Zhidong Liu

Tianjin University of Traditional Chinese Medicine

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Mingbo Qiu

Nanjing University of Aeronautics and Astronautics

Zongjun Tian

Nanjing University of Aeronautics and Astronautics

Jiaxin Pi

Tianjin University of Traditional Chinese Medicine

Dongli Qi

Shenyang Ligong University

Lida Shen

Nanjing University of Aeronautics and Astronautics

Pan Guo

Tianjin University of Traditional Chinese Medicine

Baofa Jiang

Shandong University

Hongwei Pan

Nanjing University of Aeronautics and Astronautics

Dereje Kebebe

Jimma University

Huang Yin-hui

Beijing Forestry University

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Chinese Academy of Sciences

180

Tianjin University of Traditional Chinese Medicine

157

Nanjing University of Aeronautics and Astronautics

Sun Yat-sen University

University of Chinese Academy of Sciences

Shanghai Jiao Tong University

Capital Medical University

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

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Electrochemical polishing of monocrystalline silicon with specific crystallographic planes

Materials Science in Semiconductor Processing (2017)

Hao Chen Zhidong Liu Lida Shen Mingbo Qiu Zongjun Tian

10.1016/j.mssp.2017.04.027

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Citations (3)

[Lag effect and influencing factors of temperature on other infectious diarrhea in Zhejiang province].

PubMed (2019)

Haitao Wang Zhidong Liu Jiahui Lao Zhe Zhao Baofa Jiang

Objective: To study the lag effect of temperature and the source of heterogeneity on other infectious diarrhea (OID) in Zhejiang province, so as to identify related vulnerable populations at risk. Methods: Data on OID and meteorology in Zhejiang province from 2014 to 2016 were collected. A two-stage model was conducted, including: 1) using the distributed lag non-linear model to estimate the city-specific lag effect of temperature on OID, 2) applying the multivariate Meta- analysis to pool the estimated city-specific effect, 3) using the multivariate Meta-regression to explore the sources of heterogeneity. Results: There were 301 593 cases of OID in Zhejiang province during the study period. At the provincial level, temperature that corresponding to the lowest risk of OID was 16.7 ℃, and the temperature corresponding to the highest risk was 6.2℃ (RR=2.298, 95%CI: 1.527- 3.459). 16.7 ℃ was recognized as the reference temperature. P(5) and P(95) of the average daily temperature represented low and high temperature respectively. When the temperature was cold, the risk was delayed by 2 days, with the highest risk found on the 5(th) day (RR=1.057, 95%CI: 1.030-1.084) before decreasing to the 23(rd) day. When the temperature got hot, the risk of OID occurred on the first day (RR=1.081, 95%CI: 1.045-1.118) and gradually decreasing to the 8(th) day. Differences on heterogeneous sources related to the risks of OID in different regions, presented on urban latitude and the rate of ageing in the population. Conclusions: Both high or low temperature could increase the risk of OID, with a lag effect noticed. Prevention program on OID should be focusing on populations living in the high latitude and the elderly population at the low temperature areas.目的：研究气温对浙江省不同城市其他感染性腹泻的滞后效应，并探讨其异质性来源，找出脆弱人群。方法：收集2014－2016年浙江省其他感染性腹泻资料及同期气象资料。采用两阶段模型，首先在各个市利用分布滞后非线性模型评价气温对其他感染性腹泻的滞后效应，然后采用多变量Meta分析合并效应值，再通过Meta回归进一步探索其异质性来源。结果：研究期间浙江省共发生其他感染性腹泻301 593例。在全省水平上，其他感染性腹泻发病风险最低时对应的温度为16.7 ℃，以16.7 ℃作为参照温度，发病风险最高时对应的温度为6.2 ℃（RR=2.298，95%CI：1.527~3.459）。以日平均气温的P(5)、P(95)分别代表低温和高温，低温时其他感染性腹泻的发病风险滞后2 d显现，第5天时风险最高（RR=1.057，95%CI：1.030~1.084），然后持续降低至第23天。高温对应的发病风险当天就会出现（RR=1.081，95%CI：1.045~1.118），并逐渐减小至第8天。不同地区其他感染性腹泻发病风险差异的异质性来源有城市纬度及人口老龄化率。结论：高温或低温均会增加其他感染性腹泻的发病风险，且存在滞后效应。低温时应加强对高纬度地区人群及老年人群其他感染性腹泻的预防。.

