroendocrine cells. Multiple methods have been used to identify P-SCs in adult prostates. These include in vivo renal capsule implantation of a single epithelial cell with urogenital mesenchymal cells, in vitro prostasphere and organoid cultures, and lineage tracing with castration-resistant Nkx3.1 expression (CARN), in conjunction with expression of cell type-specific markers. Both organoid culture and CARN tracing show the existence of P-SCs in the luminal compartment. Although prostasphere cells predominantly express basal cell-specific cytokeratin and P63, the lineage of prostasphere-forming cells in the P-SC hierarchy remains to be determined. Using lineage tracing with P63(CreERT2), we show here that the sphere-forming P-SCs are P63-expressing cells and reside in the basal compartment. Therefore we designate them as basal P-SCs (P-bSCs). P-bSCs are capable of differentiating into AR(+) and CK18(+) organoid cells, but organoid cells cannot form spheres. We also report that prostaspheres contain quiescent stem cells. Therefore, the results show that P-bSCs represent stem cells that are early in the hierarchy of overall prostate tissue stem cells. Understanding the contribution of the two types of P-SCs to prostate development and prostate cancer stem cells and how to manipulate them may open new avenues for control of prostate cancer progression and relapse.

Compartment (ship)

Basal (medicine)

10.1074/jbc.m115.661033

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PSEN1, PSEN2, and APP mutations in 404 Chinese pedigrees with familial Alzheimer's disease

Alzheimer s & Dementia (2020)

Longfei Jia Yue Fu Luxi Shen Heng Zhang Min Zhu

Abstract Introduction The PSENs/APP mutation distribution in Chinese patients with familial Alzheimer's disease (FAD) remains unclear. We aimed to analyze the genetic features of Chinese FAD pedigrees with and without PSENs/APP mutations. Methods In total, 1330 patients with Alzheimer's disease (AD) or mild cognitive impairment in 404 pedigrees were enrolled from the Chinese Familial Alzheimer's Disease Network. PSENs/APP mutations and APOE frequencies were determined. Results In total, 13.12% of pedigrees carried PSENs/APP missense mutations, 3.71% carried PSENs/APP synonymous/untranslated region variants, and 83.17% did not carry PSENs/APP mutations. Eleven missense mutations were first identified. In patients without PSENs/APP mutations, 44.31% carried one APOEε4 allele, and 14.85% two APOEε4 alleles. Discussion The new PSENs/APP mutations indicate heterogeneity in AD pathogenesis between Chinese and other ethnic groups. The low mutation rate suggests the involvement of other genes/factors in Chinese FAD. APOEε4 might be a major gene for some FAD without PSENs/APP mutations.

Pedigree chart

PSEN1

Apolipoprotein E

10.1002/alz.12005

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Citations (64)