Guoliang Wang

Tianjin University of Science and Technology

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Shiru Jia

Tianjin University of Science and Technology

Yujie Dai

Tianjin University of Science and Technology

Qing Liu

University of Shanghai for Science and Technology

Zhilei Tan

Tianjin University of Science and Technology

Yonghong Chang

Third Affiliated Hospital of Harbin Medical University

Nan Chen

Sichuan University

Soo‐Ung Lee

Jeonnam Bioindustry Foundation

Weina Li

Qingdao Agricultural University

Helong Quan

Northeast Normal University

Feng Zhang

Chinese Academy of Inspection and Quarantine

Cooperative Institutions

Tianjin University of Science and Technology

Konkuk University

Chinese Academy of Sciences

Tianjin University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Tianjin Medical University

Peking Union Medical College Hospital

Shanghai Normal University

Southern Medical University

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The Application and Functional Progress of γ-Poly-Glutamic Acid in Food: A Mini-Review

Current Pharmaceutical Design (2020)

Guoliang Wang Qing Liu Ying Wang Jingyuan Li Yue Chen

γ-Poly-glutamic acid (γ-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. As a biopolymer substance, γ-PGA possesses a few predominant features containing good water solubility, biocompatibility, degradability and non-toxicity. Based on this, γ-PGA can be used in pharmaceutical, such as drug carrier/deliverer, vaccine adjuvant, and coating material for microencapsulation, etc. Moreover, it has also been applied in a broad range of industrial fields including food, medicine, bioremediation, cosmetics, and agriculture. Especially, γ-PGA is an extremely promising food ingredient. In this mini-review, our aim is to review the function and application progress of γ-PGA in the food industry: e.g., improving taste and flavor, enhancing physical property, and promoting health.

Glutamic acid

10.2174/1381612826666200717090016

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Citations (8)

Fractionation and characterization of ɛ-poly-l-lysine from Streptomyces albulus CGMCC 1986

Food Science and Biotechnology (2010)

Shiru Jia Fan Bao-qing Yujie Dai Guoliang Wang Peng Peng

Molecular mass

Micrococcus luteus

10.1007/s10068-010-0051-9

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Citations (31)

Analysis of P-glycoprotein structure and binding sites

Yujie Dai Feng Zhang Nan Chen Guoliang Wang Shiru Jia

Multidrug resistance is one of the major causes for the failure to successful chemotherapy. Although there are many mechanisms responsible for MDR, classic MDR is associated with the over expression of P-glycoprotein (P-gp), resulting in increased efflux of chemotherapy from cancer cells. It is proposed to operate as a "hydrophobic vacuum cleaner", expelling non-polar compounds from the membrane bilayer to the exterior, driven by the energy of ATP hydrolysis. Usually, its efflux function can be inhibited by various reverse agents. Structure diversity is a hallmark of P-gp reverse agents, thus a structural description of poly-specific drug-binding is important for the rational design of MDR inhibitors. In this study, the analysis of structure and binding sites of P-gp was carried out based on the crystal structure of mouse P-gp (ABCB1). There were 10 pockets with the volume larger than Ǻ ³ were found with the online tool of Q-SiteFinder. The docking of typical P-gp efflux pump inhibitors such as XR9576 and OC144-093 were carried out and analyzed with Accelrys Discovery Studio. XR9576 and OC144-093 may bind to the nucleotide-binding domain (NBD) and the pocket at the entrance of the transporting site respectively according to the docking results.

Efflux

P-glycoprotein

Docking (animal)

Cancer Chemotherapy

10.1109/icise.2010.5689524

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Citations (3)

Improvement of epsilon-Poly-L-Lysine Production by Streptomyces albulus TUST2 Employing a Feeding Strategy

Shiru Jia Guoliang Wang Yanfang Sun Zhilei Tan

Streptomyces albulus TUST2, separated from a soil sample of Hainan Island, was cultivated in a stirred, submerged aerated 5-1 bioreactor. Carbon source and nitrogen source effects were clarified in fed-batch fermentation, particularly glucose and ammonium sulfate feedings for enhancing the epsiv-poly-L-lysine (epsiv-PL) production were elucidated. The culture was divided into two control phases. In phase I , the pH was maintained at its initial 6.8 for 36 h for acquiring high biomass; In phase II, the pH was maintained at 4.0 aiming at increasing the epsiv-PL accumulation. Moreover, pulsed feeding of glucose (800 g/l) was carried out accompanied by ammonium sulfate (80 g/l) discontinuously when their concentration reached a lower level (nearly 10 g/l) in the medium, so that the final concentration of glucose can be kept at 13 g/l. By using this feeding policy, the elevation of antibacterial activity of epsiv-PL by S. albulus TUST2 is 16.67%, and its accumulation in 4-days cultivation is 20.20 g/l. We have illuminated that substrate feeding strategy is a doable method for improving epsiv-PL production by S. albulus TUST2.

