Ju‐Yeon Kim

Gyeongsang National University Hospital

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Young‐Tae Ju

Gyeongsang National University Hospital

Eun‐Jung Jung

Gyeongsang National University

Sang‐Ho Jeong

Gyeongsang National University

Chi‐Young Jeong

Gyeongsang National University Hospital

Taejin Park

Changwon National University

Young‐Joon Lee

Gyeongsang National University Hospital

Soon‐Chan Hong

Gyeongsang National University Hospital

Seung-Jin Kwag

Gyeongsang National University Hospital

Ji‐Ho Park

Korea Advanced Institute of Science and Technology

Sun Ju Chung

University of Ulsan

Cooperative Institutions

Gyeongsang National University Hospital

Gyeongsang National University

University of Ulsan

Ulsan College

Seoul National University

Asan Medical Center

Korea University

Yonsei University

Sungkyunkwan University

Korea University Medical Center

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Galectin-3 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta42 Neurotoxicity In Vitro

Biophysical Journal (2011)

Ju‐Yeon Kim Dong Hyun Kim Dal‐Soo Kim Ji Hyun Kim Sang Young Jeong

Cord lining

Neurotoxicity

Galectin

Placenta cord banking

Galectin-1

Galectin-3

Cord blood

10.1016/j.bpj.2010.12.2460

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Citations (3)

Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study

World Journal of Surgical Oncology (2019)

Jin-Kyu Cho Woohyung Lee Jae Yool Jang Han-Gil Kim Jae‐Myung Kim

While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection for T2 GBC is unclear. This study aimed to identify the necessity of hepatic resection in patients with T2 GBC. Data of 81 patients with histopathologically proven T2 GBC who underwent surgical resection between January 1999 and December 2017 were enrolled from a retrospective database. Of these, 36 patients had peritoneal-side (T2a) tumors and 45 had hepatic-side (T2b) tumors. To identify the optimal surgical management method, T2 GBC patients were classified into the hepatic resection group (n = 44, T2a/T2b = 20/24) and non-hepatic resection group (n = 37, T2a/T2b = 16/21). The recurrence pattern and role of hepatic resection for T2 GBC were then investigated. Mean age of the patients was 69 (range 36–88) years, and the male-to-female ratio was 42:39 (male, 51.9%; female, 48.1%). Hepatic-side GBC had a higher rate of recurrence than peritoneal-side GBC (44.4% vs. 8.3%, p = 0.006). The most common type of recurrence in T2a GBC was para-aortic lymph node recurrence (n = 2, 5.6%); the most common types of recurrence in T2b GBC were para-aortic lymph node recurrence (n = 7, 15.6%) and intrahepatic metastasis (n = 6, 13.3%). Hepatic-side GBC patients had worse survival outcomes than peritoneal-side GBC patients (76.0% vs. 96.6%, p = 0.041). Hepatic resection had no significant treatment effect in T2 GBC patients (p = 0.272). Multivariate analysis showed that lymph node metastasis was the only significant prognostic factor (p = 0.002). Hepatic resection is not essential for curative treatment in T2 GBC, and more systemic treatments are needed for GBC patients, particularly for those with T2b GBC.

Gallbladder Cancer

Surgical oncology

10.1186/s12957-018-1556-6

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Citations (35)

Galectin‐3 secreted by human umbilical cord blood‐derived mesenchymal stem cells reduces amyloid‐β42 neurotoxicity in vitro

FEBS Letters (2010)

Ju‐Yeon Kim Dong Hyun Kim Dal‐Soo Kim Ji Hyun Kim Sang Young Jeong

In this study, we found that expression and secretion of galectin‐3 (GAL‐3) were upregulated by amyloid‐β42 (Aβ42) exposure in human umbilical cord blood‐derived mesenchymal stem cell (hUCB‐MSC) without cell death. Aβ42‐exposed rat primary cortical neuronal cells co‐treated with recombinant GAL‐3 were protected from neuronal death in a dose‐dependent manner. hUCB‐MSCs were cocultured with Aβ42‐exposed rat primary neuronal cells or the neuroblastoma cell line, SH‐SY5Y in a Transwell chamber. Coculture of hUCB‐MSCs reduced cell death of Aβ42‐exposed neurons and SH‐SY5Y cells. This neuroprotective effect of hUCB‐MSCs was reduced significantly by GAL‐3 siRNA. These data suggested that hUCB‐MSC‐derived GAL‐3 is a survival factor against Aβ42 neurotoxicity.

