Supplementary Figure 1, Table 1 from <i>De novo</i> Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel <i>In vivo</i> Breast Tumor Model
DNA methylation inhibitors (azacitidine, decitabine) have revolutionized the treatment dilemma of myelodysplastic syndromes (MDS), a group of malignant hematopoietic disorders. This study evaluates the adverse drug reactions (ADRs) following the use of DNA methylation inhibitors in the World Health Organization (WHO) VigiAccess database and compares the characteristics of ADRs between the two drugs to select the drug with the minimum individualized risk for patients.
Supplementary Tables 1-8 from Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer
Asymptomatic infection is a big challenge in curbing the spread of COVID-19. However, its identification and pathogenesis elucidation remain issues. Here, by performing comprehensive lipidomic characterization of serum samples from 89 asymptomatic COVID-19 patients and 178 healthy controls, we screened out a panel of 15 key lipids that could accurately identify asymptomatic patients using a new ensemble learning model based on stacking strategy with a voting algorithm. This strategy provided a high accuracy of 96.0% with only 3.6% false positive rate and 4.8% false negative rate. More importantly, the unique lipid metabolic dysregulation was revealed, especially the enhanced synthesis of membrane phospholipids, altered sphingolipids homeostasis, and differential fatty acids metabolic pattern, implicating the specific host immune, inflammatory, and antiviral responses in asymptomatic COVID-19. This study provides a potential prediagnostic method for asymptomatic COVID-19 and molecular clues for the pathogenesis and therapy of this disease.
Supplementary Table 1 from Constitutive Short Telomere Length of Chromosome 17p and 12q but not 11q and 2p Is Associated with an Increased Risk for Esophageal Cancer
Background: The unreliability of reference intervals (RIs) for children’s blood cell analysis has led to an unnecessary effort in interpreting results. The Standard published in 2021 is expected to solve this problem in China but should be clinically evaluated before its application. Methods: Compared with the laboratory’s original RIs, the RIs’ numerical trends were mapped and analyzed, and the data of the past seven years were retrospectively re-interpreted. Pediatricians were then consulted to discuss the data analyses. Results: The new RIs were summarized as follows: 1) The age stratification is more detailed; 2) The venous blood and peripheral blood are characterized; 3) The numerical range was relatively more comprehensive, and some parameters were unilaterally shifted. Retrospective analysis showed that the revised RIs could correct previously abnormal results to the normal range in a large proportion. The recovery ratio of three lineage cells was white blood cells > red blood cells > platelets, and the ratio sorted by age is 28 days~1-year-old > 1~13years old > 13~18 years old. The leukocyte recovery ratio of 28 days~1 year was the largest, approximately 55% to 83%. Pediatricians recognized the value of the new RIs. The only exception is that the platelets’ RIs were too broad, recommending maintaining the original RI. The missing 0~28 days RIs were recommended to be supplemented with other reference books. Conclusions: The new RIs were optimized and, combined with clinical feedback, produced new RIs derived from accumulated experience, evolving a better set of RIs.
Abstract Objective Investigate the link between live dietary microbe consumption and the prevalence of periodontitis. Methods and Materials National health and nutrition examination survey (2009–2014) data was used to assess the association among adults. Live dietary microbe intake was categorized as low or medium to high. Regression models were employed to assess this association, adjusting for demographic variables and other covariates. Examined dose–response relationship and conducted subgroup analyses by ethnicity, age and gender. Multiplicative interactions were evaluated using likelihood ratio tests. Results The analysis included 8574 participants. After adjusting for various factors including age, gender, ethnicity, dietary habits, dietary inflammatory index, alcohol consumption, smoking status, hypertension, diabetes mellitus and oral health behaviors, individuals with daily intake of medium to high levels of live dietary microbes showed a significantly reduced risk of periodontitis compared to those who did not consume such microbes with a dose–response trend ( p for trend <0.0001, p < 0.01). Significant differences in the impact of live microbe intake on periodontitis were also observed across different age groups in all Models ( p for interaction ≤0.05). Conclusion Medium to high live dietary microbe consumption independently correlates with lower periodontitis risk, irrespective of traditional risk factors and demographics.
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