Shaoyang Sun

Fudan University

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Co-Authors

Xu Wang

Fudan University

Yuxiao Yao

Guangzhou Medical University

Fei Fei

Nanjing Drum Tower Hospital

Zhao‐Ru Dong

Qilu Hospital of Shandong University

Min Yu

Sichuan University

Guo‐Ming Shi

Ministry of Education of the People's Republic of China

Ruoyu He

Changsha University of Science and Technology

Minbiao Ji

Fudan University

Ai–Wu Ke

Zhongshan Hospital

Zhiyuan Gong

National University of Singapore

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Fudan University

123

Sun Yat-sen University

Chinese Academy of Sciences

Shanghai Jiao Tong University

Zhongshan Hospital

Shanghai Medical College of Fudan University

The First Affiliated Hospital, Sun Yat-sen University

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Children's Hospital of Fudan University

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Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult

Cancer Research (2018)

Yuxiao Yao Shaoyang Sun Jingjing Wang Fei Fei Zhao‐Ru Dong

Abstract There is limited understanding of the effects of major oncogenic pathways and their combinatorial actions on lipid composition and transformation during hepatic tumorigenesis. Here, we report a negative correlation of Wnt/Myc activity with steatosis in human hepatocellular carcinoma (HCC) and perform in vivo functional studies using three conditional transgenic zebrafish models. Double-transgenic zebrafish larvae conditionally expressing human CTNNB1mt and zebrafish tcf7l2 or murine Myc together with krasv12 in hepatocytes led to severe hepatomegaly and significantly attenuated accumulation of lipid droplets and cell senescence triggered by krasv12 expression alone. UPLC-MS–based, nontargeted lipidomic profiling and transcriptome analyses revealed that Wnt/Myc activity promotes triacylglycerol to phospholipid transformation and increases unsaturated fatty acyl groups in phospholipids in a Ras-dependent manner. Small-scale screenings suggested that supplementation of certain free fatty acids (FA) or inhibition of FA desaturation significantly represses hepatic hyperplasia of double-transgenic larvae and proliferation of three human HCC cells with and without sorafenib. Together, our studies reveal novel Ras-dependent functions of Wnt signaling in remodeling the lipid metabolism of cancerous hepatocytes in zebrafish and identify the SCD inhibitor MK8245 as a candidate drug for therapeutic intervention. Significance: These findings identify FA desaturation as a significant downstream therapeutic target for antagonizing the combinatorial effects of Wnt and Ras signaling pathways in hepatocellular carcinoma. Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/78/19/5548/F1.large.jpg. Cancer Res; 78(19); 5548–60. ©2018 AACR.

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10.1158/0008-5472.can-17-3964

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Citations (55)

Construction and formulation optimization of prothioconazole nanoemulsions for the control of Fusarium graminearum: Enhancing activity and reducing toxicity

Colloids and Surfaces B Biointerfaces (2023)

Ze Lv Xiaohan Meng Shaoyang Sun Tianzhen Jiang Yan Li

Dispersity

Biosafety

EC50

10.1016/j.colsurfb.2023.113379

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Citations (6)

HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish

Molecular Neurobiology (2015)

Yingzi He Zhengmin Wang Shaoyang Sun Dongmei Tang Wenyan Li

HDAC3

Primordium

Lateral line

Morpholino

10.1007/s12035-015-9433-6

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Citations (13)

Preparation and Characterization of a Novel Artemisia Oil Packaging Film and Its Application in Mango Preservation

Foods (2023)

Xiaohan Meng Ze Lv Tianzhen Jiang Yifei Tan Shaoyang Sun

In this work, a new food packaging film was synthesized via blending Artemisia oil (AO) into soybean protein isolate (SPI) and gelatin (Gel) for the postharvest storage of mango. The morphological architecture and mechanical properties of the films were characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), X-ray diffractometer (XRD), and other technologies. The results show that the prepared films had relatively flat surfaces with good mechanical properties. AO enhanced the light-blocking ability of the film, increased the hydrophobicity, and affected the moisture content and water solubility of the film to a certain extent. Furthermore, the antioxidant performance and antifungal (Colletotrichum gloeosporioides) capacity of the films increased with higher AO concentration due to the presence of the active components contained in AO. During mango storage applications, the films showed good freshness retention properties. The above results indicate that SPI–Gel films containing AO have excellent physicochemical and application properties and have great potential in the field of food packaging.

Active packaging

Diffractometer

10.3390/foods12152969

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Citations (5)

Table S2 from Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult

Yuxiao Yao Shaoyang Sun Jingjing Wang Fei Fei Zhao‐Ru Dong

List of raw data of complete lipidomic mass spectrometry data

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Table (database)

LRP6

10.1158/0008-5472.22419876