Haojie Wang

Stanford University

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i-10 index

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Co-Authors

Limin Zhang

University of Hong Kong

Ping Sun

Chinese Academy of Geological Sciences

Tao Pang

China Pharmaceutical University

Jian He

Hong Kong University of Science and Technology

Jian Ren

Second Institute of Oceanography

Hongyu Luo

Sichuan University

Te Xiao

Shanghai Jiao Tong University

Luyong Zhang

Guangdong Pharmaceutical University

Shuai Zhang

Chinese Academy of Geological Sciences

Wenchen Ruan

State Key Laboratory of Natural Medicine

Cooperative Institutions

Chinese Academy of Sciences

Chinese Academy of Geological Sciences

University of Hong Kong

Hong Kong University of Science and Technology

University of Chinese Academy of Sciences

Ministry of Natural Resources

China Pharmaceutical University

Ministry of Agriculture and Rural Affairs

Soochow University

State Key Laboratory of Natural Medicine

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Papers

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PSLSA v2.0: An automatic Python package integrating machine learning models for regional landslide susceptibility assessment

Environmental Modelling & Software (2025)

Zizheng Guo Haojie Wang Jun He Da Huang Yixiang Song

Python

10.1016/j.envsoft.2025.106367

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Citations (0)

Liposomal 9-Aminoacridine for Treatment of Ischemic Stroke: From Drug Discovery to Drug Delivery

Nano Letters (2020)

Haojie Wang Xiao Xu Xin‐Yuan Guan Shiyang Shen Xuechao Huang

Neuroinflammation plays a pivotal part in the pathogenesis of stroke. Orphan nuclear receptor NR4A1 is involved in the inflammatory response of microglia and macrophages. In this study, we discovered an old drug, 9-aminoacridine (9-AA), as a novel NR4A1 activator from our in-house FDA-approved drug library, which exhibited anti-inflammatory activities through an NR4A1/IL-10/SOCS3 signaling pathway and modulated the microglia activation. To improve the druggability of 9-AA, different liposomal formulations were screened and investigated. 9-AA-loaded liposome (9-AA/L) was prepared to reduce the adverse effect of 9-AA. Furthermore, 9-AA-loaded PEG/cRGD dual-modified liposome (9-AA/L-PEG-cRGD) was obtained, which displayed prolonged circulation, improved biodistribution, and increased brain accumulation. In the transient middle cerebral artery occlusion (tMCAO) rat model, 9-AA/L-PEG-cRGD significantly reduced brain infarct area, ameliorated ischemic brain injury, and promoted long-term neurological function recovery. This "from drug discovery to drug delivery" methodology provides a potential therapeutic strategy using the liposomal 9-AA, the NR4A1 activator to suppress neuroinflammation for treatment of ischemic stroke.

Stroke

10.1021/acs.nanolett.9b04018

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Citations (52)

Determination and analysis of harmful components in synthetic running tracks from Chinese primary and middle schools

Scientific Reports (2019)

Xiaoxiao Wu Ning Li Hanxu Ji Haifeng Zhang Jiangtao Bu

Abstract In China, incidences involving pupils suffering health problems caused by synthetic running tracks have attracted the public’s attention. However, the existence of known and unknown harmful chemicals in the tracks have not yet been explored. Here, the levels of 16 known harmful ingredients were firstly analyzed in 167 school running tracks. In all samples, the recognized toxic solvents and additives, such as the benzene series, soluble mercury, 3,3′-dichloro-4,4′-diaminodiphenylmethane (MOCA) and toluene diisocyanate monomer (TDI) were under the limits of detection. In contrast, polycyclic aromatic hydrocarbons (PAHs), phthalates, Short chain chlorinated paraffins (SCCPs) soluble lead, cadmium and chromium were found in 86%, 88%, 46%, 81%, 43% and 83% of the specimens, respectively. The levels, toxicology and distribution of these known chemicals were evaluated. Then, a static-headspace gas chromatography-mass spectrometer (GC-MS) method in full scan mode was employed to screen for unknown volatile chemicals. Three groups of chemicals reflecting different kinds of pollution sources were discovered: new solvents, such as N, N-Dimethylformamide, new additives, such as 2-ethylhexanoic acid, and by-products, such as carbon disulfide. In summary, the existence of potential risk factors in school plastic tracks was revealed through exhaustive testing. Moreover, most of the hazardous components detected have been recently included in a new national standard to improve the safety performance of synthetic running tracks.

Carbon disulfide

Mercury

Chlorinated paraffins

Dimethyl formamide

Primary (astronomy)

10.1038/s41598-019-49142-9

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Citations (4)

Transfer learning improves landslide susceptibility assessment

Gondwana Research (2022)

Haojie Wang Lin Wang Limin Zhang

Transfer of learning

Negative transfer

Knowledge Transfer

10.1016/j.gr.2022.07.008

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Citations (41)

A profile tracking system for investigating the behaviour of discharges in moving environments

Experiments in Fluids (2001)

Haojie Wang M. J. Davidson

Dimensionless quantity

Tracking (education)

Tracking system

Constant (computer programming)

10.1007/s003480100323

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Citations (2)

PTFE Stent Membrane Based on the Electrospinning Technique and Its Potential for Replacing ePTFE

ACS Applied Bio Materials (2024)

