Xiaohong Hu

Second Hospital of Yichang

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jiake Chai

Chinese PLA General Hospital

Lingying Liu

Chinese PLA General Hospital

Yu Wang

Zunyi Medical University

Yanan Liu

Fujian Agriculture and Forestry University

Yonghui Yu

Beijing Technology and Business University

Zhongyuan Li

Nanjing Medical University

Jacqueline Gonzales

National Institute of Allergy and Infectious Diseases

Dan Li

Hubei University of Medicine

Decheng Wang

China Agricultural University

Lifang Song

Zhengzhou Children's Hospital

Cooperative Institutions

Chinese PLA General Hospital

Shanghai Jiao Tong University

First Affiliated Hospital of Chinese PLA General Hospital

Sichuan University

China Three Gorges University

Second Military Medical University

Nanjing Medical University

Shanghai Changzheng Hospital

Wenzhou Medical University

Sun Yat-sen University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Genome-Wide SNP Study and Clinical Analysis of a Chinese Inbred Family With Pulmonary Alveolar Microlithiasis

CHEST Journal (2016)

Duchao Zhang Xiaohong Hu Peng Yan Wei Guan Hongjun Gu

SNP

Lung biopsy

10.1016/j.chest.2016.02.259

Cite

Citations (0)

Optic nerve sheath diameter and optic nerve sheath diameter/eyeball transverse diameter ratio in prediction of malignant progression in ischemic stroke

Frontiers in Neurology (2022)

Yuan Guo Yinjuan Chen Chaoxiong Shen Daofeng Fan Xiaohong Hu

The optic nerve sheath diameter (ONSD)/eyeball transverse diameter (ETD) ratio has been suggested in the evaluation of intracranial pressure (ICP). The aim of this study was to evaluate the predictive value of ONSD and ONSD/ETD in relation to risk for secondary malignant middle cerebral artery infarction (MMI).A total of 91 patients with MCA occlusion were included in this study. Data were divided into two groups based on development of MMI or not. ONSD and ETD were measured by unenhanced computed tomography (CT). The differences in ONSD and the ONSD/ETD ratios between the MMI and non-MMI groups were compared. Receiver operating characteristic curve analyses were used to test the diagnostic value of ONSD and ONSD/ETD independently, to predict MMI.The ONSD in the MMI group and non-MMI group were 5.744 ± 0.140 mm and 5.443 ± 0.315 mm, respectively (P = 0.001). In addition, the ONSD/ETD ratios in the MMI group and non-MMI group were 0.258 ± 0.008 and 0.245 ± 0.006, respectively (P = 0.001). The receiver operating characteristic (ROC) curve demonstrated an area under the curve (AUC) for ONSD of 0.812 [95% confidence interval (CI): 0.718-0.906, P = 0.001], with a sensitivity of 97.4% and a specificity of 66.0% at the cut-off value of 5.520 mm. The AUC for ONSD/ETD ratio in predicting occurrence of MMI was 0.895 (95% CI: 0.823-0.968, P = 0.001), with a sensitivity of 84.2% and a specificity of 92.5% at a cut-off value of 0.250.In acute stroke patients with massive cerebral infarction, an increased ONSD or ONSD/ETD ratio increases the odds of malignant progression and may be used as an indicator for emergent therapeutic interventions. In addition, the ONSD/ETD ratio may be more valuable than ONSD in predicting the malignant progression of acute stroke patients.

Area under curve

Stroke

10.3389/fneur.2022.998389

Cite

Citations (4)

Central mechanism of indomethacin analgesia

European Journal of Pharmacology (1994)

Xiaohong Hu Hai-Wang Tang Qi-Song Li Xian-Fen Huang

Phentolamine

Pethidine

Visceral pain

10.1016/0014-2999(94)90522-3

Cite

Citations (22)

Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Acute Lung Injury Caused by Severe Burn via Secreting TSG-6 and Inhibiting Inflammatory Response

Stem Cells International (2022)

