<p>Supplementary Figure S1. Identification of 3'UTR shortening of RALA and RAC1 from UCB, colorectal carcinoma, hepatocellular carcinoma and non-small cell lung cancer samples. Supplementary Figure S2. RAC1 with short 3'UTR promotes tumorigenesis and produces more protein due to evasion of miRNA-mediated repression. Supplementary Figure S3. Screening of APA factors that contribute to the PAS selection of RAC1 in UCB. Supplementary Figure S4. CSTF2 regulates colony formation and invasiveness abilities of shorter RAC1 isoform in UCB. Supplementary Table S1. PDUI value calculated from DaPars analysis of 15 pairs of UCB and adjacent normal bladder tissues. Supplementary Table S2. KEGG pathway analyses of APA genes identified from RNA-Seq. Supplementary Table S3. RAC1 genomic mutations identified from TCGA UCB database. Supplementary Table S4. Correlation between the expression of CSTF2 and clinicopathologic characteristics of UCB patients</p>
This study aimed to evaluate and summarize the contrast-enhanced computed tomography (CECT) imaging features of micronodular thymoma with lymphoid stroma (MTWLS) based on all MTWLS patients at our institution and was the first imaging study of MTWLS worldwide.This retrospective study included 10 MTWLS patients who underwent CECT between April 2012 and November 2021. We collected and analyzed the CECT imaging features, including the location, size, shape, tumor density, classification, and CT value of the solid component. Descriptive statistical analysis was performed using the SPSS software (version 26.0; IBM).Ten patients (five males [50%], five females [50%]; median age, 61.4 years; range, 54-72 years) underwent CECT. Of the 10 cases, one case was purely cystic, seven cases were cystic-solid, and two cases were purely solid. Six cases were round/oval in shape, and four cases were irregularly shaped. Excluding a purely cystic tumor with an unmeasurable degree of enhancement, two cases showed moderate enhancement, and seven cases showed significant enhancement. Among the solid or cystic-solid cases, the mean CT value of the measurable solid component on the enhanced scan was 93.9 HU. Nine masses were located adjacent to the mediastinal pleura, pericardium, or large vessels. Additionally, there were no malignant tumor signs in any patient, including penetration of the mediastinal pleura or involvement of the pericardium, pleural effusion, elevation of the diaphragm, or direct vascular invasion.MTWLS demonstrates certain features on CECT, such as a high rate of cystic change, significant solid component enhancement, and no malignant, invasive imaging features. These CECT features are helpful for diagnosing MTWLS.
Objective
To systematically evaluate the effectiveness and safety of pantoprazole sodium(PAN) and omeprazole(OME) treatments in patients with duodenal ulcer.
Methods
Pantoprazole sodium, omeprazole, ulcer, and randomized controlled trial were selected as key words and Pub Med, Embase, the Cochrane Library, VIP, CNKI, and Wanfang databases from the inception to September 2014 were searched. Randomized controlled trials(RCT) on comparison of PAN and OME treatments in patients with duodenal ulcer were selected. According to the intervention measures, the subjects were divided into the PAN group and the OME group. The medication comprised oral and intravenous administration. The Meta-analysis was performed using Rev Man 5.2 software.The outcomes included the ulcer healing rate, the pain relief rate and time, the incidence of adverse drug reactions, and the recurrence rate at six months.
Results
A total of 17 RCTs involving 1 847 patients were entered, including 1 008 in the PAN group and 839 in the OME group. The patients in 12 RCTs received drugs by mouth and the patients in other 5 RCTs received intravenously and the Meta-analysis was performed respectively. The ulcer healing rates in patients with 2 or 4 weeks of oral PAN treatment, the pain relief rates in patients with 1, 2 or 4 weeks of oral PAN treatment were compared with those in patients with oral OME treatment at the same period and the differences were not significant. The pain relief rates in patients with 3 days of oral PAN treatment were higher than those in patients with 3 days of oral OME treatment [relative risk(RR)=1.27, 95% confidence interval(CI): 1.03-1.57, P=0.03]. The differences of the pain relief time, the incidence of adverse drug reactions, and the recurrence rates of six months between the patients with oral PAN treatment and the patients with OME treatment were not significant. The differences of the ulcer healing rates, the pain relief rates, the incidence of adverse drug reactions, and the recurrence rates of six months between the patients with intravenous PAN treatment and the patients with intravenous OME treatment were not significant.
Conclusion
Both PAN and OME are safe and effective drugs for duodenal ulcer treatment.
Key words:
Pantoprazole; Omeprazole; Duodenal ulcer; Meta-analysis
We propose a new paradigm for universal information extraction (IE) that is compatible with any schema format and applicable to a list of IE tasks, such as named entity recognition, relation extraction, event extraction and sentiment analysis. Our approach converts the text-based IE tasks as the token-pair problem, which uniformly disassembles all extraction targets into joint span detection, classification and association problems with a unified extractive framework, namely UniEX. UniEX can synchronously encode schema-based prompt and textual information, and collaboratively learn the generalized knowledge from pre-defined information using the auto-encoder language models. We develop a traffine attention mechanism to integrate heterogeneous factors including tasks, labels and inside tokens, and obtain the extraction target via a scoring matrix. Experiment results show that UniEX can outperform generative universal IE models in terms of performance and inference-speed on $14$ benchmarks IE datasets with the supervised setting. The state-of-the-art performance in low-resource scenarios also verifies the transferability and effectiveness of UniEX.
