Libo Li

Second Affiliated Hospital of Xi'an Jiaotong University

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Qiaojun Zhang

Second Affiliated Hospital of Xi'an Jiaotong University

Yanping Hui

Second Affiliated Hospital of Xi'an Jiaotong University

Yih‐Ing Hser

University of California, Los Angeles

Elizabeth Evans

University of Massachusetts Amherst

Bohdan Nosyk

Simon Fraser University

Zhongheng Wu

Second Affiliated Hospital of Xi'an Jiaotong University

Darren Urada

University of California, Los Angeles

Wu Xiang

Second Affiliated Hospital of Xi'an Jiaotong University

David Huang

University of North Carolina at Chapel Hill

Yihua Bai

Second Affiliated Hospital of Xi'an Jiaotong University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Second Affiliated Hospital of Xi'an Jiaotong University

Xi'an Jiaotong University

Peking Union Medical College Hospital

University of California, San Francisco

Sichuan University

Central South University

Capital Medical University

Qiqihar Medical University

Southern Medical University

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Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model

Folia Neuropathologica (2023)

Hua Rong Xiaoming Li YU Chun-lei Wenbao Wang Libo Li

AMA Rong H, Li X, Yu C, et al. Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.133039. APA Rong, H., Li, X., Yu, C., Wang, W., Li, L., & Xu, T. et al. (2023). Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model. Folia Neuropathologica. https://doi.org/10.5114/fn.2023.133039 Chicago Rong, Hua, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, and Yisong Ding et al. 2023. "Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model". Folia Neuropathologica. doi:10.5114/fn.2023.133039. Harvard Rong, H., Li, X., Yu, C., Wang, W., Li, L., Xu, T., Ding, Y., Su, Y., and Wang, X. (2023). Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model. Folia Neuropathologica. https://doi.org/10.5114/fn.2023.133039 MLA Rong, Hua et al. "Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model." Folia Neuropathologica, 2023. doi:10.5114/fn.2023.133039. Vancouver Rong H, Li X, Yu C, Wang W, Li L, Xu T et al. Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.133039.

MPTP

Ecdysterone

10.5114/fn.2023.133039

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Transcranial direct current stimulation of the prefrontal cortex improves depression-like behaviors in rats with Parkinson's disease

Brain Research (2023)

Lei Zhang Yuan Guo Jian Liu Libo Li Yixuan Wang

Transcranial Direct Current Stimulation

Medial forebrain bundle

Neuromodulation

10.1016/j.brainres.2023.148649

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Pioglitazone protects PC12 cells against oxidative stress injury: An in vitro study of its antiapoptotic effects via the PPARγ pathway

Experimental and Therapeutic Medicine (2023)

Yali Li Jun Long Libo Li Ziyao Yu Yanjing Liang

To the best of our knowledge, the role of peroxisome proliferator-activated receptor γ (PPARγ) in oxidative stress-induced PC12 cell damage is unknown. Using a PC12 cell model with H2O2 treatment, the present study investigated the expression levels of apoptosis-related genes and neuronal apoptosis after oxidative stress injury. The present study further investigated the protective effect and mechanism of pioglitazone, a PPARγ agonist. PC12 cells treated with H2O2 were used as a model of oxidative stress injury. An MTT assay and flow cytometry were used to detect the effect of H2O2 on PC12 cell viability and the protective effect of pioglitazone. A TUNEL assay was used to detect neuronal apoptosis. The expression levels of PPARγ, Bax, Bcl-2 and caspase-3 were examined by reverse transcription-quantitative PCR and western blotting. H2O2 reduced PC12 cell viability in a dose- and time-dependent manner. H2O2 significantly upregulated the protein expression levels of Bax and the cleaved caspase-3/caspase-3 ratio (P<0.01), decreased the protein expression levels of Bcl-2 (P<0.01), and increased the apoptosis rate of PC12 cells. Pioglitazone significantly reduced the protein expression levels of Bax and the cleaved caspase-3/caspase-3 ratio (P<0.01), increased the expression levels of Bcl-2 (P<0.01), decreased the Bax/Bcl-2 expression ratio (P<0.01) and increased the viability of H2O2-damaged PC12 cells in a dose-dependent manner. Treatment with the PPARγ antagonist GW9662 or PPARγ small interfering RNA counteracted the protective effect of pioglitazone on PC12 cells to different extents (P<0.01). Therefore, the present study reported the role of PPARγ in protecting PC12 cells against oxidative stress injury, which may lead to novel therapeutic approaches for neurodegenerative diseases.

