Objective To study the effect of collagen peptide-chromium(Ⅲ) complex (CPCC) on the immunity in diabetic mice induced by alloxan. Methods A diabetic mouse model was set up by injecting alloxan i.p. The effects of collagen peptide-chromium(Ⅲ) complex on blood glucose,spleen index,thymus index,proliferation ability of spleen cells,NK cell killing activity and expression of CD40 and CD40L were assessed. Results Collagen peptide-chromium(Ⅲ) complex effectively prevented blood glucose rising in mice,had certain effect of restoration on spleen index and thymus index,enhanced the proliferation ability of spleen cells obviously,enhanced the NK cell killing activity and increased positive expression rates of CD40 and CD40L. Conclusion Collagen peptide-chromium(Ⅲ) complex can activate immune cells,restore and improve mouse immunological function,enhance mouse immunity,reduce the toxic effect of alloxan in certain extent,then reduce the the blood glucose level.

Alloxan

Cellular immunity

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STUDY ON THE PROTECTIVE EFFECTS OF POLYPEPTIDE-Fe ON ACUTE HEPATIC INJURY IN MICE

Acta Nutrimenta Sinica (2007)

Anjun Liu

Objective: To study the protective effects of polypeptide-Fe on acute hepatic injury induced by CCl4 in mice. Method:Mice model of acute hepatic injury was set up by CCl4 ig (50mg/kg·d ). and fed with polypeptide-Fe 67.5 mg/kg·d, 675 mg/kg·d and 2 025 mg/kg·d for 30 d respectively. The effects on serum ALT, AST, and ALP and liver TG, TC, GSH, MDA, and SOD avtivities were observed. Results: Polypeptide-Fe decreased the activities of ALT, AST, and ALP in serum and the levels of TG, TC, and MDA in liver, and increased the level of GSH in liver. Middle dosage group of polypeptide-Fe was the most effective one. Conclusion:Polypeptide-Fe showed significant antioxidant ability in protecting acute hepatic injury induced by CCl4 in mice.

CCL4

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STUDY ON THE STABILITY AND A NEW GANODERMA HEALTH-CARE DRINK TECHNIQUE OF PRODUCTION

Shipin yanjiu yu kaifa (2009)

Anjun Liu

Obtain the Ganoderma health care drink by liquid fermentation and test the drink stability. Get the polysaccharide fermentation broth by liquid fermentation,orthogonal test to determine the optimal formula of drink taste.Result,optimal formula fermentation fluid 10 % ,sucrose 6 % ,citric acid 0.07 % ,and drink's stability shows that pressure 25 MPa,pH6 and 68 ℃ sterlized 15 min,the drink has the best stability and taste.

Organoleptic

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Structural characterization of a low molecular weight Bletilla striata polysaccharide and antitumor activity on H22 tumor-bearing mice

International Journal of Biological Macromolecules (2022)

Chao Liu Keyao Dai Haiyu Ji Xiaoyu Jia Anjun Liu

Periodate

10.1016/j.ijbiomac.2022.02.073

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Preliminary Study of the Inhibitory Effect of Selenic Acid Cartilage Polysaccharide on Hca-F Hepatocarcinoma Tumor-bearing Mice

Anjun Liu

To study the inhibitory effect of selenic acid cartilage polysaccharide(CA-Se) on the Hca-F hepatomacarcinoma cell in mice,mice model was established by injecting hepatoma cell line Hca-F cells into their right axilla.Forty mice were divided into four groups,which were control group,model group,treated group and prevented group.Then the tumor-inhibition rate,spleen index(SI),thymus index(TI) and the HE staining of tumor cells were analyzed and the expression of Fas and PCNA proteins were studied by SP immunity histochemistry method.Result showed that CA-Se can inhibit liver cancer cells Hca-F of the mice,and the tumor-inhibition rate of the prevented group was higher than that of the treated group.The results of HE staining of tumor cells by paraffin slice also showed that most tumor cells of the treated group and prevented group were necrosis.The Fas protein expression rates of the treated group and prevented group were much higher than that of the model group,while the PCNA protein expression rates of the treated group and prevented group were much lower than that of the model group.It was concluded that CA-Se can inhibit the growth of Hca-F cells in mice,and can be used as a prophylactic agent to hepatocarcinoma

Group A

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