Yang Lu

China Pharmaceutical University

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Xijing Chen

China Pharmaceutical University

Di Zhao

Second Hospital of Shandong University

Di Zhao

Dalian Minzu University

Ning Li

Jilin Academy of Traditional Chinese Medicine

Ning Li

Sichuan University

Yongjie Zhang

Carnegie Mellon University

Pengbo Zhang

Second Affiliated Hospital of Xi'an Jiaotong University

Jiake He

Second Affiliated Hospital of Nanchang University

Xinlin Chen

Shanghai University of Traditional Chinese Medicine

Ning Chen

China Pharmaceutical University

Cooperative Institutions

China Pharmaceutical University

156

Chinese Academy of Sciences

Sun Yat-sen University

Shanghai Jiao Tong University

Nanjing Medical University

Central South University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sichuan University

Xi'an Jiaotong University

Southern Medical University

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A systematic metabolic pathway identification of Common Gardenia Fruit (Gardeniae Fructus) in mouse bile, plasma, urine and feces by HPLC-Q-TOF-MS/MS

Journal of Chromatography B (2020)

Jing Zhou Yongjie Zhang Ning Li Di Zhao Yang Lu

Metabolic pathway

Biotransformation

Glucuronide

10.1016/j.jchromb.2020.122100

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Citations (14)

Influences of ABC transporter and CYP3A4/5 genetic polymorphisms on the pharmacokinetics of lenvatinib in Chinese healthy subjects

European Journal of Clinical Pharmacology (2020)

Jiaming Li Xiaoqian Wang Ning Chen Zhaoyu Wang Yao Wang

Lenvatinib

10.1007/s00228-020-02879-z

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Citations (15)

Interactions between Oroxylin A with the solute carrier transporters and ATP-binding cassette transporters: Drug transporters profile for this flavonoid

Chemico-Biological Interactions (2020)

Guanghui Ren Zhiying Qin Nan Yang Huili Chen Kejia Fu

HEK 293 cells

Abcg2

Probenecid

Solute carrier family

Efflux

10.1016/j.cbi.2020.109097

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Citations (9)

Changes of fractional anisotropy and RGMa in crossed cerebellar diaschisis induced by middle cerebral artery occlusion

Experimental and Therapeutic Medicine (2019)

Yong Zhang Xiao Wang Jingliang Cheng Yanan Lin Yang Lu

Crossed cerebellar diaschisis (CCD) is the phenomenon of hypoperfusion and hypometabolism of the contralateral cerebellar hemisphere caused by dysfunction of the associated supratentorial region. The aim of the present study was to analyze the changes in fractional anisotropy (FA) in CCD induced by middle cerebral artery occlusion (MCAO) using magnetic resonance-diffusion tensor imaging (MR-DTI). Furthermore, the role of repulsive guidance molecule a (RGMa) in CCD was assessed by measuring RGMa expression using histochemical analysis. In the present study, the cerebellar hemisphere was serially scanned with T2-weighted, serial diffusion-weighted and diffusion tensor (DT) imaging using a 3.0T GE Signa HDxt Scanner to analyze the changes in FA over 72 h. Subsequently, immunohistochemistry analyses of the corresponding cerebellar hemisphere sections were performed to assess the expression of RGMa. Results indicated that FA of both sides of the cerebellar hemisphere, particularly that of the contralateral cerebellar hemisphere (right side) derived from DTI, was reduced during the 72-h time period following MCAO, and the decrease was maximal and statistically significant at 12 h (P<0.05). Immunohistochemistry analysis revealed a significant increase in the expression of RGMa protein in the affected region of the contralateral cerebellar hemisphere (right side) at 24 h following MCAO injury (P<0.05). Furthermore, the expression of RGMa and FA was negatively correlated in MCAO (P<0.05). The results suggest that MR-DTI is an important assessment to evaluate changes of FA in CCD induced by MCAO. Furthermore, the present results suggest that RGMa, which was negatively correlated with FA in MCAO rats, may serve an important role in CCD.

Diaschisis

Cerebellar hemisphere

10.3892/etm.2019.7986

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Citations (3)

Synergistic effect of Cu doping and Z-scheme heterojunction on ZnIn2S4/Cu-doped WO3·0.5H2O for boosting photocatalytic H2 evolution

International Journal of Hydrogen Energy (2024)

Binhua Zhou Junqin Wang Pengfei Tan Yang Lu Huanhuan Zhai

10.1016/j.ijhydene.2024.01.100

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Citations (4)

Tissue distribution and ontogeny of multidrug resistance protein 2, a phosphatidylcholine translocator, in rats

European Journal of Drug Metabolism and Pharmacokinetics (2014)

Qiuyang Zhang Wei Yang Hanlin Song Hui Wu Yang Lu

Flippase

10.1007/s13318-014-0226-5

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Citations (1)

Pharmacokinetics of Vicagrel, a Promising Analog of Clopidogrel, in Rats and Beagle Dogs