Distributed lag

Maximum temperature

Lag time

10.3760/cma.j.issn.0254-6450.2019.08.016

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Citations (6)

Analysis of Glucose-6-Phosphate Dehydrogenase Genetic Polymorphism in the Hakka Population in Southern China

Medical Science Monitor (2018)

Zhixiong Zhong Heming Wu Bin Li Cunren Li Zhidong Liu

BACKGROUND In southern China, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a significant health problem. The aim of this study was to investigate the molecular epidemiological characteristic of the G6PD gene among Chinese Hakka in southern Guangdong province. MATERIAL AND METHODS We screened 611 unrelated subjects for G6PD genetic polymorphism analyzed by a gene chip analysis for common Chinese G6PD mutations. G-6-PD enzyme activity was determined by use of the G-6-PD quantitative detection kit. RESULTS Seven mutation sites were detected from subjects in our study. G6PD Canton (c.1376 G→T)(33.06%), G6PD Kaiping (c.1388 G→A)(30.67%), and polymorphism (c.1311 C→T)(25.89%) account for 89.62% of mutations, followed by G6PD Gaohe (c.95 A→G)(5.97%), G6PD Chinese-5 (c.1024 C→T)(3.58%), G6PD Maewo (c.1360 C→T)(0.39%), and G6PD Viangchan (c.871G→A)(0.39%). CONCLUSIONS We studied the genetic polymorphisms and frequencies of G6PD gene in the Hakka population of Meizhou. Our results coincide with the results among the Chinese Jiangxi Hakka population. It was consistent with previous research reports on Chinese people. There were differences in the results of reports from some other Asian populations. Our results could be useful for future prevention and control of G6PD deficiency aimed at the Chinese Hakka population.

Southern china

Glucose-6-Phosphate Dehydrogenase Deficiency

10.12659/msm.908402

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Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry

Asian Journal of Pharmaceutical Sciences (2018)

Pan Guo Nan Li Lili Fan Jun Lu Boying Liu

Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, and is extensively used in topical, transdermal, and oral pharmaceutical preparations as an emulsifier and absorption enhancer. Recent studies in our laboratory have indicated that labrasol has a strong absorption enhancing effect on different types of drugs in vitro and in vivo. This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Western blot, and immunohistochemical staining. The results indicated that labrasol obviously enhance the transcorneal permeability of fluorescein sodium, and the enhancement was realized by interacting with and down-regulating the associated proteins, such as F-actin, claudin-1 and β-catenin, which were contributed to cell-cell connections, respectively.

Ussing chamber

Paracellular transport

Penetration (warfare)

10.1016/j.ajps.2018.05.005

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Citations (14)

Partial Discharge Fault Diagnosis in Power Transformer Based on Symplectic Geometry Mode Decomposition and Optimized Convolutional Neural Networks

Haikun Shang Zhidong Liu Tao Huang Ranzhe Zhang Feng Li

To address challenges in feature extraction, such as difficulty in accurately extracting valuable information and low recognition accuracy during pattern recognition, this paper proposes a novel method for power transformer PD fault diagnosis based on symplectic geometry mode decomposition (SGMD) and optimized Convolutional Neural Networks (CNN). First, three different types of power transformer PD fault signals are extracted, namely floating discharge (FD), corona discharge (CD), and bubble discharge (BD), in a laboratory environment. Second, PD signals are decomposed using SGMD to obtain different symplectic geometric components (SGCs). Afterwards, approximate entropy (ApEn) values of each SGC are calculated as PD feature parameters. Subsequently, the sparrow search algorithm (SSA) algorithm is utilized to optimize and configure the CNN parameters to enhance the diagnostic accuracy and stability. Finally, the obtained feature parameters are fed into the optimized CNN for fault diagnosis. Simulation and experimental analysis verify the effectiveness of the proposed method.

