Junping Li

Shanxi Agricultural University

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Libin Liang

Shanxi Agricultural University

Hualan Chen

Harbin Veterinary Research Institute

Chenghuai Yang

China Institute of Veterinary Drug Control

Chengjun Li

Harbin Veterinary Research Institute

Ruiyuan Wang

Beihang University

Guangwen Wang

Commercial Aircraft Corporation of China (China)

Ruiyuan Wang

Shaanxi Normal University

Qibing Li

Chinese Academy of Agricultural Sciences

Qihong Li

Chinese PLA General Hospital

Peibiao Mai

Sun Yat-sen University

Cooperative Institutions

Chinese Academy of Agricultural Sciences

Sun Yat-sen University

Harbin Veterinary Research Institute

Guangzhou Medical University

Chinese Academy of Sciences

Second Affiliated Hospital of Guangzhou Medical University

Shanxi Agricultural University

Chinese Academy of Medical Sciences & Peking Union Medical College

Wuhan University

Sun Yat-sen Memorial Hospital

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Effects of a Low-Carbohydrate High-Fat Diet Combined with High-Intensity Interval Training on Body Composition and Maximal Oxygen Uptake: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health (2021)

Jing Hu Zhen Wang Bingkai Lei Junping Li Ruiyuan Wang

The low-carbohydrate high-fat (LCHF) diet has recently been subject to attention on account of its reported influences on body composition and physical performance. However, the combined effect of LCHF with high-intensity interval training (HIIT) is unclear. A systematic review and meta-analysis were conducted to explore the effect of the LCHF diet combined with HIIT on human body composition (i.e., body weight (BM), body mass index (BMI), fat mass (FM), body fat percentage (BFP), fat-free mass (FFM)) and maximal oxygen uptake (VO2max). Online libraries (PubMed, Web of Science, EMBASE, Cochrane Library, EBSCO, CNKI, Wan Fang) were used to search initial studies until July 2021, from which 10 out of 2440 studies were included. WMD served as the effect size with a confidence interval value of 95%. The results of meta-analysis showed a significant reduction in BM (WMD = −5.299; 95% CI: −7.223, −3.376, p = 0.000), BMI (WMD = −1.150; 95% CI: −2.225, −0.075, p = 0.036), BFP (WMD = −2.787; 95% CI: −4.738, −0.835, p = 0.005) and a significant increase in VO2max (WMD = 3.311; 95% CI: 1.705, 4.918, p = 0.000), while FM (WMD = −2.221; 95% CI: −4.582, 0.139, p = 0.065) and FFM (WMD = 0.487; 95% CI: −3.512, 4.469, p = 0.814) remained unchanged. In conclusion, the LCHF diet combined with HIIT can reduce weight and fat effectively. This combination is sufficient to prevent muscle mass loss during LCHF, and further enhance VO2max. Further research might be required to clarify the effect of other types of exercise on body composition and physical performance during LCHF.

High-Intensity Interval Training

Interval training

Intensity

10.3390/ijerph182010740

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Citations (10)

Downhill running induced DNA damage enhances mitochondrial membrane permeability by facilitating ER-mitochondria signaling

Journal of Muscle Research and Cell Motility (2022)

Junping Li Binting Zhao Sheng-Ju Chen Zhen Wang Kexin Shi

Immunofluorescence

Mitochondrial apoptosis-induced channel

10.1007/s10974-022-09634-0

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Citations (2)

Advances in Application of Fertilizer to Okra

Chinese Journal of Tropical Agriculture (2008)

Junping Li

The edible value, medicinal function, cultural characteristic of okra, and the effects of NPK, biofertilizer, microfertilizer on okra are reviewed in this paper, and the prospects for high yielding cultural practices for okra are discussed.