Ammonium sulfate

Carbon source

10.1109/icbbe.2009.5162940

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Citations (14)

Applications and Functions of γ-Poly-Glutamic Acid and its Derivatives in Medicine

Current Pharmaceutical Biotechnology (2020)

Guoliang Wang Qing Liu Young Mok Yang Soo‐Ung Lee Jeesoo Han

Background: γ-Poly-Glutamic Acid (γ-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. It is made from repeating units of L-glutamic acid, D-glutamic acid, or both connected through amide linkages between α-amino and γ-carboxylic acid groups. As a biopolymer substance, the attractive properties of γ-PGA are that it is water-soluble, biodegradable, biocompatible, non-toxic, non-immunogenic, and edible. Therefore, it can be used as a green and environmentally friendly biological material. Methods: The review concentrates on the reports revealing the functions and potential use of γ-PGA and its derivatives in medicine. Results & Discussion: γ-PGA is described to possess several properties that may be exploited in medicine. The biopolymer reportedly has been successfully applied not only as a metal chelator, drug carrier/ deliverer, and gene vector, but also used safely as a vaccine adjuvant, tissue engineering material, and contrast agent. Conclusion: γ-PGA could be potentially considered as a potential biomedical material in the field of medicine.

Biopolymer

Glutamic acid

Amide

Polyglutamic Acid

Biocompatible material

10.2174/1389201021999201118161155

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Citations (6)

Effect of Ferrous Ion on ε-Poly-l-Lysine Biosynthesis by Streptomyces diastatochromogenes CGMCC3145

Current Microbiology (2010)

Guoliang Wang Shiru Jia Tian Wang Liye Chen Qingchao Song

Streptomycetaceae

10.1007/s00284-010-9828-6

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Citations (14)

Mutagenesis and selective breeding of a high producing ɛ-poly-L-lysine strain

Frontiers of Chemical Science and Engineering (2012)

Tian Wang Shiru Jia Zhilei Tan Yujie Dai Shuai Song

Strain (injury)

10.1007/s11705-012-1273-6

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Citations (6)

Broth Recycling in Liquid Cultivation of Nostoc Flagelliforme Cells

Advances in intelligent and soft computing (2012)

Yujie Dai Feng Zhang Guoliang Wang Yonghong Chang Shiru Jia

Nostoc

10.1007/978-3-642-27537-1_6

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Citations (0)

Interaction of Zn(II) and Cu(II) with ε-poly-L-lysine and properties of the complexes

E3S Web of Conferences (2019)

Yanyan Xie Mengya Gao Yang Liu Qiang Fu Guoliang Wang

ε-Poly-L-lysine (ε-PL) is a natural food preservative with high safety to humans and a wide antimicrobial spectra. It was found that ε-PL could form precipitates when it contacted to Cu(II) and Zn(II). Thus in this study, two complexes of ZnCl 2 and CuCl 2 with ε-poly-L-lysine having molecular weights between 2 and 5 kDa were prepared and characterized by elemental analysis (EA), atom absorption spectrometry (AAS), chlorine assay, etc. The results show that the compositions of two complexes can be expressed as [ NH-(CH 2 ) 5 -CO ] 2n •(ZnCl 2 ) n •2nH 2 O and [ NH-(CH 2 )5-CO ] 2n •(CuCl 2 )n•2nH 2 O (n=6-18), respectively. The results of FT-IR reveal that the formation of Zn-N and Cu-N coordination bonds. X-RD patterns indicat that the two complexes are new phases different from the raw ε-PL material. On the basis of TG-DTA curves, the complexes have a coordination reaction. From the results of the bacteriostatic test, ε-PL-Zn(II) and ε-PL-Cu(II) have similar antibacterial activity to ligand ε-PL.

Natural bond orbital

10.1051/e3sconf/201913101003

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Citations (3)

Extraction, Structure and Bioactivity of Polysaccharides from Tricholoma matsutake (S. Ito et Imai) Singer (Review)

Applied Biochemistry and Microbiology (2022)

Guoliang Wang J.-Y. Li Y. Wang Y. Chen Q.-L. Wen

Functional food

10.1134/s0003683822040184

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Citations (3)