Xinhui Li

State Forestry and Grassland Administration

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James C. Eisenach

Brigham and Women's Hospital

Vince D. Calhoun

Center for Translational Research in Neuroimaging and Data Science

Zhi‐Qiang Xiao

Central South University

Yi Hong

Guizhou University

Maoyu Li

Shandong Provincial Hospital

Michael P. Milham

Child Mind Institute

Pengfei Zhang

Sichuan University

Xueping Feng

Central South University

Zhuchu Chen

Central South University

Bin Yi

Central South University

Cooperative Institutions

Chinese Academy of Sciences

Central South University

Chongqing Medical University

Xiangya Hospital Central South University

National Institutes of Health

First Affiliated Hospital of Chongqing Medical University

Sun Yat-sen University

Shanghai Jiao Tong University

Centre National de la Recherche Scientifique

University of Chinese Academy of Sciences

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The anti-malarial atovaquone selectively increases chemosensitivity in retinoblastoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition

Biochemical and Biophysical Research Communications (2018)

Ke Feng Jinqiang Yu Wei Chen Xiaomin Si Xinhui Li

Retinoblastoma

Atovaquone

10.1016/j.bbrc.2018.06.049

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Citations (27)

Moving Beyond Processing and Analysis-Related Variation in Neuroscience

bioRxiv (Cold Spring Harbor Laboratory) (2021)

Xinhui Li Nathália Bianchini Esper Lei Ai Steve Giavasis Hecheng Jin

Abstract When fields lack consensus standard methods and accessible ground truths, reproducibility can be more of an ideal than a reality. Such has been the case for functional neuroimaging, where there exists a sprawling space of tools and processing pipelines. We provide a critical evaluation of the impact of differences across five independently developed minimal preprocessing pipelines for functional MRI. We show that even when handling identical data, inter-pipeline agreement was only moderate, critically shedding light on a factor that limits cross-study reproducibility. We show that low inter-pipeline agreement mainly becomes appreciable when the reliability of the underlying data is high, which is increasingly the case as the field progresses. Crucially, we show that when inter-pipeline agreement is compromised, so too are the consistency of insights from brainwide association studies. We highlight the importance of comparing analytic configurations, as both widely discussed and commonly overlooked decisions can lead to marked variation.

Variation (astronomy)

10.1101/2021.12.01.470790

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Citations (49)

Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke

Molecular Medicine Reports (2021)

Jin Wang Zun Zhang Shaojing Fu Xiaojie Li Xinhui Li

Ischemic stroke is one of the most common diseases that has a high rate of mortality, and has become a burden to the healthcare system. Previous research has shown that EPH receptor B4 (EphB4) promotes neural stem cell proliferation and differentiation in vitro. However, little is known regarding its role in the neurogenesis of ischemic stroke in vivo. Thus, the present study aimed to verify whether EphB4 was a key regulator of neurogenesis in ischemic stroke in vivo. Cerebral ischemia was induced in C57BL/6J mice via middle cerebral artery occlusion (MCAO), followed by reperfusion. Immunofluorescence staining was performed to evaluate the effect of EphB4 on the neurogenesis in cerebral cortex. The levels of inflammatory cytokines were determined using an ELISA kit. The expression levels of ABL proto‑oncogene 1, non‑receptor tyrosine kinase (ABL1)/Cyclin D1 signaling pathway‑related proteins were detected via western blotting. The current findings indicated that EphB4 expression was significantly increased in the cerebral cortex of MCAO model mice in comparison with sham‑operated mice. Moreover, EphB4 appeared to be expressed in neural stem cells (Nestin+), and persisted as these cells became neuronal progenitors (Sox2+), neuroblasts [doublecortin (DCX)+], and eventually mature neurons [neuronal nuclei (NeuN)+]. Overexpression of EphB4 elevated the number of proliferating (bromodeoxyuridine+, Ki67+) and differentiated cells (Nestin+, Sox2+, DCX+ and NeuN+), indicating the promoting effect of EphB4 on the neurogenesis of ischemic stroke. Furthermore, EphB4 overexpression alleviated the inflammation injury in MCAO model mice. The expression levels of proteins‑related to the ABL1/Cyclin D1 signaling pathway were significantly increased by the overexpression of EphB4, which suggested that restoration of EphB4 promoted the activation of the ABL1/Cyclin D1 signaling pathway. In conclusion, this study contributes to the current understanding of the mechanisms of EphB4 in exerting neurorestorative effects and may recommend a potential new strategy for ischemic stroke treatment.

