Wenguang Zhang

First Affiliated Hospital of Zhengzhou University

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Pengli Zhou

First Affiliated Hospital of Zhengzhou University

Xinwei Han

First Affiliated Hospital of Zhengzhou University

Xinwei Han

First Affiliated Hospital of Zhengzhou University

Dechao Jiao

Zhengzhou University

Peng‐Xu Ding

First Affiliated Hospital of Zhengzhou University

Zhaonan Li

First Affiliated Hospital of Zhengzhou University

Yonghua Bi

First Affiliated Hospital of Zhengzhou University

Jianzhuang Ren

First Affiliated Hospital of Zhengzhou University

Xueliang Zhou

First Affiliated Hospital of Zhengzhou University

Juanfang Liu

Chongqing University

Cooperative Institutions

First Affiliated Hospital of Zhengzhou University

Zhengzhou University

Air Force Medical University

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

National Clinical Research Center for Digestive Diseases

Xijing Hospital

Universitat de Barcelona

Sun Yat-sen University

Instituto de Salud Carlos III

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

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125I seeds inhibit proliferation and promote apoptosis in cholangiocarcinoma cells by regulating the AGR2-mediated p38 MAPK pathway

Cancer Letters (2021)

Xueliang Zhou Wenguang Zhang Mengmeng Dou Zhaonan Li Zaoqu Liu

10.1016/j.canlet.2021.10.014

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Citations (17)

Fluoroscopic Removal of Embedded Esophageal Self-Expanding Metal Stents: Stent-in-Stent Combined with Guidewire Lasso Technique

Annals of Thoracic and Cardiovascular Surgery (2021)

Yonghua Bi Hongmei Chen Wenguang Zhang Xinwei Han Jianzhuang Ren

We report the use of the guidewire lasso technique for the removal of an embedded esophageal self-expanding metal stent (SEMS), following a failure of distal to proximal invagination by removal hook caused by stent incorporation. During a removal procedure of an embedded SEMS using the hook retrieval device, the strut fractured and the stent retained. Attempts to pull up the retained stent using hook were not effective. Thus, the lasso technique with a guidewire over the retained stent was performed and successfully removed with no procedure-related complications. The patient is alive without dysphagia after 3 months follow-up.

Hook

Lasso

10.5761/atcs.cr.21-00120

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Asymptomatic gastric tuberculosis in the gastric body mimicking an isolated microscopic erosion

Medicine (2022)

Wenguang Zhang Fusheng Song Zhimei Zhang Jun J. Yang Zhao Linlin

Gastric tuberculosis is rarely seen in clinical practice, which occurs mostly secondary to lung tuberculosis, intestinal tuberculosis, and other common tuberculosis. Gastric tuberculosis rarely presents as a single microscopic superficial erosion. We recently diagnosed such a case, hence reporting it herein.A 40-year-old female patient was admitted with a chief complaint of painful enlarged cervical lymph nodes. She had no other symptoms or any previous history of remarkable diseases.Physical examination found multiple enlarged cervical lymph nodes. Computer tomography revealed multiple circular well-defined soft tissue masses in the bilateral carotid sheath spaces. A cervical lymph node biopsy showed caseous necrosis with infiltration of neutrophils and lymphocytes, and most importantly, mycobacteria through staining for acid fast bacilli. Routine gastroscopy showed a 0.5 cm × 0.5 cm well-defined erosion on the large curvature of the gastric body. Gastric biopsy revealed chronic granulomatous inflammation with mycobacteria through staining for acid fast bacilli. The patient was diagnosed as having cervical lymph node tuberculosis and gastric tuberculosis.She received 6 months of standard anti-tuberculosis therapy. The enlarged cervical lymph nodes shrank in size and the pain was relieved.Gastroscopy should be performed to look for gastric tuberculosis if the patient presents primary tuberculosis in other organs/tissues such as cervical lymph nodes. If any small erosion is found, a biopsy is justified for checking the possibility of gastric tuberculosis.

