Wenya Li

First Hospital of China Medical University

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Bin Ma

Murdoch University

Xinyu Zhang

Nanjing Medical University

Peiwen Li

Gansu Agricultural University

Pei-Wen Li

National Yang Ming Chiao Tung University

Shulei Gong

First Hospital of China Medical University

Yiyao Zhang

Jinan University

Peiwen Li

China Medical University

Yizi Wang

China Medical University

Xiangli Liu

University of Bradford

Ningquan Liu

Zhongshan Hospital of Xiamen University

Cooperative Institutions

China Medical University

First Hospital of China Medical University

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Army Medical University

Nanjing Medical University

Central South University

Shanghai Jiao Tong University

Chinese Academy of Sciences

Dalian University of Technology

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What is the true effect of endoscopic full-thickness resection on early colorectal cancer?

Gastrointestinal Endoscopy (2019)

Peiwen Li Bin Ma Wenya Li

Endoscopic submucosal dissection

Endoscopic mucosal resection

10.1016/j.gie.2019.04.202

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Citations (2)

Is endoscopic resection more effective than laparoscopic resection in gastric gastrointestinal stromal tumours?

European Journal of Surgical Oncology (2020)

Pei-Wen Li Wenya Li Bin Ma

Stromal tumor

Endoscopic mucosal resection

10.1016/j.ejso.2020.04.053

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Citations (1)

Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation

Fundamental Research (2024)

Wenya Li Zilu Xu Boyuan Zou Dongcheng Yang Yue Lu

Tissue engineering and regenerative medicine are effective strategies for the treatment of damaged tissues and end-stage organ failure. Damaged tissue regeneration and organ transplantation require blood vessel reconstruction to facilitate tissue remodeling, the bottleneck for application research in this field. Immune cells are heavily involved in coordinating neovascularization, in which macrophage aggregation is a key factor in angiogenesis and arteriogenesis. Previous studies have promoted tissue vascularization by regulating macrophages; however, the mechanisms underlying macrophage-mediated vascularization remain nebulous. Studies on material-based regulation have primarily been observational and lack systematic and targeted research. Macrophages from different sources exhibit different phenotypes or functions in tissues, such as peripheral blood monocytes and tissue-resident macrophages, with each exhibiting complicated mechanisms for promoting tissue injury and graft remodeling. Therefore, in this review, we discuss the role of different tissue-resident macrophages and circulating monocytes in vascularization during injured tissue regeneration and graft remodeling and summarize the current strategies for the use of biomaterials to regulate macrophages and promote the vascularization of injured tissues and during organ transplantation. A better understanding of these mechanisms will facilitate future tissue engineering research that promotes vascularization by regulating macrophage reactions.

Arteriogenesis

Regenerative Medicine

10.1016/j.fmre.2023.12.015

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Feasibility and clinical effectiveness of transjugular intrahepatic portosystemic shunt creation in pediatric and adolescent patients: a meta-analysis

Pediatric Surgery International (2022)

Yizi Wang Bin Ma Peiwen Li Wenya Li Da Liu

Etiology

10.1007/s00383-022-05066-6

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Citations (4)

Association of primary tumor location with prognosis in postoperative colorectal cancer patients

Chin J Colorec Dis (Electronic Edition) (2017)

Jing Liu Wenya Li Xiujuan Qu Jinglei Qu Ying Chen

Objective To investigate the association of primary tumor location with clinical pathologic features and prognosis in postoperative colorectal cancer patients. Methods Patients with stage I~III colorectal cancer treated in the First Hospital of China Medical University from September 2000 to April 2016 were collected, and the relationship between primary tumor location and clinical pathological features was analyzed. The effect of primary tumor location on the prognosis was also investigated. Results In total, 1 345 patients with colorectal cancer were grouped according to primary tumor location: the rectum, left-sided, and right-sided colon group. The primary tumor location was associated with gender ( (χ2=10.943; P=0.004), histological grade (χ2=12.402; P=0.015), pathological T stage (χ2=49.794; P<0.001) and TNM stage (χ2=30.102; P<0.001) . Survival analysis showed no significant difference in three groups (χ2=4.806; P=0.09). Cox univariate analysis did not show any correlation between primary tumor location and survival (χ2=2.938; P=0.088) , but showed a significant correlation between positive lymph nodes、TNM stage and prognosis (χ2=39.739, χ2=23.872; P<0.001). Multivariable analyses showed a significant correlation between positive lymph nodes and survival (95%CI: 1.210~2.317; P=0.002). Conclusion In postoperative colorectal cancer, different primary tumor location correlated with different clinical pathological characteristics. There was no relationship between primary tumor location and prognosis. Number of positive lymph nodes was an independent prognostic factor for survival. Key words: Colorectal neoplasms; Prognosis; Primary tumor location; Clinicopathological characteristics