Xiaohong Hu Lingying Liu Yu Wang Yonghui Yu Zhongyuan Li

Objectives. To investigate whether hUC-MSCs attenuated severe burn-induced ALI and the effects were based on TSG-6 secreted from hUC-MSCs. Method. A rat model was established and evaluated as follows: cytokine expression was measured by ELISA, and both inflammatory cell infiltration and lung injury were assessed by immunohistochemistry assay. Results. In vitro, TSG-6 levels in serum from the burn group were significantly increased compared with those from the sham group. In vivo, TSG-6 levels of lung tissues and serum in the burn+hUC-MSC group were significantly increased compared with those in the burn group. Both in lung tissues and in serum, increased levels of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) were remarkably decreased, but the anti-inflammatory cytokine IL-10 increased after hUC-MSC administration (

p < 0.05

). These significant positive effects after hUC-MSC transplantation did not occur in the burn+siTSG-6 group. Conclusion. The intratracheal implantation of hUC-MSCs has been an effective treatment for severe burn-induced ALI via promoting TSG-6 secretion and inhibiting inflammatory reaction in lung tissue.

Proinflammatory cytokine

Infiltration (HVAC)

10.1155/2022/8661689

Cite

Citations (8)

IQGAP1 domesticates macrophages to favor mycobacteria survival via modulating NF-κB signal and augmenting VEGF secretion

International Immunopharmacology (2024)

Xin Wen Dan Li Hankun Wang Ding Zhang Jingrui Song

IQGAP1

10.1016/j.intimp.2024.112549

Cite

Citations (0)

TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

Scientific Reports (2016)

Lingying Liu Huifeng Song Hongjie Duan Jiake Chai Jing Yang

Abstract The hMSCs have become a promising approach for inflammation treatment in acute phase. Our previous study has demonstrated that human umbilical cord-MSCs could alleviate the inflammatory reaction of severely burned wound. In this study, we further investigated the potential role and mechanism of the MSCs on severe burn-induced excessive inflammation. Wistar rats were randomly divided into following groups: Sham, Burn, Burn+MSCs, Burn+MAPKs inhibitors and Burn, Burn+MSCs, Burn+Vehicle, Burn+siTSG-6, Burn+rhTSG-6 in the both experiments. It was found that MSCs could only down-regulate P38 and JNK signaling, but had no effect on ERK in peritoneal macrophages of severe burn rats. Furthermore, suppression of P38 and JNK activations significantly reduced the excessive inflammation induced by severe burn. TSG-6 was secreted by MSCs using different inflammatory mediators. TSG-6 from MSCs and recombinant human (rh)TSG-6 all significantly reduced activations of P38 and JNK signaling induced by severe burn and then attenuated excessive inflammations. On the contrary, knockdown TSG-6 in the cells significantly increased phosphorylation of P38 and JNK signaling and reduced therapeutic effect of the MSCs on excessive inflammation. Taken together, this study suggested TSG-6 from MSCs attenuated severe burn-induced excessive inflammation via inhibiting activation of P38 and JNK signaling.

Severe burn

10.1038/srep30121

Cite

Citations (55)

TSG-6 Secreted from Human Umbilical Cord-Derived Mesenchymal Stem Cells Attenuate Severe Burn-Induced Acute Lung Injury Via Inhibiting Inflammatory Reactions

Xiaohong Hu L. Liu Y. Wang Yonghao Yu Y. Liu

Cord lining

Inflammatory response

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7242

Cite

Citations (0)

Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Acute Lung Injury Caused by Severe Burn via Secreting TSG-6 and Inhibiting Inflammatory Response

Research Square (Research Square) (2021)

