Fei Shen

Nanjing University of Finance and Economics

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Bryan P. Schneider

Indiana University – Purdue University Indianapolis

Nancy E. Davidson

University of Washington

Joseph A. Sparano

Icahn School of Medicine at Mount Sinai

Guanglong Jiang

Indiana University – Purdue University Indianapolis

George W. Sledge

Caris Life Sciences (United States)

Kathy D. Miller

Indiana University Health

Milan Radovich

Caris Life Sciences (United States)

Yong Fang

Nanjing University of Finance and Economics

Laura Gardner

Northwestern University

Dongbing Lai

Indiana University – Purdue University Indianapolis

Cooperative Institutions

Nanjing University of Finance and Economics

Chinese Academy of Sciences

Sichuan Agricultural University

Zhejiang University

Indiana University – Purdue University Indianapolis

Ministry of Agriculture and Rural Affairs

Sun Yat-sen University

Indiana University School of Medicine

Shanghai Jiao Tong University

Nanjing Tech University

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Thermodynamic models for determination of the solid–liquid equilibrium of oxytocin in (acetonitrile+acetone) binary solvent mixtures

Fluid Phase Equilibria (2015)

Qi Zhang Yonghong Hu Fei Shen Wenge Yang Gang Wu

Gravimetric analysis

10.1016/j.fluid.2015.08.009

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Citations (2)

Data from Impeding Circulating Tumor Cell Reseeding Decelerates Metastatic Progression and Potentiates Chemotherapy

Qian Chen Asurayya Worrede Fei Shen Anthony DiNatale Ramanpreet Kaur

<div>AbstractCirculating tumor cells (CTCs) are commonly detected in the systemic blood of patients with cancer with metastatic tumors. However, the mechanisms controlling the viability of cancer cells in blood and length of time spent in circulation, as well as their potential for generating additional tumors are still undefined. Here, it is demonstrated that CX3CR1, a chemokine receptor, drives reseeding of breast CTCs to multiple organs. Antagonizing this receptor dramatically impairs the progression of breast cancer cells in a relevant model of human metastatic disease, by affecting both tumor growth and numerical expansion. Notably, therapeutic targeting of CX3CR1 prolongs CTC permanence in the blood, both promoting their spontaneous demise by apoptosis and counteracting metastatic reseeding. These effects lead to containment of metastatic progression and extended survival. Finally, targeting CX3CR1 improves blood exposure of CTCs to doxorubicin and in combination with docetaxel shows synergistic effects in containing overall tumor burden.Implications:The current findings shed light on CTCs reseeding dynamics and support the development of CX3CR1 antagonism as a viable strategy to counteract metastatic progression.</div>

Circulating tumor cell

Tumor progression

10.1158/1541-7786.c.6540148

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Multivariate classification of rice wines according to ageing time and brand based on amino acid profiles

Food Chemistry (2011)

Fei Shen Yibin Ying Bobin Li Yunfeng Zheng Qing Zhuge

10.1016/j.foodchem.2011.04.062

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Citations (53)

Use of FI-IR and Miniature Fiber Optic Spectrometers in Measurements of Soluble Solids Content of Pear Juice

2009 Reno, Nevada, June 21 - June 24, 2009 (2009)

Tong Sun Fei Shen Minglin Chen Yibin Ying

The objective of this research was to measure soluble solids content (SSC) of pear juice using FT-NIR and USB4000 spectrometer, also the results of FT-NIR and USB4000 spectra were compared. The absorption spectra of 228 pear juice samples were collected by FT-NIR spectrometer with wavelength range of 660-1100 nm and USB4000 spectrometer with wavelength range of 345-1040 nm. The partial least squares regression (PLSR) combined with four spectral pre-processing methods and stepwise multiple linear regression (SMLR) were used to develop calibration models. The results show that both FT-NIR spectra and USB4000 spectra are suitable for assessing SSC of pear juice, and FT-NIR spectra is better than USB4000 spectra to measure SSC of pear juice. The coefficients of determination (R2), root mean square error of calibration (RMSEC) and root mean square error of prediction (RMSEP) for FT-NIR spectra and USB4000 spectra are 0.97, 0.141, 0.167, and 0.85, 0.325, 0.370, respectively. SMLR using sensitive wavelengths for FT-NIR spectra also obtains acceptable results.

Content (measure theory)

10.13031/2013.26932

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Supplementary Table 4 from Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199

Bryan P. Schneider Lang Li Milan Radovich Fei Shen Kathy D. Miller

Supplementary Table 4 - Summary of SNPs with p<0.0001 in EA patients with Grade 2-4 NE in E5103.