Primary tumor

Univariate analysis

10.3877/cma.j.issn.2095-3224.2017.04.007

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Efficacy and safety of endoscopic full-thickness resection in the colon and rectum using an over-the-scope device: a meta-analysis

Surgical Endoscopy (2020)

Peiwen Li Bin Ma Shulei Gong Xinyu Zhang Wenya Li

Perforation

Endoscopic mucosal resection

Colorectal adenoma

Polypectomy

10.1007/s00464-020-07387-w

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Citations (31)

Safety and oncological outcomes of natural orifice specimen extraction surgery compared with conventional laparoscopic surgery for right hemicolectomy: a systematic review and meta-analysis

Updates in Surgery (2022)

Kang Wang Wenya Li Ningquan Liu Jianchun Cai Yiyao Zhang

CLs upper limits

10.1007/s13304-022-01276-8

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Citations (1)

Diagnosis and treatment of 26 cases of thoracic limited Castleman′s disease

Chinese Journal of Asthma (2017)

Xuexi Zhang Sanyang Zhang Shuhua Ren Zhenglun Yu Shuguang Zhang

Objective To investigate the diagnosis and treatment of thoracic limited Castleman′s disease, and to improve the understanding of the disease. Methods The clinical data and pathologic data of 26 cases of thoracic limited Castleman′s disease were analyzed retrospectively from January 2010 to December 2016 in the First Hospital of China Medical University. Results Among the 26 patients, 14 cases were male and 12 cases were female.The median age was 36.5 (24.8-69.3) years old.The median course of disease was 2.8 (0.2-7.8) months.All patients underwent surgical treatment, including conventional thoracotomy in 16 cases, video-assisted thoracoscopic surgery in 10 cases.All of the 26 patients were followed up for 46.6 (4.2-70.6) months.The pathological type of 22 cases was hyaline vascular type, four cases were plasma cell type.In addition to a case of plasma cell type recurring in 42 months after the surgery, the remaining patients achieved complete remission after surgery. Conclusions The surgery treatment of thoracic limited Castleman′s disease is effective, especially for hyaline vascular type.However, there is a possibility of recurrence after the operation for plasma cell type. Key words: Castleman′s disease; Limitations; Clinical features; Treatment

Thoracotomy

Hyaline

Cardiothoracic surgery

Castleman disease

10.3760/cma.j.issn.1673-436x.2017.15.006

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Expression and Role of Oct3/4 in Injury-Repair Process of Rat Alveolar Epithelium after 5-Fu Treatment

BioMed Research International (2017)

Wenya Li Xu-lv Ye Xinshan Jia Lanling Jia

Objective . We aimed to investigate how the embryonic stem cell-related gene Oct3/4 changes during the injury-repair process of distal pulmonary epithelium induced by 5-fluorouracil (5-Fu). Methods . We have developed the lung injury model induced by 5-Fu and observed the dynamic changes of Oct3/4 by indirect immunofluorescence, Western blot, and quantitative real-time PCR. Immunofluorescence double staining was used to compare the positions of Oct3/4(+) cells and other reported alveolar epithelial stem cells. Results . Oct3/4(+) cells were not found in normal rat lung epithelial cells. However, after treatment with 5-Fu, Oct3/4(+) cells appeared at 12 h, reached the peak at 24 h, then decreased at 48 h, and eventually disappeared at 72 h. Oct3/4 was localized in the nucleus. We found that the sites of Clara cell secretory protein and surfactant protein-C dual positive cells were apparently different from Oct3/4(+) cells. Conclusions . Our results revealed that, in rat alveolar epithelium, expression of Oct3/4 could be induced after treatment with 5-Fu, then decreased gradually, and was silenced following the alveolar epithelial differentiation. We hold that Oct3/4(+) cells are lung stem cells, which can provide new evidence for identification and isolation of lung epithelial stem cells.

Immunofluorescence

Alveolar Epithelium

10.1155/2017/3856839

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Effect of dynamic position changes during colonoscope withdrawal: a meta-analysis of randomized controlled trials

Surgical Endoscopy (2020)

Pei-Wen Li Bin Ma Shulei Gong Xinyu Zhang Wenya Li

Subgroup analysis

Position (finance)

10.1007/s00464-020-07483-x

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Citations (14)