Cord lining

Neurotoxicity

Galectin

Placenta cord banking

Galectin-1

Cord blood

Galectin-3

10.1016/j.febslet.2010.07.028

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Citations (55)

Mortality of advanced Parkinson's disease patients treated with deep brain stimulation surgery

Journal of the Neurological Sciences (2016)

Ho‐Sung Ryu Mi Sun Kim Sooyeoun You Mi‐Jung Kim Young Jin Kim

10.1016/j.jns.2016.08.041

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Citations (10)

The Difference of Awareness Level on Positive and Negative Effects of Permitting Online Gambling's Expansion: Focused on Gambling Users, Gambling Addicts, and General Population

The Journal of the Korea Contents Association (2017)

Ju‐Yeon Kim Hyunjoo Choi Kyung-Mo Ahn

온라인베팅은 누구나 언제 어디서나 접속이 가능하며 ICT기술의 발전에 따라 베팅의 편리성과 다양한 기회로 국내 불법 도박규모는 합법 사행산업의 4배 이상에 달하며, 불법 온라인베팅 시장 또한 가파르게 커지고 있다. 이에, 국내에서 운영되고 있는 체육진흥투표권과 전자복권 외에 다른 유형의 온라인베팅도 확대허용하고 관리해야 할 필요성이 제기되고 있다. 본 연구는 온라인베팅 확대허용에 대한 인식, 온라인베팅 확대허용 시 운영방안과 불법 온라인베팅 축소방안에 대한 인식을 온라인베팅 이용자, 중독자 및 일반인 대상으로 파악하였다. 분석결과, 온라인베팅 확대허용에 대한 긍정적 부정적 인식에 집단별 유의한 차이가 있는 것으로 검증되었으며, 합법 온라인베팅 종목으로 경주류 베팅 확대허용 시 운영방안에 대한 인식 차이도 의미 있는 차이를 보였다. 이를 통해 온라인베팅 확대허용으로 양성화하게 되면 불법 온라인베팅 이용자가 합법 온라인베팅 이용자로 전환하게 될 가능성과 건전하게 이용할 수 있는 가능성이 있다는 것이 확인된 만큼 온라인베팅 확대허용의 긍정적 효과를 기대할 수 있을 것이다. Since online betting occurs on online where anybody can access through internet, thus, the online gambling market has been expanding. Domestic illegal gambling market size is 4 times bigger than that of legal gambling market, and illegal online betting market is rapidly growing as well. Currently online gambling does exist domestically in form of Sports promotion voting rights, also known as, Toto and Proto and internet lottery. However, the need for other types of online gambling to be permitted, expanded and managed has been suggested. This research has analyzed online gambling users, online gambling addicts and general population's awareness on expansion and operation of online gambling, contraction measures of illegal online gambling and operation measures in case of permitted expansion of online gambling. The result of this research's analysis showed that each group has significantly different awareness level on positive and negative effects of permitting online gambling's expansion. Also, it showed that each group has significantly different awareness on permitting expansion of racing betting as a legal gambling item. Since it is the proven fact that illegal online gambling users could turn into legal users and that users could use the service more positively if online gambling is legalized through allowance and expansion process; one could expect the positive effects from permitting expansion of online gambling.

Allowance (engineering)

Lottery

Promotion (chess)

Internet users

10.5392/jkca.2017.17.01.426

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Citations (3)

Evaluation of Automated Architect Syphilis TP as a Diagnostic Laboratory Screening Test for Syphilis

Annals of Laboratory Medicine (2008)

Jeeyong Kim Woohyeun Kim Chi Hyun Cho Ju‐Yeon Kim Ga-Yeong Kim

Jeeyong Kim, M.D., Woo-Hyeun Kim, M.D., Chihyun Cho, M.D., Juyeon Kim, M.D., Ga-Yeong Kim, M.D., Myung-Hyun Nam, M.D., Jang Su Kim, M.D., Sook Young Bae, M.D., and Yunjung Cho, M.D.. Korean J Lab Med 2008;28:475-82. https://doi.org/10.3343/kjlm.2008.28.6.475

Concordance

Rapid plasma reagin

Syphilis Serodiagnosis

10.3343/kjlm.2008.28.6.475

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Citations (9)

Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis

BMC Cancer (2020)

Ju‐Yeon Kim Eun‐Jung Jung Jae‐Myung Kim Han Shin Lee Seung-Jin Kwag

Abstract Background We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are more useful predictors after initial intention to treat than at the time of diagnosis. Methods We collected the medical data of 533 patients. The results of the peripheral blood sampling before the primary treatments were labeled as initial cohort, and those obtained between 24 and 36 months after initial treatment were defined as the 2nd cohort. Delayed metastasis has been defined as distant metastasis 2 years after treatment, and survival outcome was estimated and compared across groups. Results Median follow-up duration was 74 months (24–162 months), and 53 patients experienced delayed metastasis. In univariate analysis, metastasis-free survival, patient age at diagnosis, tumor size, axillary lymph node metastasis, HER-2 status, initial NLR and PLR, and 2nd NLR and PLR were found to be significantly associated with delayed metastasis. However, in multivariate analysis, only the 2nd NLR and PLR were found to be significantly associated with delayed metastasis, excluding initial NLR and PLR. Metastasis-free survival was analyzed through the pattern changes of NLR or PLR. The results revealed that patients with continued low NLR and PLR values at pre- and post-treatment (low initial values and 2nd values) showed a significantly better prognosis than those with a change in value or continued high NLR and PLR. Conclusions We identified that patients with persistent high NLR and PLR after initial treatment have significant worse prognosis in terms of late metastasis. Therefore, these results suggest that NLR and PLR are more useful in predicting prognosis post-treatment.

