Tianhong Zhang

Shenyang Pharmaceutical University

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Zhonggui He

Shenyang Pharmaceutical University

Qikun Jiang

Shenyang Pharmaceutical University

Jin Sun

Shenyang Pharmaceutical University

Xiaolong Xu

Shenyang Pharmaceutical University

Yongjun Wang

Shenyang Pharmaceutical University

Chenxia Bai

Shenyang Pharmaceutical University

Jiaming Zhang

Shenyang Pharmaceutical University

Yingchao Li

Hebei Medical University

Fengxiao Li

Shenyang Pharmaceutical University

Jiaqi Fan

University Hospital Cologne

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Shenyang Pharmaceutical University

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Chinese Academy of Sciences

Peking University

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Academy of Military Medical Sciences

Sun Yat-sen University

Tsinghua University

Zhejiang University

Capital Medical University

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Simultaneous Analysis of Seven Bioactive Compounds inSambucus Chinensis Lindlby HPLC

Analytical Letters (2010)

Tianhong Zhang Meng Zhu Xiaohong Chen Kaishun Bi

Following optimization of extraction, separation, and analytical conditions, a simple, rapid, and sensitive HPLC-UV method was developed for the simultaneous determination of seven major bioactive components in Sambucus chinensis Lindl, including chlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, kaempferol-3-O-β-D-galactopyranoside, kaempferol-3-O-β-D-glucopyran-oside, and kaempferol-3-O-(6-actyl)-β-D-galacto-pyranoside. The good chromatographic separation was performed on a Gemini C18 reversed-phase analytical column (250 mm × 4.6 mm, 5 μm) by gradient elution with acetonitrile and formate aqueous buffer (containing 0.8% formic acid, V/V) at a flow rate of 1.0 mL/min. The detection wavelength was set at 326 nm. The intra-day and inter-day precisions were evaluated with the R.S.D. values less than 4.0%. The mean recoveries of the seven compounds were in the range of 92.4%–104.8%. The method was successfully applied to determine the seven bioactive compounds in six different origins of Sambucus chinensis Lindl samples, and there was a significant variation in the contents of the seven compounds among the six samples. Therefore, this method provided a new basis of overall assessment for routine use in the quality control of Sambucus chinensis Lindl.

Chlorogenic Acid

Vanillic acid

10.1080/00032711003731399

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Citations (7)

Accumulation of intact sulfur mustard in adipose tissue and toxicokinetics by chemical conversion and isotope-dilution liquid chromatography–tandem mass spectrometry

Archives of Toxicology (2016)

Bin Xu Cheng Zong Yajiao Zhang Tianhong Zhang Xiaoying Wang

Sulfur mustard

Isotope dilution

Antidote

10.1007/s00204-016-1774-z

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Citations (21)

An LC‐MS/MS method for simultaneous determination of vincristine and verapamil in rat plasma after oral administration of a dual agent formulation

Biomedical Chromatography (2010)

Guixia Ling Peng Zhang Jin Sun Wenping Zhang Qiang Fu

Abstract A rapid and sensitive method for simultaneous determination of vincristine and verapamil in rat plasma was first developed and validated, using high‐performance liquid chromatography–tandem mass spectrometry (LC‐MS/MS) in multiple reaction monitoring (MRM) mode via electrospray ionization (ESI). The method, which required a small sample volume (25 µL) of plasma, was linear in the concentration range of 0.5–500 ng/mL for vincristine and 0.1–100.0 ng/mL for verapamil. Finally, the method was successfully employed in a pharmacokinetic study of vincristine and verapamil in rats after an oral administration of a dual‐agent formulation containing vincristine and verapamil. Copyright © 2010 John Wiley & Sons, Ltd.

10.1002/bmc.1565

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Citations (13)

Development and validation of a high-throughput HPLC-MS/MS method for the simultaneous determination of exatecan and its cathepsin B-sensitive prodrug in rat plasma

New Journal of Chemistry (2025)

Xiaolong Xu Jing Li Xiaohua Ran Chenxia Bai Yan Qing

A reliable and high-throughput LC-MS/MS method was established and validated for simultaneous determination of exatecan and its cathepsin B-sensitive prodrug (C12-VC-PAB-Exa) in rat plasma and successfully applied to the pharmacokinetic study.

