Zibiao Li

Agency for Science, Technology and Research

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Xian Jun Loh

Agency for Science, Technology and Research

169

Enyi Ye

Agency for Science, Technology and Research

Yun‐Long Wu

Xiamen University

Chaobin He

Agency for Science, Technology and Research

Jayven Chee Chuan Yeo

Agency for Science, Technology and Research

Xiaoshan Fan

Huanghe Science and Technology College

Sheng Wang

Soochow University

Qiang Zhu

Institute of Materials Research and Engineering

Joseph Kinyanjui Muiruri

Agency for Science, Technology and Research

Beng Hoon Tan

Institute of Materials Research and Engineering

Cooperative Institutions

Agency for Science, Technology and Research

231

Institute of Materials Research and Engineering

188

National University of Singapore

165

Chinese Academy of Sciences

151

Nanyang Technological University

109

Xiamen University

University of Chinese Academy of Sciences

Zhejiang University

University of Science and Technology of China

Sun Yat-sen University

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Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer

Frontiers in Bioengineering and Biotechnology (2023)

Yanfen Zheng Zhiguo Li Chuyi Liu Xiaotong Fan Zheng Luo

Introduction: Diabetic oral mucosa ulcers face challenges of hypoxia, hyperglycemia and high oxidative stress, which result in delayed healing process. Oxygen is regarded as an important substance in cell proliferation, differentiation and migration, which is beneficial to ulcer recovery. Methods: This study developed a multi-functional GOx-CAT nanogel (GCN) system for the treatment of diabetic oral mucosa ulcers. The catalytic activity, ROS scavenge and oxygen supply ability of GCN was validated. The therapeutic effect of GCN was verified in the diabetic gingival ulcer model. Results: The results showed that the nanoscale GCN was capable of significantly eliminating intracellular ROS, increasing intracellular oxygen concentration and accelerating cell migration of human gingival fibroblasts, which could promote diabetic oral gingival ulcer healing in vivo by alleviating inflammation and promoting angiogenesis. Discussion: This multifunctional GCN with ROS depletion, continuous oxygen supply and good biocompatibility, which might provide a novel therapeutic strategy for effective treatment of diabetic oral mucosa ulcers.

Oral mucosa

10.3389/fbioe.2023.1194398

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Citations (8)

Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe₂O₄ Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging

ACS Omega (2022)

Enhui Qiu Xiaofang Chen Da‐Peng Yang Michelle D. Regulacio Rufus Mart Ceasar R. Ramos

Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core-shell structured plasmonic-magnetic nanocomposite system that can serve as a dual-functional agent due to its combined photothermal therapeutic and magnetic resonance imaging (MRI) functions. The photothermal activity of the hybrid is attributed to its plasmonic Au core, which is capable of absorbing near-infrared (NIR) light and converting it into heat. Meanwhile, the magnetic MgFe2O4 shell exerts its ability to act as a MRI contrast agent. Our in vivo studies using tumor-bearing mice demonstrated the nanohybrids' excellent photothermal and MRI properties. As a photothermal therapeutic agent, the nanohybrids were able to dramatically shrink solid tumors in mice through NIR-induced hyperthermia. As T2-weighted MRI contrast agents, the nanohybrids were found capable of substantially reducing the MRI signal intensity of the tumor region at 10 min postinjection. With their dual plasmonic-magnetic functionality, these Au@MgFe2O4 nanohybrids hold great promise not only in the biomedical field but also in the areas of catalysis and optical sensing.

Plasmonic Nanoparticles

Photothermal effect

10.1021/acsomega.1c05486

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Citations (18)

Hierarchically Self-Assembled Supramolecular Host–Guest Delivery System for Drug Resistant Cancer Therapy

Biomacromolecules (2018)

Hongwei Cheng Xiaoshan Fan Xiaoyuan Wang Enyi Ye Xian Jun Loh

In this report, a new star-like copolymer β-CD-g-(PNIPAAm-b-POEGA)x, consisting of a β-CD core, grafted with temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(oligo(ethylene glycol) acrylate) (POEGA) in a block copolymer of the arms, was used to deliver chemotherapeutics to drug resistant cancer cells and tumors. The first step of the self-assembly process involves the encapsulation of chemotherapeutics through host–guest inclusion complexation between the β-cyclodextrin cavity and the anticancer drug. Next, the chain interaction of the PNIPAAm segment at elevated temperature drives the drug-loaded β-CD-g-(PNIPAAm-b-POEGA)x/PTX inclusion complex to hierarchically self-assemble into nanosized supramolecular assemblies at 37 °C, whereas the presence of poly(ethylene glycol) (PEG) chains in the distal end of the star-like copolymer arms impart enhanced stability to the self-assembled structure. More interestingly, this supramolecular host–guest nanocomplex promoted the enhanced cellular uptake of chemotherapeutics in MDR-1 up-regulated drug resistant cancer cells and exhibited high therapeutic efficacy for suppressing drug resistant tumor growth in an in vivo mouse model, due to the increased stability, improvement in aqueous solubility, enhanced cellular uptake, and partial membrane pump impairment by taking the advantage of PEGylation and supramolecular complex between this star-like copolymer and chemotherapeutics. This work signifies that temperature-sensitive PEGylated supramolecular nanocarriers with good biocompatibility are effective in combating MDR-1 mediated drug resistance in both in vitro and in vivo models, which is of significant importance for the advanced drug delivery platform designed to combat drug resistant cancer.