Univariate analysis

Surgical oncology

10.1186/s12885-020-07700-9

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Citations (64)

Metastatic B-Cell Lymphoma Masquerading as Tolosa-Hunt Syndrome

Journal of the Korean Neurological Association (2011)

Ji Wan Jang Ju‐Yeon Kim Bong Kyung Shin Ji Hyun Kim

Tolosa–Hunt syndrome

Source

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Citations (0)

Transcriptome Analysis and the Prognostic Role of NUDC in Diffuse and Intestinal Gastric Cancer

Technology in Cancer Research & Treatment (2021)

Sang‐Ho Jeong Miyeong Park Sun Yi Park Ji-Ho Park Tae-Han Kim

Introduction: There have been few studies about gene differences between patients with diffuse-type gastric cancer and those with intestinal-type gastric cancer. The aim of this study was to compare the transcriptomes of signet ring cell gastric cancer (worst prognosis in diffuse-type) and well-differentiated gastric cancer (best prognosis in intestinal-type); NUDC was identified, and its prognostic role was studied. Materials and Methods: We performed next-generation sequencing with 5 well-differentiated gastric cancers and 3 of signet ring cell gastric cancer surgical samples. We performed gene enrichment and functional annotation analysis using the Database for Annotation, Visualization and Integrated Discovery bioinformatics resources. Immunohistochemistry was used to validate NUDC expression. Results: Overall, 900 genes showed significantly higher expression, 644 genes showed lower expression in signet ring cell gastric cancer than in well-differentiated gastric cancers, and there was a large difference in adhesion, vascular development, and cell-to-cell junction components between the 2 subtypes. We performed variant analysis and found 52 variants and 30 cancer driver genes, including NUDC. We analyzed NUDC expression in gastric cancer tissue and its relationship with prognosis. Cox proportional hazard analysis identified T stage, N stage, and NUDC expression as independent risk factors for survival ( P < 0.05). The overall survival of the NUDC-positive group was significantly higher (53.2 ± 0.92 months) than that of the NUDC-negative group (44.6 ± 3.7 months) ( P = 0.001) in Kaplan-Meier survival analysis. Conclusion: We found 30 cancer driver gene candidates and found that the NUDC-positive group showed significantly better survival than the NUDC-negative group via variant analysis.

Signet ring cell

10.1177/15330338211019501

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Citations (4)

MiR‑221 and miR‑222 regulate cell cycle progression and affect chemosensitivity in breast cancer by targeting ANXA3

Experimental and Therapeutic Medicine (2023)

Ju‐Yeon Kim Eun‐Jung Jung Jae‐Myung Kim Youngsim Son Han Shine Lee

Breast malignancy remains one of the most common causes of cancer‑associated mortalities among women. MicroRNA (miR)‑221 and miR‑222 are homologous miRs and have a substantial impact on cancer progression. In the present study, the regulatory mechanisms of miR‑221/222 and its target annexin A3 (ANXA3) in breast cancer cells were investigated. Breast tissue samples were collected to evaluate the expression patterns of miR‑221/222 levels in breast cancer cell lines and cancer tissues according to clinical characteristics. The levels of miR‑221/222 were increased or decreased in cancer cell lines compared with normal breast cell lines according to cell line subtype. Subsequently, the changes in the progression and invasion of breast cancer cells were investigated using cell proliferation, invasion assay, gap closure and colony formation assays. Western blotting of cell cycle proteins and flow cytometry were performed to evaluate the possible pathway of miR‑221/222 and ANXA3 axis. Chemosensitivity tests were performed to explore the suitability of the miR‑221/222 and ANXA3 axis as a therapeutic target in breast cancer. The expression levels of miR‑221/222 were associated with aggressive characteristics of breast cancer subtypes. Cell transfection assay demonstrated the regulation of breast cancer proliferation and invasiveness by miR‑221/222. MiR‑221/222 directly targeted the 3'‑untranslated region of ANXA3 and suppressed the expression of ANXA3 at the mRNA and protein levels. In addition, miR‑221/222 negatively regulated cell proliferation and the cell cycle pathway in breast cancer cells by targeting ANXA3. In combination with adriamycin, downregulation of ANXA3 may sensitize adriamycin‑induced cell death to induction of persistent G₂/M and G₀/G₁ arrest. Decreased expression of ANXA3 through increased expression of miR‑221/222 reduced breast cancer progression and increased the effectiveness of the chemotherapy drug. The present results indicated the miR‑221/222 and ANXA3 axis to be a possible novel therapeutic target for the treatment of breast cancer.

10.3892/etm.2023.11826

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Citations (15)