10.1039/d4nj04475d

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Citations (0)

LC–MS/MS Analysis and Pharmacokinetics of Daidzein and its 7-O-Glucuronide in Rats After Oral Administration of 7-O-L-Valyl Carbamate Prodrug

Bioanalysis (2021)

Xiaolong Xu Yingchao Li Xiaochen Bai Farong Lu Yawei Zhang

Background: A valine carbamate prodrug (7-P) was designed to enhance the low bioavailability of daidzein due to its low water solubility and membrane permeability. Here, we developed a high-throughput HPLC–MS/MS method to measure daidzein and its 7-O-glucuronide after oral administration of daidzein or 7-P. Materials & methods: A HPLC–MS/MS method was validated and successfully applied to assess the pharmacokinetic behavior of daidzein and its 7-O-glucuronide after orally administrating daidzein or 7-P. The validated method on selectivity, linearity (r ≥ 0.995), precision (relative standard deviation <11.4%), accuracy (relative error <7.1%), extraction recovery (>92.4%), matrix effect (<8.2%) and stability were satisfied. Conclusion: The proposed economical, rapid and sensitive method will be an alternative analytical procedure for daidzein and its metabolite in biological samples.

Glucuronide

10.4155/bio-2020-0276

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Citations (2)

Ultra‐high performance supercritical fluid chromatography‐tandem mass spectrometry method for simultaneous determination of atorvastatin, 2‐hydroxy atorvastatin, and tangeretin in rat plasma and its application to the pharmacokinetic study

Journal of Separation Science (2022)

Wenchao Li Simeng Wang Weiping Wang Lihong Gong Dan-rong Ni

Recent studies strongly suggest that atorvastatin combination therapy with tangeretin could be beneficial in the treatment of hyperlipidemia. This study aimed to investigate the pharmacokinetic interactions among atorvastatin, its active metabolite 2-hydroxy atorvastatin, and tangeretin after oral administration of atorvastatin with tangeretin in rats. A rapid, selective, and sensitive assay was developed and validated based on ultra-high performance supercritical fluid chromatography-tandem mass spectrometry for the simultaneous measurement of atorvastatin, 2-hydroxy atorvastatin, and tangeretin concentrations in rat plasma. Chromatographic separation of the analytes was conducted on an ACQUITY Torus 1-AA column in gradient elution mode. The mass transition ion pairs were m/z 559.0→440.0 for atorvastatin, m/z 575.2→440.0 for 2-hydroxy atorvastatin, m/z 373.0→358.1 for tangeretin, and m/z 254.8→136.7 for daidzein (internal standard). Calibration curves showed good linear correlations at the following concentration range: 1-400 (r = 0.9952), 1-400 (r = 0.9980), and 3-1200 (r = 0.9945) for atorvastatin, 2-hydroxy atorvastatin, and tangeretin, respectively. The method was fully validated and satisfied the acceptance criteria recommended by the United States Food and Drug Administration. Finally, it was successfully applied in a pharmacokinetic study in rats to evaluate the pharmacokinetic behavior of atorvastatin, 2-hydroxy atorvastatin, and tangeretin.

10.1002/jssc.202200185

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Citations (3)

Improving permeability and oral absorption of mangiferin by phospholipid complexation

Fitoterapia (2013)

Hequn Ma Hongming Chen Le Sun Tong Lijin Tianhong Zhang

Mangiferin

Lipophilicity

10.1016/j.fitote.2013.10.016

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Citations (87)

Development and optimization of a high-throughput LC-MS/MS method for the simultaneous determination of Exatecan and its Cathepsin B-sensitive prodrug, and ARV-825 in rat plasma: Application to pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis (2025)

Xiaolong Xu Yangyang Liu Yan Qing Chenxia Bai Xiaohua Ran

10.1016/j.jpba.2025.116746

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Citations (0)

Determination of Ferulic Acid in Rat Plasma by Liquid Chromatography–Tandem Mass Spectrometry Method: Application to a Pharmacokinetic Study

Analytical Letters (2009)

Tianhong Zhang Xiuli Yang Peng Zhang Meng Zhu Zhonggui He

Abstract A rapid, sensitive, and specific liquid chromatography–tandem mass spectrometric (HPLC-MS/MS) method has been developed for quantification of ferulic acid in rat plasma. The analyte and docetaxel (internal standard) were extracted from plasma samples with diethyl ether and analyzed on a C18 column. The chromatographic separation was achieved within 3.5 min by using acetonitrile-water as the mobile phase and the flow rate was 0.2 mL · min−1. The method was linear within the range of 0.5 − 800 ng · mL−1. The lower limit of quantification (LLOQ) was 0.5 ng · mL−1. Finally, the method is successfully applied for the pharmacokinetic study of ferulic acid in rats following intravenous administration. Keywords: Ferulic acidHPLC-MS/MSpharmacokineticsplasma concentrationrat

Diethyl ether

10.1080/00032710903137418

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Citations (7)

An improvement of separation and response applying post-column compensation and one-step acetone protein precipitation for the determination of coenzyme Q10 in rat plasma by SFC-MS/MS

Journal of Chromatography B (2016)

Rujie Yang Yingchao Li Cuiru Liu Youjun Xu Longshan Zhao

Protein precipitation

10.1016/j.jchromb.2016.07.050

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Citations (11)