Yuelin Zhang

University of British Columbia

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i-10 index

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Xin Li

Canada's Michael Smith Genome Sciences Centre

Tongjun Sun

Agricultural Genomics Institute at Shenzhen

Hainan Tian

Sichuan University

Fang Xu

Shandong University

Pingtao Ding

University of Bonn

Weijie Huang

University of British Columbia

Yu Ti Cheng

Dalian University of Technology

Minghui Gao

Guangzhou Institutes of Biomedicine and Health

Kevin Ao

Canada's Michael Smith Genome Sciences Centre

Kirstin Feussner

University of Göttingen

Cooperative Institutions

University of British Columbia

Chinese Academy of Sciences

Canada's Michael Smith Genome Sciences Centre

China Agricultural University

National Institute of Biological Sciences, Beijing

Chinese Academy of Agricultural Sciences

Peking University

Zhejiang University

Sichuan University

Southern Medical University

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Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid

Science (2019)

Dmitrij Rekhter Daniel Lüdke Yuli Ding Kirstin Feussner Krzysztof Zienkiewicz

Spontaneous degradation in hormone synthesis The phytohormone salicylic acid (SA) helps plants respond to biological and physical stresses. Rekhter et al. identified the biosynthetic pathway that produces SA in response to pathogens. A precursor, isochorismic acid, is formed in the chloroplast and then exported to the cytosol. There, enzymatically produced isochorismate-9-glutamate spontaneously decomposes to release SA plus a by-product. The results clarify key steps in the mechanisms involved in synthesizing this important regulator of plant immunity. Science , this issue p. 498

Plant hormone

10.1126/science.aaw1720

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Citations (354)

Study on Content & Extracting Technology of Flavonoids from Locust

Yuelin Zhang

The content,extracting technology and preparatory isolation of locust flavonoids was studied in this paper.The result showed that there was a great difference among species and latitudes.Methanol had preferable extraction effect for flavonoids and the optimum technological condition was dipping dried locust in methanol with the scale 1:30 of raw material and solvent for 24h.The extracting content of flavonoids was 293.2mg/100g.

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Two redundant receptor-like cytoplasmic kinases function downstream of pattern recognition receptors to regulate activation of SA biosynthesis in Arabidopsis

PLANT PHYSIOLOGY (2016)

Qing Kong Tongjun Sun Na Qu Junling Ma Meng Li

Salicylic acid (SA) serves as a critical signaling molecule in plant defense. Two transcription factors, SARD1 and CBP60g, control SA biosynthesis through regulating pathogen-induced expression of Isochorismate Synthase1, which encodes a key enzyme for SA biosynthesis. Here, we report that Pattern-Triggered Immunity Compromised Receptor-like Cytoplasmic Kinase1 (PCRK1) and PCRK2 function as key regulators of SA biosynthesis. In the pcrk1 pcrk2 double mutant, pathogen-induced expression of SARD1, CBP60g, and ICS1 is greatly reduced. The pcrk1 pcrk2 double mutant, but neither of the single mutants, exhibits reduced accumulation of SA and enhanced disease susceptibility to bacterial pathogens. Both PCRK1 and PCRK2 interact with the pattern recognition receptor FLS2, and treatment with pathogen-associated molecular patterns leads to rapid phosphorylation of PCRK2. Our data suggest that PCRK1 and PCRK2 function downstream of pattern recognition receptor in a signal relay leading to the activation of SA biosynthesis.

WRKY protein domain

10.1104/pp.15.01954

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Citations (53)

Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g

Molecular Plant (2019)

Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing

Chromatin immunoprecipitation

10.1016/j.molp.2019.10.016

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Activation of Plant Immune Responses by a Gain-of-Function Mutation in an Atypical Receptor-Like Kinase

PLANT PHYSIOLOGY (2010)