Biofertilizer

Value (mathematics)

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FSTL1 protects against acute aortic dissection by suppressing vascular smooth muscle cell phenotypic switching and degradation of the extracellular matrix

Journal of Molecular and Cellular Cardiology (2024)

Junping Li Wenhao He Shenyue Xu Jingzhi Liu Zhao-qi Huang

Degradation

10.1016/j.yjmcc.2024.11.008

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Clinical features and risk factors of pure red cell aplasia following major ABO-incompatible allogeneic hematopoietic stem cell transplantation

Hematology (2007)

Kanger Zhu Junping Li Tao Zhang Juan Zhong Jie Chen

The objective of this paper was to study the incidence, risk factors, clinical outcome, management and prevention of pure red cell aplasia (PRCA) following major ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively analyzed 11 cases of PRCA from a series of 42 patients undergoing major ABO-incompatible allo-HSCT from April 1997 to December 2005. Eleven out of the 42 patients developed PRCA (26.1%). All the 11 cases of PRCA were in blood group O recipients of grafts from blood group A donor (n = 9) or blood group B donor (n = 2). The following factors were associated with an increased risk of PRCA: (1) blood group O recipient; (2) blood group A donor; and (3) blood group O/A in recipient/donor pair. Only blood group a/A in recipient/donor pair was identified as being significantly associated with the occurrence of PRCA by multivariate analysis. Six patients who received donor-type plasma exchange did not develop PRCA and among them 5 cases were the blood group O recipients. Eight patients obtained spontaneous remission and in the remaining 3 patients 2 with long-lasting PRCA were successfully treated with plasma exchange with donor-type plasma replacement and the other one who was also complicated by EBV-associated lymphoproliferative disorder (EBV-PTLD) responded rapidly to anti-CD20 monoclonal antibody and achieved complete resolution of clinical finding and symptom of both EBV-PTLD and PRCA. We conclude that blood group A/O in donor/recipient pair is identified as being significantly associated with the occurrence of PRCA by multivariate analysis. Donor-type plasma exchange and anti-CD20 monoclonal antibody is an effective approach for the treatment of PRCA. PRCA could be prevented by plasma exchange prior to transplantation.

Blood type (non-human)

10.1080/10245330601111540

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Citations (31)

Avian leukosis virus contamination in live vaccines: A retrospective investigation in China

Veterinary Microbiology (2020)

Yaqing Mao Qi Su Junping Li Taozhen Jiang Yixin Wang

Newcastle Disease

Attenuated vaccine

Infectious bursal disease

10.1016/j.vetmic.2020.108712

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Citations (13)

[Effect of emodin on proliferation and cell cycle of human oral squamous carcinoma Tca8113 cells in vitro].

PubMed (2015)

Kailiang Zhang Kangli Jiao Yujuan Zhu Fang Wu Junping Li

To investigate the effect of emodin on proliferation and cell cycle distribution of human oral squamous carcinoma cells in vitro.Cultured human oral squamous carcinoma Tca8113 cells were treated with 2.5, 5, 10, 20, 40, 60 and 80 µmol/L emodin for 24, 48 or 72 h, with the cells treated with 0.1% DMSO as control. MTT assay and flow cytometry were used to evaluate the changes in cell proliferation and cell cycle distribution, respectively. Western blotting was employed to analyze the changes in the expression levels of the cell cycle-related proteins CDK2, cyclin E and P21 after emodin treatment.Emodin significantly inhibited the growth and proliferation of Tca8113 cells within 72 h in a time- and dose-dependent manner, and caused cell cycle arrest in G0-G1 phase. Western blotting revealed that emodin treatment significantly lowered the expression levels of CDK2, cyclin E and P21 proteins in Tca8113 cells (P<0.05).Emodin can inhibit the proliferation of Tca8113 cells and affect their cell cycle distribution possibly by inhibiting the signaling pathways of cell cycle regulation.

MTT assay

Cyclin E

Squamous carcinoma

Cyclin B1

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Morphological and functional characteristics of the meibomian gland in pediatric patients with epiblepharon

BMC Ophthalmology (2024)

