Xiang Zhong

Fourth Hospital of Changsha

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Guisen Li

University of Electronic Science and Technology of China

Laihu Peng

Zhejiang Sci-Tech University

Xin Ru

Zhejiang Sci-Tech University

Xudong Hu

Zhejiang Sci-Tech University

Yang Liangliang

Howard W. Barker

Environment and Climate Change Canada

Weimin Shi

Shanghai Jiao Tong University

Bai Dao-yuan

Mineral Resources

Huang Wenyi

China University of Geosciences

Jia Pengyuan

Cooperative Institutions

Chinese Academy of Sciences

Nanjing Medical University

Wuhan University

University of Electronic Science and Technology of China

Affiliated Hospital of Nantong University

Nantong University

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Peking University

Lanzhou University

Zhongnan Hospital of Wuhan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

RNF2 promotes chondrosarcoma progression by regulating ubiquitination and degradation of CBX7

Cancer & Metabolism (2024)

Yue Wu Zheng Huang Ping Luo Xiang Zhong Meng Zhang

Chondrosarcoma (CHS) is resistant to conventional chemotherapy and radiotherapy and currently lacks effective treatment options when in advanced stages. Accordingly, this research investigated the mechanism of RNF2/CBX7 in CHS to drive the development of molecularly targeted drugs for CHS. RNF2 and CBX7 levels were detected in CHS cells and tissues. RNF2 and CBX7 expression was modulated through cell transfection to examine their effects on cell proliferation, apoptosis, migration, and angiogenesis. The correlation between RNF2 and CBX7 levels was determined, and the ubiquitination level of CBX7 was tested. Protein synthesis was blocked in RNF2-knockdown/overexpressing cells with CHX to assess the effect of RNF2 on CBX7 stability. JJ012 cells transfected with LV-sh-RNF2 were subcutaneously injected into nu/nu nude mice to ascertain the action of RNF2 in the growth and metastasis of CHS. RNF2 was highly expressed in CHS cells and tissues. RNF2 knockdown curbed CHS cell proliferation, migration, and angiogenesis while promoting apoptosis. RNF2 knockdown in JJ012 cells upregulated CBX7 protein levels and reduced CBX7 ubiquitination, whilst RNF2 had no effect on CBX7 mRNA expression. CBX7 knockdown partially nullified the repressing effects of RNF2 knockdown on CHS cell proliferation, migration, and angiogenesis, and CBX7 overexpression partially abolished the promotional effects of RNF2 overexpression. LV-sh-RNF2 prominently restricted tumor growth and weight and declined lung metastatic nodules and Ki-67-positive cells in mice. RNF2 fosters CHS progression by elevating CBX7 degradation via the ubiquitination pathway.

Degradation

10.1186/s40170-024-00359-x

Cite

Citations (0)

The Association Between Variants in PLA2R and HLA-DQA1 and Renal Outcomes in Patients With Primary Membranous Nephropathy in Western China

Research Square (Research Square) (2020)

Shulei Fan Qiuxia Wang Ying Wang Ping Zhang Xiang Zhong

Abstract Background： Both Genome-wide associations and our previous study have shown that single nucleotide polymorphisms (SNPs) of M-type phospholipase A2 receptor (PLA2R) and human leukocyte antigen complex class II HLA-DQα-chain 1 (HLA-DQA1) gene were identified to be associated with primary membranous nephropathy (PMN). However, whether these SNPs affect clinical manifestation and renal outcome for PMN patients is poorly defined. Here, we evaluated whether there is an association between these SNPs and clinical manifestations and renal outcomes of PMN in a western Chinese cohort. Methods: Seven SNPs within PLA2R and one SNP in HLA-DQA1 were selected in our study. Clinical data from 314 patients with PMN were collected and the relationship between the genotype and phenotype was evaluated. A total of 186 patients had follow-up data. We assessed the treatment responses and renal outcomes between patients with these gene polymorphisms after a median follow-up of 18.6 months. Results: Eight SNPs were not associated clinical manifestations of PMN patients (Pc<0.05). rs3828323 T allele was marginally significantly associated with hypertension ( P =0.008, Pc =0.064, OR=1.821). After treatment for PMN, urea (OR=1.184, 95%CI:1.030-1.361, P =0.017) was a risk factor for non-remission of the disease, eGFR (OR=0.984, 95%CI:0.970-0.998, P =0.028) and albumin (OR=0.922, 95%CI:0.880-0.966, P =0.001) were protective factors for non-remission of the disease. We also identified that PMN patients with CT/TT genotype for rs3828323 achieved higher cumulative survival rate than patients with CC genotype. Conclusions： Rs3828323 may influence hypertension and renal outcome in patients with PMN. Further research is needed to explore the mechanism for this genotype-disease phenotype association.