Postoperative pain after artificial joint replacement is intense and remains an unsolved problem. Some studies have shown that parecoxib can provide better analgesia in postoperative multimodal analgesia, however, doubts arise about whether its multimodal preemptive analgesia can reduce postoperative pain.The purpose of this systematic review and meta-analysis was to evaluate the impact of preoperative injection of parecoxib on postoperative pain in patients undergoing artificial joint replacement.Systematic review and meta-analysis.Embase, PubMed, Cochrane Library, CNKI, VIP, Wangfang databases were searched to identify relevant randomized controlled trials. The last search was in May 2022.Randomized controlled trials of efficacy and adverse reactions of intra-operative and postoperative injection of parecoxib in artificial joint replacement were collected. The primary outcome was postoperative visual analog scale scores and the secondary outcomes included cumulative postoperative opioid consumption and incidence of adverse reactions. Using the Cochrane systematic review method to screen the studies, evaluate the quality of the included studies, and extract feature information, RevMan 5.4 software performs a meta-analysis of the corresponding research indicators.In total, nine studies were involved in the meta-analysis with 667 patients. The trial and control group were given the same dose of parecoxib or placebo at the same time point before and after surgery. The results showed that compared with the control group, the trial group is associated with substantially reduced visual analog scale scores in 24, 48 h at rest (P < 0.05), visual analog scale scores in 24, 48, 72 h at movement (P < 0.05), dose of opioid need in trial group is notably lower than that in control group (P < 0.05), but shows no obvious effect on visual analog scale scores in 72 h at rest, and adverse events (P > 0.05).The major limitation of this meta-analysis relates to some low-quality studies.Our results support parecoxib multimodal preemptive analgesia in reducing postoperative acute pain in hip and knee replacement patients, and reduces cumulative opioid consumption without increasing the risk of adverse drug events. Its multimodal preemptive analgesia is safe and effective in hip and knee replacement.CRD42022379672.
Background: With the implementation of Antimicrobial Stewardship Program, clinical pharmacists' consultation (CPC) for infectious diseases (ID) is gradually adopted by many hospitals in China. We conducted a cohort study to evaluate the effectiveness of CPC in ID treatment on patient outcomes and potential determinants. Methods: Based on a registry database, a prospective cohort study was conducted in Guizhou Provincial People's Hospital. The main exposure factor was whether clinician adopted the suggestion from clinical pharmacist. The outcome was effective response rate (ERR) of ID patients. The variables associated with the outcome (e.g. age, gender, severity of infection, liver function, and kidney function) were also prospectively recorded. A multilevel model was performed to analyze the factors related to ERR. Results: A total of 733 ID inpatients were included in the final analysis according to the predesigned inclusion and exclusion criteria. The proportion of clinical pharmacists' suggestions adopted by clinicians and ERR were 88.13% and 69.03%, respectively. Significant data aggregation (P < 0.05) for individuals at the level of department was observed. According to the two-level variance component model, liver dysfunction (Adjusted Odds Ratio (AOR) = 0.649, 95%Credible Interval (CI): 0.432~0.976), severity of infection (AOR = 0.602, 95%CI: 0.464~0.781), and adopting the suggestion from pharmacist (AOR = 1.738, 95%CI: 1.028~2.940) had significant association with ERR. Conclusions: Our study suggests that the effect of CPC on ID treatment is significant. The policy/decision makers or hospital managers should be cognizant of the critical value of clinical pharmacists in ID treatment.
Present evidence suggests that the administration of antibiotics, particularly aminopenicillins, may increase the risk of rash in children with infectious mononucleosis (IM). This retrospective, multicenter cohort study of children with IM was conducted to explore the association between antibiotic exposure in IM children and the risk of rash. A robust error generalized linear regression was performed to address the potential cluster effect, as well as confounding factors such as age and sex. A total of 767 children (aged from 0 to 18 years) with IM from 14 hospitals in Guizhou Province were included in the final analysis. The regression analysis implied that exposure to antibiotics was associated with a significantly increased incidence of overall rash in IM children (adjusted odds ratio [AOR], 1.47; 95% confidence interval [CI], ~1.04 to 2.08; P = 0.029). Of 92 overall rash cases, 43 were probably related to antibiotic exposure: two cases (4.08%) in the amoxicillin-treated group and 41 (8.15%) in the group treated with other antibiotics. Regression analysis indicated that the risk of rash induced by amoxicillin in IM children was similar to that induced by other penicillins (AOR, 1.12; 95% CI, ~0.13 to 9.67), cephalosporins (AOR, 2.45; 95% CI, ~0.43 to 14.02), or macrolides (AOR, 0.91; 95% CI, ~0.15 to 5.43). Antibiotic exposure may be associated with an increased risk of overall rash in IM children, but amoxicillin was not found to be associated with any increased risk of rash during IM compared to other antibiotics. We suggest that clinicians be vigilant against the occurrence of rash in IM children receiving antibiotic therapy, rather than indiscriminately avoiding prescribing amoxicillin.
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