Wenbin Dong

Affiliated Hospital of Southwest Medical University

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Xiaoping Lei

Affiliated Hospital of Southwest Medical University

Lan Kang

Dalian Medical University

Qingping Li

Southern Medical University

Xuesong Zhai

Shanxi Provincial Children's Hospital

Lingping Zhang

Nanjing Normal University

Xiaodan Zhu

First Affiliated Hospital Zhejiang University

Lianyu Zhang

Qinghai No.3 People's Hospital

Yuan Shi

West China Hospital of Sichuan University

Xiuying Tian

Tianjin Central Hospital of Gynecology Obstetrics

Hui Wu

Jilin University

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Chinese Academy of Sciences

132

Capital Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Network Group (Czechia)

Affiliated Hospital of Southwest Medical University

Shanghai Jiao Tong University

Sichuan University

Central South University

University of Chinese Academy of Sciences

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Cytokines and meconium aspiration syndrome

Foreign Medical Sciences Section of Maternal and Child Health (2005)

Wenbin Dong

Meconium aspiration syndrome(MAS) is a common respiratory disease of neonates. C ytokines play very important roles in development of MAS, especially in meconium -induced lung injury. After meconium aspiration, many cy tokines such as TNF, IL-1, IL-2, IL-6, IL-8 and so on are released , which ind uces and aggravates inflammatory reactions in the lungs. The aim of this article is to describe the roles of some important cytokines in development of MAS, so as to provide a new thinking for treatment of MAS.

Meconium aspiration syndrome

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Resveratrol alleviates alveolar epithelial cell injury induced by hyperoxia by reducing apoptosis and mitochondrial dysfunction

Experimental Biology and Medicine (2020)

Xiaodan Zhu Fan Wang Xiaoping Lei Wenbin Dong

Bronchopulmonary dysplasia is a severe and long-term pulmonary disease in premature infants. Hyperoxia-induced acute lung injury plays a critical role in bronchopulmonary dysplasia. Resveratrol is a polyphenolic phytoalexin and a natural agonist of Sirtuin 1. Many studies have shown that resveratrol has a protective effect on hyperoxia-induced lung damage, but its specific protective mechanism is still not clear. Further exploration of the possible protective mechanism of resveratrol was the main goal of this study. In this study, human alveolar epithelial cells were used to establish a hyperoxia-induced acute lung injury cell model, and resveratrol (Res or R), the Sirtuin 1 activator SRT1720 (S) and the Sirtuin 1 inhibitor EX-527 (E) were administered to alveolar epithelial cells, which were then exposed to hyperoxia to investigate the role of Res in mitochondrial function and apoptosis. We divided human alveolar epithelial cells into the following groups: (1) the control group, (2) hyperoxia group, (3) hyperoxia+Res20 group, (4) hyperoxia+Res20+E5 group, (5) hyperoxia+Res20+E10 group, (6) hyperoxia+S2 group, (7) hyperoxia+S2+E5 group, and (8) hyperoxia+S2+E10 group. Hyperoxia-induced cell apoptosis and mitochondrial dysfunction were alleviated by Res and SRT1720. Res and SRT1720 upregulated Sirtuin 1, PGC-1α, NRF1, and TFAM but decreased the expression of acetyl-p53 in human alveolar epithelial cells that were exposed to hyperoxia. These findings revealed that Res may alleviated hyperoxia-induced mitochondrial dysfunction and apoptosis in alveolar epithelial cells through the SIRT1/PGC-1a signaling pathway. Thus, Sirtuin 1 upregulation plays an important role in lung protection.

Hyperoxia

Bronchopulmonary Dysplasia

10.1177/1535370220975106

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RETRACTED: Valsartan treatment of congestive heart failure based on FPGA and dynamic image sampling

Microprocessors and Microsystems (2020)

Wenbin Dong Feng Li Ping Ma

10.1016/j.micpro.2020.103721

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Developing Citrus Germplasm Resistant to Asian Citrus Psyllid Using CRISPR/Cas9 Gene Editing Technology: Recent Advances and Challenges

International Journal of Horticulture (2024)

Xi Wang Yiwei Li Fuping Liu Wenbin Dong Liyu Liang

This study aims to explore recent advances and challenges in developing citrus germplasm resistant to the Asian citrus psyllid (ACP) using CRISPR/Cas9 gene editing technology.The focus is on identifying key genetic targets, evaluating the effectiveness of CRISPR/Cas9-mediated edits, and discussing the implications for sustainable citrus production.Several case studies demonstrate the potential of CRISPR/Cas9 to enhance resistance without compromising yield and fruit quality.Advances in CRISPR/Cas9 techniques, such as base and prime editing, have improved the precision and efficiency of gene editing in citrus.Additionally, field trials have validated the effectiveness of these edited plants in real-world conditions.The findings underscore the significant potential of CRISPR/Cas9 technology in developing ACP-resistant citrus germplasm.However, technical challenges, off-target effects, genetic stability, and regulatory and public acceptance issues remain.Continued research, interdisciplinary collaboration, and clear regulatory frameworks are essential to fully realize the benefits of CRISPR/Cas9 in citrus breeding.These efforts are crucial for ensuring the long-term sustainability and resilience of the citrus industry.