NeuN

Nestin

Doublecortin

Brain ischemia

10.3892/mmr.2021.12396

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Citations (3)

Painful heating for evaluating trigeminal small nerve fiber function in patients with migraine

Zhonghua wuli yixue zazhi (2016)

Guoping Yan Dawei Zang Xinhui Li Xiaoxia Wang

Objective To study any functional changes in the trigeminal nociceptive system in cases of migraine with aura (MWA) using painful heat-evoked potentials (CHEPs), and to explore the value of CHEP in evaluating the trigeminal small nerve fibers of patients with MWA. Methods Sixty patients with MWA were recruited as the MWA group, and 60 healthy persons were selected as a normal control group. Thermal stimulation at 51 ℃ was applied to the skin above the patients' right and left eyebrows. The N wave latencies and N-P amplitudes of the CHEPs were recorded at the vertex (Cz) of the head. The intensity of the stimulus was graded using a visual analogue scale (VAS). Results In the control group the simulation produced no significant differences in the N550 or P750 latencies or in the N-P amplitudes. In the MWA group no significant differences were observed when the headache side was stimulated, but the N550 and P750 latencies were both significantly shorter than those of the control group and the N-P amplitude was significantly greater than that of the control group. The average VAS score on both sides in the patients with migraine was significantly higher than those of the control group. However, there was no significant difference in average VAS scores between the headache and non-headache sides of the patients with migraine. Conclusions CHEP is a reliable method for detecting any pathological changes in the trigeminal small nerve sensory pathway. Increased cutaneous allodynia in acute migraine attacks is detectable using CHEPs. Key words: Pain; Heat-evoked potentials; Migraine; Aura; Trigeminal nerves

Trigeminal Nerve

Allodynia

10.3760/cma.j.issn.0254-1424.2016.03.015

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A study on the application of Servperf model in measuring obstetrical care service quality

The Journal of practical nursing (2015)

Wang Ping-fang Yue Yun Qijiang Wan Xinhui Li

Objective We aimed to explore the value of Servperf model in evaluation of nursing service quality of obstetrics. Methods This survey was conducted by modified Servperf model. A total of 315 maternal in obstetrics of a certain hospital in Xinjiang province were studied. Results The total scores of nursing service quality in obstetrics were (117.78±17.60) and score index was 81.2%. The score index from high to low for each dimension turned out as: the score of assurance was (37.09 ± 5.15), and score index was 82.4%; the score of reliability was (12.19 ± 2.08) and score index was 81.3%; the score of care was (32.27 ± 5.13) and score index was 80.7%; the score of responsiveness was (36.24 ± 6.13) and score index was 80.5%. The maternal who had different occupations, hospitalization days, education levels and perceived health status had significant difference in perception of nursing service quality. Conclusions On the basis of ensuring assurance and reliability, nursing managers should give priorities to responsiveness and empathy care in terms of nursing service quality. In addition, nursing interventions should be given according to influencing factors in order to effectively improve nursing service quality of obstetrics. Key words: Servperf model; Nursing; Obstetrics; Quality evaluation

10.3760/cma.j.issn.1672-7088.2015.01.020

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Hematoma Ventricle Distance on Computed Tomography Predicts Poor Outcome in Intracerebral Hemorrhage

Frontiers in Neuroscience (2020)

Lan Deng Yundong Zhang Jian-Wen Ji Wen‐Song Yang Wei Xiao

Objective To investigate the relationship between hematoma ventricle distance (HVD) and clinical outcome in patients with intracerebral hemorrhage (ICH). Methods We prospectively enrolled consecutive patients with ICH in a tertiary academic hospital between July 2011 and April 2018. We retrospectively reviewed images for all patients receiving a computed tomography (CT) within 6 h after onset of symptoms and at least one follow-up CT scan within 36 h. The minimum distance of hematoma border to nearest ventricle was measured as HVD. Youden index was used to evaluate the cutoff of HVD predicting functional outcome. Logistic regression model was used to assess the HVD data and clinical poor outcome (modified Rankin Scale 4–6) at 90 days. Results A total of 325 patients were included in our final analysis. The median HVD was 2.4 mm (interquartile range, 0–5.7 mm), and 119 (36.6%) patients had poor functional outcome at 3 months. After adjusting for age, admission Glasgow coma scale, intraventricular hemorrhage, baseline ICH volume, admission systolic blood pressure, blood glucose, hematoma expansion, withdrawal of care, and hypertension, HVD ≤ 2.5 mm was associated with increased odds of clinical poor outcome [odd ratio, 3.59, (95%CI = 1.72–7.50); p = 0.001] in multivariable logistic regression analysis. Conclusion Hematoma ventricle distance allows physicians to quickly select and stratify patients in clinical trials and thereby serve as a novel and useful addition to predict ICH prognosis.

