Changyuan Wang

Dalian Medical University

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i-10 index

Research Trends

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Co-Authors

Huijun Sun

Dalian Medical University

151

Kexin Liu

Shanghai Ninth People's Hospital

142

Qiang Meng

Dalian Medical University

137

Jinyong Peng

Dalian Medical University

Xiaokui Huo

Dalian Medical University

Zhihao Liu

Peking University First Hospital

Xiaodong Ma

Dalian Medical University

Qi Liu

Henan Provincial People's Hospital

Pengyuan Sun

Northeast Agricultural University

Jingjing Wu

Dalian Medical University

Cooperative Institutions

Dalian Medical University

287

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Shandong University

Peking University

First Affiliated Hospital of Dalian Medical University

Sichuan University

Dalian University

Sun Yat-sen University

Shanghai Jiao Tong University

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Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice

Food & Function (2015)

Qiang Meng Han Y. H. Chen Changyuan Wang Qi Liu Huijun Sun

Alisol B 23-acetate protects against CCl₄-induced hepatotoxicity via FXR and STAT3-mediated gene regulation in mice.

Hepatoprotection

CCL4

10.1039/c5fo00082c

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Citations (35)

Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice

European Journal of Pharmacology (2017)

Xue Sun Xingping Duan Changyuan Wang Zhihao Liu Pengyuan Sun

Lipogenesis

Gluconeogenesis

Steatosis

10.1016/j.ejphar.2017.04.021

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Citations (67)

Clinical analyses of laparoscopic congenital bladder diverticulectomy with target-guided method

Zhonghua xiaoerwaike zazhi (2017)

Yang Wang Changyuan Wang Zhiyong Shen

Objective To summarize the experiences of mini-invasive surgery for congenital bladder diverticulum (CBD) by target-guided method of urethral catheter and cystoscope light source in children. Methods Retrospective reviews were conducted for age, gender, chief complaint, diverticula size, clinical and urodynamic findings and surgical approaches of 12 CBD patients from January 2006 to January 2016. Results All children were successfully operated without any conversion into laparotomy. The average operative duration was 135 (120-160) mins and the average volume of blood loss 40 (20-75) ml. Two cases of bladder calculus were detected. And another two cases of mild vesicoureteral reflux did not undergo ureteral bladder replantation. There was no onset of overt postoperative complications. Two cases were followed up for 3 months and the remainder for 1 year. Re-examinations included urinary culture and urinary ultrasound after 3 months; voiding cystourethrography (VCUG) and urodynamic examination after 6 months; urinary ultrasound after 1 year. The follow-up outcomes were excellent. Conclusions Congenital bladder diverticulum should be differentiated from lower urinary tract obstruction due to secondary diverticulum. As a gold diagnostic standard, VCUG may be combined with cystoscopy and urodynamic examination for a definite diagnosis. Surgical intervention criteria for congenital bladder diverticula have not been made. Recommended surgical indications include a diverticulum with a diameter of >3 cm or a diverticulum associated with such clinical symptoms as urinary tract infection, dysuria and urinary retention The above targeted method may aid the identification of diverticulum wall of bladder, avoid the damages of ureter, vas deferens, seminal vesicles and pelvic plexus and reduce the occurrences of operative complications during complete removal of diverticulum. Key words: Surgical procedures, laparoscopic; Bladder; Diverticulum

Cystoscope

Urethral Diverticulum

Ectopic ureter

Dysuria

Voiding cystourethrogram

10.3760/cma.j.issn.0253-3006.2017.11.011

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Citations (0)

Resveratrol-derived carbon dots integrated into gelatin/chitosan multifunctional films for intelligent packaging

Food Chemistry X (2025)

Tianxin Fu Yuchao Feng Shu Zhang Yanan Sheng Changyuan Wang

In this study, multifunctional Resveratrol-derived carbon dots (Res-CDs) were prepared using a hydrothermal method. Res-CDs exhibited good free-radical scavenging activities, attributed to abundant surface hydroxyl groups, and effectively inhibited Staphylococcus aureus and Escherichia coli growth at a concentration of 2 mg/mL. Composite films were prepared by combining Res-CDs with gelatin/chitosan. As well as excellent mechanical properties, the prepared films exhibited smooth surfaces, thermal stability, and good antioxidant, ultraviolet-shielding, antibacterial, and pH-responsive properties. Furthermore, cell viability measurements showed that the films were safe. When applied to keeping pork fresh, the gelatin/chitosan/Res-CDs film significantly reduced the total viable bacterial count on the pork surface and effectively prevented pork discoloration. Additionally, pH, total volatile basic nitrogen, and weight loss measurements confirmed the preservative effects of the film on pork. This work provides a new approach for synthesizing bionanocomposite films with applicability in the food industry.