Pioglitazone

Viability assay

MTT assay

Bcl-2-associated X protein

10.3892/etm.2023.12221

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The diagnostic value of three‑dimensional CT angiography for patients with acute coronary artery disease

Experimental and Therapeutic Medicine (2018)

Libo Li Jing Hao Shi Qu Yancheng Fang

Computed tomography angiography (CTA) is an efficient method for the diagnosis of heart disease. However, few contemporary studies have evaluated the prognostic value of three-dimensional (3D)-CTA for patients with acute coronary artery disease. The aim of the present study was to investigate the diagnostic value of 3D-CTA for patients with acute coronary artery disease. A total of 136 patients with suspected acute coronary artery disease were recruited and received conventional coronary angiography (CCA) and 3D-CTA. 3D-CTA was used to assess calcified plaques in the coronary arteries (CCTA), the ratio of calcified plaque volume to vessel circumference (RVTC) and diagnostic accuracy. The results revealed that 3D-CTA was a more effective diagnostic method for identifying calcified plaques in patients with acute coronary artery disease compared with CCA. 3D-CTA demonstrated a significantly better area under curve, sensitivity, specificity, positive predictive value and negative predictive value compared with CCA (P<0.01). In the present study, 3D-CTA was used to successfully diagnose 86 patients with acute coronary artery disease, 34 with myocardial infarction and 16 with stable angina. 3D-CTA images clearly showed global noise levels and target-to-background ratios determined by manually delineated coronary plaque lesions compared with CCA. Furthermore, 3D-CTA was significantly better for discriminating ischemia compared with CCA (P<0.01). In conclusion, the results of the present study suggest that 3D-CTA provides superior diagnostic performance compared with CCA alone in patients with acute coronary artery disease.

Computed Tomography Angiography

Coronary arteries

Unstable angina

10.3892/etm.2018.6257

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Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas

Frontiers in Oncology (2023)

Jia Jiang Anjie Li Xiaolian Lai Hanqun Zhang Chonghong Wang

Colorectal cancer is a common malignancy, and the incidence and mortality rates continue to rise. An important factor in the emergence of inflammation-induced colorectal carcinogenesis is elevated cyclooxygenase-2. Prostaglandin E2 (PGE 2 ) over-production is frequently equated with cyclooxygenase-2 gene over-expression. PGE 2 can be assessed by measuring the level of prostaglandin’s main metabolite, PGE-M, in urine. Colorectal adenoma is a precancerous lesion that can lead to colorectal cancer. We conducted research to evaluate the association between urinary levels of the PGE-M and the risk of colorectal adenomas. In a western Chinese population, we identified 152 cases of adenoma and 152 controls patients without polyps. Adenoma cases were categorized into control, low-risk and high-risk groups. There was no significant change in PGE-M levels, between the control group and the low-risk adenoma group. In the high-risk group, the PGE-M levels were 23% higher than the control group. When compared to people with the lowest urine PGE-M levels (first quartile), people with greater urinary PGE-M levels had a higher chance of developing high-risk colorectal adenomas, with an adjusted odds ratio (95% CI) of 1.65 (0.76-3.57) in the fourth quartile group, (p= 0.013). We conclude urinary PGE-M is associated with the risk of developing high-risk adenomas. Urinary PGE-M level may be used as a non-invasive indicator for estimating cancer risk.

Colorectal adenoma

Quartile

10.3389/fonc.2023.1068469

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Author response for "Acute Intermittent Theta‐Burst Stimulation Produces Antidepressant‐Like Effects by Modulating Neuronal Oscillations and Serotonin Levels of the Medial Prefrontal Cortex in Experimental Parkinson's Disease"

Yixuan Wang Jian Liu Yanping Hui Zhongheng Wu Wu Xiang

10.1002/jnr.70022/v3/response1

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Client and program factors associated with dropout from court mandated drug treatment

Evaluation and Program Planning (2008)