R. Martínez

Universidad Politécnica de Madrid

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Pedro Gómez‐Vilda

Universidad Politécnica de Madrid

AÁ

Agustín Álvarez-Marquina

Universidad Politécnica de Madrid

V. Rodellar

Universidad Politécnica de Madrid

Victor M. Garca Nieto

Hospital Universitario Infantil San José

Luis Miguel Mazaira-Fernández

Universidad Politécnica de Madrid

Cristina Muñoz-Mulas

Universidad Politécnica de Madrid

Victor Nieto‐Lluis

Universidad Politécnica de Madrid

José Manuel Ferrández Vicente

Universidad Politécnica de Cartagena

Daniel Palacios‐Alonso

Universidad Rey Juan Carlos

Luis Miguel Mazaira Fernández

National Training Service

Cooperative Institutions

Universidad Politécnica de Madrid

Hospital General Universitario Gregorio Marañón

Universidad Autónoma Metropolitana

Universidad de Navarra

Clinica Universidad de Navarra

Universidad Rey Juan Carlos

Universidad Autónoma de Madrid

Universidad Complutense de Madrid

Mexican Social Security Institute

Universidad de Alcalá

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Supplementary Data from A TaqMan Low-Density Array to Predict Outcome in Advanced Hodgkin's Lymphoma Using Paraffin-Embedded Samples

Beatriz Sánchez‐Espiridión Abel Sánchez‐Aguilera Carlos Montalbán Carmen Martín R. Martínez

Supplementary Data from A TaqMan Low-Density Array to Predict Outcome in Advanced Hodgkin's Lymphoma Using Paraffin-Embedded Samples

TaqMan

10.1158/1078-0432.22439955

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A robust mel-scale subband voice activity detector for a car platform

Interspeech 2022 (2007)

Agustín Álvarez-Marquina R. Martínez Pedro Gómez‐Vilda Victor M. Garca Nieto V. Rodellar

10.21437/interspeech.2007-92

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Material de osteosíntesis como causa de disfagia extraesofágica

44 Congreso de la Sociedad Española de Endoscopia Digestiva Abstracts Publication (2022)

Alicia De Vicente José María Arroyo Laura López de Frutos R. Martínez Manuel Ojeda

10.48158/seed2022.p188

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Estimating the Dispersion of the Biometric Glottal Signature in Continuous Speech

Springer eBooks (2007)

Pedro Gómez‐Vilda Agustín Álvarez-Marquina L. M. Mazaira Roberto Fernández V. Rodellar

Signature (topology)

Vocal tract

10.1007/978-3-540-77347-4_22

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Spectral perturbation parameters for voice pathology detection

Pedro Gómez‐Vilda Francisco Díaz Carlos Lázaro-Carrascosa Kathleen Murphy R. Martínez

In recent years special emphasis has been placed upon the early detection of voice pathologies by using the signal processing of voice to evaluate certain time and spectrum domain parameters which may infer the presence of pathology. The present work is aimed at establishing the suitability of these voice spectral parameters in determining a clear distinction between pathologic and normophonic voice, and to further classify the specific patient's pathology. Principal component analysis will be used in parameter pruning. Results for normal and pathological cases will be presented and discussed.

Emphasis (telecommunications)

Voice analysis

Spectral Analysis

10.1109/isscs.2005.1509913

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Data from A TaqMan Low-Density Array to Predict Outcome in Advanced Hodgkin's Lymphoma Using Paraffin-Embedded Samples

Beatriz Sánchez‐Espiridión Abel Sánchez‐Aguilera Carlos Montalbán Carmen Martín R. Martínez

<div>AbstractPurpose: Despite major advances in the treatment of classic Hodgkin's lymphoma (cHL), ∼30% of patients in advanced stages may eventually die as result of the disease, and current methods to predict prognosis are rather unreliable. Thus, the application of robust techniques for the identification of biomarkers associated with treatment response is essential if new predictive tools are to be developed.Experimental Design: We used gene expression data from advanced cHL patients to identify transcriptional patterns from the tumoral cells and their nonneoplastic microenvironment, associated with lack of maintained treatment response. Gene-Set Enrichment Analysis was used to identify functional pathways associated with unfavorable outcome that were significantly enriched in either the Hodgkin's and Reed-Sternberg cells (regulation of the G2-M checkpoint, chaperones, histone modification, and signaling pathways) or the reactive cell microenvironment (mainly represented by specific T-cell populations and macrophage activation markers).Results: To explore the pathways identified previously, we used a series of 52 formalin-fixed paraffin-embedded advanced cHL samples and designed a real-time PCR-based low-density array that included the most relevant genes. A large majority of the samples (82.7%) and all selected genes were analyzed successfully with this approach.Conclusions: The results of this assay can be combined in a single risk score integrating these biological pathways associated with treatment response and eventually used in a larger series to develop a new molecular outcome predictor for advanced cHL.</div>