Caseous necrosis

Cervical lymph nodes

10.1097/md.0000000000028888

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Drug-eluting bead trans-arterial chemoembolization combined with microwave ablation therapy vs. microwave ablation alone for early stage hepatocellular carcinoma: a preliminary investigation of clinical value

Journal of Cancer Research and Clinical Oncology (2021)

Juanfang Liu Wenguang Zhang Huibin Lu Hongbin Li Xueliang Zhou

To assess the clinical value of drug-eluting bead trans-arterial chemoembolization (DEB-TACE) combined with microwave ablation (MWA) vs. MWA treatment alone for early stage hepatocellular carcinoma (HCC).Consecutive data from 102 HCC patients at early stage who were referred to our hospital from December 2014 to May 2016 were retrospectively collected. Forty-seven patients underwent DEB-TACE combined with MWA treatment, whereas 55 patients underwent MWA alone. After 1 month of treatment, the tumour responses of the patients were assessed using the mRECIST criteria. Treatment-related complications and hepatic function were also analysed for the two groups. In addition, overall survival (OS) and progression-free survival (PFS) were calculated and compared.Patients in the combined treatment group (DEB-TACE combined with MWA) presented a better objective response rate (ORR) and disease control rate (DCR) compared with those in the monotherapy group (MWA treatment). The median OS and PFS were longer in the combined treatment group compared with the monotherapy group. Multivariate Cox's regression further illustrated that DEB-TACE + MWA vs. MWA was an independent protective factor for PFS and OS. No serious treatment-related complications were observed in any of the patients.Combined treatment with DEB-TACE appeared to have advantages in prolonging OS and PFS compared to MWA. Therefore, combined treatment was efficient and should be strongly recommended to early stage HCC patients.

Microwave ablation

Liver function

10.1007/s00432-021-03760-x

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Endovascular Treatment for Extrahepatic Portal Vein Bifurcation Stenosis after a Whipple Procedure Using the Kissing Stents Technique

Annals of Vascular Surgery (2013)

Wenguang Zhang Dongmei Liu Zhen Li Yanli Wang Peng‐Xu Ding

Superior mesenteric vein

Splenic vein

10.1016/j.avsg.2013.04.017

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Citations (9)

Treatment of aortic thrombosis with retrievable stent filter and thrombolysis: a case report

BMC Cardiovascular Disorders (2019)

Yonghua Bi Hongmei Chen Wenguang Zhang Jianzhuang Ren Xinwei Han

The retrievable stent filter (RSF) has been previously used for the treatment of vena cava thrombosis. In this study, the RSF was implanted to treat aortic thrombosis and then withdrawn. A 47-years-old woman presented with severe abdominal pain and fever. Computed tomography showed massive mural thrombosis in the thoracic and abdominal aorta complicated by portal venous thrombosis. The RSF was implanted, a transjugular intrahepatic portosystemic stent shunt was established and a thrombolytic catheter was inserted for portal vein thrombolysis. The aortic thrombus was successfully compressed and fixed without thrombosis. After 15 days, abdominal pain had ceased, the abdominal aortic thrombus was mostly dissolved and the RSF was retrieved. Catheter angiography confirmed the recovery of portal vein thrombosis. The RSF was able to compress and fix aortic thrombus without the usual complications of stenting after removal.

Angiology

Vascular surgery

10.1186/s12872-019-1037-z

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Citations (1)

Antibacterial and antihyperplasia polylactic acid/silver nanoparticles nanofiber membrane-coated airway stent for tracheal stenosis

Colloids and Surfaces B Biointerfaces (2021)

Zhaonan Li Dechao Jiao Wenguang Zhang Kewei Ren Lingxiao Qiu

Antibacterial and antihyperplasia airway stents are highly desirable for tracheal stenosis. Herein, a series of polylactic acid (PLA) and silver nanoparticles (AgNPs) nanofiber membranes (PLA, PLA-4 %AgNPs and PLA-6 % AgNPs) were prepared by electrospinning. The physicochemical and biological properties of the resultant nanofiber membranes were examined. The SEM and drug release results indicated that the AgNPs were successfully introduced into PLA, and could be sustained to be released from membranes. The membranes showed antibacterial activity against S. aureus and P. aeruginosa, and cytocompatibility towards CCC-HPF-1 and NHBE cells. Furthermore, the membranes were used to cover a self-expandable metallic stent for use in the treatment of rabbit tracheal stenosis. The in vivo results revealed that the membranes, especially the AgNPs-coated airway stent could suppress tracheal stenosis by reducing inflammation and collagen deposition. Additionally, the study further confirmed that the inhibition of bacterial content in the trachea could be positively correlated with the reduction in tracheal granulation tissue hyperplasia. Conclusively, the PLA/AgNPs nanofiber membrane-coated airway stent has practical value for patients with clinical tracheal stenosis.

