Jiaojiao Zhang

Guangxi Normal University

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Francesca Giampieri

Marche Polytechnic University

Maurizio Battino

Jiangsu University

Tamara Y. Forbes‐Hernández

Universidad de Granada

Danila Cianciosi

Universidad Europea del Atlántico

Patricia Reboredo‐Rodríguez

Universidade de Vigo

Sadia Afrin

Washington University in St. Louis

Hua‐Bin Li

Eye & ENT Hospital of Fudan University

Ya Li

First Affiliated Hospital of Henan University

Massimiliano Gasparrini

Marche Polytechnic University

Mikael Johansson

KTH Royal Institute of Technology

Cooperative Institutions

Chinese Academy of Sciences

169

Zhejiang University

131

Shanghai Jiao Tong University

105

Peking University

Sun Yat-sen University

Xi'an Jiaotong University

Fudan University

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Agriculture and Rural Affairs

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Label-free Raman imaging for screening of anti-inflammatory function food

Food Chemistry X (2024)

Qi Zeng Yangyao Peng Xianzhen Zhou Jiaojiao Zhang Yuhang Yang

Natural bioactive compounds and plant constituents are considered to have a positive anti-inflammatory effect. This study aimed to establish a screening technique for anti-inflammatory function in foods based on label-free Raman imaging. A visible anti-inflammatory analysis method based on coherent anti-Stokes Raman scattering (CARS) was established with an LPS-induced RAW264.7 cell model. Dynamic changes in proteins and lipids were determined at laser pump light wavelengths of 2956 cm−1 and 2856 cm−1, respectively. The method was applied to a plant-based formula (JC) with anti-inflammatory activity. Q-TOF-MS and HPLC analyses revealed the main active constituents of JC as quercetin, kaempferol, l-glutamine, and sodium copper chlorophyllin. In in vitro and in vivo verification experiments, JC showed significant anti-inflammatory activity by regulating the TLR4/NF-κB pathway. In conclusion, this study successfully established a label-free and visible method for screening anti-inflammatory constituents in plant-based food products, which will facilitate the evaluation of functional foods.

Functional food

Anti-inflammatory

10.1016/j.fochx.2024.101297

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Application of Bronze Decorative Patterns in Fashion Design in Shang and Zhou Dynasties

Advances in Social Science, Education and Humanities Research/Advances in social science, education and humanities research (2022)

Jiaojiao Zhang Zhao Fu Junying Wang

Starting with the historical background and formation style of bronze art in the Shang and Zhou dynasties, this paper analyzes and summarizes the characteristics and significance of bronze decorative patterns, and discusses the application of bronze decorative patterns in clothing from the aesthetic characteristics of bronze patterns.

Bronze

Shang dynasty

Six Dynasties

10.2991/assehr.k.220109.044

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Dietary intervention in depression – a review

Food & Function (2022)

Tao Wu Ran Liu Ling Zhang Mohamed Rifky Wenjie Sui

Depression is a mental illness that affects the normal lives of over 300 million people. Unfortunately, about 30% to 40% of patients do not adequately respond to pharmacotherapy and other therapies. This review focuses on exploring the relationship between dietary nutrition and depression, aiming to find safer and efficient ingredients to alleviate depression. Diet can affect depression in numerous ways. These pathways include the regulation of tryptophan metabolism, inflammation, hypothalamic-pituitary-adrenal (HPA) axis, microbe-gut-brain axis, brain-derived neurotrophic factor (BDNF) and epigenetics. Furthermore, probiotics, micronutrients, and other active substances exhibit significant antidepressant effects by regulating the above pathways. These provide insights for developing antidepressant foods.

