Yumeng Wang

Shenyang Pharmaceutical University

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Co-Authors

Gordon B. Mills

Oregon Health & Science University

Han Liang

The University of Texas MD Anderson Cancer Center

John N. Weinstein

The University of Texas MD Anderson Cancer Center

Jun Li

Rush University Medical Center

Leng Han

Prevention Institute

Chad J. Creighton

Baylor College of Medicine

Yiling Lu

The University of Texas MD Anderson Cancer Center

Douglas A. Levine

Merck & Co., Inc., Rahway, NJ, USA (United States)

Nina Thiessen

Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Phillip H. Lai

University of Southern California

Cooperative Institutions

The University of Texas MD Anderson Cancer Center

292

Harvard University

228

Chinese Academy of Sciences

219

National Institutes of Health

193

Broad Institute

182

Dana-Farber Cancer Institute

166

Baylor College of Medicine

166

Heidelberg University

142

Chinese University of Hong Kong

141

Chinese Academy of Medical Sciences & Peking Union Medical College

140

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Poly(Dopamine) Coating on 3D-Printed Poly-Lactic-Co-Glycolic Acid/β-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering

Molecules (2019)

Zhimin Xu Ningning Wang Peng Liu Yidan Sun Yumeng Wang

Bone defects caused by osteoporosis, bone malignant tumors, and trauma are very common, but there are many limiting factors in the clinical treatment of them. Bone tissue engineering is the most promising treatment and is considered to be the main strategy for bone defect repair. We prepared polydopamine-coated poly-(lactic-co-glycolic acid)/β-tricalcium phosphate composite scaffolds via 3D printing, and a series of characterization and biocompatibility tests were carried out. The results show that the mechanical properties and pore-related parameters of the composite scaffolds are not affected by the coatings, and the hydrophilicities of the surface are obviously improved. Scanning electron microscopy and micro-computed tomography display the nanoscale microporous structure of the bio-materials. Biological tests demonstrate that this modified surface can promote cell adhesion and proliferation and improve osteogenesis through the increase of polydopamine (PDA) concentrations. Mouse cranial defect experiments are conducted to further verify the conclusion that scaffolds with a higher content of PDA coatings have a better effect on the formation of new bones. In the study, the objective of repairing critical-sized defects is achieved by simply adding PDA as coatings to obtain positive results, which can suggest that this modification method with PDA has great potential.

Glycolic acid

Biocompatibility

PLGA

Bone tissue

10.3390/molecules24234397

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Citations (49)

Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours

Nature Communications (2022)

Vinayak Bhandari Constance H. Li Robert G. Bristow Paul C. Boutros Lauri A. Aaltonen

Hypoxia

10.1038/s41467-022-32339-4

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Citations (0)

Vehicle Preventive Fault Detector and Data Acquisition Scheme

Advances in transdisciplinary engineering (2024)

Yumeng Wang Xin Wang Xu Zhang

Vehicle reliability is one of the important indicators for evaluating vehicle performance. Drivers or technicians often cannot detect or accurately determine the failure location and form in the early stage of vehicle component failure, which is very detrimental to the safety of vehicle users and the brand effect of production enterprises. Therefore, a set of automotive preventive fault detectors has been developed, which can be used on the complete vehicle and automotive component test benches. The detectors can monitor the status of various automotive components through sensors, evaluate and judge the vehicle status through software, and issue an alarm to the driver and test personnel when early failures may occur. Therefore, it can ensure the safety of vehicle users or test personnel, and is also beneficial for analyzing the initial status and cause of failure components. The equipment and testing method have been applied in the vehicle and component testing platform and the results indicate that the device can accurately determine the failure location and form in the early stage of component failure.

10.3233/atde240656

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Citations (0)

Additional file 10 of Comprehensive assessment of computational algorithms in predicting cancer driver mutations

Figshare (2020)

Hu Chen Jun Li Yumeng Wang Patrick Kwok‐Shing Ng Yiu Huen Tsang

Additional file 10. Performance metrics of 17 algorithms using default categorical predictions for benchmark 2.

10.6084/m9.figshare.11880453

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Citations (0)

Smartphone-based Retinal Imaging to Characterize Early Functional Retinal Vascular Changes in Diabetic Retinopathy

Carol Y. Cheung Yumeng Wang John H.K. Liu Kenny H.W. Lai Robert T. Chang

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Citations (0)

Re: Saxena et al.: Atropine for treatment of childhood myopia in India: multicentric randomized trial (Ophthalmology. 2021;128:1367-1369)

Ophthalmology (2021)

Xiu Juan Zhang Yumeng Wang Chi Pui Pang Jason C. Yam

10.1016/j.ophtha.2021.08.003

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Novel Compound Heterozygous CBS Mutations Cause Homocystinuria in a Han Chinese Family

Scientific Reports (2015)

Bo Gong Liping Liu Zhiwei Li Zimeng Ye Ying Xiao

Abstract The cystathionine β-synthase ( CBS ) gene has been shown to be related to homocystinuria. This study was aimed to detect the mutations in CBS in a Han Chinese family with homocystinuria. A four-generation family from Shandong Province of China was recruited in this study. All available members of the family underwent comprehensive medical examinations. Genomic DNA was collected from peripheral blood of all the participants. The coding sequence of CBS was amplified by polymerase chain reaction (PCR), followed by direct DNA sequencing. Among all the family members, three affected individuals showed typical clinical features of homocystinuria. Two novel compound heterozygous mutations in the CBS gene, c.407T > C (p. L136P) and c.473C > T (p.A158V), were identified by sequencing analysis in this family. Both of the two missense mutations were detected in the three patients. Other available normal individuals, including the patients’ parents, grand parents, her younger sister and brother in this family either carried one of the two mutations, or none. In addition, the two mutations were not found in 600 ethnically matched normal controls. This study provides a mutation spectrum of CBS resulting in homocystinuriain a Chinese population, which may shed light on the molecular pathogenesis and clinical diagnosis of CBS -associated homocystinuria.

