Claudia Fernandes de Almeida Oliveira

Universidade Estadual de Feira de Santana

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Edson Antunes

Universidade Estadual de Campinas (UNICAMP)

Gilberto De Nucci

Universidade Estadual de Campinas (UNICAMP)

Iara M. S. De Luca

Universidade Estadual de Campinas (UNICAMP)

Blenda Maria Dos Santos Erdes

Luciana Piovesan Nathan

Universidade Estadual de Campinas (UNICAMP)

Ariel Lopez

Gemini South Observatory

Konradin Metze

Universidade Estadual de Campinas (UNICAMP)

Ana Azevedo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Ana Cristina Lima Leite

Universidade Federal de Pernambuco

Andrew Szentgyorgyi

Center for Astrophysics Harvard & Smithsonian

Cooperative Institutions

Universidade Estadual de Campinas (UNICAMP)

Universidade de São Paulo

Universidade Federal de Pernambuco

Universidade Estadual de Feira de Santana

Universidade Federal de São Paulo

Universidade Federal do Ceará

Universidade Estadual Paulista (Unesp)

Universidade Brasil

Universidade Federal de Juiz de Fora

Hospital Universitário da Universidade de São Paulo

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Development of cardiomyocyte hypotrophy in rats under prolonged treatment with a low dose of a nitric oxide synthesis inhibitor

European Journal of Pharmacology (2000)

Claudia Fernandes de Almeida Oliveira Karine Angélica Cintra Simone A. Teixeira Iara M. S. De Luca Edson Antunes

Myocardial fibrosis

10.1016/s0014-2999(99)00929-2

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Citations (24)

Associação entre Síndrome Metabólica e função renal em homens na Região Metropolitana de Feira de Santana/BA

Anais do ... Seminário de Iniciação Científica/Anais Seminário de Iniciação Científica (2024)

Guilherme Henrique Moura Guimarães Claudia Fernandes de Almeida Oliveira

Define-se Síndrome Metabólica (SM) como um conjunto de anormalidades metabólicas que incluem hipertensão, resistência à insulina, obesidade central e dislipidemia aterogênica, as quais são associadas a um elevado risco para desenvolvimento de doença cardiovascular aterosclerótica.

10.13102/semic.vi27.10723

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Citations (0)

Optimization of multiobject observations with GMT-MANIFEST: a case for the G-CLEF exposure time calculator

Daniel May T. Zafar Vitor Neves-Hartmann Thais R. M. B. Silva Ariel Lopez

Clef

Calculator

10.1117/12.3020531

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Citations (1)

Modulation of Coronary Flow and Cardiomyocyte Size by Sensory Fibers

Hypertension (1999)

Angelina Zanesco Soraia K.P. Costa Sonia Regina Riado Luciana Piovesan Nathan Claudia Fernandes de Almeida Oliveira

Cardiac tissue is densely innervated by sensory neurons that are believed to play important modulatory roles in cardiac functions. In this study, pretreatment of neonate rats with capsaicin was performed. In adult rats, cardiomyocyte size and amount of fibrous tissue in left ventricles as well as in vitro coronary flow were evaluated. The chronotropic and inotropic responses to beta-adrenoceptor agonists (norepinephrine and isoproterenol), muscarinic agonists (carbachol and pilocarpine), and calcitonin gene-related peptide (CGRP) were also investigated with the use of the isolated right atria preparation. Capsaicin pretreatment significantly (P<0.05) reduced both basal coronary flow (18% reduction) and cardiomyocyte size (34% reduction) without affecting the amount of fibrous tissues in the left ventricles. The positive inotropic and chronotropic effects in response to norepinephrine in the isolated rat heart did not significantly differ between control and capsaicin-treated rats. Similarly, the positive chronotropic effects in response to norepinephrine, isoproterenol, and CGRP as well as the negative chronotropic responses to carbachol and pilocarpine in the isolated right atria were not affected by capsaicin pretreatment. Our data are consistent with the suggestion that reductions of both basal coronary flow and cardiomyocyte size seen in hearts from capsaicin-pretreated rats may be consequences of CGRP depletion. The cardiomyocyte size reduction produced by capsaicin treatment may be related to a modulatory role of CGRP as a growth factor.

Capsaicin

10.1161/01.hyp.34.4.790

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Citations (9)

ASSOCIAÇÃO ENTRE OBESIDADE E HIPOGONADISMO COMPENSADO EM UMA POPULAÇÃO MASCULINA DE FEIRA DE SANTANA-BA

Anais do ... Seminário de Iniciação Científica/Anais Seminário de Iniciação Científica (2023)

Blenda Maria Dos Santos Erdes Claudia Fernandes de Almeida Oliveira

Em homens obesos, é esperada a presença de níveis baixos de testosterona (TT) devido à conversão da TT em estradiol pela enzima aromatase. De forma contraria, no hipogonadismo compensado (HC) espera-se que o eixo hipotálamo-hipófise-gonadal (HPG) aumente níveis de hormônio (LH), já que os níveis de TT tendem a diminuir.