Dongling Bi Yu Ti Cheng Xin Li Yuelin Zhang

Abstract Arabidopsis (Arabidopsis thaliana) suppressor of npr1-1, constitutive1 (snc1) contains a gain-of-function mutation in a Toll/interleukin receptor-nucleotide binding site-leucine-rich repeat Resistance (R) protein and it has been a useful tool for dissecting R-protein-mediated immunity. Here we report the identification and characterization of snc4-1D, a semidominant mutant with snc1-like phenotypes. snc4-1D constitutively expresses defense marker genes PR1, PR2, and PDF1.2, and displays enhanced pathogen resistance. Map-based cloning of SNC4 revealed that it encodes an atypical receptor-like kinase with two predicted extracellular glycerophosphoryl diester phosphodiesterase domains. The snc4-1D mutation changes an alanine to threonine in the predicted cytoplasmic kinase domain. Wild-type plants transformed with the mutant snc4-1D gene displayed similar phenotypes as snc4-1D, suggesting that the mutation is a gain-of-function mutation. Epistasis analysis showed that NON-RACE-SPECIFIC DISEASE RESISTANCE1 is required for the snc4-1D mutant phenotypes. In addition, the snc4-1D mutant phenotypes are partially suppressed by knocking out MAP KINASE SUBSTRATE1, a positive defense regulator associated with MAP KINASE4. Furthermore, both the morphology and constitutive pathogen resistance of snc4-1D are partially suppressed by blocking jasmonic acid synthesis, suggesting that jasmonic acid plays an important role in snc4-1D-mediated resistance. Identification of snc4-1D provides us a unique genetic system for analyzing the signal transduction pathways downstream of receptor-like kinases.

Positional cloning

Protein kinase domain

Jasmonic acid

Genetic screen

10.1104/pp.110.158501

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The Ankyrin-Repeat Transmembrane Protein BDA1 Functions Downstream of the Receptor-Like Protein SNC2 to Regulate Plant Immunity

PLANT PHYSIOLOGY (2012)

Yuanai Yang Yaxi Zhang Pingtao Ding Kaeli Johnson Xin Li

Plants utilize a large number of immune receptors to recognize pathogens and activate defense responses. A small number of these receptors belong to the receptor-like protein family. Previously, we showed that a gain-of-function mutation in the receptor-like protein SNC2 (for Suppressor of NPR1, Constitutive2) leads to constitutive activation of defense responses in snc2-1D mutant plants. To identify defense signaling components downstream of SNC2, we carried out a suppressor screen in the snc2-1D mutant background of Arabidopsis (Arabidopsis thaliana). Map-based cloning of one of the suppressor genes, BDA1 (for bian da; "becoming big" in Chinese), showed that it encodes a protein with amino-terminal ankyrin repeats and carboxyl-terminal transmembrane domains. Loss-of-function mutations in BDA1 suppress the dwarf morphology and constitutive defense responses in snc2-1D npr1-1 (for nonexpressor of pathogenesis-related genes1,1) and also result in enhanced susceptibility to bacterial pathogens. In contrast, a gain-of-function allele of bda1 isolated from a separate genetic screen to search for mutants with enhanced pathogen resistance was found to constitutively activate cell death and defense responses. These data suggest that BDA1 is a critical signaling component that functions downstream of SNC2 to regulate plant immunity.

Ankyrin repeat

Ankyrin

Plant Immunity

10.1104/pp.112.197152

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Citations (84)

Imaging characteristics of and embolization therapy for giant hepatic hemangioma

Zhōnghuá xiāohuà wàikē zázhì/Zhonghua xiaohua waike zazhi (2013)

Chun‐Hui Nie Jun‐Hui Sun Yuelin Zhang Jian-liang Lou Liming Chen

With the development of interventional radiology,transcatheter arterial embolization has been the main treatment method for hepatic hemangioma,especially for patients who are not suitable to receive surgical resection.The clinical data of 16 patients with hepatic hemangioma who received interventional therapy at the First Affiliated Hospital of Zhejiang University were retrospectively analyzed,and the imaging characteristics of hepatic hemangioma and efficacy of embolization therapy were investigated.A catheter was inserted into the celiac artery for angiography in order to recognize the feeding arteries of the hepatic hemangioma.Lipiodol mixed with pingyangmycin for embolism was injected until the tumor was surrounded by them.All patients were followed up till September 2012,the tumor size and the symptoms were observed.Preoperative hepatic angiography showed multiple abnormal vascular lakes in phase which was known as early leaving but late returning,hanging nut on a twig sign.After the therapy of intervention,the tumor became smaller and the condition of the patients was improved.Embolization therapy is good and secure for treating giant hepatic hemangioma. Key words: Hepatic hemangioma; Imaging diagnosis ; Interventional therapy