Cancer Therapy

10.1021/acs.biomac.7b01693

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Citations (58)

Efficient Detection, Quantification and Enrichment of Subtle Allelic Alterations

DNA Research (2012)

Jianbin Chen Xinghua Zhang T. Wang Zibiao Li Guijun Guan

Gene targeting (GT) can introduce subtle alterations into a particular locus and represents a powerful tool for genome editing. Engineered zinc finger nucleases (ZFNs) are effective for generating minor allelic alterations. Efficient detection of such minor alterations remains one of the challenges in ZFN-mediated GT experiments. Here, we report the establishment of procedures allowing for efficient detection, quantification and enrichment of such subtle alterations. In a biallelic model, polyacrylamide gel electrophoresis (PAGE) is capable of detecting rare allelic variations in the form of DNA heteroduplexes at a high efficiency of ~0.4% compared with ~6.3% by the traditional T7 endonuclease I-digestion and agarose gel electrophoresis. In a multiple allelic model, PAGE could discriminate different alleles bearing addition or deletion of 1-18 bp as distinct bands that were easily quantifiable by densitometry. Furthermore, PAGE enables enrichment for rare alleles. We show for the first time that direct endogenous GT is possible in medaka by ZFN RNA injection, whereas PAGE allows for detection and cloning of ZFN-targeted alleles in adults arising from ZFN-injected medaka embryos. Therefore, PAGE is effective for detection, quantification and enrichment of multiple fine allelic differences and thus offers a versatile tool for screening targeted subtle gene alterations.

Zinc finger nuclease

Agarose gel electrophoresis

10.1093/dnares/dss023

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Citations (55)

Carbon-based Nanomaterials

The Royal Society of Chemistry eBooks (2022)

Hong Chi Yaoguang Wang Zibiao Li Enyi Ye

Due to the full spectral absorption characteristics, versatile functionalization method, unique physical properties, biological compatibility, and high photothermal conversion efficiency, carbon-based nanomaterials are widely used in photothermal conversion. This chapter introduces the mechanism of photothermal conversion of carbon materials, shortlists and compares various hybrid carbon nanomaterials, and begins with the preparation of various carbon nanocomposites, with the properties of carbon dots, graphene, and carbon nanotube-supported metals, including semiconductors and polymer nanocomposites being of key interest. It then goes on to focus on photo-thermal catalytic conversion, seawater desalination, photothermal therapy, and photoacoustic/fluorescence imaging applications.

Nanomaterials

Carbon fibers

Surface Modification

Photothermal effect

10.1039/9781839165177-00305

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Citations (3)

Biomass-Derived Carbonaceous Materials: Recent Progress in Synthetic Approaches, Advantages, and Applications

ACS Sustainable Chemistry & Engineering (2019)

Da‐Peng Yang Zibiao Li Minghuan Liu Xiaoyan Zhang Lanying Li

Current energy shortages and environmental crises have compelled researchers to look for inexpensive and sustainable resources that can be obtained via environmentally friendly routes to produce novel functional materials. Biomass has been identified as one of the promising candidates given its availability in large quantities and renewable nature. Among the various feasible synthetic strategies, hydrothermal carbonization (HTC) has been admired for its energy efficiency and ability to synthesize carbonaceous materials for use in a wide range of applications. In this review, the different types of biomass and strategies available for the synthesis of carbon-based materials are discussed. Furthermore, factors influencing the efficiency of each strategy are analyzed and evaluated. Subsequently, the utilization of carbonaceous materials in environmental, catalytic, electrical, and biological applications are reviewed to further demonstrate their functionalities across different fields.

Hydrothermal Carbonization

Environmentally Friendly

Economic shortage

Carbon fibers

Renewable resource

10.1021/acssuschemeng.8b06030

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Citations (192)

FRONT MATTER

Sustainable chemistry series (2018)

Nicholas Gathergood Xian Jun Loh Dan Kai Zibiao Li

10.1142/9781786345219_fmatter

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Citations (0)

Next‐Generation Vitrimers Design through Theoretical Understanding and Computational Simulations

Advanced Science (2023)

Ke Li Nam V. Tran Yuqing Pan Sheng Wang Zhicheng Jin

Abstract Vitrimers are an innovative class of polymers that boast a remarkable fusion of mechanical and dynamic features, complemented by the added benefit of end‐of‐life recyclability. This extraordinary blend of properties makes them highly attractive for a variety of applications, such as the automotive sector, soft robotics, and the aerospace industry. At their core, vitrimer materials consist of crosslinked covalent networks that have the ability to dynamically reorganize in response to external factors, including temperature changes, pressure variations, or shifts in pH levels. In this review, the aim is to delve into the latest advancements in the theoretical understanding and computational design of vitrimers. The review begins by offering an overview of the fundamental principles that underlie the behavior of these materials, encompassing their structures, dynamic behavior, and reaction mechanisms. Subsequently, recent progress in the computational design of vitrimers is explored, with a focus on the employment of molecular dynamics (MD)/Monte Carlo (MC) simulations and density functional theory (DFT) calculations. Last, the existing challenges and prospective directions for this field are critically analyzed, emphasizing the necessity for additional theoretical and computational advancements, coupled with experimental validation.

Computational simulation

Computational model

10.1002/advs.202302816

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Citations (15)

Reduction-responsive shell cross-linked micelles derived from amphiphilic triblock copolymer as anticancer drug delivery carrier

Materials Science and Engineering C (2018)

Wenqiang Li Xiaoshan Fan Xianglin Lv Jiang Du Qing Liu

Anticancer drug

10.1016/j.msec.2018.11.015

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Citations (26)