Yiqing Wang

Nanjing University

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Liqun Zhang

Beijing University of Chemical Technology

Youping Wu

Beijing University of Chemical Technology

Jian Hu

Zhejiang University

Wang Lv

Wenzhou City People's Hospital

Shuming Nie

University of Illinois Urbana-Champaign

Qian Lu

Shandong Academy of Sciences

Huiming Cai

Nanjing University

Sam‐Shajing Sun

Norfolk State University

Christopher J. Butch

Nanjing University

Xiaohui Wu

Nankai University

Cooperative Institutions

Chinese Academy of Sciences

Zhejiang University

Nanjing University

Fudan University

Shanghai Jiao Tong University

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Southern Medical University

Sun Yat-sen University

University of Chinese Academy of Sciences

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Bright Asymmetric Shielding Strategy-Based NIR-II Probes for Angiography and Localized Photothermal Therapy

ACS Applied Bio Materials (2023)

Li Li Xiaoxie Ma Yusong Peng Jun Yin Nida El Islem Guissi

Fluorescent probes with fluorescence emission in the NIR-II window have been widely studied due to increased imaging depth. However, the currently reported NIR-II fluorescent probes present some disadvantages, such as complicated synthesis routes and low fluorescence quantum yields (QYs). The shielding strategy has been used in the development of NIR-II probes to improve their QYs. So far, this strategy has only been used for the symmetric NIR-II probes, especially those based on the benzo[1,2-c:4,5-c']bis([1,2,5]thiadiazole) (BBTD) skeleton. This work reports the synthesis of a series of asymmetric NIR-II probes based on shielding strategies accompanied by simple synthetic routes, high synthetic yields (above 90%), high QYs, and large Stoke shifts. Furthermore, the use of d-α-tocopheryl polyethylene glycol succinate (TPGS) as a surfactant for an NIR-II fluorescence probe (NT-4) improved its water solubility. In vivo studies showed that TPGS-NT-4 NPs with a high QY (3.46%) achieve high-resolution angiography and efficient local photothermal therapy, while displaying good biocompatibility. Hence, we combined angiography and local photothermal therapy to improve the tumor uptake of nanophotothermal agents while reducing their damage to normal tissues.

10.1021/acsabm.3c00080

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Citations (3)

Pyrolysis behavior of xylan-based hemicellulose in a fixed bed reactor

Journal of Analytical and Applied Pyrolysis (2020)

Zixiang Gao Ning Li Yiqing Wang Weisheng Niu Weiming Yi

Hemicellulose

Pentose

Lignocellulosic Biomass

10.1016/j.jaap.2020.104772

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Citations (32)

IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy

Biomaterials (2013)

Caixia Yue Peng Liu Mingbin Zheng Pengfei Zhao Yiqing Wang

10.1016/j.biomaterials.2013.05.071

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Citations (352)

HIF-1α promotes osteogenic regeneration of titanium implants by coupling angiogenesis and osteogenesis via HIF-1α/VEGF/AKT/mTOR signaling pathway

Research Square (Research Square) (2023)

Shuang Song Guanhua Zhang Xutao Chen Jian Zheng Xiangdong Liu

Abstract Background: Stabilization and increased activity of hypoxia-inducible factor 1-α (HIF-1α) could directly increase cancellous bone formation and was playing an essential role in bone modeling and remodeling. However, whether an increase of HIF-1α in ADSCs promoted osteogenic differentiation and bone formation was not known. Results: In this study, ADSCs transfected with small interfering RNA and HIF-1α overexpression cDNA were established to investigate the proliferation, migration, adhesion, and osteogenic capacity in ADSCs, and angiogenic ability in HUVEC. Overexpression of HIF-1α could promote cell proliferation, migration, adhesive and osteogenic capacity of ADSCs and angiogenic ability of HUVEC. Western blotting showed that the protein levels of osteogenesis-related factors were upregulated when overexpression of HIF-1α. Furthermore, the influence of up-regulating HIF-1α in ADSCs sheets on osseointegration had evaluated using the SD rats implant model, in which the bone mass and osteoid mineralization speed were evaluated by radiological and histological analysis. The over-expression of HIF-1α in ADSCs enhanced osteogenic differentiation and osseointegration around implants. Whereas transfecting HIF-1α-silenced ADSCs attenuated the osteogenic and angiogenic capacity. Finally, to explore the mechanism underlying HIF-1α promoted osteogenesis and angiogenesis, Western blotting was measured to analyze the VEGF/AKT/mTOR signaling pathway. Conclusions: These data first demonstrated that up-regulation of HIF-1α in ADSCs significantly improved the osteogenic capacity and peri-implant bone formation via VEGF/AKT/mTOR signaling pathway. Our findings revealed that HIF-1α exerts a critical effect on promoting osseointegration by improving osteogenesis and angiogenesis via VEGF/AKT/mTOR signaling pathway, and hence offered the considerable therapeutic potential for modifying stem cells to enhance osseointegration.