Homocystinuria

Compound heterozygosity

Coding region

genomic DNA

10.1038/srep17947

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Citations (9)

When MicroRNAs Meet RNA Editing in Cancer: A Nucleotide Change Can Make a Difference

BioEssays (2017)

Yumeng Wang Han Liang

RNA editing is a major post‐transcriptional mechanism that changes specific nucleotides at the RNA level. The most common RNA editing type in humans is adenosine (A) to inosine (I) editing, which is mediated by ADAR enzymes. RNA editing events can not only change amino acids in proteins, but also affect the functions of non‐coding RNAs such as miRNAs. Recent studies have characterized thousands of miRNA RNA editing events across different cancer types. Importantly, individual cases of miRNA editing have been reported to play a role in cancer development. In this review, we summarize the current knowledge of miRNA editing in cancer, and discuss the mechanisms on how miRNA‐related editing events modulate the initiation and progression of human cancer. Finally, we discuss the challenges and future directions of studying miRNA editing in cancer.

ADAR

Inosine

10.1002/bies.201700188

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Citations (39)

Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology (2024)

Yanli Liu Zhuqing Zheng Chaohui Wang Yumeng Wang Xi Sun

Abstract Background Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality rate. Three-dimensional (3D) chromatin architecture takes part in disease processing by regulating transcriptional reprogramming. The study is carried out to investigate the alterations of hepatic 3D genome and H3K27ac profiling in early fatty liver (FLS) and reveal their effect on hepatic transcriptional reprogramming in laying hens. Results Results show that FLS model is constructed with obvious phenotypes including hepatic visible lipid deposition as well as higher total triglyceride and cholesterol in serum. A/B compartment switching, topologically associating domain (TAD) and chromatin loop changes are identified by high-throughput/resolution chromosome conformation capture (HiC) technology. Targeted genes of these alternations in hepatic 3D genome organization significantly enrich pathways related to lipid metabolism and hepatic damage. H3K27ac differential peaks and differential expression genes (DEGs) identified through RNA-seq analysis are also enriched in these pathways. Notably, certain DEGs are found to correspond with changes in 3D chromatin structure and H3K27ac binding in their promoters. DNA motif analysis reveals that candidate transcription factors are implicated in regulating transcriptional reprogramming. Furthermore, disturbed folate metabolism is observed, as evidenced by lower folate levels and altered enzyme expression. Conclusion Our findings establish a link between transcriptional reprogramming changes and 3D chromatin structure variations during early FLS formation, which provides candidate transcription factors and folate as targets for FLS prevention or treatment.

Reprogramming

Chromosome conformation capture

Transcription

10.1186/s40104-024-01001-y

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Citations (4)

IL-10-dependent Effect of Chinese Medicine Abelmoschus manihot on Alleviating Intestinal Inflammation and Modulating Gut Microbiota

The American Journal of Chinese Medicine (2023)

Chengxi Li Yumeng Wang Wenjing Zhang Shu Zhang Jianping Li

Inflammatory bowel disease (IBD) is a recurrent disease associated with a potential risk of colorectal cancer. Abelmoschus manihot (AM), a Chinese herbal medicine, is known to alleviate IBD. However, its mechanism of action requires further clarification. Here, we focused on the role of IL-10 and the gut microbiota in the mechanism of action of AM. The effects of AM on intestinal inflammation, mucus production, and gut microbes were evaluated in dextran sodium sulfate (DSS)-induced acute and chronic IBD models and in IL-10-deficient mice (IL-10[Formula: see text]). AM exhibited protective effects on acute and chronic models of IBD in wild-type mice by restoring body weight and colon length, promoting IL-10 secretion, and decreasing TNF-[Formula: see text] levels. Moreover, AM alleviated inflammatory infiltration, increased mucin 2 transcription, and increased the number of goblet cells in the colon. On the contrary, these effects were diminished in IL-10[Formula: see text] mice, which implied that the effect of AM on intestinal inflammation is IL-10-dependent. A gut microbial sequencing analysis showed that gut microbial dysbiosis was modulated by AM intervention. The regulatory effects of AM on Eggerthellaceae, Sutterellaceae, Erysipelotrichaceae, Burkholderiaceae, Desulfovibrionaceae, and Enterococcaceae were dependent on IL-10. These results revealed that AM ameliorated IBD and modulated gut microbes by promoting IL-10 secretion, indicating that AM has the potential to improve IBD and that AM is IL-10-dependent.

Dysbiosis

10.1142/s0192415x23500696

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Citations (1)