Gelatin

Active packaging

10.1016/j.fochx.2025.102182

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Citations (0)

Rapid and Selective LC–MS–MS Method for the Determination of cyclo-trans-4-l-Hydroxyprolyl-l-serine (JBP485) in Rat Plasma

Chromatographia (2011)

Changyuan Wang Jian Cang Qi Liu Qiang Meng Huijun Sun

Protein precipitation

Tandem

10.1007/s10337-011-1920-y

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Citations (3)

WITHDRAWN: SUV39H1 alleviates MAFLD through inhibition of the FABPs/CEPT1 signaling pathway

Research Square (Research Square) (2025)

Yi Sun Changyuan Wang Yang Wang Ruyi Hao Lu Liu

Abstract The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.

Preprint

Wish

10.21203/rs.3.rs-5776822/v2

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Citations (0)

Protective Effects of Calycosin Against CCl4-Induced Liver Injury with Activation of FXR and STAT3 in Mice

Pharmaceutical Research (2014)

Han Y. H. Chen Qiang Meng Changyuan Wang Qi Liu Huijun Sun

Calycosin

10.1007/s11095-014-1483-3

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Citations (44)

A many-objective surrogate optimization model driven by hybrid pilot-test data, molecular reconstruction, and crude oil direct cracking reaction mechanism

Chemical Engineering Journal (2025)

Xin Zhou Zhibo Zhang Changyuan Wang Lianying Wu Hao Yan

10.1016/j.cej.2025.160389

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Citations (0)

SUV39H1 alleviates MAFLD through inhibition of the FABPs/CEPT1 signaling pathway

Research Square (Research Square) (2025)

Yi Sun Changyuan Wang Yang Wang Ruyi Hao Lu Liu

Abstract Background Epigenetics modification has emerged as a potential mechanism of action for MAFLD. The histone methylase SUV39H1 is a key epigenetic transcription factor that regulates adipogenesis and inflammation, but its potential role in MAFLD progression remains largely unknown. Methods In this study, the high fat diet (HFD) induced mice and palmitic acid (PA) induced primary mouse hepatocytes were adopted to investigate the effects and mechanisms of SUV39H1 on MAFLD. Point mutation and knockdown of SET domain of SUV39H1 in PA-stimulated AML12 cells and high-fat diet fed mice were adopted to confirm the function of SET domain in MAFLD. RNA–sequencing was used to screen the downstream genes affected by SUV39H1 overexpression in PA-induced AML12 cells. The functional relationship between SUV39H1 and its downstream FABPs was elucidated by CHIP, DNA Pull Down and dual-luciferase reporter assays. Results SUV39H1 could attenuate MAFLD by affecting lipid metabolism, suppressing inflammation and insulin resistance. And the SET domain of SUV39H1 was proved to be the functional domain mediating its effects on MAFLD in vivo and in vitro. Further studies revealed that overexpression of FABPs or CEPT1, the downstream genes of SUV39H1 could accelerate the disorder of lipid metabolism in MAFLD. Meanwhile, FABP could promote CEPT1 expression. Histone methylation modification of FABP promoters by SUV39H1 could inhibit the progression of MAFLD.In addition, FABPs derived from hepatocytes could aggravate the progression of MAFLD by promoting M1 polarization of the macrophages. Conclusion SUV39H1 alleviates MAFLD through inhibition of the FABPs/CEPT1 signaling pathway.

10.21203/rs.3.rs-5776822/v1

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Corrigendum to “Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway” [Int. Immunopharmacol. 36 (2016) 132–141]

International Immunopharmacology (2019)

Hong Yao Changsheng Hu Lianhong Yin Xufeng Tao Lina Xu

INT

Signal pathway

Inflammatory response

10.1016/j.intimp.2019.105786

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Citations (2)