Journal of Pharmaceutical Sciences (2012)

Zhixia Qiu Ning Li Xin Wang Fengjie Tian Qi Liu

Beagle

Active metabolite

10.1002/jps.23394

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Citations (25)

Pharmacokinetics of thiamphenicol glycinate and its active metabolite by single and multiple intravenous infusions in healthy Chinese volunteers

Xenobiotica (2014)

Bing Yang Ning Li Yang Lu Zhixia Qiu Di Zhao

1. The aim of this study was to investigate the pharmacokinetics of thiamphenicol glycinate (TG) and thiamphenicol (TAP) after intravenous (i.v.) infusion of TG hydrochloride in healthy Chinese by evaluating the pharmacokinetic parameters, to provide clinical guidance in TG application.2. In this double-blinded, phase I clinical trial, 24 healthy Chinese volunteers were recruited and divided into three groups which received a single dose of 500, 1000 or 1500 mg TG hydrochloride. Subjects in 500 mg group received further administrations at the same dose every 12 h for 5 days. The pharmacokinetic parameters were fitted on the basis of bi-phasic or tri-phasic plasma concentration–time profiles of TG and TAP.3. Following a single dose of 500, 1000, 1500 mg TG hydrochloride, the AUC0–∞ of TG and TAP was 849.1 ± 100.3, 1305.2 ± 301.8, 2315.9 ± 546.9 and 4509.0 ± 565.9, 7506.5 ± 1112.4, 12 613.3 ± 2779.8 µgmL−1 min, respectively. The total clearance of TG was calculated as 0.58 ± 0.07, 0.41 ± 0.10 and 0.68 ± 0.18 L min−1. The transformed rate constant from TG to TAP was fitted as 0.153, 0.113 and 0.118 min−1, respectively. TAP was mainly excreted as unchanged form with no tendency of accumulation via kidney (71.9 ± 19.4%) with the renal clearance estimated at 0.097 L min−1.4. The established modeling was applied successfully to evaluate the pharmacokinetics of TG and TAP, providing meaningful guidance in TG clinical application.

Thiamphenicol

Hydrochloride

Active metabolite

Tap water

10.3109/00498254.2014.897010

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Citations (6)

An Investigation on Glucuronidation Metabolite Identification, Isozyme Contribution, and Species Differences of GL-V9 In Vitro and In Vivo

Molecules (2019)

Han Xing Dexuan Kong Ning Chen Ying Kong Chang Ren

GL-V9 is a prominent derivative of wogonin with a wide therapeutic spectrum and potent anti-tumor activity. The metabolism characteristics of GL-V9 remain unclear. This study aimed to clarify the metabolic pathway of GL-V9 and investigate the generation of its glucuronidation metabolites in vitro and in vivo. HPLC-UV-TripleTOF was used to identify metabolites. The main metabolite that we found was chemically synthesized and the synthetic metabolite was utilized as standard substance for the subsequent metabolism studies of GL-V9, including enzyme kinetics in liver microsomes of five different species and reaction phenotyping metabolism using 12 recombinant human UDP-glucuronosyltransferase (UGT) isoforms. Results indicated that the glucuronidation reaction occurred at C5-OH group, and 5-O-glucuronide GL-V9 is the only glucuronide metabolite and major phase II metabolite of GL-V9. Among 12 recombinant human UGTs, rUGT1A9 showed the strongest catalytic capacity for the glucuronidation reaction of GL-V9. rUGT1A7 and rUGT1A8 were also involved in the glucuronidation metabolism. Km of rUGT1A7-1A9 was 3.25 ± 0.29, 13.92 ± 1.05, and 4.72 ± 0.28 μM, respectively. In conclusion, 5-O-glucuronide GL-V9 is the dominant phase II metabolite of GL-V9 in vivo and in vitro, whose formation rate and efficiency are closely related to isoform-specific metabolism profiles and the distribution of UGTs in different tissues of different species.

Wogonin

Glucuronide

Metabolic pathway

10.3390/molecules24081576

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Citations (7)

Quantitative Determination of Sophoricoside in Rat Plasma by HPLC

Acta Universitatis Medicinalis Secondae Shanghai (2005)

Yang Lu

Objective To determine quantitatively sophoricoside in rat plasma. Methods A RP-HPLC method was established with YWG C18 column, acetonitrile-water as mobile phase, 7-hydroxyl-4-methylcoumarin as the internal standard. Results The linear range of sophoricoside was from 20. 2 to 2016 ng/mL (r =0.9998, n=5), that of genistein was from 50 to 2 000 ng/mL( r =0. 9993 , n=5). The recovery was more than 95 %. The relative standard deviation ( RSD) of both intraday and interday was less than 5 % ( n = 5). Conclusion The method is reliable. It can be used for the study on the pharmacokinetics of sophoricoside.

Relative standard deviation

Linear range

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Citations (1)