Yanmin Li

Weifang People's Hospital

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Jianbo Tian

Wuhan University

Zequn Lu

Wuhan University

Caibo Ning

Huazhong University of Science and Technology

Linyun Fan

Wuhan University

Yizhuo Liu

Fuzhou University

Zhidong Zhang

Southwest Minzu University

Yimin Cai

Zhongnan Hospital of Wuhan University

Xiaojun Yang

Air Force Medical University

Shuoni Chen

Wuhan University

Ying Zhu

Zhejiang Chinese Medical University

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Wuhan University

Chinese Academy of Sciences

Huazhong University of Science and Technology

Chinese Academy of Agricultural Sciences

Lanzhou Veterinary Research Institute

The Pirbright Institute

University of Chinese Academy of Sciences

Renmin Hospital of Wuhan University

Zhongnan Hospital of Wuhan University

Zhejiang University

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Research on Practical Teaching of Interaction Design Course under the Background of Educational Informatization

Frontiers in Educational Research (2024)

Yanmin Li Zewen Wang

In the context of educational informatization, this article takes the course "Interaction Design" as the research object, and deeply explores the impact of information technology on practical teaching and corresponding strategies. Research has found that educational informatization has expanded subject resources and learning opportunities, providing students with a wide and profound learning experience. The introduction of digital tools not only makes teaching more flexible, but also provides students with more practical operation opportunities to simulate real work scenarios. The precise personalized learning path design promotes the improvement of learning efficiency. In addition, this article focuses on the integration of design thinking and practical applications. Through interactive learning and virtual team projects on online learning platforms, students are encouraged to organically integrate design thinking into practice, cultivating more innovative and practical interaction design professionals. The article summarizes the opportunities and challenges brought by educational informatization, emphasizing that educators should continuously innovate teaching models in the era of rapid development of information technology, and promote the deepening and development of educational informatization in the field of interactive design.

Informatization

Course (navigation)

10.25236/fer.2024.070119

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Data from Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk Loci

Bin Li Yimin Cai Can Chen Gaoyuan Li Ming Zhang

<div>AbstractAlternative polyadenylation (APA) is emerging as a major mechanism of posttranscriptional regulation. APA can impact the development and progression of cancer, suggesting that the genetic determinants of APA might play an important role in regulating cancer risk. Here, we depicted a pan-cancer atlas of human APA quantitative trait loci (apaQTL), containing approximately 0.7 million apaQTLs across 32 cancer types. Systematic multiomics analyses indicated that cancer apaQTLs could contribute to APA regulation by altering poly(A) motifs, RNA-binding proteins (RBP), and chromatin regulatory elements and were preferentially enriched in genome-wide association studies (GWAS)–identified cancer susceptibility loci. Moreover, apaQTL-related genes (aGene) were broadly related to cancer signaling pathways, high mutational burden, immune infiltration, and drug response, implicating their potential as therapeutic targets. Furthermore, apaQTLs were mapped in Chinese colorectal cancer tumor tissues and then screened for functional apaQTLs associated with colorectal cancer risk in 17,789 cases and 19,951 controls using GWAS-ChIP data, with independent validation in a large-scale population consisting of 6,024 cases and 10,022 controls. A multi-ancestry–associated apaQTL variant rs1020670 with a C>G change in DNM1L was identified, and the G allele contributed to an increased risk of colorectal cancer. Mechanistically, the risk variant promoted aberrant APA and facilitated higher usage of DNM1L proximal poly(A) sites mediated by the RBP CSTF2T, which led to higher expression of DNM1L with a short 3′UTR. This stabilized DNM1L to upregulate its expression, provoking colorectal cancer cell proliferation. Collectively, these findings generate a resource for understanding APA regulation and the genetic basis of human cancers, providing insights into cancer etiology.Significance:Cancer risk is mediated by alternative polyadenylation quantitative trait loci, including the rs1020670-G variant that promotes alternative polyadenylation of DNM1L and increases colorectal cancer risk.</div>

Genome-wide Association Study

10.1158/0008-5472.c.6908364

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On the Effect of Artistic Quality Development in Education

Hundred Schools in Art (2003)

Yanmin Li

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Supplementary Data from Pan-Cancer Analysis of Microbiome Quantitative Trait Loci

Can Chen Yimin Cai Yizhuo Liu Shuoni Chen Yanmin Li

Supplementary Data from Pan-Cancer Analysis of Microbiome Quantitative Trait Loci

Trait

10.1158/0008-5472.22432556.v1

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Sero-Epidemiology and Associated Risk Factors of Foot-and-Mouth Disease (FMD) in the Northern Border Regions of Pakistan

Veterinary Sciences (2023)