Taxane

Table (database)

Genome-wide Association Study

Genetic Association

10.1158/1078-0432.22456365.v1

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Data from Prognostic and Predictive Value of Tumor Vascular Endothelial Growth Factor Gene Amplification in Metastatic Breast Cancer Treated with Paclitaxel with and without Bevacizumab; Results from ECOG 2100 Trial

Bryan P. Schneider Robert J. Gray Milan Radovich Fei Shen Gail H. Vance

<div>AbstractPurpose: Clinically validated biomarkers for anti-angiogenesis agents are not available. We have previously reported associations between candidate VEGFA single-nucleotide polymorphisms (SNP) and overall survival (OS) in E2100. The associations between tumor VEGFA amplification and outcome are evaluated here.Experimental Design: E2100 was a phase III trial comparing paclitaxel with or without bevacizumab for patients with metastatic breast cancer. FISH to assess gene amplification status for VEGFA was conducted on paraffin-embedded tumors from 363 patients in E2100. Evaluation for association between amplification status and outcomes was conducted.Results: Estrogen receptor (ER)+ or progesterone receptor (PR)+ tumors were less likely to have VEGFA amplification than ER/PR− tumors (P = 0.020). VEGFA amplification was associated with worse OS (20.2 vs. 25.3 months; P = 0.013) in univariate analysis with a trend for worse OS in multivariate analysis (P = 0.08). There was a significant interaction between VEGFA amplification, hormone receptor status, and study arm. Patients with VEGFA amplification and triple-negative breast cancers (TNBC) or HER2 amplification had inferior OS (P = 0.047); amplification did not affect OS for those who were ER+ or PR+ and HER2−. Those who received bevacizumab with VEGFA amplification had inferior progression-free survival (PFS; P = 0.010) and OS (P = 0.042); no association was seen in the control arm. Test for interaction between study arm and VEGFA amplification with OS was not significant.Conclusion:VEGFA amplification in univariate analysis was associated with poor outcomes; this was particularly prominent in HER2+ or TNBCs. Additional studies are necessary to confirm the trend for poor OS seen on multivariate analysis for patients treated with bevacizumab. Clin Cancer Res; 19(5); 1281–9. ©2012 AACR.</div>

10.1158/1078-0432.c.6521718.v1

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Supplementary Figure 1 from Genome-Wide Association Study for Anthracycline-Induced Congestive Heart Failure

Bryan P. Schneider Fei Shen Laura Gardner Milan Radovich Lang Li

Genome wide genotyping of E5103 samples. Quality controls for GWAS.

Genome-wide Association Study

10.1158/1078-0432.22465634

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DEM Study of the Motion Characteristics of Rice Particles in the Indented Cylinder Separator

Sensors (2022)

Xinzhi Yu Xuesong Jiang Haiyang Gu Fei Shen

The precise separation of rice particles is an important step in rice processing. In this paper, discrete element simulations of the motion of rice particles of different integrity in an indented cylinder separator were carried out using numerical simulation methods. The effects of single factors (cylinder rotation rate, cylinder axial inclination angle, and collection trough inclination angle) on the motion trajectories of particles are investigated and the probability distribution functions of particles are obtained. The statistical method of Kullback-Leibler divergence is used to quantitatively evaluate the differences in the probability distribution functions of the escape angles of particles of different degrees of integrity. The purpose of this paper is to determine the optimum parameters for an indent cylinder separator by understanding the material cylinder separating process from particle scale and to provide a basis for the numerical design of a grain particle cylinder separators.

Separator (oil production)

Gravity separation

10.3390/s23010285

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Citations (1)

Determination of Amino Acids in Chinese Rice Wine by Fourier Transform Near-Infrared Spectroscopy

Journal of Agricultural and Food Chemistry (2010)

Fei Shen Xiaoying Niu Danting Yang Yibin Ying Bobin Li

Chinese rice wine is abundant in amino acids. The possibility of quantitative detection of 16 free amino acids (aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, lysine, histidine, and arginine) in Chinese rice wine by Fourier transform near-infrared (NIR) spectroscopy was investigated for the first time in this study. A total of 98 samples from vintage 2007 rice wines with different aging times were analyzed by NIR spectroscopy in transmission mode. Calibration models were developed using partial least-squares regression (PLSR) with high-performance liquid chromatography (HPLC) by postcolumn derivatization and diode array detection as a reference method. To validate the calibration models, full cross (leave-one-out) validation was employed. The results showed that the calibration statistics were good (rcal > 0.94) for all amino acids except proline, histidine, and arginine. The correlation coefficient in cross validation (rcv) was >0.81 for 12 amino acids. The residual predictive deviation (RPD) value obtained was >1.5 in all amino acids except proline and arginine, and it was >2.0 in 6 amino acids. The results obtained in this study indicated that NIR spectroscopy could be used as an easy, rapid, and novel tool to quantitatively predict free amino acids in Chinese rice wine without sophisticated methods.

Isoleucine

Alanine

10.1021/jf1017912

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Citations (116)

Analysis of characteristic volatile flavor components in aseptic vacuum packaged spiced mutton.

He Bai Luo Ruiming Wang Yongrui Dan Ding Fei Shen

Vacuum packing

Aseptic processing

Sous vide

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