10.21203/rs.3.rs-2839598/v1

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871 GUT MICROBIOME STRUCTURE AND METABOLIC ACTIVITY IN DIVERTICULITIS

Gastroenterology (2023)

Wenjie Ma Raaj S. Mehta Long H. Nguyen Yiqing Wang Amrisha Bhosle

Diverticulitis

Gut microbiome

10.1016/s0016-5085(23)01423-3

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Encapsulating maytansinoid in pH-sensitive nanocarriers: The importance of using extremely potent cytotoxic agents and fast release for nanomedicine to achieve tumor elimination

Nano Research (2019)

Bo Dai Xingyu Wu Christopher J. Butch Jianquan Wang Ziyang Wang

Nanocarriers

10.1007/s12274-019-2464-y

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Citations (7)

A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands

ACS Nano (2010)

Xiaohua Huang Xianghong Peng Yiqing Wang Yuxiang Wang Dong M. Shin

The targeted delivery of nanoparticles to solid tumors is one of the most important and challenging problems in cancer nanomedicine, but the detailed delivery mechanisms and design principles are still not well understood. Here we report quantitative tumor uptake studies for a class of elongated gold nanocrystals (called nanorods) that are covalently conjugated to tumor-targeting peptides. A major advantage in using gold as a "tracer" is that the accumulated gold in tumors and other organs can be quantitatively determined by elemental mass spectrometry (gold is not a natural element found in animals). Thus, colloidal gold nanorods are stabilized with a layer of polyethylene glycols (PEGs) and are conjugated to three different ligands: (i) a single-chain variable fragment (ScFv) peptide that recognizes the epidermal growth factor receptor (EGFR); (ii) an amino terminal fragment (ATF) peptide that recognizes the urokinase plasminogen activator receptor (uPAR); and (iii) a cyclic RGD peptide that recognizes the avβ3 integrin receptor. Quantitative pharmacokinetic and biodistribution data show that these targeting ligands only marginally improve the total gold accumulation in xenograft tumor models in comparison with nontargeted controls, but their use could greatly alter the intracellular and extracellular nanoparticle distributions. When the gold nanorods are administered via intravenous injection, we also find that active molecular targeting of the tumor microenvironments (e.g., fibroblasts, macrophages, and vasculatures) does not significantly influence the tumor nanoparticle uptake. These results suggest that for photothermal cancer therapy, the preferred route of gold nanorod administration is intratumoral injection instead of intravenous injection.

10.1021/nn102055s

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Citations (413)

Corrigendum to “Research on design and optimization of green warehouse system based on case analysis” [J. Clean. Prod. 388 (2023) 135998]

Journal of Cleaner Production (2023)

Qiang Ren Yaoyao Ku Yiqing Wang Peng Wu

10.1016/j.jclepro.2023.137240

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Citations (1)

Research on ultra-wideband terahertz absorber with graphene loaded dielectric hemi-ellipsoid

2022 47th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz) (2020)

Yang Long Renbin Zhong Zhenhua Wu Yilin Lv Chen Jin Han

An ultra-wideband terahertz absorber is presented with dielectric hemi-ellipsoid on a monolayer graphene layer. The absorber has achieved an ultra-wideband absorption bandwidth from 2 THz to more than 10 THz with an average absorbance of 95.72%, the relative bandwidth reaches 133%. The excellent absorption properties owing to multiple discrete graphene plasmonic resonances(GPRS) and the continuous multimode Fabry-Perot (FP) resonances, the mechanism for the its ultrawideband absorption are analyzed in details.

Wideband

10.1109/irmmw-thz46771.2020.9370864

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A biosensing model system: selective interaction of biotinylated PPEs with streptavidin-coated polystyrene microspheresElectronic supplementary information (ESI) available: experimental, including details of preparation and spectroscopic characterization of all new compounds and biotinylation assay of 3 by streptavidin. See http://www.rsc.org/suppdata/cc/b3/b303700m/

Chemical Communications (2003)

James N. Wilson Yiqing Wang John J. Lavigne Uwe H. F. Bunz

Formation of a highly fluorescent composite formed from the biotinylated PPE 3 and streptavidin covered polystyrene microspheres is reported.

Streptavidin

Polystyrene

Characterization

10.1039/b303700m

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Citations (52)