Depression

Gut–brain axis

Pharmacotherapy

10.1039/d2fo02795j

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Citations (13)

PCDH9 suppresses melanoma proliferation and cell migration

Frontiers in Oncology (2022)

Jiaojiao Zhang Hui-Zhi Yang Shuang Liu Md Obaidul Islam Yue Zhu

Melanoma has dramatically increased during last 30 years with low 5-year survival and prognosis rate.Melanoma cells (A375 and G361) were chosen as the in vitro model. The immunohistochemical (IHC) analysis and bioinformatics mining exhibited the suppression of PCDH9 on melanoma. The interference and overexpression of PCDH9 were infected by lentivirus. The effects of PCDH9 on melanoma cells were assessed in terms of alteration of PCDH9 such as cell viability, apoptosis, cell cycle, and wound-healing assay. Moreover, expressions of PCDH9 with other genes (MMP2, MMP9, CCND1, and RAC1) were also assessed by PCR.The alteration of PCDH9 has a negative correlation with MMP2, MMP9, and RAC1 but had a positive correlation with CCND1 (Cyclin D1) and apoptosis. Increase of PCDH9 could suppress melanoma cells and inhibit migration but not exert significant effects on cell cycle. IHC showed lower PCDH9 expression in melanoma tissue with main expression in cytoplasm.Overexpressed PCDH9 suppressed melanoma cells, and PCDH9 can be considered as an independent prognostic factor for melanoma; even re-expression of PCDH9 can serve as a potential therapeutic strategy for melanoma treatment.

MMP2

MMP9

Viability assay

10.3389/fonc.2022.903554

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Citations (2)

From dysfunction to healing: advances in mitochondrial therapy for Osteoarthritis

Journal of Translational Medicine (2024)

Minghang Zhang Junfeng Wu K. P. Cai Yang Liu Botao Lu

Osteoarthritis (OA) is a chronic degenerative joint condition characterised by cartilage deterioration and changes in bone morphology, resulting in pain and impaired joint mobility. Investigation into the pathophysiological mechanisms underlying OA has highlighted the significance of mitochondrial dysfunction in its progression. Mitochondria, which are cellular organelles, play a crucial role in regulating energy metabolism, generating reactive oxygen species, and facilitating essential biological processes including apoptosis. In recent years, the utilisation of exogenous drugs and MT to improve mitochondrial function in chondrocytes has shown great promise in OA treatment. Numerous studies have investigated the potential of stem cells and extracellular vesicles in mitochondrial transfer. This review aims to explore the underlying mechanisms of mitochondrial dysfunction in OA and assess the progress in utilising mitochondrial transfer as a therapeutic approach for this disease.

10.1186/s12967-024-05799-z

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Citations (3)

Variation and selection of Melia azedarach provenances and families.

Dongbei linye daxue xuebao (2019)

He Xia LI Jing-jian Wang Fang Jiaojiao Zhang Chen XiaoYang

Melia azedarach

Variation (astronomy)

Source

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Characterization and optimization of hydrothermal extraction of quercetin from Quercus leaves using response surface methodology

The Canadian Journal of Chemical Engineering (2021)

Haoling Shen Jiaojiao Zhang Chensi Guo Gao X Junying Chen

Abstract A hydrothermal process using subcritical water and ethanol as an extraction solvent has been studied to extract high‐value flavonoid compounds from Quercus leaves. The univariate analysis showed that the maximum quercetin yield was 34.6 mg/g obtained at the liquid–solid ratio of 30:1 ml/g, concentration of ethanol 60% (V/V), extraction temperature of 180°C, and extraction duration of 5 h. Based on the Box–Behnken experiment design, the response surface methodology (RSM) was used to optimize the liquid‐to‐solid ratio, extraction time, extraction temperature, ethanol concentration, and other operating conditions of hydrothermal extraction of quercetin. The regression equation showed that the maximum yield of quercetin was 36.1 mg/g under the conditions of solvent ethanol concentration of 65% (V/V), liquid–solid ratio of 40:1 ml/g, extraction temperature of 189°C, and extraction duration of 5.5 h. The quercetin yield of 36.1 mg/g obtained by the hydrothermal method was 5.6 times the 6.4 mg/g obtained by the traditional ethanol reflux extraction at the same concentration of ethanol 65% (V/V), liquid–solid ratio of 40:1 ml/g, and extraction duration of 5.5 h, but at the boiling point of the solvent.