Germ plasm

10.5376/ijh.2024.14.0016

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Evaluation of mild hypothermia therapy for neonatal hypoxic-ischaemic encephalopathy on brain energy metabolism using 18F-fluorodeoxyglucose positron emission computed tomography

Experimental and Therapeutic Medicine (2014)

Mei Luo Qingping Li Wenbin Dong Xuesong Zhai Lan Kang

It remains unclear whether mild hypothermia affects energy metabolism in the brain tissue of newborns with hypoxic-ischaemic encephalopathy (HIE). The current study aimed to investigate the effect of mild hypothermia on energy metabolism in neonatal HIE and assess brain energy metabolism using position emission tomography/computed tomography (PET/CT) scanning. The mean standardised uptake values of 18F-fluorodeoxyglucose (18F-FDG) were used to determine the glucose metabolic rate in various brain anatomical regions, including the thalamus, basal ganglia and the frontal, parietal and occipital lobes. The rate of glucose metabolism significantly improved following treatment with mild hypothermia therapy and conventional therapy (P<0.001). Prior to the treatment, no significant differences were identified between the groups (P>0.05). Following treatment, the rate of glucose metabolism was significantly improved in the mild hypothermia therapy group compared with that in the conventional therapy group (P<0.001). Thus, these results indicate that mild hypothermia therapy effectively promotes the recovery of patients with neonatal HIE. 18F-FDG PET/CT scanning may be used to provide reference values for the assessment of energetic metabolism in patients with neonatal HIE.

Fluorodeoxyglucose

10.3892/etm.2014.1884

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99Tcm-EHIDA SPECT combined with planar hepatobiliary scintigraphy for the differentiation between infant biliary atresia and neonatal hepatitis

Zhonghua heyixue yu fenzi yingxiang zazhi (2016)

Wenlu Zheng Yue Chen Zhanwen Huang Liang Cai Wenbin Dong

Objective To evaluate the value of 99Tcm-EHIDA SPECT combined with planar hepatobiliary scintigraphy (combined scintigraphy) in the differentiation of infant biliary atresia (BA) from neonatal hepatitis (NH). Methods This is a retrospective study on 32 infants with cholestasis (18 males, 14 females; age: 28-83 d) from June 2013 to June 2014. All infants underwent sequential 99Tcm-EHIDA hepatobiliary planar scintigraphy and combined scintigraphy, and the diagnostic efficacy of the 2 methods for differentiating infant BA from NH was analyzed by χ2 test. Results In sequential planar scintigraphy, the diagnostic sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 76.2%(16/21), 6/11, 68.8%(22/32), 76.2%(16/21) and 6/11, respectively. In combined scintigraphy, the diagnostic parameters were 95.2%(20/21), 8/11, 87.5%(28/32), 87.0%(20/23) and 8/9, respectively. Combined scintigraphy correctly identified 4 BA cases that were misdiagnosed as NH by planar scintigraphy. The sensitivity of combined scintigraphy was significantly higher than that of planar scintigraphy (χ2=4.285, P 0.05). Conclusions Combined scintigraphy has incremental value for the differentiation of infant BA from NH. Key words: Biliary atresia; Hepatitis; Infant; Infant, newborn; Radionuclide imaging; Tomography, emission-computed, single-photon; EHIDA

Neonatal hepatitis

10.3760/cma.j.issn.2095-2848.2016.04.005

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Mechanism of p47phox-induced increase of reactive oxygen species in peripheral blood mononuclear cells from premature infants on oxygen therapy

The Journal of Maternal-Fetal & Neonatal Medicine (2016)

Lingping Zhang Wenbin Dong Qingping Li Lan Kang Lianyu Zhang

Objective: This study aimed to explore the mechanism of p47phox-induced increase of reactive oxygen species (ROS) in peripheral blood mononuclear cells (PBMCs) from premature infants after oxygen therapy, and determine a new target for oxidative stress injury alleviation in clinical setting.Methods: First, ROS levels as well as p47phox translocation and expression in PBMC samples were evaluated after treatment of premature infants with different concentrations of oxygen. Then, changes of all various parameters were detected after in vitro treatment of PBMCs with diphenyleneiodonium (DPI), apocynin, and high oxygen levels.Results: In premature infants, ROS levels increased significantly after treatment with oxygen, in a concentration-dependent manner (p < 0.05); meanwhile, p47phox translocation and expression were significantly enhanced (p < 0.05) as well. In agreement, PBMCs cultured in vitro showed increased ROS levels after treatment with high oxygen concentrations; p47phox translocation, and expression increased as well (p < 0.05). However, treatment with DPI or apocynin resulted in opposite effects.Conclusion: Treatment with oxygen increases p47phox translocationand expression, which in turn induce ROS production. DPI and apocynin have the opposite effects.

Apocynin

10.3109/14767058.2015.1135119

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Caffeine and neonatal acute kidney injury

Pediatric Nephrology (2023)

Kun Yang Jinjing Liu Ting He Wenbin Dong

10.1007/s00467-023-06122-6

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Structural elucidation of metabolites of lapachol in rats by liquid chromatographytandem mass spectrometry

Acta Pharmacologica Sinica (2013)