Yuan Liao

Shenzhen Nanshan Center for Chronic Disease Control

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Fadi Chen

Ministry of Agriculture and Rural Affairs

Jiafu Jiang

Nanjing Agricultural University

Sumei Chen

Ministry of Agriculture and Rural Affairs

Zhiyong Guan

Nanjing Agricultural University

Weimin Fang

Nanjing Agricultural University

Weimin Fang

Nanjing Agricultural University

Haibin Wang

Xiamen University

Guoji Guo

Zhejiang University

Haide Chen

Zhejiang University

Xiaoping Han

Zhejiang University

Cooperative Institutions

Zhejiang University

Chinese Academy of Sciences

Nanjing Agricultural University

Ministry of Agriculture and Rural Affairs

First Affiliated Hospital Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

University of Chinese Academy of Sciences

Peking University

Harbin Medical University

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Analysis and Design of Financial Wealth Management Platform Based on Cloud Edge Collaboration

Yuan Liao Yingru Gou Zibo Liu Jie Zhang

Financial Management

10.1109/aiotc63215.2024.10748328

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Oridonin inhibits hypoxia-induced epithelial–mesenchymal transition and cell migration by the hypoxia-inducible factor-1α/matrix metallopeptidase-9 signal pathway in gallbladder cancer

Anti-Cancer Drugs (2019)

Kunlun Chen Jianwen Ye Lei Qi Yuan Liao Renfeng Li

Hypoxia has crucial roles in cancer development and progression. Our previous study indicated that cell migration was increased in a hypoxic microenvironment in GBC-SD gallbladder cancer (GBC) cells. Oridonin, a bioactive diterpenoid compound that is isolated from the plant Rabdosia rubescens, has been identified as an anticancer agent in various types of cancer. However, its roles in cell proliferation, apoptosis, and migration in a hypoxic microenvironment and the associated regulatory mechanisms have not yet to be fully elucidated in GBC. The present study investigated the effect of oridonin on cell proliferation, apoptosis, the cell cycle and cell migration in GBC in vitro and in vivo. Furthermore, the role of oridonin in hypoxia-induced cell migration and its underlying mechanisms were explored in GBC. The results indicated that treatment with oridonin significantly suppressed cell proliferation and the metastatic ability of GBC-SD cells in a dose-dependent manner, increased the level of cell apoptosis and induced cell cycle arrest at the G0/G1 phase. Further experiments demonstrated that oridonin could inhibit hypoxia-induced epithelial–mesenchymal transition and cell migration by downregulating the expression levels of hypoxia-inducible factor (HIF)-1α/matrix metallopeptidase (MMP)-9. In addition, oridonin suppressed GBC cell growth and downregulated the expression levels of HIF-1α and MMP-9 in a GBC-SD cell xenograft model. Taken together, these results suggest that oridonin possesses anticancer properties in GBC. Notably, oridonin can suppress tumor epithelial–mesenchymal transition and cell migration by targeting the HIF-1α/MMP-9 signaling pathway.

10.1097/cad.0000000000000797

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Search-Based Path Planning among Movable Obstacles

arXiv (Cornell University) (2024)

Zhongqiang Ren Bunyod Suvonov Guofei Chen Botao He Yuan Liao

This paper investigates Path planning Among Movable Obstacles (PAMO), which seeks a minimum cost collision-free path among static obstacles from start to goal while allowing the robot to push away movable obstacles (i.e., objects) along its path when needed. To develop planners that are complete and optimal for PAMO, the planner has to search a giant state space involving both the location of the robot as well as the locations of the objects, which grows exponentially with respect to the number of objects. The main idea in this paper is that, only a small fraction of this giant state space needs to be explored during planning as guided by a heuristic, and most of the objects far away from the robot are intact, which thus leads to runtime efficient algorithms. Based on this idea, this paper introduces two PAMO formulations, i.e., bi-objective and resource constrained problems in an occupancy grid, and develops PAMO*, a search method with completeness and solution optimality guarantees, to solve the two problems. We then further extend PAMO* to hybrid-state PAMO* to plan in continuous spaces with high-fidelity interaction between the robot and the objects. Our results show that, PAMO* can often find optimal solutions within a second in cluttered environments with up to 400 objects.

10.48550/arxiv.2410.18333

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High-throughput Microwell-seq 2.0 profiles massively multiplexed chemical perturbation

Cell Discovery (2021)

Haide Chen Yuan Liao Guodong Zhang Zhongyi Sun Lei Yang

10.1038/s41421-021-00333-7

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New Insights into the Plutella xylostella Detoxifying Enzymes: Sequence Evolution, Structural Similarity, Functional Diversity, and Application Prospects of Glucosinolate Sulfatases

Journal of Agricultural and Food Chemistry (2023)

Wei Chen Muhammad Bilal Amir Yuan Liao Hai‐Zhong Yu Weiyi He

Brassica plants have glucosinolate (GLs)-myrosinase defense mechanisms to deter herbivores. However, Plutella xylostella specifically feeds on Brassica vegetables. The larvae possess three glucosinolate sulfatases (PxGSS1–3) that compete with plant myrosinase for shared GLs substrates and produce nontoxic desulfo-GLs (deGLs). Although PxGSSs are considered potential targets for pest control, the lack of a comprehensive review has hindered the development of PxGSSs-targeted pest control methods. Recent advances in integrative multi-omics analysis, substrate-enzyme kinetics, and molecular biological techniques have elucidated the evolutionary origin and functional diversity of these three PxGSSs. This review summarizes research progress on PxGSSs over the past 20 years, covering sequence properties, evolution, protein modification, enzyme activity, structural variation, substrate specificity, and interaction scenarios based on functional diversity. Finally, we discussed the potential applications of PxGSSs-targeted pest control technologies driven by artificial intelligence, including CRISPR/Cas9-mediated gene drive, transgenic plant-mediated RNAi, small-molecule inhibitors, and peptide inhibitors. These technologies have the potential to overcome current management challenges and promote the development and field application of PxGSSs-targeted pest control.