Electrospinning

Granulation tissue

Polylactic Acid

Silver nanoparticle

10.1016/j.colsurfb.2021.111949

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Citations (30)

Endovascular embolism treatment for 92 patients with ruptured anterior communicating artery aneurysms

Guoji yiyao weisheng daobao (2014)

Xiaohui Li Ge Huang Yi‐Long Wu Zhibin Li Jiyong Gu

Objective To summarize and discuss the experience of endovascular embolization treatment for ruptured anterior communicating artery aneurysm.Methods The clinical data of 92 patients with ruptured anterior communicating artery aneurysm treated by endovascular embolization were retrospectively analyzed and followed up.Results Among the 92 patients,81 were 100％ obliterated,5 were 95％ obliterated,3 were 90％ obliterated,3 died of second rupture of aneurysm,5 suffered postoperative cerebral infarction,and 2 died.87 cases were followed up and 1 recurred.Conclusions Endovascular embolism is effective for treating ruptured anterior communicating artery aneurysm though it is difficult to treat. Key words: Anterior communicating artery aneurysm; Endovascular treatment

Anterior communicating artery

Anterior cerebral artery

10.3760/cma.j.issn.1007-1245.2014.20.013

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Topical use of ozone effectively alleviates the acute symptoms and quality of life of patients with moderate to severe bullous pemphigoid: a randomized controlled trial^†

Frontiers of Nursing (2020)

Li Li Li-Yun Sang Wenguang Zhang Tong Wang Shuping Guo

Abstract Objective To evaluate the adjuvant treatment of acute stage symptoms and quality of life of patients with bullous pemphigoid (BP) with ozone. Methods We included 74 patients with moderate and severe BP hospitalized from July 2018 to December 2020. The participants were randomly divided into the control group and the ozone group, with 37 patients in each group (n = 37). The control group used tap water to wash the whole body, and mupirocin ointment was used for the erosions. The ozone group used ozone water to wash the whole body, and the erosion place was coated with ozone oil. The bullous pemphigoid disease area index (BPDAI) score of BP disease was used to observe the clinical symptoms and skin lesions of the two groups before and on day 3, 7, and 14 after treatment. Pruritus and sleep were observed before and on day 3, 7, and 14 after treatment. The Dermatology Life Quality Index (DLQI) was used to observe the quality of life before and after treatment and the adverse reactions were recorded. Results The total BPDAI score and erythema score in the ozone group were significantly different from those in the control group on day 3, 7, and 14 after treatment ( P < 0.050). The scab drying time and erosion drying time of ozone group were shorter than that of control group ( P < 0.001). There were statistically significant differences between the ozone group and the control group in pruritus score and sleep score on day 3, 7, and 14 after treatment ( P < 0.001). There was statistically significant difference in skin disease quality of life between the two groups 14 days after treatment ( P < 0.001). No significant adverse reactions and complications were observed in both groups. Conclusions Ozone external use can rapidly improve the acute stage of edema erythema, erosion, and itching of BP, improve the quality of life of patients, is an effective treatment method, and worthy of clinical promotion.

Ozone Therapy

Erythema

10.2478/fon-2020-0024

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Citations (4)

Clinical study of transjugular intrahepatic portosystemic shunt combined with AngioJet thrombectomy for acute portal vein thrombosis in non-cirrhosis

Medicine (2021)

Zhaonan Li Wenguang Zhang Dechao Jiao Xueliang Zhou Pengli Zhou

To evaluate the outcomes of the transjugular intrahepatic portosystemic shunt (TIPS) combined with AngioJet thrombectomy in patients with noncirrhotic acute portal vein (PV) thrombosis.Retrospective analysis from January 2014 to March 2017, 23 patients underwent TIPS combined with AngioJet thrombectomy for acute PV thrombosis in noncirrhosis. The rates of technical success, the patency of the PV, liver function changes, and complications were evaluated.Twenty-three patients underwent combined treatment, with a technical success rate of 100%. Twenty-four hours after treatment, PV thrombosis grade was improved significantly (P = .001). Before and after treatment, Albumin (gm/dl), aspartate transaminase (IU/l), alanine transaminase (IU/l), and platelets (109/L) were all significantly improved (P < .05). Minor complications include hematoma, hematuria, and hepatic encephalopathy. After 1 week of treatment, computed tomography scan revealed 8.7% (2/23) cases of hepatic envelope hematoma (thickness less than 2 cm). Hemoglobinuria occurred in 18/23 (78.3%) patients after treatment and returned to normal within 1 to 2 days. Two patients 2/23 (8.7%) had transient grade I encephalopathy after TIPS. The 1-year overall survival rate was 100% (23/23). No major complications during treatment in all patientsAngioJet thrombectomy via TIPS has a favorable short-term effect in clearing thrombus and alleviating symptoms in diffuse acute PVT. The long-term efficacy of this treatment needs to be further studied.

Portal vein thrombosis

Hepatic Encephalopathy

Liver function

10.1097/md.0000000000024465

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Citations (2)