Song Gao

Ministry of Education of the People's Republic of China

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Corrine Ying Xuan Chua

Houston Methodist

Lynette M. Phillips

The University of Texas MD Anderson Cancer Center

Jason B. Fleming

The University of Texas Southwestern Medical Center

Paul J. Chiao

The University of Texas MD Anderson Cancer Center

Yuexin Liu

Ministry of Agriculture and Rural Affairs

Limei Hu

Southwest University

Rongfeng Hu

Anhui University of Traditional Chinese Medicine

Yan Sun

Tianjin University

Jihui Hao

Tianjin Medical University Cancer Institute and Hospital

He Ren

Beijing Shijitan Hospital

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Murdoch Children's Research Institute

Chinese Academy of Sciences

Sun Yat-sen University

South Australia Pathology

University of Melbourne

Anhui University of Traditional Chinese Medicine

China Medical University

Royal Children's Hospital

Victorian Clinical Genetics Services

Chinese Academy of Medical Sciences & Peking Union Medical College

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DNAチップ技術を用いて,IN VITROでの大腸菌の病原性遺伝子の発現を研究した。【JST・京大機械翻訳】

Weishengwu Xuebao (2008)

Haixia Huan Qiong Zhou Lixiang Zhao Song Gao Xiufan Liu

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不可逆电穿孔消融技术治疗兔肌肉VX 2 移植瘤的研究

肿瘤 (2016)

宁周雨 Ning Zhouyu Wang Peng Peng Wang Hao Chen

目的通过观察不可逆电穿孔(irreversible electroporation,IRE)消融技术应用于治疗兔肌肉VX 2 移植瘤的疗效及安全性,以期为该技术应用于临床提供可靠的实验依据。方法建立兔肌肉VX 2 移植瘤模型(10只),随机分为IRE治疗组(8只)和对照组(2只,不予以IRE治疗)。分别于IRE治疗的当日处死对照组的兔子、治疗后第1、3、5和14天时分批处死IRE治疗组的兔子(每组2只),同时收集血浆和血清;肿瘤组织行HE染色,并采用免疫组织化学法检测Bcl-2、热休克蛋白70(heat shock protein 70,HSP70)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在肌肉VX 2 移植瘤中的表达情况;应用TUNEL法检测移植瘤组织中细胞凋亡的情况;ELISA法检测血浆中caspase 3、肿瘤坏死因子α (tumor necrosis factor-α,TNF-α)和VEGF的分泌情况,以及血清中实验兔肝肾功能指标、肌酸激酶-MB同功酶(creatine kinase-MB isoenzyme,CK-MB)及心肌肌钙蛋白Ⅰ(cardiactroponin Ⅰ,CTn Ⅰ)的表达水平。结果 HE染色结果显示,IRE治疗组中治疗区域和正常组织区域边界清晰,IRE治疗后第3天时,移植瘤组织的边缘区可见大量红细胞以及炎性细胞的浸润,第14天时术区肌肉组织出现纤维化。ELISA法检测结果显示,IRE能有效地增加兔子机体中caspase 3和TNF-α的分泌水平( P 值均 P 值均 < 0.01),但HSP70的表达水平不一。TUNEL检测结果显示,IRE治疗组移植瘤组织中细胞的凋亡率明显增加。术后实验兔的肾功能未见明显异常,谷草转氨酶(aspartateaminotransferase,AST)、谷丙转氨酶(alanine transaminase,ALT)以及CK-MB的表达水平有不同程度的升高,但CTnⅠ的水平未见升高。结论 IRE能够通过诱导细胞凋亡、产生特异的抗肿瘤免疫效应及抑制血管生成来抑制肌肉移植瘤的生长,是一种安全且有效的肌肉肿瘤局部治疗的微创手段。

Irreversible Electroporation

10.3781/j.issn.1000-7431.2016.11.912

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Supplementary Table 3 from IGFBP2 Activates the NF-κB Pathway to Drive Epithelial–Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma

Song Gao Yan Sun Xuebin Zhang Limei Hu Yuexin Liu

Relationship of expression of nuclear p65, E-cadherin, and vimentin with lymph node metastasis in surgical PDAC specimens

Table (database)

10.1158/0008-5472.22412516.v1

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鼠伤寒沙门菌 rtsB 基因缺失株的构建及其生物学特性

信素华 Xin Su-Hua 王少辉 Shaohui Wang Wu Jun -

背景鼠伤寒沙门菌(Salmonella typhimurium)是一种重要的人畜共患病原菌，严重危害养殖业及人类健康。调控蛋白在病原菌的生存及感染过程中发挥重要作用。目的构建鼠伤寒沙门菌调控基因rtsB缺失株和互补株，分析调控蛋白RstB对鼠伤寒沙门菌生物学特性和致病性的影响。方法利用Red同源重组的方法构建鼠伤寒沙门菌SAT52的rtsB基因缺失株，并利用互补质粒构建互补株。然后比较分析野生株SAT52、缺失株∆rtsB和互补株C∆rtsB的生长特性、运动性、生物被膜形成能力、黏附入侵能力、胞内存活能力及致病性的差异。结果缺失rtsB基因不影响SAT52的生长速度，但导致运动能力增强，生物被膜形成能力减弱。细胞感染试验结果表明，rtsB基因有助于鼠伤寒沙门菌对Hela细胞的黏附入侵及RAW264.7细胞内的存活。动物试验结果表明rtsB基因缺失显著降低鼠伤寒沙门菌的致病力。结论rtsB基因在鼠伤寒沙门菌感染过程中发挥重要作用，可为阐释鼠伤寒沙门菌的致病机制提供参考。