Myrosinase

10.1021/acs.jafc.3c03246

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A Transcriptomic Analysis Targeting Genes Involved in the Floral Transition of Winter-Flowering Chrysanthemum

Journal of Plant Growth Regulation (2017)

Peilei Cheng Bin Dong Heng Wang Peipei Cao Tao Liu

Flowering Locus C

RNA-Seq

MADS-box

10.1007/s00344-017-9720-8

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Uneven Levels of 5S and 45S rDNA Site Number and Loci Variations across Wild Chrysanthemum Accessions

Genes (2022)

Jun He Yongheng Zhao Shuangshuang Zhang Yanze He Jiafu Jiang

Ribosomal DNA (rDNA) is an excellent cytogenetic marker owing to its tandem arrangement and high copy numbers. However, comparative studies have focused more on the number of rDNA site variations within the Chrysanthemum genus, and studies on the types of rDNA sites with the same experimental procedures at the species levels are lacking. To further explore the number and types of rDNA site variations, we combined related data to draw ideograms of the rDNA sites of Chrysanthemum accessions using oligonucleotide fluorescence in situ hybridization (Oligo-FISH). Latent variations (such as polymorphisms of 45S rDNA sites and co-localized 5S-45S rDNA) also occurred among the investigated accessions. Meanwhile, a significant correlation was observed between the number of 5S rDNA sites and chromosome number. Additionally, the clumped and concentrated geographical distribution of different ploidy Chrysanthemum accessions may significantly promote the karyotype evolution. Based on the results above, we identified the formation mechanism of rDNA variations. Furthermore, these findings may provide a reliable method to examine the sites and number of rDNA variations among Chrysanthemum and its related accessions and allow researchers to further understand the evolutionary and phylogenetic relationships of the Chrysanthemum genus.

Concerted evolution

10.3390/genes13050894

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Early observation and nursing of common symptoms with kidney transplantation in polycystic kidney patients without removing the original kidneys

Zhonghua huli zazhi (2007)

Xiangzhi Li Xiaohua Liu YI Chunyan Yuan Liao Hai-dan Ye

目的探讨多囊肾保留原肾肾移植术后早期常见症状的观察与护理.方法回顾性分析32例多囊肾保留原肾肾移植患者术前及术后早期的临床资料.结果患者肾移植术前均存在不同程度的腰部胀痛、腹胀及高血压,26例有血尿病史,19例术前有肉眼血尿;术后早期所有患者腰部胀痛、腹胀症状缓解不明显;7例患者术后1个月内血压恢复正常,18例患者口服降压药剂量逐渐减少,余7例患者术后1个月内降压药物剂量未减; 6例患者术后3d内尿色转为正常,19例术前有血尿病史的患者移植术后血尿逐渐减轻,持续1～2周后消失,7例患者在移植术后5～10周内肉眼血尿反复,5例伴有低热,经抗感染治疗后症状消失.结论多囊肾保留原肾肾移植与由其他原发病引起的肾功能衰竭的移植术后护理相比有其特殊性.认为多囊肾保留原肾肾移植术后除了应做好普通肾移植术后的相关护理之外,应加强对腰痛、腹胀、高血压、血尿等原多囊肾伴随症状的观察与护理,且加强术后的活动、饮食、用药指导及健康宣教具有重要意义.

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Exploring karyotype by developing novel oligonucleotide probes for Leucanthemum paludosum and other plant species

Scientia Horticulturae (2024)

Xinyu Rao Shuangshuang Zhang Jun He Yongheng Zhao Yueyang Wang

10.1016/j.scienta.2024.113397

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Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization

Scientific Reports (2017)

Ying Shi Xiangru Lai Lingyan Ye Keqiang Chen Zheng Cao

Abstract The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we investigated the role of HCA2 in macrophage-mediated inflammation and the underlying mechanisms. We found that proinflammatory stimulants LPS, IL-6 and IL-1β up-regulated the expression of HCA2 on macrophages. Niacin significantly inhibited macrophage chemotaxis in response to chemoattractants fMLF and CCL2 by disrupting polarized distribution of F-actin and Gβ protein. Niacin showed a selected additive effect on chemoattractant-induced activation of ERK1/2, JNK and PI3K pathways, but only the MEK inhibitor UO126 reduced niacin-mediated inhibition of macrophage chemotaxis, while activation of ERK1/2 by EGF alone did not inhibit fMLF-mediated migration of HEK293T cells co-expressing HCA2 and fMLF receptor FPR1. In addition, niacin induced heterologous desensitization and internalization of FPR1. Furthermore, niacin rescued mice from septic shock by diminishing inflammatory symptoms and the effect was abrogated in HCA2 −/− mice. These results suggest that Gβγ/PKC-dependent ERK1/2 activation and heterologous desensitization of chemoattractant receptors are involved in the inhibition of chemoattractant-induced migration of macrophages by niacin. Thus, HCA2 plays a critical role in host protection against pro-inflammatory insults.

Niacin

Homologous desensitization

10.1038/srep42279

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Citations (32)