Linna Wang

Chinese Academy of Fishery Sciences

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Zhentong Li

Nanfang Hospital

Yongsheng Tian

Chinese Academy of Fishery Sciences

Yan Xiang

Beijing University of Chinese Medicine

Jieming Zhai

Thermo Fisher Scientific (China)

Yangang Lan

Anhui Agricultural University

Wenhui Ma

Xinjiang University

Ziqi Li

The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

Shuai Chen

Neurology, Inc

Zunfang Pang

Thermo Fisher Scientific (China)

Shangyong Li

Qingdao University

Cooperative Institutions

Chinese Academy of Fishery Sciences

Chinese Academy of Sciences

Ministry of Agriculture and Rural Affairs

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Qingdao University

Peking University

Qingdao National Laboratory for Marine Science and Technology

Anhui Agricultural University

China Pharmaceutical University

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Comprehensive Identification and Expression Analysis of the Multidrug and Toxic Compound Extrusion (MATE) Gene Family in Brachypodium distachyon

Plants (2024)

Sirui Ma Yixian Guo Tianyi Zhang Di Liu Linna Wang

The Multidrug and Toxic Compound Extrusion (MATE) proteins serve as pivotal transporters responsible for the extrusion of metabolites, thereby playing a significant role in both plant development and the detoxification of toxins. The MATE gene family within the Brachypodium distachyon, which is an important model organism of the Poaceae family, remains largely unexplored. Here, a comprehensive identification and analysis of MATE genes that complement B. distachyon were conducted. The BdMATE genes were systematically categorized into five distinct groups, predicated on an assessment of their phylogenetic affinities and protein structure. Furthermore, our investigation revealed that dispersed duplication has significantly contributed to the expansion of the BdMATE genes, with tandem and segmental duplications showing important roles, suggesting that the MATE genes in Poaceae species have embarked on divergent evolutionary trajectories. Examination of ω values demonstrated that BdMATE genes underwent purifying selection throughout the evolutionary process. Furthermore, collinearity analysis has confirmed a high conservation of MATE genes between B. distachyon and rice. The cis-regulatory elements analysis within BdMATEs promoters, coupled with expression patterns, suggests that BdMATEs play important roles during plant development and in response to phytohormones. Collectively, the findings presented establish a foundational basis for the subsequent detailed characterization of the MATE gene family members in B. distachyon.

Brachypodium distachyon

Brachypodium

Segmental duplication

10.3390/plants13182586

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Citations (15)

Properties of soybean oil bodies and oleosin proteins as edible films and coatings

Linna Wang

Oleosin

Soybean oil

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Citations (9)

Cryopreservation of embryos of humpback grouper (Cromileptes altivelis) using combinations of non-permeating cryoprotectants

Aquaculture (2021)

Linlin Li Yongsheng Tian Zhentong Li Ziqi Li Pengfei Duan

Cryoprotectant

10.1016/j.aquaculture.2021.737524

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Citations (7)

Geranyl diphosphate synthase large subunits OfLSU1/2 interact with small subunit OfSSUII and are involved in aromatic monoterpenes production in Osmanthus fragrans

International Journal of Biological Macromolecules (2023)

Yangang Lan Rui Xiong Kaimei Zhang Linna Wang Min Wu

Osmanthus fragrans

Monoterpene

Prenyltransferase

Ornamental plant

10.1016/j.ijbiomac.2023.128328

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Citations (0)

Combined enzymatic hydrolysis and selective fermentation for green production of alginate oligosaccharides from Laminaria japonica

Bioresource Technology (2019)

Shangyong Li Zhipeng Wang Linna Wang Jixing Peng Yanan Wang

Enzymatic Hydrolysis

Solid-State Fermentation

10.1016/j.biortech.2019.02.056

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Citations (52)

Effects of IGF-1 on Neurogenesis after Focal Cerebral Ischemia In Young and Older Rats

Xiandai shengwu yixue jinzhan (2008)

Linna Wang

Objective:In order to examine the effect of IGF-1 on neurogenesis after focal cerebral ischemia in young and older rats.IGF-1 was applied by transventricular injection one day before operation of permanent middle cerebral artery occlusion (MCAO).In contrast,the control groups were treated with vehicle.Methods:Bromodeoxyuridin (BrdU)was used as a marker of the proliferating cells,and PSA-NCAM as a marker of neural precursor cells,BrdU-labeled cells immunoreacted with MAP2 as a marker of differentiated neural precursor cells 28d aider MCAO.Rats were administered with BrdU 6 days after MCAO.Immunohistochemistry was used to de- tect the expression of BrdU and PSA-NCAM immunoreactivity in cortex and hippocampus 7 days and 28 days after MCAO,double im- munohistochemistry was used to detect the expression of MAP2 of BrdU-labeled cells 28d after MCAO.Results:The number of Br- dU-labeled cells and PSA-NCAM positive cells increased 5.1 fold and 3.2 7d after IGF-1 infusion in older rats, and 5.5 fold and 3.2 fold in young rats,compared with vehicle-treated group(p0.05).The residual rate of BrdU-labeled cells were 79.2% and 75.1% respectively in young and older rats (p0.05),in contrary to 77.1% and 52.3% (p0.05)in vehicle-treated groups 28d after MCAO.BrdU/MAP2 pos- itive cells increased after IGF-1 infusion with more clear effect in young group (p0.05),compared with vehicle-treated group.Conclu- sion:Our results indicated that IGF-1 pretreatment induced the neurogenesis,ameliorated the survival of post-proliferation cells in MCAO rats and induced neural precursor cells to differentiate into neuron.Our finding will be helpful to developing therapeutic applica- tion ofIGF-1 after brain injury in older patients.

