Objective To observe clinical curative effect investigation of Ganju Bingmei tablets on chronic laryngitis.Methods 180 patients were randomly divided into two groups. The control group was treated with oral antibiotic、atomization inhalation,The treatment group was treated with Ganju Bingmei tablets.Observe the clinical effective rate,examinated voice acoustic analysis,discuss on effects of chronic laryngitis on laryngeal vocal function.Results The total effective rate of the treatment group was 77.8%,the total effective rate of the control group was 61.1%. The total effective rate was significant differences in the two groups (P0.05) after treatment ,Voice acoustic analysis:jitter、NNE in the treatment group before and after therapy had significant meaning(P0.01),the difference of shimmer in the two groups has significant meaning(P0.05).Conclusion There was a good effect of Ganju Bingmei tablets in treatment of chronic laryngitis,it is worth of be recommended in the clinical application.
ABSTRACT Incomplete Miller‐Fisher syndrome (MFS) is a rare autoimmune disorder affecting the nervous system. In contrast to classical MFS, its clinical manifestations are often atypical and may be characterized by the absence of certain features, such as extraocular muscle paralysis and the loss of tendon reflexes. The presence of anti‐GD3 antibodies is infrequently observed in these patients. This case report describes a patient diagnosed with incomplete MFS who exhibited positive anti‐GD3 antibody results and presented with pyramidal tract signs. This suggests that anti‐GD3 antibodies may play a role in the pathogenesis of some atypical forms of MFS, warranting attention in clinical practice.
Objective: To investigate the mRNA expression and its differences of vitamin D receptor (VDR) and renin, angiotensin II receptor type 1 and type 2 (AT1R and AT2R) in patients with essential hypertension(EH) in Xinjiang Han, Uyghur and Kazak nationality. Design and Method: 204 EH outpatients and inpatients (including Han, Uyghur and Kazak populations), were recruited from hypertensive department, the First Affiliated Hospital of Xinjiang Medical University during September 2013 to April 2014. And during the same period, 208 healthy control subjects were recruited from the medical examination center of the same hospital. VDR, renin, AT1R and AT2R mRNA expressions in peripheral blood were detected by real-time quantitative polymerase chain reaction (qPCR). Results: There were statistically significant differences for the mRNA expression on VDR, renin, AT1R and AT2R level in research objects with high blood pressure or not or belong to different nationalities system, and there are interactions between blood pressure factor and the ethnic factor. VDR mRNA of EH subjects was reduced, especially for Uyghur EH subjects, while rennin and AT1R mRNA were increased in Han and Uyghur EH subjects. In the Kazak population, there were no significant difference in such indicators between EH patients and control cases. Multiple linear regression analysis showed that VDR mRNA was negatively related to renin mRNA and AT1RmRNA in Han and Uyghur population. Conclusions: The mRNA expression of VDR was reduced while rennin and AT1R were increased and VDR mRNA was negatively correlated with renin and AT1RmRNA in Han and Uyghur EH group. There were ethnic differences in mRNA expressions of VDR, renin and AT1R between Han, Uyghur and Kazak nationalities.
To observe the effects of heroin on intracellular free Ca2+ in rat myocardium.The effects of heroin on intracellular free Ca2+ were observed in cultured neonatal rat myocardium by measuring intracellular free Ca2+ concentration using calcium fluorescent probe Flou-3/AM and laser scanning confocal microscope.Different doses and concentrations of heroin appeared to have different effects on intracellular free Ca2+ concentrations, with a dosage dependent short linear increase in the fluorescence intensity (i.e., Ca2+ concentration) leading to [Ca2+]i peak.Heroin could affect concentrations of [Ca2+]i in myocardium and its dosage related effect needs further investigation.
The etiology and pathogenesis of dermatosis mainly include zang-fu disharmony,derangement of qi and blood,blockage of channel,exogenous pathogenic factors and so on in TCM.Conventional therapy based on pathogenesis may lead to the negligence of classic formulae in the textbook and clinic.The theory of formula corresponding to syndromes,which is based on clinical experience and classics,is a unique model contained in classics of TCM when we diagnose and treat diseases.Making symptoms and signs as the therapeutic targets,related formula is selected directly according to formula syndrome differentiation.Under the guidance of the principle of formulae corresponding to syndromes,we successfully treated chronic urticaria by bupleurum and cinnamon decoction,guizhi decoction and mahuang lianqiao chixiaodou decoction,cutaneous pruritus by maxing yi gan decoction.
Objective To explore the clinical characteristics of peripheral neuropathy in patients with occupational chronic arsenic poisoning,and to provide the scientific evidence for the early diagnosis.Methods The associativity between peripheral neuropathy and arsenic level in hair was evaluated in 72 patients with occupational chronic arsenic poisoning by correlative statistical analysis.Results The chief symptoms of these patients were acratia and limbs anesthesia.The arsenic level in hair was negatively correlated with nervous conductive velocity(NCV),but positively correlated with the latent phase of peripheral nerve(LPN).The higher the arsenic level in hair,the more obvious the lesion of peripheral nerve.Conclusions Slowed NCV and prolonged LPN are the dominant pathological changes for the peripheral neuropathy of occupational chronic arsenic poisoning.There is an obvious relationship between the impaired degree of peripheral neuropathy and the increasing arsenic level in hair.The results suggest that there is an apparent relationship between peripheral neuropathy for chronic exposure to arsenic and accumulated arsenic level in human body.
This study aims to investigate the expression and significance of the αvβ6 integrin, collagen fibres and matrix metalloproteinases (MMP)-3 in oral squamous cell carcinoma (OSCC) and to analyse the possible regulatory relationships between αvβ6, collagen fibres and MMP-3.A series of 80 patients (mean age 56.4 years) diagnosed with OSCC were enrolled. Associations between αvβ6, MMP-3, collagen fibre expression levels and clinicopathological parameters were evaluated using the Fisher exact test. Survival analysis was performed with Kaplan-Meier curves. Spearman rank correlation was used to analyse interactions between αvβ6, MMP-3 and collagen fibres.αvβ6 and MMP-3 were strongly expressed in human OSCC, especially at the peripheral borders of invasive tumour islands, and collagen fibres were generally disrupted and degraded in the same areas. The expression intensity of αvβ6 was associated with the differentiation state of cells. β6 mRNA was expressed in almost all cancer cells. In carcinomas, αvβ6 and MMP-3 expression were correlated with the distribution of collagen fibres.Tumour cells highly expressing αvβ6 have a strong capability for invasion and migration, due to concomitant protease production and the destruction and remodelling of collagen fibres. Increased αvβ6 integrin and MMP-3 expression and collagen fibre changes in human OSCCs are related to unfavourable clinical prognostic factors and decreased survival.
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