Abstract To investigate the relationship between Helicobacter pylori (Hp) infection and the long-term outcome in acute coronary syndrome (ACS) patients with drug-eluting stent (DES) implantation and so as to explore the significance of Hp eradication therapy in preventing major adverse cardiac events (MACE) and upper gastrointestinal bleeding (UGIB). 539 ACS patients with DES implantation from January 1, 2010 to December 31, 2012 were analyzed. All the patients were divided into two groups according to the result of 13 C urea breath test. 253 patients with Hp infection were put into group A (Hp + ), and 286 cases without Hp infection were put into group B (Hp − ). Demographic data was collected and all patients went through biochemical indicators and other routine blood examinations. We explored the correlations of Hp infection with MACE and UGIB after 3 to 5 years of follow-up using survival analysis. Survival analysis showed that Hp infection was a predictor of MACE and UGI. Sub-group analysis showed that patients with Hp eradication therapy had no relationship with MACE but had a lower rate of UGIB than those without Hp eradication therapy.
Abstract Background: Prostate cancer is one of the most frequently diagnosed solid malignancies and is accountable for the second highest cancer-related deaths in males worldwide. Despite the success of targeting the androgen receptor signaling pathway with androgen deprivation therapy (ADT) and androgen receptor blockage (ARB), relapse and resistance to treatment leads to castration resistant prostate cancer (CRPC) or metastatic CRPC (mCRPC), resulting in poor clinical prognosis and therapeutic outcome. Prostate cancer is a highly heterogeneous disease, with different molecular pathways playing a role in the advanced disease, such as androgen receptor mutations, DNA repair gene deletions, P53 aberrations, RB1 function loss, as well as gene rearrangements, like TMPRSS2-ERG2. Preclinical models representing CRPC heterogeneity and clinically relevant responses to standard of care treatments are needed to better understand the biology and mechanisms of this malignancy. METHODS: CRPC PDX models derived from metastases of prostate cancer patients, which failed anti-androgen therapies, were established via subcutaneous engraftment in immunodeficient mice. Model classification and characterization were performed by histopathology and immunohistochemistry (IHC) with prostate-specific biomarkers. Genomic profiling of these models was performed by next generation sequencing (NGS). Chemotherapies such as docetaxel and target therapies, including anti-androgen, were evaluated in these prostate models. Tumor volume over time was used to determine growth rate and response to treatment in uncastrated and castrated mice. RESULTS: A series of CRPC PDX models derived from metastatic lesions in patients, including metastases from lymph nodes, bladder, ascites and rib/soft bone, were established and characterized. Histopathology by H&E staining presented distinct features of adenocarcinoma and the immunohistochemistry data indicated various expression levels of prostate-specific markers, such as prostate-specific antigen (PSA) and androgen receptor (AR). Most of the models showed loss of PTEN expression. Sequencing data also detected different gene aberrations such as TMPRSS2-ERG fusion, TP53 deletion and mutations, RB1 mutations, and AR alterations. In vivo modeling of these models presented tumor progression under castration. Docetaxel and enzalutamide, commonly used in mCRPC patients, presented varied responses. CONCLUSIONS: Prostate cancer presents high heterogenicity in clinical and molecular features, and treatment response. A panel of mCRPC PDX models have been established and characterized to provide clinically relevant preclinical models for prostate cancer therapeutic evaluation. Citation Format: Jessie Jingjing Wang, Leilei Chen, Xueying Yang, Likun Zhang, Wubin Qian, Henry Qixiang Li. Establishment and characterization of a panel of advanced prostate cancer patient-derived xenograft (PDX) models for cancer therapeutic evaluation [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2021 Oct 7-10. Philadelphia (PA): AACR; Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P005.
Translationally controlled tumor protein (TCTP) is a highly conserved and ubiquitously expressed protein in all eukaryotes—highlighting its important functions in the cell. Previous studies revealed that TCTP is implicated in many biological processes, including cell growth, tumor reversion, and induction of pluripotent stem cell. A recent study on the solution structure from fission yeast orthologue classifies TCTP under a family of small chaperone proteins. There is growing evidence in the literature that TCTP is a multifunctional protein and exerts its biological activity at the extracellular and intracellular levels. Although TCTP is not a tumor-specific protein, our research group, among several others, focused on the role(s) of TCTP in cancer progression. In this paper, we will summarize the current scientific knowledge of TCTP in different aspects, and the precise oncogenic mechanisms of TCTP will be discussed in detail.
In the process of combating the coronavirus disease 2019 (COVID-19) epidemic, medical personnel were at the forefront of the fight. As the future medical workforce, medical students often experienced firsthand how their seniors and teachers had to commit to working hard in combating the epidemic. Many were directly involved in the front line of the fight and that experience could easily have affected their intention to seek employment in a medically related career.The study intended to evaluate the impact of the COVID-19 pandemic on Chinese medical students' employment intentions and the factors associated with them to put forward relevant suggestions to provide a basis for medical education in the future.The research team conducted a cross-sectional study, using an anonymous online questionnaire.The study took place in many provinces and cities in China and was conducted in an online questionnaire.Participants were 1114 college students studying clinical medicine, college students studying nursing, and students interning during standardized resident training, medical interns.The participants completed a self-administered questionnaire, which investigated their psychological statuses related to anxiety and depression as well as COVID-19's impact on their intentions related to job searches, regarding their willingness to engage in clinical or basic research in epidemic-related specialties and epidemic-related work.Compared to college students studying clinical medicine, the employment intentions of nursing students and medical interns were more vulnerable to the epidemic. Females and nursing students were more reluctant to choose clinical work, and the choice was associated with depression. Nursing college students and medical interns were significantly less willing to engage in infection medicine, respiratory medicine, and intensive care medicine (all P < .001). Medical students with a bachelor's degree and postgraduate degrees were significantly less willing to engage in infection medicine and respiratory medicine (all P < .001), but medical students from regions with stable epidemics were more willing to engage in intensive care medicine. Medical students with a bachelor's degree were significantly less likely to be involved in epidemiology-related work than undergraduate students, and students from severe epidemic regions were significantly less willing to work in isolation wards or to go to Wuhan as volunteers.Participants' psychological statuses related to anxiety and depression, genders, degrees, current educational statuses, and regions affected employment intentions during the epidemic.
<p>The total mRNA levels of AZIN1 (left panel) and FLNB (right panel) in 69 matched pairs of ESCC and NT specimens in Cohort 1 (Paired Student's t test).</p>
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