Xiaohong Hu Lingying Liu Yu Wang Zhongyuan Li Yonghui Yu

Abstract Objectives To investigate whether hUC-MSCs attenuated severe burn-induced ALI and the effects were based on TSG-6 secreted from hUC-MSCs. Method Rat model was established and evaluated as follows：Anires2005 animal pulmonary function tester for pulmonary function; micro-CT scanner for lung imaging manifestations; cytokine expression was measured by ELISA assay, and both inflammatory cell infiltration and lung injury were assessed by immunohistochemistry assay. Results In vitro, TSG-6 levels in serum from the burn group were significantly increased than that of the sham group. In vivo, TSG-6 levels of lung tissues and serum in the burn+ hUC-MSCs group were significantly increased than those of that in the burn group. Higher parameters of airway resistance（Ri, Re, etc）were markedly decreased, and the disordered lung texture and funicular density shadows were significantly improved after hUC-MSCs administration. Both in lung tissues and serum, increased levels of proinflammatory cytokines（TNF-α, IL-1β, IL-6）were remarkably decreased, but anti-inflammatory cytokine IL-10 increased after hUC-MSCs administration (p<0.05). These significant positive effects after hUC-MSCs transplantation did not occur in the Burn+siTSG-6 group. Conclusion Intra-tracheal implantation of hUC-MSCs has been an effective treatment for severe burn-induced ALI via promoting TSG-6 secretion and inhibiting inflammatory reaction in lung tissue.

Proinflammatory cytokine

10.21203/rs.3.rs-127492/v2

Cite

Citations (3)

E3 Ligase FBXW7 Facilitates Mycobacterium Immune Evasion by Modulating TNF-α Expression

Frontiers in Cellular and Infection Microbiology (2022)

Jingrui Song Chao Jin Xiaohong Hu Xin Wen Cairong Ding

Tumor necrosis factor alpha (TNF-α) is a crucial factor in the control of Mycobacterium tuberculosis ( Mtb ) infection. Pathogenic mycobacteria can inhibit and/or regulate host cell TNF-α production in a variety of ways to evade antituberculosis (anti-TB) immunity as well as facilitate immune escape. However, the mechanisms by which TNF-α expression in host cells is modulated to the benefit of mycobacteria is still an interesting topic and needs further study. Here, we report that macrophages infected with Mycobacterium marinum ( Mm )—a close relative of Mtb —upregulated the expression of E3 ubiquitin ligase FBXW7. Specific silencing FBXW7 with small interfering RNA (siRNA) significantly elevates TNF-α expression and eventually promotes the elimination of intracellular bacteria. In turn, overexpression of FBXW7 in Raw264.7 macrophages markedly decreased TNF-α production. Furthermore, partial inhibition of FBXW7 in an Mm -infected murine model significantly reduced TNF-α tissue content, alleviated tissue damage as well as reduced the bacterial load of mouse tails. Finally, FBXW7 could decrease TNF-α in a K63-linked ubiquitin signaling dependent manner. Taken together, our study uncovered a previously unknown role of FBXW7 in regulating TNF-α dynamics during mycobacterial infection, which provides new insights into understanding the role of FBXW7 in anti-tuberculosis immunity and its related clinical significance.

10.3389/fcimb.2022.851197

Cite

Citations (7)

Dermatofibrosarcoma protuberans：clinical and pathological analysis of Asian samples from one center experience.

Research Square (Research Square) (2023)

Qili Peng Yi Lu Renhua Huang Pengpeng Tong Xiaohong Hu

Abstract Background ：Dermatofibrosarcoma protuberans（DFSP）is one of rare and low-grade fibrohistiocytic tumor with malignant potential biological behavior. With the pathological character of the finger-like lesion invading soft tissues, DFSP is considered to be high rate of local recurrence. Method : In this study, we reported a retrospective study of 17 DFSP patients with surgery medical history and long-time follow-up period. All the cases were reviewed by research group with the clinical features, operation outcomes and pathological parameters. Results : 17 Asian patients were included in this study (the mean age is 41.82 years old with 9 females and 8 males). Location of DFSP are the belly (7/17 41.2%), the chest（2/17 11.8%）,the shoulder(5/17 29.4%), the face(1/17 5.9%), the perineum（1/17 5.9%） and the right leg（1/17 5.9%）. 6 cases were closed by plastic surgical suture（35.29%），3 cases by full thickness skin graft（17.65%）and 8 cases by pedicled flap（47.06%）. CD34 and Vimentin positively is 100%, 90% respectively. Desmin and S-100 negatively were 100%. The median value of Ki-67 is 12%. Conclusion : The challenge of DFSP is clinical local control after operation. The first choice of DFSP treatment is surgery with the aim of clear margin and properly reconstruction. For the clinical practice, Enhancing the clinical recognition of DFSP in the initial medical visit is important for proper management and operation opportunity.

10.21203/rs.3.rs-2623456/v1

Cite

Citations (0)