Membranous Nephropathy

SNP

10.21203/rs.3.rs-136132/v1

Cite

Citations (0)

WISP-1のIgA腎症患者における発現と腎間質繊維化の関係【JST・京大機械翻訳】

Zhonghua Shenzangbing Zazhi (2017)

Xiang Zhong Peng Ting Tu Yueju LI Gui-sen Wang Li

Source

Cite

Citations (0)

The Application of Two-Dimensional Impedance Inversion to the Southern East China Sea

offshore Oil (2012)

Xiang Zhong

The disadvantaged factor,such as deep-seated reservoir,worse rock petro-physical property,longer survey line and well data incomplete,results to the weak seismic reflection and lower seismic resolution in late Mesozoic.Therefore,it is hard to make a study on reservoir characterization in this area.In this paper,2D seismic impedance inversion for late Mesozoic interval has been executed in the south ECS area.The results of inversion show that upper basalt and lower glutenite reservoir concentrated in the structure SE in K_1-K_2 strata,in the middle of which is dominated by thin alternating layers of sandstone and mudstone;better petrophysical property reservoir in J,strata,thin and tight sandstone reservoir in J_2-J_3 strata.

Petrophysics

Lithology

Source

Cite

Citations (0)

Evaluation of Clear-Sky Surface Downwelling Shortwave Fluxes Computed by Three Atmospheric Radiative Transfer Models

Jordann Brendecke Xiquan Dong Baike Xi Xiang Zhong Jiangnan Li

Download This Paper Open PDF in Browser Add Paper to My Library Share: Permalink Using these links will ensure access to this page indefinitely Copy URL Copy DOI

Downwelling

Shortwave

Shortwave radiation

Longwave

10.2139/ssrn.4776617

Cite

Citations (0)

湖南省北西部の瓦屋塘プルトンの年代学,成因と構造環境【JST・京大機械翻訳】

Dadi Gouzao yu Chengkuangxue (2016)

Bai Dao-yuan Wu Nengjie Xiang Zhong Jia Pengyuan Xiong Xiong

Source

Cite

Citations (0)

Bacterial Community Composition and Function in a Tropical Municipal Wastewater Treatment Plant

Water (2022)

Yaqiong Gu Beiying Li Xiang Zhong Conghe Liu Bin Ma

Bacterial diversity and community composition are of great importance in wastewater treatment; however, little is known about the diversity and community structure of bacteria in tropical municipal wastewater treatment plants (WWTPs). Therefore, in this study, activated sludge samples were collected from the return sludge, anaerobic sludge, anoxic sludge, and aerobic sludge of an A2O WWTP in Haikou, China. Illumina MiSeq high-throughput sequencing was used to examine the 16S ribosomal RNA (rRNA) of bacteria in the samples. The microbial community diversity in this tropical WWTP was higher than in temperate, subtropical, and plateau WWTPs. Proteobacteria, Bacteroidota, Patescibacteria, and Chloroflexi were the dominant phyla. Nitrification bacteria Nitrosomonas, and Nitrospira were also detected. Tetrasphaera, instead of Candidatus Accumulibacter, were the dominant polyphosphate accumulating organisms (PAOs), while, glycogen accumulating organisms (GAOs), such as Candidatus Competibacter and Defluviicoccus were also detected. The bacterial community functions predicted by PICRUSt2 were related to metabolism, genetic information processing, and environmental information processing. This study provides a reference for the optimization of tropical municipal WWTPs.

Nitrospira

Chloroflexi (class)

Nitrosomonas

10.3390/w14101537

Cite

Citations (26)

Geramage重合磁器パッチ修復体が生髄前歯美容の歯周関連指標に及ぼす影響【JST・京大機械翻訳】

Zhongguo Meirong Yixue (2018)

Xiang Zhong Liu Zhiwen

Source

Cite

Citations (0)