10.2139/ssrn.4604844

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Influence of the physical properties of the layered oxyselenides Bi₂YO₄Cu₂Se₂ through Ni doping

RSC Advances (2023)

Lin Xu Jing‐Yuan Wu Zhidong Liu Weiao Kong Chuanhe Wang

A layered oxyselenide Bi 2 YO 4 Ni 2 Se 2 which has a similar crystal structure to KNi 2 Se 2 .

10.1039/d3ra03136e

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Improvement of part straightness accuracy by controlling discharge energy in WEDM

The International Journal of Advanced Manufacturing Technology (2023)

Cong Deng Zhidong Liu Hongwei Pan Mingbo Qiu

Electrical Discharge Machining

10.1007/s00170-023-11462-6

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Citations (2)

Detection for p53 protein and Ser15 phosphorylation levels in patients with non-small cell lung cancer.

Xiandai shengwu yixue jinzhan (2010)

Xiaoyun Song Shaofa Xu Zhidong Liu Liu ShuKu Shijie Zhou

Objective:To study p53 protein and the phosphorylation status of mutant p53 Ser(serine) 15 loci in non-small-cell lung cancer(NSCLC) tissue samples, and the relationships between p53 protein, the phosphorylation of p53 Ser15 and the clinicopathological characteristics and prognosis of NSCLC patients.Methods:Enzyme Linked-Immuno-Sorbent Assay(ELISA)and Immunohistochemical analysis were used to respectively examined the levels of p53 protein and p53 Ser15 phosphorylation in 50 paired samples obtained from dissected NSCLC and normal neighboring tissue, and 10 benign pulmonary disease samples.At same time metastasis and recrudescence of NSCLC patients was investigated at any time.Results:The levels of p53 protein and p53 [pS15] in NSCLC were significantly higher than those in benign pulmonary disease and normal tissue(p53 P0.001,p53 [pS15]P0.05).The rates of p53 protein and p53[pS15] positive in lymph nodal involvement was higher than no lymph nodal metastasis (P0.05).5 NSCLC with metastasis or recurrence exhibited high expression in p53 protein and p53 [pS15] during observation stage (P0.05).Conclusion:It is possible to quantitative analyse p53 protein and p53 [pS15] by ELISA .High expression in p53 protein and p53 [pS15] may have a growth advantage to tumour cells.

P53 protein

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The Impact of Environmental Regulation on Green TFP：A Quasi-Natural Experiment Based on China's Carbon Emissions Trading Pilot Policy

Energy (2024)

Zhongbo Jing Zhidong Liu Ting Wang Xuan Zhang

Natural experiment

Carbon fibers

10.1016/j.energy.2024.132357

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Citations (7)

Integrative analysis identifies two molecular and clinical subsets in Luminal B breast cancer

iScience (2023)

Huina Wang Bo Liu Junqi Long Jiangyong Yu Xinchan Ji

Comprehensive multiplatform analysis of Luminal B breast cancer (LBBC) specimens identifies two molecularly distinct, clinically relevant subtypes: Cluster A associated with cell cycle and metabolic signaling and Cluster B with predominant epithelial mesenchymal transition (EMT) and immune response pathways. Whole-exome sequencing identified significantly mutated genes including TP53, PIK3CA, ERBB2, and GATA3 with recurrent somatic mutations. Alterations in DNA methylation or transcriptomic regulation in genes (FN1, ESR1, CCND1, and YAP1) result in tumor microenvironment reprogramming. Integrated analysis revealed enriched biological pathways and unexplored druggable targets (cancer-testis antigens, metabolic enzymes, kinases, and transcription regulators). A systematic comparison between mRNA and protein displayed emerging expression patterns of key therapeutic targets (CD274, YAP1, AKT1, and CDH1). A potential ceRNA network was developed with a significantly different prognosis between the two subtypes. This integrated analysis reveals a complex molecular landscape of LBBC and provides the utility of targets and signaling pathways for precision medicine.

Exome

10.1016/j.isci.2023.107466

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Citations (7)