10.1002/cjce.24196

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Citations (4)

Thermal performance analysis of pool boiling on an enhanced surface modified by the combination of microstructures and wetting properties

Applied Thermal Engineering (2017)

Zhongchao Zhao Jiaojiao Zhang Dandan Jia Kai Zhao Xiao Zhang

10.1016/j.applthermaleng.2017.02.014

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Citations (48)

Self-Assembly of Peptide–Lipid Nanoparticles for the Efficient Delivery of Nucleic Acids

Langmuir (2023)

Jiaojiao Zhang Zixuan Wang Jiwei Min Xuelin Zhang Rongxin Su

A transfection formulation is successfully developed to deliver nucleic acids by adding an auxiliary lipid (DOTAP) to the peptide, and the transfection efficiency of pDNA reaches 72.6%, which is close to Lipofectamine 2000. In addition, the designed KHL peptide–DOTAP complex exhibits good biocompatibility by cytotoxicity and hemolysis analysis. The mRNA delivery experiment indicates that the complex had a 9- or 10-fold increase compared with KHL or DOTAP alone. Intracellular localization shows that KHL/DOTAP can achieve good endolysosomal escape. Our design provides a new platform for improving the transfection efficiency of peptide vectors.

Lipofectamine

Biocompatibility

10.1021/acs.langmuir.3c00834

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Citations (1)

Oxidative Stress Amelioration of Novel Peptides Extracted from Enzymatic Hydrolysates of Chinese Pecan Cake

International Journal of Molecular Sciences (2022)

Jiaojiao Zhang Shaozhen Wu Qingqing Wang Qinjie Yuan Yane Li

Pecan (Carya cathayensis) is an important economic crop, and its hydrolyzed peptides have been evidenced to reduce the effect of oxidative stress due to their antioxidant capacity. Hence, the protocols of ultrafiltration and gel filtration chromatography were established to obtain bioactive peptides from by-products of C. cathayensis (pecan cake). As measured by DPPH/ABTS radical scavenging, the peptides with less molecular weight (MW) possess higher antioxidant capacity. PCPH-III (MW < 3 kDa) presented higher radical scavenging capacity than PCPH-II (3 kDa < MW < 10 kDa) and PCPH-I (MW > 10 kDa) measured by DPPH (IC50: 111.0 μg/ mL) and measured by ABTs (IC50: 402.9 μg/mL). The secondary structure and amino acid composition varied by their MW, in which PCPH-II contained more α-helices (26.71%) and β-sheets (36.96%), PCPH-III contained higher ratios of β-turns (36.87%), while the composition of different secondary of PCPH-I was even 25 ± 5.76%. The variation trend of α-helix and random experienced slightly varied from PCPH-I to PCPH-II, while significantly decreased from PCPH-II to PCPH-III. The increasing antioxidant capacity is followed by the content of proline, and PCPH-III had the highest composition (8.03%). With regard to the six peptides identified by LC-MS/MS, two of them (VYGYADK and VLFSNY) showed stronger antioxidant capacity than others. In silico molecular docking demonstrated their combining abilities with a transcription factor Kelch-like ECH-associated protein 1 (Keap1) and speculated that they inhibit oxidative stress through activating the Keap1-Nrf2-ARE pathway. Meanwhile, increased activity of SOD and CAT—antioxidant markers—were found in H2O2-induced cells. The residue of tyrosine was demonstrated to contribute the most antioxidant capacity of VYGYADK and its position affected less. This study provided a novel peptide screening and by-product utilization process that can be applied in natural product developments.

ABTS

10.3390/ijms232012086

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Citations (10)