Bromodeoxyuridine

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[Incidence of seroresistance of syphilis and its relevant factors].

PubMed (2008)

Linna Wang Ya‐Gang Zuo Yongxin Liu Xiurong Liu Heyi Zheng

To investigate the incidence of seroresistance of syphilis and analyze its relevant factors.The clinical data of 131 patients with syphilis were retrospectively analyzed. The incidence of seroresistance was investigated and the correlation between seroresistance and factors including age, gender, original titer, disease course, and medications were analyzed.The incidence of seroresistance was not significantly different among patients with different ages and genders, but was significantly different among patients with different disease courses, antibody titers, and medications. Patients with a baseline serum rapid plasma reagin (RPR) titer of greater than 1: 8, a latent course, or a macrolide therapy history had higher incidences of seroresistance (i. e., 61%, 45.6%, and 72.7% respectively) than those who had a lower RPR titer, a primary course, or a benzathine penicillin therapy history.Syphilis patients with a high baseline RPR titer, a latent course, and a macrolides therapy are prone to be seroresistant.

Rapid plasma reagin

Antibody titer

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Abstract 5529: CD177 suppresses breast cancer progression by regulating the canonical WNT β-Catenin pathway

Cancer Research (2017)

Paige Kluz Ryan Kolb Qing Xie Nicholas Borcherding Linna Wang

Abstract To better treat breast cancer patients, it is imperative to be able to predict breast cancer relapse and metastasis. Here, we identified the cluster of differentiation 177 (CD177) expression is positively correlated with relapse-free and metastasis-free survival of breast cancer patients. CD177 protein is highly expressed in normal breast epithelial cells and is significantly reduced in invasive cancers. Using mouse models, we found that CD177 suppresses breast cancer, primarily by forming a complex with E-Cadherin and b-Catenin at adherens junctions. The physical interaction prevents the activation of b-Catenin-mediated transcription by the canonical WNT signaling as demonstrated by a TOP-flash dual luciferase assay. In conclusion, we have identified CD177 as a novel breast cancer suppressor and uncovered a new regulatory mechanism for the canonical WNT/b-Catenin-mediated oncogenic signaling transduction. Citation Format: Paige N. Kluz, Ryan Kolb, Qing Xie, Nicholas Borcherding, Linna Wang, James P. De Andrade, Phillip M. Spanheimer, Wei Li, Katherine N. Gibson-Corley, Andy W. Tao, Sonia Sugg, Ronald J. Weigel, Weizhou Zhang. CD177 suppresses breast cancer progression by regulating the canonical WNT β-Catenin pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5529. doi:10.1158/1538-7445.AM2017-5529

10.1158/1538-7445.am2017-5529

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Purification and Characterization of a New Alginate Lyase from Marine Bacterium Vibrio sp. SY08

Marine Drugs (2016)

Shangyong Li Linna Wang Jianhua Hao Mengxin Xing Jingjing Sun

Unsaturated alginate disaccharides (UADs), enzymatically derived from the degradation of alginate polymers, are considered powerful antioxidants. In this study, a new high UAD-producing alginate lyase, AlySY08, has been purified from the marine bacterium Vibrio sp. SY08. AlySY08, with a molecular weight of about 33 kDa and a specific activity of 1070.2 U/mg, showed the highest activity at 40 °C in phosphate buffer at pH 7.6. The enzyme was stable over a broad pH range (6.0–9.0) and retained about 75% activity after incubation at 40 °C for 2 h. Moreover, the enzyme was active in the absence of salt ions and its activity was enhanced by the addition of NaCl and KCl. AlySY08 resulted in an endo-type alginate lyase that degrades both polyM and polyG blocks, yielding UADs as the main product (81.4% of total products). All these features made AlySY08 a promising candidate for industrial applications in the production of antioxidants from alginate polysaccharides.

Marine bacteriophage

Lyase

Vibrio alginolyticus

10.3390/md15010001

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Citations (256)

miR-125a-5p-targeted regulation of TRA2β expression inhibits proliferation and metastasis of hepatocellular carcinoma cells.

PubMed (2021)

Junde Zhou Linna Wang Yunfu Cui Lanhua Tang

To explore the regulation of miR-125a-5p in hepatocellular carcinoma (HCC) and its mechanisms.By transfecting a miR-125a-5p sequence and an interfering sequence of miR-125a-5p-s into human HCC cell lines HCC-LM3 and HepG2, miR-125a-5p-related levels were assesed by Western blot. The abilities of cell proliferation and migration were assessed by cell culture and Transwell assay, respectively.HepG2 cells showed increased miR-125a-5p levels compared with HCC-LM3 cells (P < 0.01). However, compared with QZG cells, the level of miR-125a-5p in HepG2 and HCC-LM3 cells was down-regulated. Compared with miR-125a-5p groups, miR-125a-5p-s groups showed increased colony formation rate and mobility (P < 0.01). After being transfected with miR-125a-5p, the transformation factor 2β (TRA2β) and mRNA levels were decreased, whereas 5p-s expression was increased (P < 0.01). Inhibition of TRA2β by small interfering RNA (siRNA) diminished the ability of cells.miR-125a-5p inhibits the invasive capacity of HCC cells through targeting the TRA2β pathway.

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