Interquartile range

Cerebral Ventriculography

10.3389/fnins.2020.589050

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Citations (6)

U-net model for brain extraction: Trained on humans for transfer to non-human primates

NeuroImage (2021)

Xindi Wang Xinhui Li Jae Wook Cho Brian E. Russ Nanditha Rajamani

Brain extraction (a.k.a. skull stripping) is a fundamental step in the neuroimaging pipeline as it can affect the accuracy of downstream preprocess such as image registration, tissue classification, etc. Most brain extraction tools have been designed for and applied to human data and are often challenged by non-human primates (NHP) data. Amongst recent attempts to improve performance on NHP data, deep learning models appear to outperform the traditional tools. However, given the minimal sample size of most NHP studies and notable variations in data quality, the deep learning models are very rarely applied to multi-site samples in NHP imaging. To overcome this challenge, we used a transfer-learning framework that leverages a large human imaging dataset to pretrain a convolutional neural network (i.e. U-Net Model), and then transferred this to NHP data using a small NHP training sample. The resulting transfer-learning model converged faster and achieved more accurate performance than a similar U-Net Model trained exclusively on NHP samples. We improved the generalizability of the model by upgrading the transfer-learned model using additional training datasets from multiple research sites in the Primate Data-Exchange (PRIME-DE) consortium. Our final model outperformed brain extraction routines from popular MRI packages (AFNI, FSL, and FreeSurfer) across a heterogeneous sample from multiple sites in the PRIME-DE with less computational cost (20 s~10 min). We also demonstrated the transfer-learning process enables the macaque model to be updated for use with scans from chimpanzees, marmosets, and other mammals (e.g. pig). Our model, code, and the skull-stripped mask repository of 136 macaque monkeys are publicly available for unrestricted use by the neuroimaging community at https://github.com/HumanBrainED/NHP-BrainExtraction.

Transfer of learning

Sample (material)

Non human primate

10.1016/j.neuroimage.2021.118001

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Citations (53)

Analysis of health literacy level and its influence factors among rural residents in manas county of xinjiang

AIP conference proceedings (2020)

Runlin Liu Xinhui Li Qin Yuan

To investigate the status and influencing factors of health literacy level among rural residents in Manas County, Xinjiang, and to provide evidence for formulating health education strategies. From April 2018 to July 2018, a stratified sampling method was used to conduct a questionnaire survey of 776 residents who met the inclusion criteria in 4 townships of Manas County. The results showed that the health literacy level of residents in Manas County was 8.6%, among which the basic knowledge and concept, healthy lifestyle and behavior, and health skills were 22.8%, 8.0%, and 9.5%, respectively. Safety and first aid literacy was 86.6%. Scientific health concept literacy 64.6%, chronic disease prevention and control literacy 24.2%, health information literacy 12.5%, basic medical literacy 5.9% and infectious disease prevention literacy 5.0%; logistic regression analysis showed that the main factor affecting the health literacy of rural residents in Manas County is ethnic (OR=4.333), educational level (OR=2.697, 4.711, 20.188) and annual household income (OR=4.164, 10.589). Ethnic minorities, low educational level and low-income residents should be paid attention to when formulating health education strategies.

Health Literacy

Stratified Sampling

10.1063/5.0020960

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The Reason of the Interlanguage Fossilization and Its Enlightenment to Foreign Language Teaching

Journal of Qingdao Ocean Shipping Mariners College (2005)

Xinhui Li

Interlanguage fossilization is an very important study field in second language acquisition.There are a lot of factors that result in interlanguage fossilization. We just introduce three of them in this paper:the in-ternal reason,the external reason and the interactive theory.The analysis of the factors that cause the fossiliza-tion and the classification of the fossilization have great practical significance in foreign language teaching.

Fossilization

Interlanguage

Foreign language teaching

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食用アヒルの生産パフォーマンス,屠畜体,血液生化学指標へのカテキンの影響

Hunan Nongye Daxue Xuebao. Zirankexueban (2007)

Liang Zeng Zhonghua Liu He Jianhua Tian Lili Xinhui Li

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