Munib Ullah Yanmin Li Kainat Munib Hanif Ur Rahman Zhidong Zhang

The present cross-sectional survey was carried out to investigate the distribution and risk factors of FMD in Pakistan’s northern border regions. About 385 serum samples were compiled from small ruminants (239) and large ruminants (146) and tested using 3ABC-Mab-bELISA. An overall apparent seroprevalence of 67.0% was documented. The highest seroprevalence of 81.1% was reported in the Swat, followed by 76.6% in Mohmand, 72.7% in Gilgit, 65.6% in Shangla, 63.4% in Bajaur, 46.6% in Chitral and lowest 46.5% in Khyber region. Statistically significant variations in seroprevalence of 51.5%, 71.8%, 58.3%, and 74.4% were recorded in sheep, goats, cattle, and buffaloes, respectively. From the different risk factors investigated, age, sex, species of animal, seasons, flock/herd size, farming methods, outbreak location, and nomadic animal movement were found to be significantly associated (p < 0.05) with the seroprevalence of FMD. It was concluded that proper epidemiological study, risk-based FMD surveillance in small ruminants, vaccination strategy, control measures for transboundary animal movement, collaborations, and awareness programs need to be practiced in the study regions to investigate the newly circulating virus strains in large and small ruminants and associated factors for the wide seroprevalence to plan proper control policies to bound the consequence of FMD in the region.

10.3390/vetsci10050356

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PHALAENOPSIS種子発芽のプロトコームを受容体とする遺伝形質転換システムの構築【JST・京大機械翻訳】

He'nan nongye kexue (2016)

Hechen Zhang Dong Xiaoyu Limin Wang Jing Zhang M Eng Yue’E

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Dramatic improvement in FMD DNA vaccine efficacy and cross-serotype antibody induction in pigs following a protein boost

Vaccine (2008)

Yanmin Li Catrina Stirling M. Denyer Pippa Hamblin G. Hutchings

Inactivated vaccine

10.1016/j.vaccine.2008.01.037

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Insight into Municipal Reactive Nitrogen Emissions and Their Influencing Factors: A Case Study of Xiamen City, China

Atmosphere (2023)

Yanmin Li Xu Yang Shihang Wang Shenghui Cui

Reactive nitrogen (Nr) has been confirmed as an indispensable nutrient for the city ecosystem, but high-intensity human activities have led to nitrogen pollution in cities, especially in coastal cities, jeopardizing ecosystem services and human health. Despite this, the characteristics and influencing factors of Nr remain unclear in coastal cities, particularly in the context of rapid urbanization. This study used the material flow analysis method to estimate Nr emissions in Xiamen from 1995 to 2018 and evaluated the characteristics of excessive Nr emissions. The STIRPAT model was used to identify and explore factors contributing to observed Nr levels in coastal cities. As indicated by the results, (1) the quantity of Nr generated by human activities increased 3.5 times from 1995 to 2018. Specifically, the total Nr entering the water environment showed a general increase with fluctuations, exhibiting an average annual growth rate of 3.1%, increasing from 17.2 Gg to 35.1 Gg. (2) Nr loads in the nearby sea increased notably from 8.1 Gg in 1995 to 25.4 Gg in 2018, suggesting a threefold augmentation compared with surface waters and groundwater. (3) NOx was the gaseous Nr with the greatest effect on the atmosphere in Xiamen, which was primarily due to fossil fuel consumption. (4) Population and per capita GDP were major factors contributing to Nr load in the water environment, while Nr emission to the atmosphere was influenced by population and energy consumption. These findings provide valuable insights for tailored approaches to sustainable nitrogen management in coastal cities.

Reactive nitrogen

10.3390/atmos14101549

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エストロゲンはER-ΑによってCYP2C8の発現を調節する。【JST・京大機械翻訳】

Xumu Shouyi Xuebao (2016)

Yanmin Li Cuicui Li Zheng Hang Tian Fangyuan Taian Wang

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Gut Microbiota Signatures in Tumor, Para-Cancerous, Normal Mucosa, and Feces in Colorectal Cancer Patients

Frontiers in Cell and Developmental Biology (2022)

Yanmin Li Hong Cao Bojian Fei Qizhong Gao Wanya Yi

Background: Association studies have linked microbiome alterations with colorectal cancer (CRC). However, differences in tumor, para-cancerous, normal mucosal, and fecal microbiota remain to be strengthened. Methods: We performed a study on the ecologically rich and taxonomically diverse of gut microbiota using three types of colorectal mucosa (tumor mucosa, para-cancerous mucosa, normal mucosa) and feces from 98 CRC patients. Additionally, we profiled the microbiota in the fecal occult blood test (FOBT) positive and negative groups at different sampling sites. Results: We found striking variations between tumor mucosal microbiota and normal mucosal microbiota. However, there was no significant difference between tumor and para-cancerous mucosal microbiota, as well as between para-cancerous and normal mucosal microbiota, revealing that the para-cancerous mucosal microbiota was a transitional state between the tumor and normal mucosal microbiota. And the substantial shifts in the fecal microbiota compared to mucosal microbiota indicated the risk of using fecal microbiota to define mucosal microbiota. A strong correlation between FOBT positive and Fusobacterium was discovered, indicating this adherent-invasive genus was closely related to intestinal bleeding. Furthermore, we identified six key genera, including Fusobacterium, Gemella, Campylobacter, Peptostreptococcus, Alloprevotella, and Parvimonas, which appear to be consistently over-represented in tumor mucosa compared to normal mucosa and/or in mucosa compared to feces. Conclusion: Compositional alterations in the microbiota existed in three types of colorectal mucosa and feces in CRC patients. Six key genera may contribute to the topographic variances in the microbiota of tumor-bearing colorectum.

Intestinal mucosa

10.3389/fcell.2022.916961

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