Pingyangmycin

Hepatic artery embolization

Arterial Embolization

10.3760/cma.j.issn.1673-9752.2013.09.007

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WRKY54 and WRKY70 positively regulate SARD1 and CBP60g expression in plant immunity

Plant Signaling & Behavior (2021)

Siyu Chen Yuli Ding Hainan Tian Shucai Wang Yuelin Zhang

SARD1 and CBP60g are two master regulators in plant immunity. They are required for the constitutive defense responses in the Arabidopsis snc2-1D mutant, which carries a gain-of-function mutation in a receptor-like protein. Here we report that WRKY54 and WRKY70 are required for activation of SARD1 and CBP60g expression and defense responses in snc2-1D. In addition, the induction of SARD1 and CBP60g by the bacterial pathogen Pseudomonas syringae pv. maculicola is significantly reduced in sid2 wrky54 wrky70 triple mutants compared to the sid2 single mutants, suggesting that WRKY54 and WRKY70 positively regulate the SID2-independent expression of SARD1 and CBP60g during pathogen infection. Our study revealed WRKY54 and WRKY70 as positive regulators of SARD1 and CBP60g expression in plant defense.

Pseudomonas syringae

Plant Immunity

10.1080/15592324.2021.1932142

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Citations (22)

Regulation of SOBIR1 accumulation and activation of defense responses in bir1–1 by specific components of ER quality control

The Plant Journal (2014)

Tongjun Sun Qian Zhang Minghui Gao Yuelin Zhang

Summary Receptor‐like kinases play diverse roles in plant biology. Arabidopsis BAK1‐INTERACTING RECEPTOR‐LIKE KINASE 1 (BIR1) functions as a negative regulator of plant immunity. bir1‐1 mutant plants display spontaneous cell death and constitutive defense responses that are dependent on SUPPRESSOR OF BIR1,1 (SOBIR1) and PHYTOALEXIN DEFICIENT4 (PAD4). Here we report that mutations in three components of ER quality control, CALRETICULIN3 (CRT3), ER‐LOCALIZED DnaJ‐LIKE PROTEIN 3b (ERdj3b) and STROMAL‐DERIVED FACTOR‐2 (SDF2), also suppress the spontaneous cell death and constitutive defense responses in bir1‐1 . Further analysis revealed that accumulation of the SOBIR1 protein is reduced in crt3‐1 and erdj3b‐1 mutant plants. These data suggest that ER quality control plays important roles in the biogenesis of SOBIR1, and is required for cell death and defense responses in bir1‐1 .

Phytoalexin

Plant Immunity

10.1111/tpj.12425

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Citations (24)

Tunable mid-infrared photodetector with graphene plasmon controlled by type-printable ferroelectric superdomain

arXiv (Cornell University) (2021)

Junxiong Guo Yu Liu Yu Tian Shangdong Li Yuelin Zhang

Graphene plasmons can resonantly enhance the incident light absorption and offer a potential for tunable spectral selectivity for mid-infrared (MIR) detection. High-performance tunable MIR plasmonic devices are, however, typically based on electrode-patterned graphene, which requires high power input and are technologically challenging in compact assembly. Here we demonstrate a tunable MIR photodetector based on integration of graphene on periodically type-printed ferroelectric superdomain. The plasmon resonance of graphene is tuned by the artificially nanoscale patterned ferroelectric domains and enables a selective transmission in MIR region. Our devices operate at zero-bias source-drain voltage and exhibit a peak photoresponsivity of up to near 30 mA W-1 at 8.5 um at room temperature. We also observe a tunable photodetection performance ranging from 7.2 to 8.5 um by directly re-scaling the geometry of ferroelectric superdomain. The non-volatile tunability of graphene plasmons and bias-free devices provide a great potential for smart fabrication of on-chip MIR photodetector array with tunable spectrum and low-energy consumption.

Photodetection

Biasing

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