10.13344/j.microbiol.china.190294

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supplementary information-R from PDSS2 Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism

Yan Li Shuhai Lin Lei Li Zhi Tang Yumin Hu

supplementary information (word)

Reprogramming

10.1158/0008-5472.22417164

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Research progress of engineering microbial cell factories for pigment production

Biotechnology Advances (2023)

Shumin Xu Song Gao Yingfeng An

Metabolic Engineering

Synthetic Biology

Industrial microbiology

Biological pigment

10.1016/j.biotechadv.2023.108150

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Polymer microneedles integrated with glucose-responsive mesoporous bioactive glass nanoparticles for transdermal delivery of insulin

Biomedical Physics & Engineering Express (2019)

Guohua Jiang Bin Xu Jiangying Zhu Yang Zhang Tianqi Liu

The traditional subcutaneous or intravenous injection of insulin can not effectively control the release of insulin, resulting in an unregulated the blood glucose levels on diabetic patients. It is urgently to develop a self-controllable insulin delivery system with high sensitivity to the change of blood glucose levels in vivo. In this work, polymer microneedles (MNs) integrated with glucose-responsive mesoporous bioactive glass nanoparticles (BGNs) for transdermal delivery of insulin had been developed for the self-regulate and painless transdermal administration. The hypoglycaemic drug (insulin) was loaded in the mesoporous BGNs that surface premodification by a composite enzyme layer (CEL). The CEL was consisted of polyethyleneimine (PEI), glucose oxidase (GOx) and catalase (CAT). The formed CEL could be used as the glucose-sensitive layer and 'gatekeeper' for the release of encapsulated insulin from mesoporous of BGNs. The glucose in CEL that diffused and penetrated from body fluids could be catalyzed to gluconic acid by GOx/CAT which caused the pH decrease in the CEL, resulting the structure destruction of CEL and leading to release of preloaded insulin from the BGNs. After the treatment of the as-prepared MNs on diabetic rats, a highly hypoglycemic effect and lower risk of hypoglycemia could be obtained. This study demonstrated that as-designed glucose-sensitive and pH-triggered transdermal delivery system was a promising strategy for the treatment of the diabetes.

Glucose oxidase

Gluconic acid

10.1088/2057-1976/ab3202

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Citations (32)

Duplex Detection of VibrioCholerae and VibrioParahaemolyticus by Real-time Recombinase Polymerase Amplification.

PubMed (2022)

Lei Liao Wen Shi Chao Ma Wen Lian Tang Qi Lan Qian

Recombinase Polymerase Amplification

Duplex (building)

10.3967/bes2022.148

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Polymeric Microneedles Integrated with Metformin-Loaded and PDA/LA-Coated Hollow Mesoporous SiO₂ for NIR-Triggered Transdermal Delivery on Diabetic Rats

ACS Applied Bio Materials (2018)

Yang Zhang Guohua Jiang Wenjie Hong Mengyue Gao Bin Xu

Herein, an NIR-responsive polymeric microneedle (MN) system incorporated with metformin-loaded and polydopamine/lauric-acid-coated (PDA/LA-coated) hollow mesoporous SiO2 has been developed for transdermal delivery of antidiabetic drug (metformin). First, an antidiabetic drug was loaded within hollow mesoporous SiO2 nanoparticles (HMSNs) by a diffusion method. Then, PDA as photothermal conversion agent and lauric acid (LA) as phase change material (PCM) were coated onto the HMSN to form NIR-responsive drug nanocarriers. Finally, these metformin-loaded and PDA/LA-coated HMSNs were encapsulated into poly(vinylpyrrolidone) (PVP) MNs. After insertion into skin tissue, LA could melt with the photothermal conversion of PDA under NIR light, thus enabling release of encapsulated metformin from MNs. The in vivo release behavior of metformin from MNs into skin was further studied to investigate its hypoglycemic effect on diabetic rats. Compared with the subcutaneous injection of metformin, the bioavailability of MN-NIR groups was 95.8 ± 2.7%. The antidiabetic drug can be precisely released by adjustment of exposure time and power densities of NIR light.

Nanocarriers

10.1021/acsabm.8b00470

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Site-selective immobilization of gold nanoparticles functionalized with DNA oligomers

Colloid & Polymer Science (2001)

Christof M. Niemeyer Bülent Ceyhan Song Gao Lifeng Chi St. Peschel

Oligomer

10.1007/s003960000429

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Citations (91)