Haojie Wang Rong Xu Shuangyan She Md Farooque Abdullah Kai Meng

Expanded poly(tetrafluoroethylene) (ePTFE), obtained by the paste extrusion-stretching method, is a commonly used stent membrane material for the treatment of arterial stenosis or aneurysm in clinical practice. However, the structure of ePTFE is nonfibrous, which is not friendly to cells, and the equipment consumes a lot of energy and often requires the use of flammable and toxic lubricants. In this study, electrospinning was used to prepare PTFE vascular stent membranes, following plasma treatment, dopamine, and heparin grafting to obtain an anticoagulant surface. The morphology, structure, axial and circumferential tensile strength, porosity, water penetration pressure, and heparin-releasing behaviors of the samples were studied at first. Then, the experiments of blood compatibility, cytotoxicity, and

Electrospinning

10.1021/acsabm.4c01392

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Corrigendum to ‘Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions’ [Brain Behav. Immun. 67 (2018) 101–117]

Brain Behavior and Immunity (2020)

Yunjie Wang Wenchen Ruan Junru Mi Jingzi Xu Haojie Wang

10.1016/j.bbi.2019.12.015

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Citations (1)

Urban flood analysis for Pearl River Delta cities using an equivalent drainage method upon combined rainfall-high tide-storm surge events

Journal of Hydrology (2021)

Yejia Qiang Limin Zhang Jian He Te Xiao Honghao Huang

Storm Surge

Drainage system (geomorphology)

Flood Mitigation

Outfall

10.1016/j.jhydrol.2021.126293

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Citations (54)

Genetic diversity in the camellia weevil, Curculio chinensis Chevrolat (Coleptera: Curculionidae) and inferences for the impact of host plant and human activity

Entomological Science (2018)

Shouke Zhang Jinping Shu Huai‐Jun Xue Wei Zhang Yangdong Wang

Abstract The camellia weevil, Curculio chinensis (Coleoptera: Curculionidae), is a host‐specific parasite of Camellia seeds that causes huge economic losses in China. Despite its economic impact, little is known about the species’ genetic structure and current distribution status, which are important to provide critical insights into establishing a control strategy for this pest. Here, genetic diversity and the phylogenetic structure of C. chinensis were inferred using the sequences of COI and EF1‐α among different geographical populations. Twenty‐two haplotypes for the COI gene and 26 haplotypes for EF1‐α in 215 individuals from 16 sample regions in China were found. A phylogenetic analysis revealed four distinct clades within C. chinensis . The amova analysis showed significant genetic differentiation among all the populations sampled, however, the genetic differentiation among the residual populations was not significant when JX (Jiangxi) and TC (Tengchong) populations were excluded. The M (M = Nm for haploid data, M = 2 Nm for diploid data) value analysis suggested that JX and TC populations were significantly different from other populations. Thus, these results imply that human activity and host plant could have a significant impact on C. chinensis population diversity and the current geographical population pattern.

Callosobruchus chinensis

10.1111/ens.12329

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Citations (10)

Spatio-Temporal Prediction of Three-Dimensional Stability of Highway Shallow Landslide in Southeast Tibet Based on TRIGRS and Scoops3D Coupling Model

Water (2024)

Jiarui Mao MA Xiu-min Haojie Wang Liyun Jia Yao Sun

National Highway G559 is the first highway in Southeast Tibet into Motuo County, which has not only greatly improved the difficult situation of local roads, but also promoted the economic development of Tibet. However, rainfall-induced shallow landslides occur frequently along the Bomi–Motuo section, which seriously affects the safe operation and construction work of the highway. Therefore, it is urgent to carry out geological disaster assessment and zoning along the highway. Based on remote-sensing interpretation and field investigation, the distribution characteristics and sliding-prone rock mass of shallow landslides along the Bomi–Motuo Highway were identified. Three-dimensional stability analysis of regional landslides along the Bomi-Motuo Highway under different rainfall scenarios was carried out based on the TRIGRS and Scoops3D coupled model (T-S model). The temporal and spatial distribution of potential rainfall landslides in this area is effectively predicted, and the reliability of the predicted results is also evaluated. The results show that: (1) The slope structure along the highway is mainly composed of loose gravel soil on the upper part and a strong weathering layer of bedrock on the lower part. The sliding surface is mostly a circular and plane type, and the main failure types are creep–tensile failure and flexural–tensile failure. (2) Based on the T-S coupling model, it is predicted that the potential landslide along the Bomi–Motuo Highway in the natural state is scattered. The distribution area of extremely unstable and unstable areas accounts for 4.92% of the total area. In the case of extreme rainfall once in a hundred years, the proportion of instability area (Fs < 1) predicted by the T-S coupling model 1 h after rainfall is 7.74%, which is 1.57 times that of the natural instability area. The instability area (Fs < 1) accounted for 43.40% of the total area after 12 h of rainfall. The potential landslides were mainly distributed in the Bangxin–Zhamu section and the East Gedang section. (3) The TRIGRS and T-S coupling model is both suitable for predicting the temporal–spatial distribution of rainfall-induced shallow landslides, but the TRIGRS model has the problem of over-prediction. The instability area predicted by the T-S coupling model accounted for 43.30%, and 74% of the historical landslide disaster points in the area were correctly predicted. (4) In terms of rainfall response, the T-S coupling model shows higher sensitivity. The %LRclass (Fs < 1) index of the T-S coupling model is above 50% in different time periods, and its landslide-prediction effect (%LRclass = 78.80%) was significantly better than that of the one-dimensional TRIGRS model (%LRclass = 45.50%) under a 12 h rainfall scenario. The research results have important reference significance for risk identification and disaster reduction along the G559 Bomi–Motuo Highway.

10.3390/w16091207

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Citations (1)