10.13102/semic.vi26.9468

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Citations (0)

Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics

Il Farmaco (2000)

Ana Cristina Lima Leite Renata F. F. Vieira Antônio Rodolfo de Faria Almir Gonçalves Wanderley Parviz Afiatpour

Anti-inflammatory

Gram

Peptidomimetic

Gram-Positive Bacteria

10.1016/s0014-827x(00)00099-9

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Citations (28)

ASSOCIAÇÃO ENTRE INFLAMAÇÃO E DIABETES MELLITUS EM HOMENS NA REGIÃO METROPOLITANA DE FEIRA DE SANTANA-BA

Anais do ... Seminário de Iniciação Científica/Anais Seminário de Iniciação Científica (2022)

Blenda Maria Dos Santos Erdes Claudia Fernandes de Almeida Oliveira

O processo inflamatório crônico decorrente da hiperglicemia pode contribuir significativamente para complicações da doença em indivíduos diabéticos. (Lontchi-Yimagou, 2013). A disglicemia promove anormalidades metabólicas que favorece alterações genéticas, intracelulares e teciduais que contribuem para o desenvolvimento de um ambiente pró-inflamatório.

10.13102/semic.vi25.8450

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Attenuation of Hypertension, Cardiomyocyte Hypertrophy, and Myocardial Fibrosis by β-Adrenoceptor Blockers in Rats Under Long-term Blockade of Nitric Oxide Synthesis

Journal of Cardiovascular Pharmacology (2002)

Sandra R. M. C. Pacca Ana Azevedo Claudia Fernandes de Almeida Oliveira Iara M. S. De Luca Gilberto De Nucci

The effects of propranolol and atenolol were investigated on arterial hypertension, cardiomyocyte hypertrophy, and ventricular ischaemic lesions induced by an 8-week treatment with the nitric oxide synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 20 mg/rat per day) in Wistar rats. Propranolol and atenolol (30 mg/rat per day each) were given in the drinking water concomitantly to L-NAME. Treatment with L-NAME induced marked arterial hypertension and cardiomyocyte hypertrophy, both of which were significantly reduced by propranolol and atenolol. A marked repairing fibrosis was also observed in L-NAME-treated rats and this was significantly attenuated in animals receiving the beta-blockers. In L-NAME group, 33% mortality was observed, whereas all the animals from the other groups survived. Our study demonstrates that propranolol and atenolol reduce arterial hypertension, cardiomyocyte hypertrophy and myocardial fibrosis induced by L-NAME, suggesting that beta-blockers are of beneficial value in treatment of vascular and cardiac alterations caused by chronic nitric oxide deficiency.

Atenolol

Essential hypertension

10.1097/00005344-200202000-00006

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Citations (39)

Changes in Sexual Function and Positions in Women with Severe Obesity After Bariatric Surgery

Sexual Medicine (2018)

Claudia Fernandes de Almeida Oliveira Paulo Oliveira dos Santos Reinaldo Ataide de Oliveira Hosannah Leite-Filho Alice Fernandes de Almeida Oliveira

Severe obesity is most effectively treated with bariatric surgery. The resulting weight loss is expected to improve a variety of obesity-related conditions, including sexual dysfunction.To analyze changes in the sexual function of women with obesity following bariatric surgery.A prospective study was conducted between April 2015 and April 2016 involving 62 women with obesity who underwent Roux-en-Y gastric bypass. The Female Sexual Function Index (FSFI) was used to evaluate sexual function. Sexual dysfunction was defined as an FSFI score below 26.55. Patients' clinical and demographic data were recorded. Sexual frequency of 12 different sexual positions was also evaluated.Sexual dysfunction prevalence and the frequency of sexual positions before and 6 months after surgery.The prevalence of sexual dysfunction decreased from 62% before surgery to 19% 6 months after the procedure. There was a 19.2% improvement in the mean overall FSFI score (P < .01). 6 months after surgery, the mean overall FSFI score had improved in all patients, with a statistically significant change being found in all 6 domains of the questionnaire (P < .05). There was an increase in the frequency of 3 of 12 sexual positions evaluated.Sexual function in women with obesity effectively improves after bariatric surgery. Favorable changes following weight loss included a significant reduction in the prevalence of sexual dysfunction and an increase in the frequency of different sexual positions during intercourse. Oliveira CFA, dos Santos PO, Oliveira RA, et al. Changes in sexual function and positions in women with severe obesity after bariatric surgery. Sex Med 2019;7:80-85.

Sexual intercourse

10.1016/j.esxm.2018.10.001

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Citations (22)

Effect of Ca2+ channel blockers on arterial hypertension and heart ischaemic lesions induced by chronic blockade of nitric oxide in the rat

European Journal of Pharmacology (1999)

Claudia Fernandes de Almeida Oliveira Luciana Piovesan Nathan Konradin Metze Heitor Moreno Iara M. S. De Luca

10.1016/s0014-2999(99)00267-8

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Citations (19)