Junping Li Xiaolin Qin Hong Jiang Yunan Guo Xin Liu

Abstract Background To observe morphologic and functional changes in meibomian glands in pediatric patients with and without lower eyelid epiblepharon. Methods In this prospective observation study, 55 eyes of 55 patients( 24 males, 31 females; mean age ± SD,9.82 ± 2.59 years; range 6–14 years) and 60 eyes of 60 controls ( 32 males, 28 females; mean age ± SD,10.57 ± 2.75 years; range 6–14 years) were included. The following tests were performed: eyelid margin abnormality by slit-lamp examination, measurement of noninvasive keratographic break-up time (NIKBUT), grading of absence of meibomian gland (meibography score) assessed with noncontact meibography, morphologic changes of meibomian glands (thinning, dilatation and distortion), tear production by the Schirmer 1 test, and grading of meibum quality and meibomian gland expressibility. Results The morphologic changes in meibomian glands were more common in the epiblepharon group (56.36%) than in the control group (28.33%) ( p = 0.002). The meibum quality was worse in the epiblepharon group than in the control group ( p = 0.009), and the NIKBUT was significantly shorter in the epiblepharon group than in the control group ( p = 0.012). There was no significant difference in the Schirmer 1 test, meibomian gland expressibility, eyelid margin abnormality score or total meibography score between the two groups. Morphologic changes in the meibomian glands in the upper eyelids (38.18%) were more common than those in the lower eyelids (20%) ( p = 0.036) in the epiblepharon group, and the meibography score was higher in the upper eyelids than in the lower eyelids ( p = 0.001). Conclusion There are morphological and functional changes in meibomian glands in pediatric patients with lower eyelid epiblepharon. Although the inverted eyelashes were located in the lower eyelid, morphological changes in the meibomian glands were more common in the upper eyelid.

Meibomian gland

Eyelid Diseases

Grading scale

Abnormality

10.1186/s12886-024-03345-5

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The Correlation Study of Artery Blood Gas of Cord Blood and Asphyxia Neonatorum

Junping Li

Objective:To discuss the correlation study of artery blood gas of neonate cord blood and asphyxia neonatorum.Methods:The artery blood gas of neonate cord blood of 42 cases of asphyxia neonatorum and 42 cases of mormal neonatorum.The levels of pH,PCO2,PO2 and BE between two groups were compared.Results:The levels of pH,PO_2 and BE in asphyxia neonatorum group were significantly lower than those in control group(P0.05),while PCO_2 was significantly higher than that in control group(P0.05).There were no significant differences in pH,PCO_2,PO_2 and BE between neonatal asphyxia group and intrauterine asphyxia grouo(P0.05).Conclusion:The analysis of artery blood gas of neonate cord blood for asphyxia neonatorum can judge the anaerobic condition of neonatorum,which can provide evidence for early anabiosis and salvage and prevent intrauterine asphyxia.

Asphyxia Neonatorum

Cord blood

pCO2

Arterial blood

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Empagliflozin Alleviates Atherosclerotic Calcification by Inhibiting Osteogenic Differentiation of Vascular Smooth Muscle Cells

Junping Li Changping Li Zhaoqi Huang Chunling Huang Juanzhang Liu

Objective: SGLT-2 inhibitors, such as empagliflozin, have been shown to reduce the occurrence of cardiovascular events and delay the progression of atherosclerosis. However, its role in atherosclerotic calcification remains unclear. The aim of this study is to determine if repurposing empagliflozin is beneficial in the treatment of atherosclerotic calcification.Methods: ApoE-/- mice were fed with western diet and empagliflozin was added to the drinking water for 24 weeks. Body weight was weekly monitored. After 24 weeks feeding, serum lipid levels, fasting and ad libitum blood glucose levels were measured. Arterial calcification was assessed by alizarin red and von kossa staining in aortic roots. Calcification of vascular smooth muscle cells (VSMCs) and aortic rings were induced by osteogenic media (OM) or inorganic phosphorus (Pi). RNA sequencing of VSMCs cultured in OM with or without empagliflozin was further performed to analyze the underlying mechanisms. qRT-PCR was used to detect the marker gene expression of osteogenic differentiation of VSMCs. Results: Empagliflozin treatment significantly alleviated arterial calcification during atherosclerosis in ApoE-/- mice, while had little effect on body weight and blood glucose levels. Also, empagliflozin significantly inhibits calcification of primary VSMCs and aortic rings in vitro. Additionally, empagliflozin significantly inhibits osteogenic differentiation of VSMCs.Conclusion: Empagliflozin alleviates atherosclerotic calcification by inhibiting osteogenic differentiation of VSMCs, which addressed a critical need for the discovery of a drug-based therapeutic approach in the treatment of atherosclerotic calcification.

Empagliflozin

10.2139/ssrn.4538073

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