To analyze the results of immunophenotyping in patients with acute T-lymphoblastic leukemia (T-ALL) so as to improve the understanding of early T-cell precursor acute T-lymphoblastic leukemia (ETP-ALL) and near ETP-ALL with elevated CD5.The results of immunophenotypes in 62 patients with newly diagnosed adult T-ALL in our hospital were retrospectively analyzed. According to the expression of CD5, CD1a, CD8 and My/S antigens, the patients were divided into 3 groups: ETP, near ETP and non-ETP. The immunophenotypic characteristics and basic clinical data of three groups were compared and analyzed.There were significant differences in age, white blood cell and plt counts as well as percentage of bone marrow blasts among three groups (P＜0.05). ETP and near ETP mainly belonged to Pro T and pre T, and non-ETP mainly belonged to cortical T and mature T. The positive rates of My/S, CD1a, CD8 and CD5 were significantly different among three groups (P＜0.01). The positive rates of CD4 and CD3 in non-ETP group were significantly higher than those in ETP and near-ETP group (P＜0.01). The positive rate of CD56 in near-ETP group was 50%, which was significantly higher than that in ETP group (16.7%) and non-ETP group (0%) (P＜0.01).According to the expression of CD5, CD1a, CD8 and My/S antigens, T-ALL patients can be divided into three groups: ETP, near ETP and non ETP, the immunophenotypes and basic clinical data among 3 groups are statistically different.成人急性T淋巴细胞白血病免疫表型分析.分析急性T淋巴细胞白血病（T-ALL）患者免疫分型结果，提高对早期前体T淋巴细胞白血病（ETP-ALL）及CD5增高的ETP ALL（near ETP ALL）的认识.回顾性分析62例于本院诊治的初诊成人T-ALL患者的免疫分型结果，根据CD5、CD1a、CD8及髓/干（My/S）抗原的表达情况，将其分为ETP，near ETP及非ETP（non-ETP）3组,对比分析3组患者免疫分型特点及临床基本资料.3组间年龄、白细胞数和血小板计数及骨髓白血病细胞百分比均有显著差异（P＜0.05)，ETP组及near ETP组均主要见于pro T及pre T，non-ETP 组主要见于皮质T及成熟T。3组间My/S，CD1a，CD8及CD5阳性率均具有显著差异（P＜0.001）。non-ETP组CD4及CD3阳性率均显著高于ETP组及near-ETP组（P＜0.01）。near-ETP组CD56阳性率（50%）显著高于ETP组（16.7%）及non-ETP组（0%）（P＜0.01）.根据CD5、CD1a、CD8及髓/干（My/S）抗原的表达情况，可以将T-ALL分为ETP、near ETP及non-ETP 3组，3组间免疫分型及临床基本资料有统计学差异.
To explore the role of nitrogen atoms in biochar-catalyzed persulfate degradation, pristine biochar and nitrogen-doped biochar were prepared and characterized. As the nitrogen doping ratio increased from 1:0 to 1:3, the removal rate of dimethomorph increased from 16.6% to 86.8%. More importantly, there is a good linear relationship (R 2 = 0.965) between the degradation rate and the content of N atoms in the biochar, which confirmed that the significant role of the N atom in the catalytic reaction. The experiments showed that during the process of biochar activation of potassium hydrogen persulfate to degrade dimethomorph, 1 O 2 , ·OH and O 2.− were all involved in the degradation process, 1 O 2 was the main contributor. A total of 8 dimethomorph catalytic degradation products were identified, and their degradation pathways were analyzed. These results will facilitate the production of cheap and efficient non-metal catalysts for reducing the risk of dimethomorph.
This study aimed to explore the psychiatric symptoms and associated risk and protective factors among religious adolescents after 2-month home confinement against coronavirus disease-2019 (COVID-19) in China.
A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method for the simultaneous quantitative determination of flumetsulam in 20 kinds of complicated plant-derived foods was developed and validated.
Several clinical parameters and biomarkers have been proposed as prognostic markers for stroke. However, it has not been clarified whether the risk factors affecting the prognosis of patients with recurrent and first-ever stroke are similar. In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of patients with recurrent stroke alone ( , ). sLOX-1 levels were also associated with an increased risk of unfavorable outcomes in patients with recurrent stroke with an adjusted odds ratio of 1.489 (95% confidence interval, 1.204–1.842, ). Combining the risk factors showed greater accuracy for prognosis, yielding a sensitivity of 93.2% and a specificity of 75%, with an area under the curve of 0.916, evaluated by the receiver operating characteristic curve. These findings suggest that the diagnosis and prognosis are different between patients with recurrent stroke and those with first-ever stroke, and sLOX-1 level is an independent prognostic marker in patients with recurrent stroke.
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