10.1158/1078-0432.c.6517338.v1

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Bio-inspired Dynamic Formant Tracking for Phonetic Labelling

Pedro Gómez‐Vilda Roberto Fernández-Baillo Gallego de la Sacristana M. Victoria Rodellar Biarge R. Martínez Cristina Muñoz

It is a known fact that phonetic labeling may be relevant in helping current Automatic Speech Recognition (ASR) when combined with classical parsing systems as HMM's by reducing the search space. Through the present paper a method for Phonetic Broad-Class Labeling (PCL) based on speech perception in the high auditory centers is described. The methodology is based in the operation of CF (Characteristic Frequency) and FM (Frequency Modulation) neurons in the cochlear nucleus and cortical complex of the human auditory apparatus in the automatic detection of formants and formant dynamics on speech. Results obtained informant detection and dynamic formant tracking are given and the applicability of the method to Speech Processing is discussed.

Stop consonant

Source

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Robust speech processing based on binaural hearing systems

Pedro Gómez‐Vilda V. Rodellar Agustín Álvarez-Marquina R. Martínez Victor M. Garca Nieto

Reliability is a key factor in the Spoken-Command Recognition. To increase recognition rates the methodology suggested in the present paper combines adaptive Joint-Process Estimation with Source Detection using Binaural-inspired Algorithms and Negative Beamforming. The paper proposes the use of these techniques in public transportation environments.

Adaptive beamformer

10.1109/mwscas.1999.867721

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Real time text-to-speech conversion system for spanish

J.C. Olabe A. Santos R. Martínez Erika Caballero Muñoz M.E. Martinez

Research aiming to develop a text-to-speech converter (TSC) for Spanish, that accepts a continuous source of alphanumeric characters (up to 250 words per minute) and produces good quality, natural Spanish output, is described. Four sets of problems are considered in this work: the hard-ware structure adopted for real time operation; the complex control software needed to handle the orthographic input and linguistic programs; the linguistic processing rules, and the parametrization of the Spanish language matched to a TSC. Emphasis is made on the problems of adapting a general hardware structure to a specific language.

Alphanumeric

Parametrization (atmospheric modeling)

Emphasis (telecommunications)

10.1109/icassp.1984.1172429

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Subcellular Distribution of Phospholipase A2 and Atpases During Capacitation and Acrosome Reaction in Guinea Pig Spermatozoa

Archives of Andrology (1991)

Reinaldo de la Noval García R. Martínez M. Rabago O Hernández-Pérez Alberto López-Reyes

The presence, distribution, and levels of phospholipase A2 and ATPases activities in those structures of the guinea pig spermatozoa that participate in the acrosome reaction were studied, both before and after capacitation, as well as during the acrosome reaction induced in vitro. Spermatozoa were collected from the cauda epididymis and incubated in the absence and presence of 1.15 mmol/L calcium, with and without the addition of 1 μmol/L A23187. Membrane fractions were recovered by vortexing and discontinuous sucrose density gradient centrifugation. Most of the Na +, K + -ATPase was recovered in the acrosome-free spermatozoa, but a clear, distinct presence of this enzyme was observed in the plasma membrane (25 against 101 nmoles Pi released per milligram of protein, respectively). The activity of this enzyme in the periacrosomal plasma and in the outer acrosomal membrane increased during calcium incubation. Ca2 +-dependent ATPase was found in both membrane fractions, being higher in the periacrosomal plasma membrane. The addition of calcium induced a significant inhibition of this acrosomal ATPase, whereas the activity in the acrosome-free spermatozoa increased. The activity of phospholipase A2, under all experimental conditions, was found to be restricted to the soluble fraction.

Capacitation

Acrosome reaction

10.3109/01485019108987632

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Citations (9)